Pesquisa | Secretaria de Estado da Saúde

1.

Gene Regulatory Circuits in Innate and Adaptive Immune Cells.

Saini, Ankita; Ghoneim, Hazem E; Lio, Chan-Wang Jerry; Collins, Patrick L; Oltz, Eugene M.

Annu Rev Immunol; 40: 387-411, 2022 04 26.

Artigo Inglês | MEDLINE | ID: mdl-35119910

2.

Developmental plasticity allows outside-in immune responses by resident memory T cells.

Fonseca, Raissa; Beura, Lalit K; Quarnstrom, Clare F; Ghoneim, Hazem E; Fan, Yiping; Zebley, Caitlin C; Scott, Milcah C; Fares-Frederickson, Nancy J; Wijeyesinghe, Sathi; Thompson, Emily A; Borges da Silva, Henrique; Vezys, Vaiva; Youngblood, Benjamin; Masopust, David.

Nat Immunol; 21(4): 412-421, 2020 04.

Artigo Inglês | MEDLINE | ID: mdl-32066954

3.

Beta cell-specific CD8⁺ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes.

Abdelsamed, Hossam A; Zebley, Caitlin C; Nguyen, Hai; Rutishauser, Rachel L; Fan, Yiping; Ghoneim, Hazem E; Crawford, Jeremy Chase; Alfei, Francesca; Alli, Shanta; Ribeiro, Susan Pereira; Castellaw, Ashley H; McGargill, Maureen A; Jin, Hongjian; Boi, Shannon K; Speake, Cate; Serti, Elisavet; Turka, Laurence A; Busch, Michael E; Stone, Mars; Deeks, Steven G; Sekaly, Rafick-Pierre; Zehn, Dietmar; James, Eddie A; Nepom, Gerald T; Youngblood, Ben.

Nat Immunol; 21(5): 578-587, 2020 05.

Artigo Inglês | MEDLINE | ID: mdl-32231298

4.

T cell exhaustion-a memory locked behind scars.

Yousif, Amir; Ghoneim, Hazem E.

Nat Immunol; 22(8): 938-940, 2021 08.

Artigo Inglês | MEDLINE | ID: mdl-34312546

5.

De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation.

Ghoneim, Hazem E; Fan, Yiping; Moustaki, Ardiana; Abdelsamed, Hossam A; Dash, Pradyot; Dogra, Pranay; Carter, Robert; Awad, Walid; Neale, Geoff; Thomas, Paul G; Youngblood, Ben.

Cell; 170(1): 142-157.e19, 2017 Jun 29.

Artigo Inglês | MEDLINE | ID: mdl-28648661

6.

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection.

Alfei, Francesca; Kanev, Kristiyan; Hofmann, Maike; Wu, Ming; Ghoneim, Hazem E; Roelli, Patrick; Utzschneider, Daniel T; von Hoesslin, Madlaina; Cullen, Jolie G; Fan, Yiping; Eisenberg, Vasyl; Wohlleber, Dirk; Steiger, Katja; Merkler, Doron; Delorenzi, Mauro; Knolle, Percy A; Cohen, Cyrille J; Thimme, Robert; Youngblood, Benjamin; Zehn, Dietmar.

Nature; 571(7764): 265-269, 2019 07.

Artigo Inglês | MEDLINE | ID: mdl-31207605

7.

Effector CD8 T cells dedifferentiate into long-lived memory cells.

Youngblood, Ben; Hale, J Scott; Kissick, Haydn T; Ahn, Eunseon; Xu, Xiaojin; Wieland, Andreas; Araki, Koichi; West, Erin E; Ghoneim, Hazem E; Fan, Yiping; Dogra, Pranay; Davis, Carl W; Konieczny, Bogumila T; Antia, Rustom; Cheng, Xiaodong; Ahmed, Rafi.

Nature; 552(7685): 404-409, 2017 12 21.

Artigo Inglês | MEDLINE | ID: mdl-29236683

8.

Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation.

Zebley, Caitlin C; Abdelsamed, Hossam A; Ghoneim, Hazem E; Alli, Shanta; Brown, Charmaine; Haydar, Dalia; Mi, Tian; Harris, Tarsha; McGargill, Maureen A; Krenciute, Giedre; Youngblood, Ben.

Cell Rep; 37(2): 109796, 2021 10 12.

Artigo Inglês | MEDLINE | ID: mdl-34644568

9.

Influenza A virus directly modulates mouse eosinophil responses.

LeMessurier, Kim S; Rooney, Robert; Ghoneim, Hazem E; Liu, Baoming; Li, Kui; Smallwood, Heather S; Samarasinghe, Amali E.

J Leukoc Biol; 108(1): 151-168, 2020 07.

Artigo Inglês | MEDLINE | ID: mdl-32386457

10.

Generating long-lived CD8(+) T-cell memory: Insights from epigenetic programs.

Dogra, Pranay; Ghoneim, Hazem E; Abdelsamed, Hossam A; Youngblood, Ben.

Eur J Immunol; 46(7): 1548-62, 2016 07.

Artigo Inglês | MEDLINE | ID: mdl-27230488

11.

Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections.

Ghoneim, Hazem E; Thomas, Paul G; McCullers, Jonathan A.

J Immunol; 191(3): 1250-9, 2013 Aug 01.

Artigo Inglês | MEDLINE | ID: mdl-23804714

12.

Adjunctive corticosteroid therapy improves lung immunopathology and survival during severe secondary pneumococcal pneumonia in mice.

Ghoneim, Hazem E; McCullers, Jonathan A.

J Infect Dis; 209(9): 1459-68, 2014 May 01.

Artigo Inglês | MEDLINE | ID: mdl-24273183

13.

Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59.

Ellebedy, Ali H; Lupfer, Christopher; Ghoneim, Hazem E; DeBeauchamp, Jennifer; Kanneganti, Thirumala-Devi; Webby, Richard J.

Proc Natl Acad Sci U S A; 108(7): 2927-32, 2011 Feb 15.

Artigo Inglês | MEDLINE | ID: mdl-21270336

14.

Immunopathogenic and antibacterial effects of H3N2 influenza A virus PB1-F2 map to amino acid residues 62, 75, 79, and 82.

Alymova, Irina V; Green, Amanda M; van de Velde, Nicholas; McAuley, Julie L; Boyd, Kelli L; Ghoneim, Hazem E; McCullers, Jonathan A.

J Virol; 85(23): 12324-33, 2011 Dec.

Artigo Inglês | MEDLINE | ID: mdl-21937639

15.

Fatal outcome of pandemic H1N1 2009 influenza virus infection is associated with immunopathology and impaired lung repair, not enhanced viral burden, in pregnant mice.

Marcelin, Glendie; Aldridge, Jerry R; Duan, Susu; Ghoneim, Hazem E; Rehg, Jerold; Marjuki, Henju; Boon, Adrianus C M; McCullers, Jonathan A; Webby, Richard J.

J Virol; 85(21): 11208-19, 2011 Nov.

Artigo Inglês | MEDLINE | ID: mdl-21865394

16.

Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis.

Abdelsamed, Hossam A; Moustaki, Ardiana; Fan, Yiping; Dogra, Pranay; Ghoneim, Hazem E; Zebley, Caitlin C; Triplett, Brandon M; Sekaly, Rafick-Pierre; Youngblood, Ben.

J Exp Med; 214(6): 1593-1606, 2017 06 05.

Artigo Inglês | MEDLINE | ID: mdl-28490440

17.

Cell-Intrinsic Barriers of T Cell-Based Immunotherapy.

Ghoneim, Hazem E; Zamora, Anthony E; Thomas, Paul G; Youngblood, Ben A.

Trends Mol Med; 22(12): 1000-1011, 2016 12.

Artigo Inglês | MEDLINE | ID: mdl-27825667

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