Detalhe da pesquisa
1.
Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M ß-Lactamases: Biochemical and Structural Analyses.
Antimicrob Agents Chemother
; 67(1): e0093022, 2023 01 24.
Artigo
Inglês
| MEDLINE | ID: mdl-36602311
2.
Natural protein engineering in the Ω-loop: the role of Y221 in ceftazidime and ceftolozane resistance in Pseudomonas-derived cephalosporinase.
Antimicrob Agents Chemother
; 67(11): e0079123, 2023 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37850746
3.
Different Conformations Revealed by NMR Underlie Resistance to Ceftazidime/Avibactam and Susceptibility to Meropenem and Imipenem among D179Y Variants of KPC ß-Lactamase.
Antimicrob Agents Chemother
; 66(4): e0212421, 2022 04 19.
Artigo
Inglês
| MEDLINE | ID: mdl-35311523
4.
Turnover Chemistry and Structural Characterization of the Cj0843c Lytic Transglycosylase of Campylobacter jejuni.
Biochemistry
; 60(14): 1133-1144, 2021 04 13.
Artigo
Inglês
| MEDLINE | ID: mdl-33749238
5.
Molecular recognition of S-nitrosothiol substrate by its cognate protein denitrosylase.
J Biol Chem
; 294(5): 1568-1578, 2019 02 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30538128
6.
Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency.
Hum Mol Genet
; 27(11): 1913-1926, 2018 06 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29566152
7.
Structural Insights into Ceftobiprole Inhibition of Pseudomonas aeruginosa Penicillin-Binding Protein 3.
Antimicrob Agents Chemother
; 64(5)2020 04 21.
Artigo
Inglês
| MEDLINE | ID: mdl-32152075
8.
A Standard Numbering Scheme for Class C ß-Lactamases.
Antimicrob Agents Chemother
; 64(3)2020 02 21.
Artigo
Inglês
| MEDLINE | ID: mdl-31712217
9.
Crystal Structures of KPC-2 and SHV-1 ß-Lactamases in Complex with the Boronic Acid Transition State Analog S02030.
Antimicrob Agents Chemother
; 60(3): 1760-6, 2016 Jan 04.
Artigo
Inglês
| MEDLINE | ID: mdl-26729491
10.
Detecting a quasi-stable imine species on the reaction pathway of SHV-1 ß-lactamase and 6ß-(hydroxymethyl)penicillanic acid sulfone.
Biochemistry
; 54(3): 734-43, 2015 Jan 27.
Artigo
Inglês
| MEDLINE | ID: mdl-25536850
11.
Insights into BAY 60-2770 activation and S-nitrosylation-dependent desensitization of soluble guanylyl cyclase via crystal structures of homologous nostoc H-NOX domain complexes.
Biochemistry
; 52(20): 3601-8, 2013 May 21.
Artigo
Inglês
| MEDLINE | ID: mdl-23614626
12.
ß-Lactamase inhibition by 7-alkylidenecephalosporin sulfones: allylic transposition and formation of an unprecedented stabilized acyl-enzyme.
J Am Chem Soc
; 135(49): 18358-69, 2013 Dec 11.
Artigo
Inglês
| MEDLINE | ID: mdl-24219313
13.
Exploring the inhibition of the soluble lytic transglycosylase Cj0843c of Campylobacter jejuni via targeting different sites with different scaffolds.
Protein Sci
; 32(7): e4683, 2023 07.
Artigo
Inglês
| MEDLINE | ID: mdl-37209283
14.
Identification of a Selective SCoR2 Inhibitor That Protects Against Acute Kidney Injury.
J Med Chem
; 66(8): 5657-5668, 2023 04 27.
Artigo
Inglês
| MEDLINE | ID: mdl-37027003
15.
Crystal structure of a preacylation complex of the ß-lactamase inhibitor sulbactam bound to a sulfenamide bond-containing thiol-ß-lactamase.
J Am Chem Soc
; 134(40): 16798-804, 2012 Oct 10.
Artigo
Inglês
| MEDLINE | ID: mdl-22974281
16.
Crystal structures of KPC-2 ß-lactamase in complex with 3-nitrophenyl boronic acid and the penam sulfone PSR-3-226.
Antimicrob Agents Chemother
; 56(5): 2713-8, 2012 May.
Artigo
Inglês
| MEDLINE | ID: mdl-22330909
17.
Aspartate 102 in the heme domain of soluble guanylyl cyclase has a key role in NO activation.
Biochemistry
; 50(20): 4291-7, 2011 May 24.
Artigo
Inglês
| MEDLINE | ID: mdl-21491881
18.
Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase.
J Biol Chem
; 285(29): 22651-7, 2010 Jul 16.
Artigo
Inglês
| MEDLINE | ID: mdl-20463019
19.
Novel insights into the mode of inhibition of class A SHV-1 beta-lactamases revealed by boronic acid transition state inhibitors.
Antimicrob Agents Chemother
; 55(1): 174-83, 2011 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-21041505
20.
Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase.
Antimicrob Agents Chemother
; 55(5): 2303-9, 2011 May.
Artigo
Inglês
| MEDLINE | ID: mdl-21357298