Post-identifiability in changing sociotechnological genomic data environments.

Data practices in biomedical research often rely on standards that build on normative assumptions regarding privacy and involve 'ethics work.' In an increasingly datafied research environment, identifiability gains a new temporal and spatial dimension, especially in regard to genomic data. In this paper, we analyze how genomic identifiability is considered as a specific data issue in a recent controversial case: publication of the genome sequence of the HeLa cell line. Considering developments in the sociotechnological and data environment, such as big data, biomedical, recreational, and research uses of genomics, our analysis highlights what it means to be (re-)identifiable in the postgenomic era. By showing how the risk of genomic identifiability is not a specificity of the HeLa controversy, but rather a systematic data issue, we argue that a new conceptualization is needed. With the notion of post-identifiability as a sociotechnological situation, we show how past assumptions and ideas about future possibilities come together in the case of genomic identifiability. We conclude by discussing how kinship, temporality, and openness are subject to renewed negotiations along with the changing understandings and expectations of identifiability and status of genomic data.

Designing of graphene oxide-induced p-NiO/n-MoO3 heterostructures for improved photocatalytic activity through plasmon-enhanced S-scheme mechanism and its biological and electrochemical performance.

An environmentally benign, economically advantageous microwave hydrothermal approach is used in synthesis of desirably tailored graphene oxide-induced p-NiO/n-MoO3 (GNM) heterostructures. Various analytical techniques such XPS, XRD, UPS, EIS, and Mott-Schottky were conducted to comprehend complete morphology and functioning of the novel ternary heterostructure photocatalysts. Also, SEM and HR-TEM images were presented for better interpretation. The strategic plasmonic step scheme (S-scheme) charge migration approach was used to describe the effective charge recombination process. Hydroxyl and oxide active species were corollaries of the reactive radical-scavenging experiments and electron spin resonance. The work function has been confirmed using ultraviolet photoelectron spectroscopy (UPS), which assessed an electron transfer between NiO and MoO3, yielding work function values of 6.32 eV and 5.26 eV, respectively. The cell apoptosis of the HeLa cell line approves the material's biocompatibility. Cyclic voltammetry and electrochemical impedance spectroscopy reveal electrochemical performance of GNM heterostructures. We anticipate our results would pave the way for current and future applications. In order to ensure eco-restoration such photocatalyst which are eco and cost friendly are synthesized. Assessment of pollutant risks presents the impact of them on human and terrestrial and aquatic animals. Sustainability of material is acknowledge as they use solar light for photocatalysis and dye degradation, and hence can be green material. One such material for the treatment of wastewater, dye-infused waters, and industrial water has been tailored, which is capable of dye degradation, heavy metal, and other pollutant removal. Very importantly, the synthesized material is a biocompatible one.

Developing of semi-transparent α-Fe2O3/Cu2O heterostructures with S-scheme photocatalytic activity and biological interests.

The scarcity of water has been an outgrowing problem, while population is increasing so is the demand for the water. Hence conservation of water is most important and this material might bring in drastic changes in recycling the wastewater into portable ones. The α-Fe2O3/Cu2O is a desirably tailored nanomaterial synthesized using eco-friendly cost-effective hydrothermal method, where α-Fe2O3 and Cu2O were synthesized separately and later combined to produce an effective material. The material are characterized using advanced techniques like XPS, HR-TEM, XRD, FT-IR, BET, UV-DSR, ESR, LC-MS, ICP-AES, and UPS to understand complete morphology and functioning of the material. They are examined for various application in different fields such as dye degradation, heavy metal removal and organic pollutants elimination via photocatalysis under solar irradiation. The α-Fe2O3 and Cu2O had the work function of 6.10 and 5.49 eV respectively and band energy of 1.46 and 2.6 eV. Docking analysis was carried out to know the protein docking efficiency. Biocompatibility of the materials is addressed upon the HeLa cell line and α-Fe2O3/Cu2O exposure causes inflammation in the lung fluids in a mouse model using the Bronchoalveolar lavage (BAL) assay at high concentrations, proving that the materials can help with current and future biological applications.

A phylogenetic perspective of antiviral species of the genus Artemisia (Asteraceae-Anthemideae): A proposal of anti SARS-CoV-2 (COVID-19) candidate taxa.

Introduction: Different classes of disease-causing viruses are widely distributed universally. Plant-based medicines are anticipated to be effective cures for viral diseases including the COVID-19, instigated by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). This study displays the phylogenetic perspective of Artemisia and proposes some candidate taxa against different viral diseases, including SARS-CoV-2. Methods: Data of Artemisia with antiviral activity were obtained from different published sources and electronic searches. A phylogenetic analysis of the nrDNA ITS sequences of reported antiviral Artemisia species, along with the reference species retrieved from the NCBI GenBank database, was performed using the maximum likelihood (ML) approach. Results: In total, 23 Artemisia species have been documented so far with antiviral activity for 17 different types of viral diseases. 17 out of 23 antiviral Artemisia species were included in the ITS phylogeny, which presented the distribution of these antiviral Artemisia species in clades corresponding to different subgenera of the genus Artemisia. In the resultant ML tree, 10 antiviral Artemisia species appeared within the subgenus Artemisia clade, 2 species appeared within the subgenus Absinthium clade, 3 species appeared within the subgenus Dracunculus clade, and 2 species appeared within the subgenus Seriphidium clade. Discussion: Artemisia species from different subgenera with antiviral activity are prevalent in the genus, with most antiviral species belonging to the subgenus Artemisia. A detailed analysis of taxa from all subgenera, particularly the subgenus Artemisia, is therefore proposed in order to discover compounds with potential anti-SARS-CoV-2 activity.

Reading in the Postgenomic Age: On Contemporary Literature and the Good Bionarrative Citizen.

The "postgenomic age," whose start date roughly corresponds to the turn of the millennium, is characterized not only by the rapid development of genomic technologies and commercial products but also by the widespread publication of literary works focused on genomics and its cultural implications. Defining "postgenomic literature" as literature that is both of and about the postgenomic age, this essay explores how works by nonfiction writer Rebecca Skloot and novelist Richard Powers exemplify a significant trend within the genre: the thematic exploration of ethical questions in the field of literature itself. While both authors address questions of medical and scientific ethics prompted by genomic research, with special emphasis on the exploitation of vulnerable populations, these questions lead readers directly to questions of narrative responsibility: who can tell whose story to whom-and for whose benefit? The Immortal Life of Henrietta Lacks and Generosity: An Enhancement, like other examples of postgenomic literature, invite readers to engage in critical reading practices that resist both textual and genetic determinism.

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges.

Exosomes are small intracellular membrane-based vesicles with different compositions that are involved in several biological and pathological processes. The exploitation of exosomes as drug delivery vehicles offers important advantages compared to other nanoparticulate drug delivery systems such as liposomes and polymeric nanoparticles; exosomes are non-immunogenic in nature due to similar composition as body׳s own cells. In this article, the origin and structure of exosomes as well as their biological functions are outlined. We will then focus on specific applications of exosomes as drug delivery systems in pharmaceutical drug development. An overview of the advantages and challenges faced when using exosomes as a pharmaceutical drug delivery vehicles will also be discussed.

Bounded in a nutshell and a king of infinite space: the embodied self and its intentional world.

This paper explores the implications of developments in phenomenological biology for a reconsideration of synchronicity and the self. The enactive approach of Maturana and Varela aims to reformulate the relation between biological organisms and the world in a non-Cartesian way, breaking down the conceptual division between mind and world so that meaning can be seen as a function of the species-specific way in which an organism engages with its environment. This leads to a view of the self as inherently embodied and engaged with the particularities of its material, cultural and social worlds, while being infinitely extended through the power of imagination; this enables humans to adapt to many different social and material environments. In order to understand these differences, we need to 'enter into the world of the other'. Where understanding of other animals requires immersion in their environmental milieux, understanding other humans requires us also to recognize that differences in socio-cultural milieux create significantly different worlds of meaning and experience.