Evaluation of Mandibular Projection in Class II Division 2 Subjects Following Orthodontic Treatment Using Clear Aligners.

AIM: The purpose of this study was to evaluate the mandibular growth and/or projection following maxillary incisor proclination, overbite correction, and maxillary dentoalveolar expansion without the use of any class II mechanics, in growing class II division 2 patients treated with clear aligners. MATERIALS AND METHODS: Before and after treatment cone-beam computed tomographic (CBCT) generated lateral and posteroanterior cephalograms of thirty-two patients with skeletal class II division 2, 16 in the treatment group and 16 in the untreated group, were reviewed to evaluate treatment-related changes. Upper incisors were proclined and protruded, as well as upper arch expansion and overbite correction were performed as part of their regular treatment. Cephalometric analysis was performed to evaluate skeletal and dental changes. Unpaired statistical t-tests were performed to determine if significant skeletal class II correction was achieved in the treatment group. RESULTS: In the treatment group, after treatment, the upper incisors became more proclined and protruded, and the inter-molar width increased while the overbite was reduced compared to the control group. An increase in skeletal mandibular growth and forward projection was also observed, thus contributing to an improvement of the sagittal skeletal relationship as evidenced by ANB and Wits values compared to the control group. CONCLUSION: A combination of upper incisor proclination, correction of deep overbite, and maxillary dentoalveolar expansion using clear aligners appears to contribute to an improvement of the skeletal class II relationship in growing patients with class II division 2. CLINICAL SIGNIFICANCE: This study shows that unlocking the mandible by correcting a deep overbite, proclining upper incisors, and expanding the upper arch in growing class II division 2 patients can improve skeletal class II using clear aligners. How to cite this article: Mirzasoleiman P, El-Bialy T, Wiltshire WA, et al. Evaluation of Mandibular Projection in Class II Division 2 Subjects Following Orthodontic Treatment Using Clear Aligners. J Contemp Dent Pract 2024;25(4):295-302.

The British Orthodontic Society MOrth cases prize 2014.

This paper describes the orthodontic treatment of two cases that were successful in winning the British Orthodontic Society (BOS) Membership in Orthodonitcs (MOrth) cases prize in 2014. The first case describes the management of a 26-year-old female with a Class II division 2 incisor relationship on a Class III skeletal base with reduced vertical proportions. This was complicated by: an unerupted ectopic palatally displaced upper right permanent canine, an erupted palatally displaced upper left permanent canine, retained deciduous canines, generalised microdontia, an overall Bolton tooth size discrepancy, mild crowding in the upper arch, an increased overbite (complete to tooth tissue) and crossbites. Treatment involved a surgical exposure of the ectopic canine and the use of fixed pre-adjusted edgewise appliances over a period of 24 months. The second case describes the management of a 12-year-old female with a Class II division 2 incisor relationship on a Class 2 skeletal base with reduced vertical proportions. This was complicated by: an increased overjet and overbite (complete to soft tissue), mild upper and lower arch crowding and an increased naso-labial angle. Treatment involved an initial phase of modified Clark Twin Block and sectional fixed appliances followed by complete fixed pre-adjusted edgewise appliances over a period of 24 months.

The John Kay Williams Gold Medal of the Royal College of Surgeons of England and Glasgow 2013.

This paper describes the clinical treatment of two cases treated by the recipient of the 2013 Membership in Orthodontics John Kay Williams Gold Medal of the Royal College of Surgeons of England and Glasgow. The first case describes the management of a 12-year-old male with a class II division 1 malocclusion complicated by Molar Incisal Hypominaralization, an increased overjet and severe upper arch crowding using fixed appliances with anchorage support from temporary anchorage devices. The second case involves the management of a class II division 2 malocclusion complicated by crowding of the upper and lower arches treated on an extraction basis using fixed appliances.

Clear aligner treatment assisted by mini screw for an adult with Class II division 2 malocclusion and a right upper canine completely outside of the dental arch: A case report.

This case report describes a 19-year-old man presented with a 5.7-mm deep overbite, Class II division 2 malocclusion with the right upper maxillary canine completely buccal ectopia, deviated midline in the upper arch, severe crowding and retroclination of the maxillary and mandibular incisors. The patient was treated with clear aligners to correct the Class II relationship and the deep overbite. A series of clear aligners were used to move bilateral maxillary molars distally with unilateral mini-screw anchorage. The final results showed that clear aligners with mini-screws could effectively achieve the required upper distal molar movement thanks to a reasonable design of the stages and anchorage. The treatment was completed in 19 months and the patient was satisfied with the treatment outcome in this context of mild to moderate Class II division 2 malocclusion.

Different manifestations of class II division 2 incisor retroclination and their association with dental anomalies.

OBJECTIVE: To investigate whether there is an association between dental developmental anomalies (DDAs) and different manifestations of class II division 2 (CII/2) malocclusion incisor retroclination. DESIGN: Retrospective comparative study. SETTING: Private orthodontic practice in the regions of Lisbon and Porto, Portugal. SUBJECTS AND METHODS: The sample comprised 115 CII/2 malocclusions distributed into two groups on the basis of incisor retroclination: Group I composed of 48 CII/2 with retroclination exclusively of both maxillary central incisors; Group II composed of 67 CII/2 with retroclination of all four maxillary incisors. Using the initial orthodontic records, it was determined for each patient the presence of the following DDAs: tooth impaction, tooth agenesis, maxillary lateral incisor microdontia, tooth transpositions and supernumerary teeth. RESULTS: Fifty-five per cent of patients were diagnosed with at least one of the DDAs studied. In the total sample the prevalence rates were: 20.0% of palatal maxillary canine impaction, 27.4% of third molar agenesis, and 15.7% of maxillary lateral incisor microdontia. No patient exhibited any transposition or supernumerary teeth. The distribution of the DDAs studied by groups revealed a strong association of palatal canine impaction, tooth agenesis and maxillary lateral incisor microdontia with Group II but not with Group I. CONCLUSION: The association of DDAs with CII/2 malocclusion is not common to all types of maxillary incisor retroclination, suggesting different etiologic factors among the different manifestations of CII/2 incisor retroclination.

Interdisciplinary orthodontics-implants management of a challenging hypodontia case complicated by a class II division 2, bimaxillary retroclination.

INTRODUCTION: The case in this study had moderate hypodontia, with both lower lateral incisors and the lower-left second premolar missing. A Class II division 2 relationship with severe crowding in the upper arch and a traumatic deep bite over a skeletal I base complicated the occlusion. MATERIALS AND METHODS: The plan was to extract the upper first premolars to relieve upper arch crowding and the lower-left impacted second premolar to preserve the bilateral class I molar relationship. A class I occlusal relationship was achieved through space opening in the lower lateral incisors region and space closure in the upper and lower premolars regions. RESULTS: The use of orthodontic screws for bite opening and anterior segment retraction, in conjunction with bi-metric slot size selection in bracket prescription, was effective in controlling incisor inclination and interincisal angle. The use of an implant fixture before beginning the finishing stage allowed for a reduction in total treatment time and facilitated the provision of the final prosthesis before debonding the case. As a result, the patient was able to receive a satisfactory occlusion on the day of debonding. CONCLUSION: This case of moderate hypodontia was successfully resolved by combining space closure and space opening effectively. To solve the arch problems in such Class II division 2 cases with severe crowding, extractions were required. To complete the case, this was combined with intrusive and retractive mechanics. In hypodontia cases, implants are an excellent choice for both aesthetics and functional restoration.

Thirteen-year-old female patient with class II division 2 and normodivergent mandibular retrognathia treated with a fixed buccal appliance. Clinical case No. 221052, Commission of Titularisation. European College of Orthodontics.

Date of birth>09/06/2004; sex: female. Pre-treatment documents>13years 4months old: 07/07/2017. Diagnosis>Skeletal class II with mandibular retrusion, normodivergent facial pattern; class II division 2. Treatment planning>bimaxillary buccal fixed appliance. Duration of active treatment>29months. Post-treatment documents>15years 6months; 20/12/2019. Post-retention documents>16years 7months old; 04/01/2021. Retention period>2years 9months and still continued.

Condylar remodelling in a severe class II deep bite dento-skeletal malocclusion treated with an ortho-surgical approach: A five-year follow-up case report.

Condylar displacement and remodelling are phenomena closely related to orthognathic surgery and critically involved in occlusal and skeletal stability. The aim of the present case report is to describe over time condylar displacement and surface remodelling after bilateral split sagittal osteotomy (BSSO) in an adult patient with severe class II skeletal malocclusion treated with ortho-surgical approach. A male of 21years comes to our observation. The extraoral examination shows a symmetrical square-shaped face, a convex profile, an acute nasolabial angle and a deep labiomental fold. Intraoral examination reveals a class II division 2 with a 2mm deviation of the mandibular midline to the left and the presence of a scissor bite of the bicuspids between quadrants II and III. The Spee curve and overbite are extremely accentuated (OV 14.3mm) as the overjet (11.1mm). Axiographic reconstructions of CBCT show a normal shape and position of both condyles. The cephalometric analysis shows a reduced lower facial height, a normal upper jaw position, a mandibular underdevelopment masked by a very developed symphysis and an extremely low divergence (FMA 11.2°). BSSO for mandibular setback was performed in the 13th month of orthodontic therapy. Original CBCT data before surgery (T0), at the end of treatment (T1), 2years postoperatively (T2) and 5years postoperatively (T3) were collected and reconstructed for 3-dimensional (3D) qualitative analyse. At the end of the surgical-orthodontic treatment (26months), good function and good aesthetics were achieved. The qualitative and comparative analysis of the superimpositions and the cuts made on the CBCT at T0, T1, T2, T3 showed a physiological remodelling and adaptation of the condyles.

Effectiveness of clear aligners in achieving proclination and intrusion of incisors among Class II division 2 patients: a multivariate analysis.

BACKGROUND: The predictability of incisor movement achieved by clear aligners among Class II division 2 patients is poorly understood. The aim of this retrospective study was to determine the effectiveness of clear aligners in proclining and intruding upper incisors and its influencing factors. METHODS: Eligible patients with Class II division 2 malocclusion were included. For clear aligner therapy, three types of incisor movements were designed: proclination, intrusion and labial movement. Pre-treatment and post-treatment dental models were superimposed. The differences between predicted and actual (DPA) tooth movement of incisors were analyzed. Univariate and multivariate linear regression were used to analyze the potential influencing factors. RESULTS: A total of 51 patients and their 173 upper incisors were included. Actual incisor proclination and intrusion were less than predicted ones (both P < 0.001), while actual labial movement was greater than predicted one (P < 0.001). Predictability of incisor proclination and intrusion was 69.8% and 53.3%, respectively. Multivariate linear regression revealed that DPA of proclination was significantly positively associated with predicted proclination (B = 0.174, P < 0.001), ipsilateral premolar extraction (B = 2.773, P < 0.001) and ipsilateral canine proclination (B = 1.811, P < 0.05), while negatively associated with molar distalization (B = - 2.085, P < 0.05). The DPA of intrusion was significantly positively correlated with predicted intrusion (B = 0.556, P < 0.001) while negatively associated with labial mini-implants (B = - 1.466, P < 0.001). The DPA of labial movement was significantly positively associated with predicted labial movement (B = 0.481, P < 0.001), while negatively correlated with molar distalization (B = - 1.004, P < 0.001), labial mini-implants (B = - 0.738, P < 0.001) and age (B = - 0.486, P < 0.05). CONCLUSIONS: For Class II division 2 patients, predicted incisor proclination (69.8%) and intrusion (53.3%) are partially achieved with clear aligner therapy. Excessive labial movement (0.7 mm) of incisors may be achieved. Incisor movement is influenced by predicted movement amount, premolar extraction, canine proclination, molar distalization, mini-implants and age.

Ortho- perio- prosthetic interdisciplinary approach of an adult class II division 2 with multiple premolar agenesis: A case report.

The aim of this case report is to illustrate the fixed orthodontic, surgical and periodontal implant management of a young adult with multiple agenesis associated with a class II division 2 malocclusion. The challenge here was the multidisciplinary synchronisation in order to achieve a coordinated treatment with the best possible aesthetic, prosthetic and functional prognosis. The patient suffered from a total of 10 agenesis including third molars and underwent implant replacement with bone grafting and periodontal planning of the 6 missing premolars. The orthodontic treatment lasted 22months and was followed by a period of just under a year for periodontal and implant prosthetic completion. The 3-year follow-up after the orthodontic phase showed an excellent prognosis in terms of aesthetics, function and stability.

Comparative cephalometric evaluation of tongue position in subjects with skeletal class II division 1 and division 2 malocclusion.

AIM AND OBJECTIVE: To evaluate and compare the position of the tongue from rest to centric occlusion in subjects with skeletal class II division 1 and skeletal class II division 2 malocclusions with subjects of skeletal class II normal occlusion. MATERIAL AND METHODS: The study was conducted on 30 individuals equally divided into three groups of skeletal class II division (div) 1, skeletal class II div 2, and skeletal class I normal occlusion. The study was conducted on two lateral cephalograms for each subject: one taken at rest and one in centric occlusion. RESULTS: On evaluation of tongue posture, a statistically significant difference was observed at the middle portion of the tongue in class II div 1 malocclusion, and at the posteromedial portion of the dorsum of the tongue in class II div 2 skeletal malocclusions as the tongue moved from rest to centric occlusion. While statistically significant differences were found between class II div 2 malocclusion and class I normal occlusion, no statistically significant differences were observed between class II div 1 and class II div 2 malocclusions. CONCLUSION: Tongue position was observed to be the same in both class II div 1 and class II div 2 malocclusions, with no statistically significant differences. However, a great change was seen in the tongue position from rest to centric occlusion.

Sagittal Positional Changes of the Mandible Following Alignment and Levelling of Class II Division 2 Cases: An Observational Study in Decelerating Stages of Adolescent Growth Spurt.

Introduction The objective of this observational study is to compare the dental and skeletal changes that occur following the release of incisor locking in class II division 2 patients in the decelerating phase of the adolescent growth spurt. Materials and methods Lateral cephalograms of 17 subjects with skeletal class II and division 2 malocclusion, taken at the pre-treatment (T1) and post-leveling and alignment (T2) phases, were analyzed. All these patients were treated with non-extraction methods in the initial stage. A total of 25 skeletal and dental parameters, which included linear and angular measurements, were evaluated. Statistical analysis A paired t-test was used to compare the difference in the dimensional values between (T1) and (T2) points of the time period. The results were considered statistically significant at Bonferroni adjusted p<0.002. Results A statistically significant positional change was noted in the condylar position both in the vertical and sagittal directions, resulting in sagittal changes of the mandible in the forward direction. The deep bite was relieved by vertical changes in the dental structures in both the posterior and anterior segments. Growth changes in the vertical direction were also noted but not conclusive. Conclusions There was a definite horizontal shift of the mandible, improving maxillo-mandibular relations following the unlocking of the bite in class II division 2 patients. This shift is mostly attributed to the condylar repositioning in the forward and downward directions.

Torque recovery of the maxillary incisors with a modified double J retractor in a Class II division 2 case treated with clear aligners.

A patient with a Class II division 2 malocclusion is presented, illustrating the application of a modified double J retractor (DJR) and palatal miniscrews along with clear aligners to correct the malocclusion and normalize the incisor torque. In terms of incisor torque recovery, a nonextraction approach might be a good choice if the Class II correction could be successfully achieved with total arch distalization. When maxillary molar distalization was limited by anatomical boundaries, the treatment plan was changed to bilateral maxillary first premolar extractions, which led to even more retroclination of the maxillary incisors after space closure. Anterior interdental miniscrews were used to intrude the maxillary incisors. A modified DJR and palatal miniscrews were used to regain torque and achieve palatal root movement of the maxillary incisors. The treatment effects and biomechanical designs were evaluated for torque recovery of the retroclined maxillary incisors.

Characteristics and Dynamics of Smile in Patients With Skeletal Class II Malocclusion Versus Class I Malocclusion Using Still Digital Video Captures: A Three-Group, Cross-Sectional, Comparative Study.

Background Smiling is one of the effective ways for people to express their feelings. It is an integral part of the diagnosis and planning and a key point of the treatment objectives in orthodontic care. Many factors are associated with a pleasant smile, such as correct anatomy, gingival health, and teeth proportion. Therefore, different malocclusion classes can affect the characteristics of smile esthetics. This study aimed to evaluate the effect of skeletal class II malocclusion on the characteristics and dynamics of the smile in the sagittal and frontal planes. Methodology The study sample included 60 patients comprising three groups of malocclusion classes, namely, Class I, Class II division 1, and Class II division 2. A video recording was taken for 5-10 seconds for each patient using a specific camera mounted at a fixed distance from the imaged face. Two facial expressions were captured for each patient, one representing the lips at rest and the second representing the unrestricted natural smile. The facial still images were derived from the streaming video recording, and two images were chosen for each plane (the frontal plane and the sagittal plane) for each patient. In total, 12 variables were assessed on these captured images. One-way analysis of variance (ANOVA) was used to detect significant differences between the three groups. Results There were statistically significant differences in some of the measured variables. The mean values of thickness of the upper lip, commissure height, gum width, maxillary incisor display, and interlabial gap were greater in the Class II division 1 group than in the other two groups. The proclined incisors were evident in the Class II division 1 group, while the retroclined incisors were evident in the Class II division 2 group. Conclusions The skeletal Class II malocclusion influences the characteristics of the smile, either assessed on the anterior or lateral imaging angles, in addition to its influence on the resting position of the lips. Orthodontists should always analyze patients' facial expressions, including those related to the upper and lower lips at rest and when patients smile naturally. Depending on the results of this analysis, treatment planning could be built to improve the characteristics of the natural smile in patients with Class I and Class II malocclusions.

Treatment of Class II Division 2 Pattern Malocclusion Using Protraction Utility Arch in a Prepubertal Patient: A Clinical Case Report.

Class II malocclusions are one of the most commonly encountered problems in orthodontics. A class II division 2 type of malocclusions is one in which there is distocclusion of the molars along with retroclined central incisors. These occur but quite rarely in the practice and not many varieties of treatment modalities have been published in the recent literature. The use of protraction and retraction utility arch has been advocated in the following case along with fixed orthodontic treatment in a prepubertal male child to obtain stable results. HOW TO CITE THIS ARTICLE: Kannan S, Saravanan S, Arora N, et al. Treatment of Class II Division 2 Pattern malocclusion Using Protraction Utility Arch in a Prepubertal Patient: A Clinical Case Report. Int J Clin Pediatr Dent 2020;13(4):416-420.

Comparison of the collum angle of incisors and canines in skeletal malocclusions - A CBCT study.

INTRODUCTION: The collum angle that defines the crown root angulation of the single rooted teeth plays an important in treatment planning. OBJECTIVE: To compare the collum angle (crown root angulation) of maxillary and mandibular anterior teeth in different skeletal malocclusions using Cone Beam Computed Tomography (CBCT). MATERIALS AND METHODS: Sixty subjects were categorized into four groups (fifteen subjects in each group) Class I, Class II division 1, Class II division 2 malocclusion and Class III based on Angle classification, Wits and ANB. The collum angle of maxillary and mandibular anterior teeth was measured using CBCT. One way ANOVA, Post hoc comparison with Tukey HSD and Paired t-test were used to analyse the measured data. RESULTS: The collum angle of corresponding right and left side teeth were averaged. Thus, the mean and standard deviation of the collum angle (n-30) were generated for maxillary and mandibular central incisors, lateral incisors, and canines. A statistically significant increase was observed in the maxillary central incisors of Class II division 2 and mandibular lateral incisors of class III malocclusion. The collum angle was increased in mandibular canines of Class III malocclusion when compared with class I and Class II division 2 malocclusion. The collum angle was negative in mandibular central incisors of Class II division 2. No statistically significant difference was observed in the mean collum angle between the right and left side anterior teeth in all the four groups. CONCLUSION: A variation in Collum angle was observed between the maxillary and mandibular anterior teeth and malocclusions. The effect of these variations in collum angle in torque expression and biomechanics should be kept in mind by the orthodontist before treatment planning especially in Class II division 2 malocclusion.

Mandibular posterior space in class II division 1 and 2 malocclusion in various age groups.

PURPOSE: The aim of this study was to compare the mandibular posterior space in subjects with skeletal class II division 1 and division 2 malocclusions in two different age groups. METHODS: Pretreatment cephalometric radiographs of 160 patients from 9 to 13 years of age (n = 80) and 15 to 18 years of age (n = 80) with class II division 1 or division 2 malocclusion were used for the study. Equal numbers of male and female patients (n = 20) were included in the two age groups in each of the malocclusion groups. Eight linear and six angular measurements were taken for mandibular posterior space evaluation. The data obtained from the study were compared using the independent t-test. RESULTS: In the present study, the mandibular posterior space was greater in both malocclusion groups in subjects aged 15-18 years than in those aged 9-13 years (p < 0.05). The available posterior spaces behind the mandibular first molars were 4.4 mm and 6.3 mm in females (class II divisions 1 and 2, respectively) and 5.3 mm and 7 mm in males (class II divisions 1 and 2, respectively) in the 9­ to 13-year-old age group. This space increased significantly by 6.9 mm (p < 0.001) and 3.2 mm (p < 0.01) in females (class II division 1 and 2, respectively) and 3.8 mm (p < 0.01) and 3 mm (p < 0.01) in males (class II division 1 and 2, respectively) in the 15- to 18-year-old age group. CONCLUSION: Class II division 1 and division 2 malocclusions had similar and inadequate posterior space dimensions for the eruption of the third and an unknown portion of the second molars.

Controlling incisor torque with completely customized lingual appliances.

PURPOSE: To test the null hypothesis of no significant deviation between the center of rotation (CROT) and the center of resistance (CRES) during space closure in Angle class II division 2 subjects achieved using a completely customized lingual appliance (CCLA) in combination with class II elastics and elastic chains. METHODS: This retrospective study included 29 patients (male/female 11/18; mean age 15.6 [13-27] years) with inclusion criteria of an Angle class II/2 occlusion of least of half of a cusp, maxillary dental arch spacing, completed CCLA treatment (WIN, DW Lingual Systems, Bad Essen, Germany) in one center with a standardized archwire sequence and use of class II elastics and elastic chains only. Maxillary incisor root inclination was assessed by X­ray superimpositions of the maxilla at the beginning (T1) and the end (T3) of CCLA treatment. Using Keynote software (Apple®, Cupertino, CA, USA), the incisor's CROT was assessed with the point of intersection of the incisor axes (T1; T3) following vertical correction of overbite changes. CRES was defined at 36% of the incisor's apex-incisal edge distance. RESULTS: The null hypothesis was rejected: the mean CROT - CRES difference was 52.6% (p < 0.001). The mean CROT was located at 88.6% (min-max 51-100%) of the incisor's apex-incisal edge distance. Although 6.9% of CROT were located between the CRES and the alveolar crest, the vast majority (93.1%) were assessed between the alveolar crest and the incisal edge, or beyond. CONCLUSION: CCLAs can create upper incisor palatal root torque even in cases in which lingually oriented forces applied incisally to the center of resistance of the upper incisors counteract these intended root movements.

Prevalence and patterns of tooth agenesis in Angle class II division 2 malocclusion in Italy: A case-control study.

OBJECTIVE: The aim of this case-control retrospective study was to assess the prevalence and pattern of tooth agenesis in a group of Italian Caucasian test subjects with Class II division 2 malocclusion. The findings were then compared with an Italian control group of orthodontic patients and with previous studies performed in other countries. MATERIAL AND METHOD: Six hundred patients (37 subjects with Angle Class II division 2 malocclusion and 563 orthodontic patients with other malocclusions), aged 7 or older, from the Orthodontic Department of University of Padua Dental Clinic were collected. For this investigation, two expert operators evaluated the Angle Class from dental casts, intraoral photographs and lateral cephalograms. Inclusion criteria for Class II division 2 were: U1-SN less than 90° and overbite>3mm. Tooth agenesis were assessed with digital panoramic radiographs. Third molars were excluded from the analysis. Descriptive analysis using absolute and relative frequencies were performed to check out the prevalence and pattern of tooth agenesis in the sample considered. The relative frequencies in each table were calculated as a percentage based from column total. RESULTS: The prevalence of tooth agenesis in the Angle Class II division 2 group was 18.92%, while in the general population was 8.35%. This result was sufficient to demonstrate a significant difference between the two groups concerning the tooth agenesis prevalence (P-value<0.05). CONCLUSION: Prevalence of permanent tooth agenesis was more than 2 times higher in the Class II division 2 group rather than in the control group. No agenesis of maxillary lateral incisors was found in Class II division 2 group.

Are Noffel's danger signs pathognomonic of class II division 2? A retrospective comparative study.

INTRODUCTION: The 3 Noffel signs, "Ramal height", "Smiling chin", and "B-line space", often present in class II division 2, are called "danger signs" for aesthetics, when they are strongly marked and absolutely need to be taken into account in the therapeutic strategy. The main objective was to assess whether the three measurements associated with Noffel signs (Gonion/Articulare distance, Cutaneous Pogonion/Na-B, and B-line space) were pathognomonic of class II division 2. The secondary objective was to determine whether there was a correlation between the severity of Noffel signs and the sagittal and/or vertical skeletal severity of class II division 2. MATERIALS AND METHODS: In this comparative, mono-centric study based on a retrospective cohort, lateral cephalograms of all the growing patients who were treated at the CSERD between 2012 and 2018 and had normodivergent and hypodivergent profiles, were analysed. RESULTS: The logistic regression analysis showed that only "Total chin" and "B-line space" were significantly related to class II division 2 (P=0.00199; P=0.00778, respectively). The three signs were related to the severity of the hypodivergence, but not to the severity of skeletal class II. CONCLUSION: Only "Total chin" and "B-line space" are pathognomonic of class II division 2. The correlation between the severity of Noffel's three signs and skeletal severity exists only in the vertical dimension.