Detalhe da pesquisa
1.
Crystal structure of the M5 muscarinic acetylcholine receptor.
Proc Natl Acad Sci U S A
; 116(51): 26001-26007, 2019 12 17.
Artigo
Inglês
| MEDLINE | ID: mdl-31772027
2.
Publisher Correction: Structural insights into binding specificity, efficacy and bias of a ß2AR partial agonist.
Nat Chem Biol
; 15(2): 205, 2019 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30504785
3.
Structural insights into binding specificity, efficacy and bias of a ß2AR partial agonist.
Nat Chem Biol
; 14(11): 1059-1066, 2018 11.
Artigo
Inglês
| MEDLINE | ID: mdl-30327561
4.
Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M1 Muscarinic Acetylcholine Receptors.
Mol Pharmacol
; 94(1): 770-783, 2018 07.
Artigo
Inglês
| MEDLINE | ID: mdl-29691279
5.
Purinergic Receptor Transactivation by the ß2-Adrenergic Receptor Increases Intracellular Ca2+ in Nonexcitable Cells.
Mol Pharmacol
; 91(5): 533-544, 2017 05.
Artigo
Inglês
| MEDLINE | ID: mdl-28280061
6.
Endogenous allosteric modulators of G protein-coupled receptors.
J Pharmacol Exp Ther
; 353(2): 246-60, 2015 May.
Artigo
Inglês
| MEDLINE | ID: mdl-25650376
7.
Quantification of ligand bias for clinically relevant ß2-adrenergic receptor ligands: implications for drug taxonomy.
Mol Pharmacol
; 85(3): 492-509, 2014 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-24366668
8.
Single nucleotide variations encoding missense mutations in G protein-coupled receptors may contribute to autism.
Br J Pharmacol
; 2023 Feb 14.
Artigo
Inglês
| MEDLINE | ID: mdl-36787962
9.
Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR.
Eur J Med Chem
; 258: 115588, 2023 Oct 05.
Artigo
Inglês
| MEDLINE | ID: mdl-37423123
10.
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.
Elife
; 122023 05 30.
Artigo
Inglês
| MEDLINE | ID: mdl-37248726
11.
Opportunities and challenges for the development of M1 muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits.
Br J Pharmacol
; 2022 Nov 10.
Artigo
Inglês
| MEDLINE | ID: mdl-36355830
12.
Biased Profile of Xanomeline at the Recombinant Human M4 Muscarinic Acetylcholine Receptor.
ACS Chem Neurosci
; 13(8): 1206-1218, 2022 04 20.
Artigo
Inglês
| MEDLINE | ID: mdl-35380782
13.
Development of Novel 4-Arylpyridin-2-one and 6-Arylpyrimidin-4-one Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor.
ChemMedChem
; 16(1): 216-233, 2021 01 08.
Artigo
Inglês
| MEDLINE | ID: mdl-32851779
14.
Identification of a Novel Allosteric Site at the M5 Muscarinic Acetylcholine Receptor.
ACS Chem Neurosci
; 12(16): 3112-3123, 2021 08 18.
Artigo
Inglês
| MEDLINE | ID: mdl-34351123
15.
H2 relaxin is a biased ligand relative to H3 relaxin at the relaxin family peptide receptor 3 (RXFP3).
Mol Pharmacol
; 77(5): 759-72, 2010 May.
Artigo
Inglês
| MEDLINE | ID: mdl-20159943
16.
Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias.
Front Pharmacol
; 11: 606656, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-33584282
17.
Restoring Agonist Function at a Chemogenetically Modified M1 Muscarinic Acetylcholine Receptor.
ACS Chem Neurosci
; 11(24): 4270-4279, 2020 12 16.
Artigo
Inglês
| MEDLINE | ID: mdl-33196174
18.
Author Correction: Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response.
Nat Commun
; 11(1): 1929, 2020 Apr 16.
Artigo
Inglês
| MEDLINE | ID: mdl-32300106
19.
Relaxin family peptide receptor (RXFP1) coupling to G(alpha)i3 involves the C-terminal Arg752 and localization within membrane Raft Microdomains.
Mol Pharmacol
; 75(2): 415-28, 2009 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-19029286
20.
Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response.
Nat Commun
; 10(1): 4075, 2019 09 09.
Artigo
Inglês
| MEDLINE | ID: mdl-31501422