Pesquisa | Secretaria de Estado da Saúde

1.

Germinal Centers.

Victora, Gabriel D; Nussenzweig, Michel C.

Annu Rev Immunol; 40: 413-442, 2022 04 26.

Artigo Inglês | MEDLINE | ID: mdl-35113731

2.

Antibody Affinity Shapes the Choice between Memory and Germinal Center B Cell Fates.

Viant, Charlotte; Weymar, Georg H J; Escolano, Amelia; Chen, Spencer; Hartweger, Harald; Cipolla, Melissa; Gazumyan, Anna; Nussenzweig, Michel C.

Cell; 183(5): 1298-1311.e11, 2020 11 25.

Artigo Inglês | MEDLINE | ID: mdl-33125897

3.

Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies.

Barnes, Christopher O; West, Anthony P; Huey-Tubman, Kathryn E; Hoffmann, Magnus A G; Sharaf, Naima G; Hoffman, Pauline R; Koranda, Nicholas; Gristick, Harry B; Gaebler, Christian; Muecksch, Frauke; Lorenzi, Julio C Cetrulo; Finkin, Shlomo; Hägglöf, Thomas; Hurley, Arlene; Millard, Katrina G; Weisblum, Yiska; Schmidt, Fabian; Hatziioannou, Theodora; Bieniasz, Paul D; Caskey, Marina; Robbiani, Davide F; Nussenzweig, Michel C; Bjorkman, Pamela J.

Cell; 182(4): 828-842.e16, 2020 08 20.

Artigo Inglês | MEDLINE | ID: mdl-32645326

4.

Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins.

Wang, Zijun; Muecksch, Frauke; Cho, Alice; Gaebler, Christian; Hoffmann, Hans-Heinrich; Ramos, Victor; Zong, Shuai; Cipolla, Melissa; Johnson, Briana; Schmidt, Fabian; DaSilva, Justin; Bednarski, Eva; Ben Tanfous, Tarek; Raspe, Raphael; Yao, Kaihui; Lee, Yu E; Chen, Teresia; Turroja, Martina; Milard, Katrina G; Dizon, Juan; Kaczynska, Anna; Gazumyan, Anna; Oliveira, Thiago Y; Rice, Charles M; Caskey, Marina; Bieniasz, Paul D; Hatziioannou, Theodora; Barnes, Christopher O; Nussenzweig, Michel C.

Immunity; 55(6): 998-1012.e8, 2022 06 14.

Artigo Inglês | MEDLINE | ID: mdl-35447092

5.

Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations.

Muecksch, Frauke; Weisblum, Yiska; Barnes, Christopher O; Schmidt, Fabian; Schaefer-Babajew, Dennis; Wang, Zijun; C Lorenzi, Julio C; Flyak, Andrew I; DeLaitsch, Andrew T; Huey-Tubman, Kathryn E; Hou, Shurong; Schiffer, Celia A; Gaebler, Christian; Da Silva, Justin; Poston, Daniel; Finkin, Shlomo; Cho, Alice; Cipolla, Melissa; Oliveira, Thiago Y; Millard, Katrina G; Ramos, Victor; Gazumyan, Anna; Rutkowska, Magdalena; Caskey, Marina; Nussenzweig, Michel C; Bjorkman, Pamela J; Hatziioannou, Theodora; Bieniasz, Paul D.

Immunity; 54(8): 1853-1868.e7, 2021 08 10.

Artigo Inglês | MEDLINE | ID: mdl-34331873

6.

53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.

Callen, Elsa; Di Virgilio, Michela; Kruhlak, Michael J; Nieto-Soler, Maria; Wong, Nancy; Chen, Hua-Tang; Faryabi, Robert B; Polato, Federica; Santos, Margarida; Starnes, Linda M; Wesemann, Duane R; Lee, Ji-Eun; Tubbs, Anthony; Sleckman, Barry P; Daniel, Jeremy A; Ge, Kai; Alt, Frederick W; Fernandez-Capetillo, Oscar; Nussenzweig, Michel C; Nussenzweig, André.

Cell; 153(6): 1266-80, 2013 Jun 06.

Artigo Inglês | MEDLINE | ID: mdl-23727112

7.

Combination anti-HIV antibodies provide sustained virological suppression.

Sneller, Michael C; Blazkova, Jana; Justement, J Shawn; Shi, Victoria; Kennedy, Brooke D; Gittens, Kathleen; Tolstenko, Jekaterina; McCormack, Genevieve; Whitehead, Emily J; Schneck, Rachel F; Proschan, Michael A; Benko, Erika; Kovacs, Colin; Oguz, Cihan; Seaman, Michael S; Caskey, Marina; Nussenzweig, Michel C; Fauci, Anthony S; Moir, Susan; Chun, Tae-Wook.

Nature; 606(7913): 375-381, 2022 06.

Artigo Inglês | MEDLINE | ID: mdl-35650437

8.

Prolonged viral suppression with anti-HIV-1 antibody therapy.

Gaebler, Christian; Nogueira, Lilian; Stoffel, Elina; Oliveira, Thiago Y; Breton, Gaëlle; Millard, Katrina G; Turroja, Martina; Butler, Allison; Ramos, Victor; Seaman, Michael S; Reeves, Jacqueline D; Petroupoulos, Christos J; Shimeliovich, Irina; Gazumyan, Anna; Jiang, Caroline S; Jilg, Nikolaus; Scheid, Johannes F; Gandhi, Rajesh; Walker, Bruce D; Sneller, Michael C; Fauci, Anthony; Chun, Tae-Wook; Caskey, Marina; Nussenzweig, Michel C.

Nature; 606(7913): 368-374, 2022 06.

Artigo Inglês | MEDLINE | ID: mdl-35418681

9.

Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost.

Muecksch, Frauke; Wang, Zijun; Cho, Alice; Gaebler, Christian; Ben Tanfous, Tarek; DaSilva, Justin; Bednarski, Eva; Ramos, Victor; Zong, Shuai; Johnson, Brianna; Raspe, Raphael; Schaefer-Babajew, Dennis; Shimeliovich, Irina; Daga, Mridushi; Yao, Kai-Hui; Schmidt, Fabian; Millard, Katrina G; Turroja, Martina; Jankovic, Mila; Oliveira, Thiago Y; Gazumyan, Anna; Caskey, Marina; Hatziioannou, Theodora; Bieniasz, Paul D; Nussenzweig, Michel C.

Nature; 607(7917): 128-134, 2022 07.

Artigo Inglês | MEDLINE | ID: mdl-35447027

10.

Dynamic regulation of T_FH selection during the germinal centre reaction.

Merkenschlager, Julia; Finkin, Shlomo; Ramos, Victor; Kraft, Julian; Cipolla, Melissa; Nowosad, Carla R; Hartweger, Harald; Zhang, Wenzhu; Olinares, Paul Dominic B; Gazumyan, Anna; Oliveira, Thiago Y; Chait, Brian T; Nussenzweig, Michel C.

Nature; 591(7850): 458-463, 2021 03.

Artigo Inglês | MEDLINE | ID: mdl-33536617

11.

High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape.

Schmidt, Fabian; Weisblum, Yiska; Rutkowska, Magdalena; Poston, Daniel; DaSilva, Justin; Zhang, Fengwen; Bednarski, Eva; Cho, Alice; Schaefer-Babajew, Dennis J; Gaebler, Christian; Caskey, Marina; Nussenzweig, Michel C; Hatziioannou, Theodora; Bieniasz, Paul D.

Nature; 600(7889): 512-516, 2021 12.

Artigo Inglês | MEDLINE | ID: mdl-34544114

12.

Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection.

Wang, Zijun; Muecksch, Frauke; Schaefer-Babajew, Dennis; Finkin, Shlomo; Viant, Charlotte; Gaebler, Christian; Hoffmann, Hans- Heinrich; Barnes, Christopher O; Cipolla, Melissa; Ramos, Victor; Oliveira, Thiago Y; Cho, Alice; Schmidt, Fabian; Da Silva, Justin; Bednarski, Eva; Aguado, Lauren; Yee, Jim; Daga, Mridushi; Turroja, Martina; Millard, Katrina G; Jankovic, Mila; Gazumyan, Anna; Zhao, Zhen; Rice, Charles M; Bieniasz, Paul D; Caskey, Marina; Hatziioannou, Theodora; Nussenzweig, Michel C.

Nature; 595(7867): 426-431, 2021 07.

Artigo Inglês | MEDLINE | ID: mdl-34126625

13.

Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination.

Cho, Alice; Muecksch, Frauke; Schaefer-Babajew, Dennis; Wang, Zijun; Finkin, Shlomo; Gaebler, Christian; Ramos, Victor; Cipolla, Melissa; Mendoza, Pilar; Agudelo, Marianna; Bednarski, Eva; DaSilva, Justin; Shimeliovich, Irina; Dizon, Juan; Daga, Mridushi; Millard, Katrina G; Turroja, Martina; Schmidt, Fabian; Zhang, Fengwen; Tanfous, Tarek Ben; Jankovic, Mila; Oliveria, Thiago Y; Gazumyan, Anna; Caskey, Marina; Bieniasz, Paul D; Hatziioannou, Theodora; Nussenzweig, Michel C.

Nature; 600(7889): 517-522, 2021 12.

Artigo Inglês | MEDLINE | ID: mdl-34619745

14.

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants.

Wang, Zijun; Schmidt, Fabian; Weisblum, Yiska; Muecksch, Frauke; Barnes, Christopher O; Finkin, Shlomo; Schaefer-Babajew, Dennis; Cipolla, Melissa; Gaebler, Christian; Lieberman, Jenna A; Oliveira, Thiago Y; Yang, Zhi; Abernathy, Morgan E; Huey-Tubman, Kathryn E; Hurley, Arlene; Turroja, Martina; West, Kamille A; Gordon, Kristie; Millard, Katrina G; Ramos, Victor; Da Silva, Justin; Xu, Jianliang; Colbert, Robert A; Patel, Roshni; Dizon, Juan; Unson-O'Brien, Cecille; Shimeliovich, Irina; Gazumyan, Anna; Caskey, Marina; Bjorkman, Pamela J; Casellas, Rafael; Hatziioannou, Theodora; Bieniasz, Paul D; Nussenzweig, Michel C.

Nature; 592(7855): 616-622, 2021 04.

Artigo Inglês | MEDLINE | ID: mdl-33567448

15.

Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants.

Xu, Jianliang; Xu, Kai; Jung, Seolkyoung; Conte, Andrea; Lieberman, Jenna; Muecksch, Frauke; Lorenzi, Julio Cesar Cetrulo; Park, Solji; Schmidt, Fabian; Wang, Zijun; Huang, Yaoxing; Luo, Yang; Nair, Manoj S; Wang, Pengfei; Schulz, Jonathan E; Tessarollo, Lino; Bylund, Tatsiana; Chuang, Gwo-Yu; Olia, Adam S; Stephens, Tyler; Teng, I-Ting; Tsybovsky, Yaroslav; Zhou, Tongqing; Munster, Vincent; Ho, David D; Hatziioannou, Theodora; Bieniasz, Paul D; Nussenzweig, Michel C; Kwong, Peter D; Casellas, Rafael.

Nature; 595(7866): 278-282, 2021 07.

Artigo Inglês | MEDLINE | ID: mdl-34098567

16.

Evolution of antibody immunity to SARS-CoV-2.

Gaebler, Christian; Wang, Zijun; Lorenzi, Julio C C; Muecksch, Frauke; Finkin, Shlomo; Tokuyama, Minami; Cho, Alice; Jankovic, Mila; Schaefer-Babajew, Dennis; Oliveira, Thiago Y; Cipolla, Melissa; Viant, Charlotte; Barnes, Christopher O; Bram, Yaron; Breton, Gaëlle; Hägglöf, Thomas; Mendoza, Pilar; Hurley, Arlene; Turroja, Martina; Gordon, Kristie; Millard, Katrina G; Ramos, Victor; Schmidt, Fabian; Weisblum, Yiska; Jha, Divya; Tankelevich, Michael; Martinez-Delgado, Gustavo; Yee, Jim; Patel, Roshni; Dizon, Juan; Unson-O'Brien, Cecille; Shimeliovich, Irina; Robbiani, Davide F; Zhao, Zhen; Gazumyan, Anna; Schwartz, Robert E; Hatziioannou, Theodora; Bjorkman, Pamela J; Mehandru, Saurabh; Bieniasz, Paul D; Caskey, Marina; Nussenzweig, Michel C.

Nature; 591(7851): 639-644, 2021 03.

Artigo Inglês | MEDLINE | ID: mdl-33461210

17.

Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice.

De Gasparo, Raoul; Pedotti, Mattia; Simonelli, Luca; Nickl, Petr; Muecksch, Frauke; Cassaniti, Irene; Percivalle, Elena; Lorenzi, Julio C C; Mazzola, Federica; Magrì, Davide; Michalcikova, Tereza; Haviernik, Jan; Honig, Vaclav; Mrazkova, Blanka; Polakova, Natalie; Fortova, Andrea; Tureckova, Jolana; Iatsiuk, Veronika; Di Girolamo, Salvatore; Palus, Martin; Zudova, Dagmar; Bednar, Petr; Bukova, Ivana; Bianchini, Filippo; Mehn, Dora; Nencka, Radim; Strakova, Petra; Pavlis, Oto; Rozman, Jan; Gioria, Sabrina; Sammartino, Josè Camilla; Giardina, Federica; Gaiarsa, Stefano; Pan-Hammarström, Qiang; Barnes, Christopher O; Bjorkman, Pamela J; Calzolai, Luigi; Piralla, Antonio; Baldanti, Fausto; Nussenzweig, Michel C; Bieniasz, Paul D; Hatziioannou, Theodora; Prochazka, Jan; Sedlacek, Radislav; Robbiani, Davide F; Ruzek, Daniel; Varani, Luca.

Nature; 593(7859): 424-428, 2021 05.

Artigo Inglês | MEDLINE | ID: mdl-33767445

18.

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.

Barnes, Christopher O; Jette, Claudia A; Abernathy, Morgan E; Dam, Kim-Marie A; Esswein, Shannon R; Gristick, Harry B; Malyutin, Andrey G; Sharaf, Naima G; Huey-Tubman, Kathryn E; Lee, Yu E; Robbiani, Davide F; Nussenzweig, Michel C; West, Anthony P; Bjorkman, Pamela J.

Nature; 588(7839): 682-687, 2020 12.

Artigo Inglês | MEDLINE | ID: mdl-33045718

19.

Convergent antibody responses to SARS-CoV-2 in convalescent individuals.

Robbiani, Davide F; Gaebler, Christian; Muecksch, Frauke; Lorenzi, Julio C C; Wang, Zijun; Cho, Alice; Agudelo, Marianna; Barnes, Christopher O; Gazumyan, Anna; Finkin, Shlomo; Hägglöf, Thomas; Oliveira, Thiago Y; Viant, Charlotte; Hurley, Arlene; Hoffmann, Hans-Heinrich; Millard, Katrina G; Kost, Rhonda G; Cipolla, Melissa; Gordon, Kristie; Bianchini, Filippo; Chen, Spencer T; Ramos, Victor; Patel, Roshni; Dizon, Juan; Shimeliovich, Irina; Mendoza, Pilar; Hartweger, Harald; Nogueira, Lilian; Pack, Maggi; Horowitz, Jill; Schmidt, Fabian; Weisblum, Yiska; Michailidis, Eleftherios; Ashbrook, Alison W; Waltari, Eric; Pak, John E; Huey-Tubman, Kathryn E; Koranda, Nicholas; Hoffman, Pauline R; West, Anthony P; Rice, Charles M; Hatziioannou, Theodora; Bjorkman, Pamela J; Bieniasz, Paul D; Caskey, Marina; Nussenzweig, Michel C.

Nature; 584(7821): 437-442, 2020 08.

Artigo Inglês | MEDLINE | ID: mdl-32555388

20.

Longitudinal clonal dynamics of HIV-1 latent reservoirs measured by combination quadruplex polymerase chain reaction and sequencing.

Cho, Alice; Gaebler, Christian; Olveira, Thiago; Ramos, Victor; Saad, Marwa; Lorenzi, Julio C C; Gazumyan, Anna; Moir, Susan; Caskey, Marina; Chun, Tae-Wook; Nussenzweig, Michel C.

Proc Natl Acad Sci U S A; 119(4)2022 01 25.

Artigo Inglês | MEDLINE | ID: mdl-35042816

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