Chromatin interactions in differentiating keratinocytes reveal novel atopic dermatitis- and psoriasis-associated genes.

BACKGROUND: Hundreds of variants associated with atopic dermatitis (AD) and psoriasis, 2 common inflammatory skin disorders, have previously been discovered through genome-wide association studies (GWASs). The majority of these variants are in noncoding regions, and their target genes remain largely unclear. OBJECTIVE: We sought to understand the effects of these noncoding variants on the development of AD and psoriasis by linking them to the genes that they regulate. METHODS: We constructed genomic 3-dimensional maps of human keratinocytes during differentiation by using targeted chromosome conformation capture (Capture Hi-C) targeting more than 20,000 promoters and 214 GWAS variants and combined these data with transcriptome and epigenomic data sets. We validated our results with reporter assays, clustered regularly interspaced short palindromic repeats activation, and examination of patient gene expression from previous studies. RESULTS: We identified 118 target genes of 82 AD and psoriasis GWAS variants. Differential expression of 58 of the 118 target genes (49%) occurred in either AD or psoriatic lesions, many of which were not previously linked to any skin disease. We highlighted the genes AFG1L, CLINT1, ADO, LINC00302, and RP1-140J1.1 and provided further evidence for their potential roles in AD and psoriasis. CONCLUSIONS: Our work focused on skin barrier pathology through investigation of the interaction profile of GWAS variants during keratinocyte differentiation. We have provided a catalogue of candidate genes that could modulate the risk of AD and psoriasis. Given that only 35% of the target genes are the gene nearest to the known GWAS variants, we expect that our work will contribute to the discovery of novel pathways involved in AD and psoriasis.

Demographic Transition, Human Capital and Economic Growth in China.

We assess the impact of demographic changes on human capital accumulation and aggregate output using an overlapping generations model with endogenous savings and human capital investment decisions. We focus on China as it has experienced rapid changes in demographics as well as human capital levels between 1970 and 2010. Additionally, further variations in demographics are expected due to the recently introduced two-child policy. Model simulations indicate that education shares and income per capita will be lower with a fertility rebound as compared to status quo fertility. We find education policy to be effective in mitigating these adverse outcomes associated with higher fertility. While long-run declines in output per capita can be offset by a 4.7% increase in the government education budget, it requires a 28% increase to achieve the same outcome in the short-run.

Implications of Increasing College Attainment for Aging in General Equilibrium.

We develop an overlapping generations general equilibrium model of the U.S. economy with heterogeneous consumers who face idiosyncratic earnings and health risk to study the implications of increasing college attainment, decreasing fertility, and increasing longevity (2005-2100). While all three trends contribute to a higher old age dependency ratio, increasing college attainment has different implications because it increases labor productivity. Decreasing fertility and increasing longevity require the government to increase the average labor tax rate from 33.5 to 47.1 percent. Increasing college attainment lowers the required tax increase by 12.0 percentage points. The labor tax rate required to balance the government budget is higher under general equilibrium than in a small open economy with a constant interest rate, because the reduction in the interest rate lowers capital income tax revenues.

Optimal Climate Policy and the Future of World Economic Development.

How much should the present generations sacrifice to reduce emissions today, in order to reduce the future harms of climate change? Within climate economics, debate on this question has been focused on so-called "ethical parameters" of social time preference and inequality aversion. We show that optimal climate policy similarly importantly depends on the future of the developing world. In particular, although global poverty is falling and the economic lives of the poor are improving worldwide, leading models of climate economics may be too optimistic about two central predictions: future population growth in poor countries, and future convergence in total factor productivity (TFP). We report results of small modifications to a standard model: under plausible scenarios for high future population growth (especially in sub-Saharan Africa) and for low future TFP convergence, we find that optimal near-term carbon taxes could be substantially larger.

Catching up? The educational mobility of migrants' and natives' children in Europe.

Migrants into European countries are often less educated than European natives. We analyse whether migrants' children are more or less likely than natives' children to achieve upward educational mobility across generations, and study differences in the factors, which contribute to differences in mobility for the two groups. We find that migrants' descendants are more often upwardly mobile (and less often downwardly mobile) than their native peers in the majority of countries studied, and show that the main factor contributing to these patterns is the education level of parents. Although a lower parental education means that their children are less likely to access the same amount of human, social and financial capital as children of more highly educated parents, migrants' descendants over the last two generations were able to make significant progress in reducing education gaps with natives.

Economic and labour market impacts of migration in Austria: an agent-based modelling approach.

This study examines the potential economic and labour market impacts of a hypothetical but plausible migration scenario of 250,000 new migrants inspired by Austria's experience in 2015. Using the agent-based macroeconomic model developed by Poledna et al. (Eur Econ Rev, 151:104306, 2023. 10.1016/j.euroecorev.2022.104306, the study explores the detailed labour market outcomes for different groups in Austria's population and the macroeconomic effects of the migration scenario. The analysis suggests that Austria's economy and labour market have the potential to be resilient to the simulated migration influx. The results indicate a positive impact on GDP due to increased aggregate consumption and investment. The labour market experiences an increase in the unemployment rates of natives and previous migrants. In some industries, the increase in the unemployment rates is more significant, potentially indicating competition among different groups of migrants. This research provides insights for policymakers and stakeholders in Austria and other countries that may face the challenge of managing large-scale migration in the near future. Supplementary Information: The online version contains supplementary material available at 10.1186/s40878-024-00374-3.

Marriage and divorce during a pandemic: the impact of the COVID-19 pandemic on marital formation and dissolution in Mexico.

In this study, we consider the initial effects of the COVID-19 pandemic on family formation and dissolution. We use national microdata covering all marriages and divorces in Mexico, an event-study design and a difference-in-difference specification. Our findings indicate that over March through December of 2020, marriage rates declined by 54% and divorce rates by 43%. By the end of 2020, divorce rates recover back to baseline levels, but marriage rates remain 30% below the 2017-2019 baseline level. Overall, our findings suggest that marital dissolutions quickly recovered (6 months into the pandemic), but at the end of 2020, family formation remained at persistently lower levels.

Trends in Health in Midlife and Late Life.

Gains in life expectancy have recently slowed and mortality inequalities have increased. This paper examines whether trends in health observed at ages 55 to 89 mirror those trends in mortality, which may serve as an early indicator for the future evolution of mortality. We found that many health outcomes have worsened from 1992 to 2016, especially at ages below 70, and that differentials in health between low and high education groups have increased among the more recent cohorts. Overall the findings cast a pessimistic light on the future evolution of mortality rates and mortality inequalities.

Economic complexity and fertility: insights from a low fertility country.

This paper analyzes the relationship between a new indicator of economic context, economic complexity (EC), and fertility change in Italian provinces between 2006 and 2015. We hypothesize that the level of EC is associated with fertility as it reflects a territory's capacity to innovate, grow and create job opportunities. The results illustrate a clear positive association between EC and fertility change across Italian provinces for the period considered, net of traditional fertility predictors. Those areas that stand at the frontiers of EC are also more likely to dominate and adapt to the negative consequences of globalization.

Racial Differences in the Effect of Marriageable Males on Female Family Headship.

Female family headship has strong implications for endemic poverty in the United States. Consequently, it is imperative to explore the chief factors that contribute to this problem. Departing from prior literature that places significant weight on welfare-incentive effects, our study highlights the role of male marriageability in explaining the prevalence of never-married female family headship for blacks and whites. Specifically, we examine racial differences in the effect of male marriageability on never-married female headship from 1980 to 2010. By exploiting data from IPUMS-USA (N = 4,958,722) and exogenous variation from state-level sentencing reforms, the study finds that the decline in the relative supply of marriageable males significantly increases the incidence of never-married female family headship for blacks but not for whites.

Health care expenditures, age, proximity to death and morbidity: Implications for an ageing population.

This paper uses Hospital Episode Statistics, English administrative data, to investigate the growth in admitted patient health care expenditures and the implications of an ageing population. We use two samples of around 40,000 individuals who (a) used inpatient health care in the financial year 2005/06 and died by the end of 2011/12 and (b) died in 2011/12 and had some hospital utilisation since 2005/06. We use a panel structure to follow individuals over seven years of this administrative data, containing estimates of inpatient health care expenditures (HCE), information regarding individuals' age, time-to-death (TTD), morbidities at the time of an admission, as well as the hospital provider, year and season of admission. We show that HCE is principally determined by proximity to death rather than age, and that proximity to death is itself a proxy for morbidity.