Increases in amyloid-ß42 slow cognitive and clinical decline in Alzheimer's disease trials.

Positive effects of new anti-amyloid-ß (Aß) monoclonal antibodies in Alzheimer's disease (AD) have been attributed to brain amyloid reduction. However, most anti-Aß antibodies also increase the CSF levels of the 42-amino acid isoform (Aß42). We evaluated the associations of changes in CSF Aß42 and brain Aß-PET with cognitive and clinical end points in randomized trials of anti-Aß drugs that lowered (ß- and γ-secretase inhibitors) or increased CSF Aß42 levels (anti-Aß monoclonal antibodies) to test the hypothesis that post-treatment increases in CSF Aß42 levels are independently associated with cognitive and clinical outcomes. From long-term (≥12 months) randomized placebo-controlled clinical trials of anti-Aß drugs published until November 2023, we calculated the post-treatment versus baseline difference in ADAS-Cog (cognitive subscale of the Alzheimer's Disease Assessment Scale) and CDR-SB (Clinical Dementia Rate-Sum of Boxes) and z-standardized changes in CSF Aß42 and Aß-PET Centiloids (CL). We estimated the effect size [regression coefficients (RCs) and confidence intervals (CIs)] and the heterogeneity (I2) of the associations between AD biomarkers and cognitive and clinical end points using random-effects meta-regression models. We included 25 966 subjects with AD from 24 trials. In random-effects analysis, increases in CSF Aß42 were associated with slower decline in ADAS-Cog (RC: -0.55; 95% CI: -0.89, -0.21, P = 0.003, I2 = 61.4%) and CDR-SB (RC: -0.16; 95% CI: -0.26, -0.06, P = 0.002, I2 = 34.5%). Similarly, decreases in Aß-PET were associated with slower decline in ADAS-Cog (RC: 0.69; 95% CI: 0.48, 0.89, P < 0.001, I2 = 0%) and CDR-SB (RC: 0.26; 95% CI: 0.18, 0.33, P < 0.001, I2 = 0%). Sensitivity analyses yielded similar results. Higher CSF Aß42 levels after exposure to anti-Aß drugs are independently associated with slowing cognitive impairment and clinical decline. Increases in Aß42 may represent a mechanism of potential benefit of anti-Aß monoclonal antibodies in AD.

Long-acting exenatide does not prevent cognitive decline in mild cognitive impairment: a proof-of-concept clinical trial.

PURPOSE: According to preclinical evidence, GLP-1 receptor may be an actionable target in neurodegenerative disorders, including Alzheimer's disease (AD). Previous clinical trials of GLP-1 receptor agonists were conducted in patients with early AD, yielding mixed results. The aim was to assess in a proof-of-concept study whether slow-release exenatide, a long-acting GLP-1 agonist, can benefit the cognitive performance of people with mild cognitive impairment (MCI). METHODS: Thirty-two (16 females) patients were randomized to either slow-release exenatide (n = 17; 2 mg s.c. once a week) or no treatment (n = 15) for 32 weeks. The primary endpoint was the change in ADAS-Cog11 cognitive test score at 32 weeks vs baseline. Secondary endpoints herein reported included additional cognitive tests and plasma readouts of GLP-1 receptor engagement. Statistical analysis was conducted by intention to treat. RESULTS: No significant between-group effects of exenatide on ADAS-Cog11 score (p = 0.17) were detected. A gender interaction with treatment was observed (p = 0.04), due to worsening of the ADAS-Cog11 score in women randomized to exenatide (p = 0.018), after correction for age, scholar level, dysglycemia, and ADAS-Cog score baseline value. Fasting plasma glucose (p = 0.02) and body weight (p = 0.03) decreased in patients randomized to exenatide. CONCLUSION: In patients with MCI, a 32-week trial with slow-release exenatide had no beneficial effect on cognitive performance. TRIAL REGISTRATION NUMBER: NCT03881371, registered on 21 July, 2016.

Driver Drowsiness Multi-Method Detection for Vehicles with Autonomous Driving Functions.

The article outlines various approaches to developing a fuzzy decision algorithm designed for monitoring and issuing warnings about driver drowsiness. This algorithm is based on analyzing EOG (electrooculography) signals and eye state images with the aim of preventing accidents. The drowsiness warning system comprises key components that learn about, analyze and make decisions regarding the driver's alertness status. The outcomes of this analysis can then trigger warnings if the driver is identified as being in a drowsy state. Driver drowsiness is characterized by a gradual decline in attention to the road and traffic, diminishing driving skills and an increase in reaction time, all contributing to a higher risk of accidents. In cases where the driver does not respond to the warnings, the ADAS (advanced driver assistance systems) system should intervene, assuming control of the vehicle's commands.

Optimizing Camera Exposure Time for Automotive Applications.

Camera-based object detection is integral to advanced driver assistance systems (ADAS) and autonomous vehicle research, and RGB cameras remain indispensable for their spatial resolution and color information. This study investigates exposure time optimization for such cameras, considering image quality in dynamic ADAS scenarios. Exposure time, the period during which the camera sensor is exposed to light, directly influences the amount of information captured. In dynamic scenarios, such as those encountered in typical driving scenarios, optimizing exposure time becomes challenging due to the inherent trade-off between Signal-to-Noise Ratio (SNR) and motion blur, i.e., extending exposure time to maximize information capture increases SNR, but also increases the risk of motion blur and overexposure, particularly in low-light conditions where objects may not be fully illuminated. The study introduces a comprehensive methodology for exposure time optimization under various lighting conditions, examining its impact on image quality and computer vision performance. Traditional image quality metrics show a poor correlation with computer vision performance, highlighting the need for newer metrics that demonstrate improved correlation. The research presented in this paper offers guidance into the enhancement of single-exposure camera-based systems for automotive applications. By addressing the balance between exposure time, image quality, and computer vision performance, the findings provide a road map for optimizing camera settings for ADAS and autonomous driving technologies, contributing to safety and performance advancements in the automotive landscape.

Bayesian Gaussian Mixture Models for Enhanced Radar Sensor Modeling: A Data-Driven Approach towards Sensor Simulation for ADAS/AD Development.

In the realm of road safety and the evolution toward automated driving, Advanced Driver Assistance and Automated Driving (ADAS/AD) systems play a pivotal role. As the complexity of these systems grows, comprehensive testing becomes imperative, with virtual test environments becoming crucial, especially for handling diverse and challenging scenarios. Radar sensors are integral to ADAS/AD units and are known for their robust performance even in adverse conditions. However, accurately modeling the radar's perception, particularly the radar cross-section (RCS), proves challenging. This paper adopts a data-driven approach, using Gaussian mixture models (GMMs) to model the radar's perception for various vehicles and aspect angles. A Bayesian variational approach automatically infers model complexity. The model is expanded into a comprehensive radar sensor model based on object lists, incorporating occlusion effects and RCS-based detectability decisions. The model's effectiveness is demonstrated through accurate reproduction of the RCS behavior and scatter point distribution. The full capabilities of the sensor model are demonstrated in different scenarios. The flexible and modular framework has proven apt for modeling specific aspects and allows for an easy model extension. Simultaneously, alongside model extension, more extensive validation is proposed to refine accuracy and broaden the model's applicability.

Sensor-Fused Nighttime System for Enhanced Pedestrian Detection in ADAS and Autonomous Vehicles.

Ensuring a safe nighttime environmental perception system relies on the early detection of vulnerable road users with minimal delay and high precision. This paper presents a sensor-fused nighttime environmental perception system by integrating data from thermal and RGB cameras. A new alignment algorithm is proposed to fuse the data from the two camera sensors. The proposed alignment procedure is crucial for effective sensor fusion. To develop a robust Deep Neural Network (DNN) system, nighttime thermal and RGB images were collected under various scenarios, creating a labeled dataset of 32,000 image pairs. Three fusion techniques were explored using transfer learning, alongside two single-sensor models using only RGB or thermal data. Five DNN models were developed and evaluated, with experimental results showing superior performance of fused models over non-fusion counterparts. The late-fusion system was selected for its optimal balance of accuracy and response time. For real-time inferencing, the best model was further optimized, achieving 33 fps on the embedded edge computing device, an 83.33% improvement in inference speed over the system without optimization. These findings are valuable for advancing Advanced Driver Assistance Systems (ADASs) and autonomous vehicle technologies, enhancing pedestrian detection during nighttime to improve road safety and reduce accidents.

Automated Lane Centering: An Off-the-Shelf Computer Vision Product vs. Infrastructure-Based Chip-Enabled Raised Pavement Markers.

Safe autonomous vehicle (AV) operations depend on an accurate perception of the driving environment, which necessitates the use of a variety of sensors. Computational algorithms must then process all of this sensor data, which typically results in a high on-vehicle computational load. For example, existing lane markings are designed for human drivers, can fade over time, and can be contradictory in construction zones, which require specialized sensing and computational processing in an AV. But, this standard process can be avoided if the lane information is simply transmitted directly to the AV. High definition maps and road side units (RSUs) can be used for direct data transmission to the AV, but can be prohibitively expensive to establish and maintain. Additionally, to ensure robust and safe AV operations, more redundancy is beneficial. A cost-effective and passive solution is essential to address this need effectively. In this research, we propose a new infrastructure information source (IIS), chip-enabled raised pavement markers (CERPMs), which provide environmental data to the AV while also decreasing the AV compute load and the associated increase in vehicle energy use. CERPMs are installed in place of traditional ubiquitous raised pavement markers along road lane lines to transmit geospatial information along with the speed limit using long range wide area network (LoRaWAN) protocol directly to nearby vehicles. This information is then compared to the Mobileye commercial off-the-shelf traditional system that uses computer vision processing of lane markings. Our perception subsystem processes the raw data from both CEPRMs and Mobileye to generate a viable path required for a lane centering (LC) application. To evaluate the detection performance of both systems, we consider three test routes with varying conditions. Our results show that the Mobileye system failed to detect lane markings when the road curvature exceeded ±0.016 m-1. For the steep curvature test scenario, it could only detect lane markings on both sides of the road for just 6.7% of the given test route. On the other hand, the CERPMs transmit the programmed geospatial information to the perception subsystem on the vehicle to generate a reference trajectory required for vehicle control. The CERPMs successfully generated the reference trajectory for vehicle control in all test scenarios. Moreover, the CERPMs can be detected up to 340 m from the vehicle's position. Our overall conclusion is that CERPM technology is viable and that it has the potential to address the operational robustness and energy efficiency concerns plaguing the current generation of AVs.

Assessing advanced driver assistance systems in police vehicles under demanding conditions.

Advanced driver-assistance systems (ADAS) are technologies that can enhance drivers' safety by relieving them from some driving related activities. However, police driving conditions and demands are different from those of civilian drivers. The objective of this study was to assess the impact of ADAS such as forward collision warning (FCW), automatic emergency braking (AEB), and blind spot monitoring (BSM) on police officers' driving performance, workload, and trust in vehicle safety to provide personalised solutions for police vehicles. A driving simulation study was conducted with 18 police officers. ADAS use was assessed under various driving conditions and while officers were engaged in non-driving related tasks. Findings suggested that the FCW and AEB systems improved officers' driving performance, while the BSM system had limited effectiveness due to low salience. ADAS were beneficial under normal driving conditions and when officers were using in-vehicle technology; however, they did not help officers in pursuit conditions.

A driving simulation study was conducted to assess the effect of ADAS in police vehicles under various driving and non-driving related task conditions. The results can help vehicle manufacturers improve the design and usability of ADAS in police cars.

Computational neurosciences and quantitative systems pharmacology: a powerful combination for supporting drug development in neurodegenerative diseases.

Successful clinical development of new therapeutic interventions is notoriously difficult, especially in neurodegenerative diseases, where predictive biomarkers are scarce and functional improvement is often based on patient's perception, captured by structured interviews. As a consequence, mechanistic modeling of the processes relevant to therapeutic interventions in CNS disorders has been lagging behind other disease indications, probably because of the perceived complexity of the brain. However in this report, we develop the argument that a combination of Computational Neurosciences and Quantitative Systems Pharmacology (QSP) modeling of molecular pathways is a powerful simulation tool to enhance the probability of successful drug development for neurodegenerative diseases. Computational Neurosciences aims to predict action potential dynamics and neuronal circuit activation that are ultimately linked to behavioral changes and clinically relevant functional outcomes. These processes can not only be affected by the disease state, but also by common genotype variants on neurotransmitter-related proteins and the psycho-active medications often prescribed in these patient populations. Quantitative Systems Pharmacology (QSP) modeling of molecular pathways allows to simulate key pathological drivers of dementia, such as protein aggregation and neuroinflammatory responses. They often impact neurotransmitter homeostasis and voltage-gated ion-channels or lead to mitochondrial dysfunction, ultimately leading to changes in action potential dynamics and clinical readouts. Combining these two modeling approaches can lead to better actionable understanding of the many non-linear pharmacodynamic processes active in the human diseased brain. Practical applications include a rational selection of the optimal doses in combination therapies, identification of subjects more likely to respond to treatment, a more balanced stratification of treatment arms in terms of comedications, disease status and common genotype variants and re-analysis of small clinical trials to uncover a possible clinical signal. Ultimately this will lead to a higher success rate of bringing new therapeutics to the right patient populations.

Vehicle and Driver Monitoring System Using On-Board and Remote Sensors.

This paper presents an integrated monitoring system for the driver and the vehicle in a single case of study easy to configure and replicate. On-board vehicle sensors and remote sensors are combined to model algorithms for estimating polluting emissions, fuel consumption, driving style and driver's health. The main contribution of this paper is the analysis of interactions among the above monitored features highlighting the influence of the driver in the vehicle performance and vice versa. This analysis was carried out experimentally using one vehicle with different drivers and routes and implemented on a mobile application. Compared to commercial driver and vehicle monitoring systems, this approach is not customized, uses classical sensor measurements, and is based on simple algorithms that have been already proven but not in an interactive environment with other algorithms. In the procedure design of this global vehicle and driver monitoring system, a principal component analysis was carried out to reduce the variables used in the training/testing algorithms with objective to decrease the transfer data via Bluetooth between the used devices: a biometric wristband, a smartphone and the vehicle's central computer. Experimental results show that the proposed vehicle and driver monitoring system predicts correctly the fuel consumption index in 84%, the polluting emissions 89%, and the driving style 89%. Indeed, interesting correlation results between the driver's heart condition and vehicular traffic have been found in this analysis.

Vehicle Localization Kalman Filtering for Traffic Light Advisor Application in Urban Scenarios.

The recent advancements in Intelligent Transportation Systems (ITS) have revealed significant potential for enhancing traffic management through Advanced Driver Assist Systems (ADASs), with benefits for both safety and environment. This research paper proposes a vehicle localization technique based on Kalman filtering, as accurate positioning of the ego-vehicle is essential for the proper functioning of the Traffic Light Advisor (TLA) system. The aim of the TLA is to calculate the most suitable speed to safely reach and pass the first traffic light in front of the vehicle and subsequently keep that velocity constant to overcome the following traffic light, thus allowing safer and more efficient driving practices, thereby reducing safety risks, and minimizing energy consumption. To overcome Global Positioning Systems (GPS) limitations encountered in urban scenarios, a multi-rate sensor fusion approach based on the Kalman filter with map matching and a simple kinematic one-dimensional model is proposed. The experimental results demonstrate an estimation error below 0.5 m on urban roads with GPS signal loss areas, making it suitable for TLA application. The experimental validation of the Traffic Light Advisor system confirmed the expected benefits with a 40% decrease in energy consumption compared to unassisted driving.

Car Bumper Effects in ADAS Sensors at Automotive Radar Frequencies.

Radars in the W-band are being integrated into car bumpers for functionalities such as adaptive cruise control, collision avoidance, or lane-keeping. These Advanced Driving Assistance Systems (ADAS) enhance traffic security in coordination with Intelligent Transport Systems (ITS). This paper analyzes the attenuation effect that car bumpers cause on the signals passing through them. Using the free-space transmission technique inside an anechoic chamber, we measured the attenuation caused by car bumper samples with different material compositions. The results show level drops lower than 1.25 dB in all the samples analyzed. The signal attenuation triggered by the bumpers decreases with the frequency, with differences ranging from 0.55 dB to 0.86 dB when comparing the end frequencies within the radar band. Among the analyzed bumper samples, those with a thicker varnish layer or with talc in the composition seem to attenuate more. We also provide an estimation of the measurement uncertainty for the validation of the obtained results. Uncertainty analysis yields values below 0.21 dB with a 95% coverage interval in the measured frequency band. When comparing the measured value with its uncertainty, i.e., the relative uncertainty, the lower the frequency in the measured band, the more accurate the measurements seem to be.

One-Stage Brake Light Status Detection Based on YOLOv8.

Despite the advancement of advanced driver assistance systems (ADAS) and autonomous driving systems, surpassing the threshold of level 3 of driving automation remains a challenging task. Level 3 of driving automation requires assuming full responsibility for the vehicle's actions, necessitating the acquisition of safer and more interpretable cues. To approach level 3, we propose a novel method for detecting driving vehicles and their brake light status, which is a crucial visual cue relied upon by human drivers. Our proposal consists of two main components. First, we introduce a fast and accurate one-stage brake light status detection network based on YOLOv8. Through transfer learning using a custom dataset, we enable YOLOv8 not only to detect the driving vehicle, but also to determine its brake light status. Furthermore, we present the publicly available custom dataset, which includes over 11,000 forward images along with manual annotations. We evaluate the performance of our proposed method in terms of detection accuracy and inference time on an edge device. The experimental results demonstrate high detection performance with an mAP50 (mean average precision at IoU threshold of 0.50) ranging from 0.766 to 0.793 on the test dataset, along with a short inference time of 133.30 ms on the Jetson Nano device. In conclusion, our proposed method achieves high accuracy and fast inference time in detecting brake light status. This contribution effectively improves safety, interpretability, and comfortability by providing valuable input information for ADAS and autonomous driving technologies.

Driver Identification Using Statistical Features of Motor Activity and Genetic Algorithms.

Driver identification refers to the process whose primary purpose is identifying the person behind the steering wheel using collected information about the driver him/herself. The constant monitoring of drivers through sensors generates great benefits in advanced driver assistance systems (ADAS), to learn more about the behavior of road users. Currently, there are many research works that address the subject in search of creating intelligent models that help to identify vehicle users in an efficient and objective way. However, the different methodologies proposed to create these models are based on data generated from sensors that include different vehicle brands on routes established in real environments, which, although they provide very important information for different purposes, in the case of driver identification, there may be a certain degree of bias due to the different situations in which the route environment may change. The proposed method seeks to intelligently and objectively select the most outstanding statistical features from motor activity generated in the main elements of the vehicle with genetic algorithms for driver identification, this process being newer than those established by the state-of-the-art. The results obtained from the proposal were an accuracy of 90.74% to identify two drivers and 62% for four, using a Random Forest Classifier (RFC). With this, it can be concluded that a comprehensive selection of features can greatly optimize the identification of drivers.

Road User Position and Speed Estimation via Deep Learning from Calibrated Fisheye Videos.

In this paper, we present a deep learning processing flow aimed at Advanced Driving Assistance Systems (ADASs) for urban road users. We use a fine analysis of the optical setup of a fisheye camera and present a detailed procedure to obtain Global Navigation Satellite System (GNSS) coordinates along with the speed of the moving objects. The camera to world transform incorporates the lens distortion function. YOLOv4, re-trained with ortho-photographic fisheye images, provides road user detection. All the information extracted from the image by our system represents a small payload and can easily be broadcast to the road users. The results show that our system is able to properly classify and localize the detected objects in real time, even in low-light-illumination conditions. For an effective observation area of 20 m × 50 m, the error of the localization is in the order of one meter. Although an estimation of the velocities of the detected objects is carried out by offline processing with the FlowNet2 algorithm, the accuracy is quite good, with an error below one meter per second for urban speed range (0 to 15 m/s). Moreover, the almost ortho-photographic configuration of the imaging system ensures that the anonymity of all street users is guaranteed.

Object Detection, Recognition, and Tracking Algorithms for ADASs-A Study on Recent Trends.

Advanced driver assistance systems (ADASs) are becoming increasingly common in modern-day vehicles, as they not only improve safety and reduce accidents but also aid in smoother and easier driving. ADASs rely on a variety of sensors such as cameras, radars, lidars, and a combination of sensors, to perceive their surroundings and identify and track objects on the road. The key components of ADASs are object detection, recognition, and tracking algorithms that allow vehicles to identify and track other objects on the road, such as other vehicles, pedestrians, cyclists, obstacles, traffic signs, traffic lights, etc. This information is then used to warn the driver of potential hazards or used by the ADAS itself to take corrective actions to avoid an accident. This paper provides a review of prominent state-of-the-art object detection, recognition, and tracking algorithms used in different functionalities of ADASs. The paper begins by introducing the history and fundamentals of ADASs followed by reviewing recent trends in various ADAS algorithms and their functionalities, along with the datasets employed. The paper concludes by discussing the future of object detection, recognition, and tracking algorithms for ADASs. The paper also discusses the need for more research on object detection, recognition, and tracking in challenging environments, such as those with low visibility or high traffic density.

An Optimized DNN Model for Real-Time Inferencing on an Embedded Device.

For many automotive functionalities in Advanced Driver Assist Systems (ADAS) and Autonomous Driving (AD), target objects are detected using state-of-the-art Deep Neural Network (DNN) technologies. However, the main challenge of recent DNN-based object detection is that it requires high computational costs. This requirement makes it challenging to deploy the DNN-based system on a vehicle for real-time inferencing. The low response time and high accuracy of automotive applications are critical factors when the system is deployed in real time. In this paper, the authors focus on deploying the computer-vision-based object detection system on the real-time service for automotive applications. First, five different vehicle detection systems are developed using transfer learning technology, which utilizes the pre-trained DNN model. The best performing DNN model showed improvements of 7.1% in Precision, 10.8% in Recall, and 8.93% in F1 score compared to the original YOLOv3 model. The developed DNN model was optimized by fusing layers horizontally and vertically to deploy it in the in-vehicle computing device. Finally, the optimized DNN model is deployed on the embedded in-vehicle computing device to run the program in real-time. Through optimization, the optimized DNN model can run 35.082 fps (frames per second) on the NVIDIA Jetson AGA, 19.385 times faster than the unoptimized DNN model. The experimental results demonstrate that the optimized transferred DNN model achieved higher accuracy and faster processing time for vehicle detection, which is vital for deploying the ADAS system.

Contributions to Unsupervised Online Misalignment Detection and Bumper Error Compensation for Automotive Radar.

One of the fundamental sensors utilized in the Advanced Driver Assist System (ADAS) is the radar sensor. Automotive-related functions need highly precise detection and range of traffic and surroundings; otherwise, the whole ADAS performance suffers. The radar placement beneath a bumper or a cover, the age or exposure to accidents or vehicle vibration, vehicle integration, and mounting tolerances will impact the angular performance of the radar sensor. In this research, we present an unsupervised online method for elevation mounting angle error compensation and a method for bumper and environmental error compensation in the azimuth direction. The proposed methods need no specific calibration jig and may be used to replace traditional initial calibration methods; they also enable ongoing calibration throughout the sensor's lifespan. A first proposed standalone method for vertical alignment uses stationary radar targets reflected from the environment to calculate a vertical misalignment angle with a line-fitting algorithm. The vertical mounting error compensation approach delivers two types of correction values: a dynamic value that converges quickly in the case of minor accidents and a more stable correction value that converges slowly but offers a long-term compensation value over the sensor's lifespan. A second proposed solution uses the vehicle velocity and radar targets properties, like relative velocity and measured azimuth angle, to calculate an individual azimuth correction curve. Real-world data collected from drive testing with a 77 GHz series automobile radar was used to analyze the performance of the proposed methods, yielding encouraging results.

Normative Data of Mini-Mental State Examination, Montreal Cognitive Assessment, and Alzheimer's Disease Assessment Scale-Cognitive Subscale of Community-Dwelling Older Adults in Taiwan.

INTRODUCTION: Appropriate tools and references are essential for evaluating individuals' cognitive levels. This study validated the Taiwan version of the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-cog) and provided normative data for the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), and ADAS-cog in community-dwelling older adults. METHODS: MMSE, MoCA, and ADAS-cog were administered to 150 nondemented healthy adults aged 55-85 years during 2018-2020 as part of the Northeastern Taiwan Community Medicine Research Cohort. ADAS-cog was translated from the original English version to traditional Chinese with cultural and language considerations in Taiwan. Cronbach's alpha (α) tested the reliability of ADAS-cog, and Pearson correlations examined its external validity using MMSE and MoCA as comparisons. Normative data were generated and stratified by age and education, and the one-way analysis of variance compared scores between age and education groups. Another 20 hospital-acquired participants with cognitive impairment joined the 150 healthy participants. Comparisons in the Clinical Dementia Rating (CDR) tiers tested the discriminability of the tests for different cognitive levels. The area under the receiver operating characteristic curve (AUROC) analyzed the power of ADAS-cog in predicting CDR 0.5 from CDR 0. RESULTS: The Taiwan version of ADAS-cog had fair reliability between items (α = 0.727) and good correlations to MMSE (r = -0.673, p < 0.001) and MoCA (r = -0.746, p < 0.001). The normative data of MMSE, MoCA, and ADAS-cog showed ladder changes with age (p = 0.006, 0.001, and 0.437) and education (p < 0.001, <0.001, and <0.001) in the 150 nondemented older adults. Next, in the 170 mixed participants from the communities and the hospital, MMSE, MoCA, and ADAS-cog scores were well differentiable between CDR 0, 0.5, and 1. In addition, ADAS-cog discriminated CDR 0.5 from 0 by an AUROC of 0.827 (p < 0.001). DISCUSSION/CONCLUSION: The three structured cognitive tests consistently reflect cognitive levels of healthy older adults. The Taiwan version of ADAS-cog is compatible with MMSE and MoCA to distinguish people with mildly impaired from normal cognition. In addition, this study derived MMSE, MoCA, and ADAS-cog norms tailored to demographic factors. The findings highlight the need for stratification of age and education rather than applying a fixed cutoff for defining normal and abnormal cognition.

Autistic traits and camouflaging behaviors: a cross-sectional investigation in a University student population.

BACKGROUND: Increasing research is stressing the importance of identifying autistic traits (ATs) in clinical and general populations. University students may be a group at higher risk for the presence of ATs. Recently, specific attention has been paid to camouflaging strategies used by subjects in the autism spectrum in order to cope with the social environment. The aim of this work was to evaluate the prevalence of ATs and camouflaging behaviors in a population of University students. METHODS: Subjects were requested to anonymously fill out through an online form the Adult Autism Subthreshold Spectrum and the Camouflaging AT Questionnaire. RESULTS: ATs were more represented among males and among students of specific fields of study. Camouflaging behaviors were significantly more frequent among subjects with more severe autism spectrum symptoms, without differences depending from sex. CONCLUSIONS: Our study confirms the strong association between ATs and camouflaging behaviors and the relationship between ATs, sex, and specific fields of study.