Pesquisa | Secretaria de Estado da Saúde

1.

Human Antibodies for Viral Infections.

Crowe, James E.

Annu Rev Immunol; 40: 349-386, 2022 04 26.

Artigo Inglês | MEDLINE | ID: mdl-35113730

2.

Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein.

Suryadevara, Naveenchandra; Shrihari, Swathi; Gilchuk, Pavlo; VanBlargan, Laura A; Binshtein, Elad; Zost, Seth J; Nargi, Rachel S; Sutton, Rachel E; Winkler, Emma S; Chen, Elaine C; Fouch, Mallorie E; Davidson, Edgar; Doranz, Benjamin J; Chen, Rita E; Shi, Pei-Yong; Carnahan, Robert H; Thackray, Larissa B; Diamond, Michael S; Crowe, James E.

Cell; 184(9): 2316-2331.e15, 2021 04 29.

Artigo Inglês | MEDLINE | ID: mdl-33773105

3.

Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection.

Winkler, Emma S; Gilchuk, Pavlo; Yu, Jinsheng; Bailey, Adam L; Chen, Rita E; Chong, Zhenlu; Zost, Seth J; Jang, Hyesun; Huang, Ying; Allen, James D; Case, James Brett; Sutton, Rachel E; Carnahan, Robert H; Darling, Tamarand L; Boon, Adrianus C M; Mack, Matthias; Head, Richard D; Ross, Ted M; Crowe, James E; Diamond, Michael S.

Cell; 184(7): 1804-1820.e16, 2021 04 01.

Artigo Inglês | MEDLINE | ID: mdl-33691139

4.

Pan-ebolavirus protective therapy by two multifunctional human antibodies.

Gilchuk, Pavlo; Murin, Charles D; Cross, Robert W; Ilinykh, Philipp A; Huang, Kai; Kuzmina, Natalia; Borisevich, Viktoriya; Agans, Krystle N; Geisbert, Joan B; Zost, Seth J; Nargi, Rachel S; Sutton, Rachel E; Suryadevara, Naveenchandra; Bombardi, Robin G; Carnahan, Robert H; Bukreyev, Alexander; Geisbert, Thomas W; Ward, Andrew B; Crowe, James E.

Cell; 184(22): 5593-5607.e18, 2021 10 28.

Artigo Inglês | MEDLINE | ID: mdl-34715022

5.

Pan-protective anti-alphavirus human antibodies target a conserved E1 protein epitope.

Kim, Arthur S; Kafai, Natasha M; Winkler, Emma S; Gilliland, Theron C; Cottle, Emily L; Earnest, James T; Jethva, Prashant N; Kaplonek, Paulina; Shah, Aadit P; Fong, Rachel H; Davidson, Edgar; Malonis, Ryan J; Quiroz, Jose A; Williamson, Lauren E; Vang, Lo; Mack, Matthias; Crowe, James E; Doranz, Benjamin J; Lai, Jonathan R; Alter, Galit; Gross, Michael L; Klimstra, William B; Fremont, Daved H; Diamond, Michael S.

Cell; 184(17): 4414-4429.e19, 2021 08 19.

Artigo Inglês | MEDLINE | ID: mdl-34416146

6.

Therapeutic alphavirus cross-reactive E1 human antibodies inhibit viral egress.

Williamson, Lauren E; Reeder, Kristen M; Bailey, Kevin; Tran, Minh H; Roy, Vicky; Fouch, Mallorie E; Kose, Nurgun; Trivette, Andrew; Nargi, Rachel S; Winkler, Emma S; Kim, Arthur S; Gainza, Christopher; Rodriguez, Jessica; Armstrong, Erica; Sutton, Rachel E; Reidy, Joseph; Carnahan, Robert H; McDonald, W Hayes; Schoeder, Clara T; Klimstra, William B; Davidson, Edgar; Doranz, Benjamin J; Alter, Galit; Meiler, Jens; Schey, Kevin L; Julander, Justin G; Diamond, Michael S; Crowe, James E.

Cell; 184(17): 4430-4446.e22, 2021 08 19.

Artigo Inglês | MEDLINE | ID: mdl-34416147

7.

Potent Henipavirus Neutralization by Antibodies Recognizing Diverse Sites on Hendra and Nipah Virus Receptor Binding Protein.

Dong, Jinhui; Cross, Robert W; Doyle, Michael P; Kose, Nurgun; Mousa, Jarrod J; Annand, Edward J; Borisevich, Viktoriya; Agans, Krystle N; Sutton, Rachel; Nargi, Rachel; Majedi, Mahsa; Fenton, Karla A; Reichard, Walter; Bombardi, Robin G; Geisbert, Thomas W; Crowe, James E.

Cell; 183(6): 1536-1550.e17, 2020 12 10.

Artigo Inglês | MEDLINE | ID: mdl-33306954

8.

Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection.

Williamson, Lauren E; Gilliland, Theron; Yadav, Pramod K; Binshtein, Elad; Bombardi, Robin; Kose, Nurgun; Nargi, Rachel S; Sutton, Rachel E; Durie, Clarissa L; Armstrong, Erica; Carnahan, Robert H; Walker, Lauren M; Kim, Arthur S; Fox, Julie M; Diamond, Michael S; Ohi, Melanie D; Klimstra, William B; Crowe, James E.

Cell; 183(7): 1884-1900.e23, 2020 12 23.

Artigo Inglês | MEDLINE | ID: mdl-33301709

9.

Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19.

Woodruff, Matthew C; Ramonell, Richard P; Nguyen, Doan C; Cashman, Kevin S; Saini, Ankur Singh; Haddad, Natalie S; Ley, Ariel M; Kyu, Shuya; Howell, J Christina; Ozturk, Tugba; Lee, Saeyun; Suryadevara, Naveenchandra; Case, James Brett; Bugrovsky, Regina; Chen, Weirong; Estrada, Jacob; Morrison-Porter, Andrea; Derrico, Andrew; Anam, Fabliha A; Sharma, Monika; Wu, Henry M; Le, Sang N; Jenks, Scott A; Tipton, Christopher M; Staitieh, Bashar; Daiss, John L; Ghosn, Eliver; Diamond, Michael S; Carnahan, Robert H; Crowe, James E; Hu, William T; Lee, F Eun-Hyung; Sanz, Ignacio.

Nat Immunol; 21(12): 1506-1516, 2020 12.

Artigo Inglês | MEDLINE | ID: mdl-33028979

10.

A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope.

VanBlargan, Laura A; Adams, Lucas J; Liu, Zhuoming; Chen, Rita E; Gilchuk, Pavlo; Raju, Saravanan; Smith, Brittany K; Zhao, Haiyan; Case, James Brett; Winkler, Emma S; Whitener, Bradley M; Droit, Lindsay; Aziati, Ishmael D; Bricker, Traci L; Joshi, Astha; Shi, Pei-Yong; Creanga, Adrian; Pegu, Amarendra; Handley, Scott A; Wang, David; Boon, Adrianus C M; Crowe, James E; Whelan, Sean P J; Fremont, Daved H; Diamond, Michael S.

Immunity; 54(10): 2399-2416.e6, 2021 10 12.

Artigo Inglês | MEDLINE | ID: mdl-34481543

11.

Bispecific antiviral neutralizing antibodies are twice as nice.

Crowe, James E.

Nat Immunol; 23(3): 346-347, 2022 03.

Artigo Inglês | MEDLINE | ID: mdl-35228693

12.

Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization.

Gilchuk, Pavlo; Murin, Charles D; Milligan, Jacob C; Cross, Robert W; Mire, Chad E; Ilinykh, Philipp A; Huang, Kai; Kuzmina, Natalia; Altman, Pilar X; Hui, Sean; Gunn, Bronwyn M; Bryan, Aubrey L; Davidson, Edgar; Doranz, Benjamin J; Turner, Hannah L; Alkutkar, Tanwee; Flinko, Robin; Orlandi, Chiara; Carnahan, Robert; Nargi, Rachel; Bombardi, Robin G; Vodzak, Megan E; Li, Sheng; Okoli, Adaora; Ibeawuchi, Morris; Ohiaeri, Benjamin; Lewis, George K; Alter, Galit; Bukreyev, Alexander; Saphire, Erica Ollmann; Geisbert, Thomas W; Ward, Andrew B; Crowe, James E.

Immunity; 52(2): 388-403.e12, 2020 02 18.

Artigo Inglês | MEDLINE | ID: mdl-32023489

13.

In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains.

Chen, Rita E; Winkler, Emma S; Case, James Brett; Aziati, Ishmael D; Bricker, Traci L; Joshi, Astha; Darling, Tamarand L; Ying, Baoling; Errico, John M; Shrihari, Swathi; VanBlargan, Laura A; Xie, Xuping; Gilchuk, Pavlo; Zost, Seth J; Droit, Lindsay; Liu, Zhuoming; Stumpf, Spencer; Wang, David; Handley, Scott A; Stine, W Blaine; Shi, Pei-Yong; Davis-Gardner, Meredith E; Suthar, Mehul S; Knight, Miguel Garcia; Andino, Raul; Chiu, Charles Y; Ellebedy, Ali H; Fremont, Daved H; Whelan, Sean P J; Crowe, James E; Purcell, Lisa; Corti, Davide; Boon, Adrianus C M; Diamond, Michael S.

Nature; 596(7870): 103-108, 2021 08.

Artigo Inglês | MEDLINE | ID: mdl-34153975

14.

Potently neutralizing and protective human antibodies against SARS-CoV-2.

Zost, Seth J; Gilchuk, Pavlo; Case, James Brett; Binshtein, Elad; Chen, Rita E; Nkolola, Joseph P; Schäfer, Alexandra; Reidy, Joseph X; Trivette, Andrew; Nargi, Rachel S; Sutton, Rachel E; Suryadevara, Naveenchandra; Martinez, David R; Williamson, Lauren E; Chen, Elaine C; Jones, Taylor; Day, Samuel; Myers, Luke; Hassan, Ahmed O; Kafai, Natasha M; Winkler, Emma S; Fox, Julie M; Shrihari, Swathi; Mueller, Benjamin K; Meiler, Jens; Chandrashekar, Abishek; Mercado, Noe B; Steinhardt, James J; Ren, Kuishu; Loo, Yueh-Ming; Kallewaard, Nicole L; McCune, Broc T; Keeler, Shamus P; Holtzman, Michael J; Barouch, Dan H; Gralinski, Lisa E; Baric, Ralph S; Thackray, Larissa B; Diamond, Michael S; Carnahan, Robert H; Crowe, James E.

Nature; 584(7821): 443-449, 2020 08.

Artigo Inglês | MEDLINE | ID: mdl-32668443

15.

B cell overexpression of FCRL5 and PD-1 is associated with low antibody titers in HCV infection.

Ogega, Clinton O; Skinner, Nicole E; Flyak, Andrew I; Clark, Kaitlyn E; Board, Nathan L; Bjorkman, Pamela J; Crowe, James E; Cox, Andrea L; Ray, Stuart C; Bailey, Justin R.

PLoS Pathog; 18(1): e1010179, 2022 01.

Artigo Inglês | MEDLINE | ID: mdl-34990486

16.

Epitope-focused immunogen design based on the ebolavirus glycoprotein HR2-MPER region.

Schoeder, Clara T; Gilchuk, Pavlo; Sangha, Amandeep K; Ledwitch, Kaitlyn V; Malherbe, Delphine C; Zhang, Xuan; Binshtein, Elad; Williamson, Lauren E; Martina, Cristina E; Dong, Jinhui; Armstrong, Erica; Sutton, Rachel; Nargi, Rachel; Rodriguez, Jessica; Kuzmina, Natalia; Fiala, Brooke; King, Neil P; Bukreyev, Alexander; Crowe, James E; Meiler, Jens.

PLoS Pathog; 18(5): e1010518, 2022 05.

Artigo Inglês | MEDLINE | ID: mdl-35584193

17.

A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface.

Bangaru, Sandhya; Lang, Shanshan; Schotsaert, Michael; Vanderven, Hillary A; Zhu, Xueyong; Kose, Nurgun; Bombardi, Robin; Finn, Jessica A; Kent, Stephen J; Gilchuk, Pavlo; Gilchuk, Iuliia; Turner, Hannah L; García-Sastre, Adolfo; Li, Sheng; Ward, Andrew B; Wilson, Ian A; Crowe, James E.

Cell; 177(5): 1136-1152.e18, 2019 05 16.

Artigo Inglês | MEDLINE | ID: mdl-31100268

18.

Potent neutralization of Rift Valley fever virus by human monoclonal antibodies through fusion inhibition.

Chapman, Nathaniel S; Zhao, Haiyan; Kose, Nurgun; Westover, Jonna B; Kalveram, Birte; Bombardi, Robin; Rodriguez, Jessica; Sutton, Rachel; Genualdi, Joseph; LaBeaud, A Desiree; Mutuku, Francis M; Pittman, Phillip R; Freiberg, Alexander N; Gowen, Brian B; Fremont, Daved H; Crowe, James E.

Proc Natl Acad Sci U S A; 118(14)2021 04 06.

Artigo Inglês | MEDLINE | ID: mdl-33782133

19.

Antibody affinity versus dengue morphology influences neutralization.

Fibriansah, Guntur; Lim, Elisa X Y; Marzinek, Jan K; Ng, Thiam-Seng; Tan, Joanne L; Huber, Roland G; Lim, Xin-Ni; Chew, Valerie S Y; Kostyuchenko, Victor A; Shi, Jian; Anand, Ganesh S; Bond, Peter J; Crowe, James E; Lok, Shee-Mei.

PLoS Pathog; 17(2): e1009331, 2021 02.

Artigo Inglês | MEDLINE | ID: mdl-33621239

20.

Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection.

Saphire, Erica Ollmann; Schendel, Sharon L; Fusco, Marnie L; Gangavarapu, Karthik; Gunn, Bronwyn M; Wec, Anna Z; Halfmann, Peter J; Brannan, Jennifer M; Herbert, Andrew S; Qiu, Xiangguo; Wagh, Kshitij; He, Shihua; Giorgi, Elena E; Theiler, James; Pommert, Kathleen B J; Krause, Tyler B; Turner, Hannah L; Murin, Charles D; Pallesen, Jesper; Davidson, Edgar; Ahmed, Rafi; Aman, M Javad; Bukreyev, Alexander; Burton, Dennis R; Crowe, James E; Davis, Carl W; Georgiou, George; Krammer, Florian; Kyratsous, Christos A; Lai, Jonathan R; Nykiforuk, Cory; Pauly, Michael H; Rijal, Pramila; Takada, Ayato; Townsend, Alain R; Volchkov, Viktor; Walker, Laura M; Wang, Cheng-I; Zeitlin, Larry; Doranz, Benjamin J; Ward, Andrew B; Korber, Bette; Kobinger, Gary P; Andersen, Kristian G; Kawaoka, Yoshihiro; Alter, Galit; Chandran, Kartik; Dye, John M.

Cell; 174(4): 938-952.e13, 2018 08 09.

Artigo Inglês | MEDLINE | ID: mdl-30096313

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