What Makes a Discovery Successful? The Story of Linda Buck and the Olfactory Receptors.

In 1991, Buck and Axel published a landmark study in Cell for work that was awarded the 2004 Nobel Prize. The identification of the olfactory receptors as the largest family of GPCRs catapulted olfaction into mainstream neurobiology. This BenchMark revisits Buck's experimental innovation and its surprising success at the time.

On the scientific credibility of paleoanthropology.

Smith and Smith and Wood proposed that the human fossil record offers special challenges for causal hypotheses because "unique" adaptations resist the comparative method. We challenge their notions of "uniqueness" and offer a refutation of the idea that there is something epistemologically special about human prehistoric data. Although paleontological data may be sparse, there is nothing inherent about this information that prevents its use in the inductive or deductive process, nor in the generation and testing of scientific hypotheses. The imprecision of the fossil record is well-understood, and such imprecision is often factored into hypotheses and methods. While we acknowledge some oversteps within the discipline, we also note that the history of paleoanthropology is clearly one of progress, with ideas tested and resolution added as data (fossils) are uncovered and new technologies applied, much like in sciences as diverse as astronomy, molecular genetics, and geology.

Why ex post peer review encourages high-risk research while ex ante review discourages it.

Peer review is an integral component of contemporary science. While peer review focuses attention on promising and interesting science, it also encourages scientists to pursue some questions at the expense of others. Here, we use ideas from forecasting assessment to examine how two modes of peer review-ex ante review of proposals for future work and ex post review of completed science-motivate scientists to favor some questions instead of others. Our main result is that ex ante and ex post peer review push investigators toward distinct sets of scientific questions. This tension arises because ex post review allows investigators to leverage their own scientific beliefs to generate results that others will find surprising, whereas ex ante review does not. Moreover, ex ante review will favor different research questions depending on whether reviewers rank proposals in anticipation of changes to their own personal beliefs or to the beliefs of their peers. The tension between ex ante and ex post review puts investigators in a bind because most researchers need to find projects that will survive both. By unpacking the tension between these two modes of review, we can understand how they shape the landscape of science and how changes to peer review might shift scientific activity in unforeseen directions.

Disruption, transformation and silos: medical humanities and the management gurus.

To disrupt, to transform and to break through silos are common sense aims for the medical humanities and other interdisciplinary endeavours. These keywords arise because of the influence upon the academy of management and business gurus, reputed experts who arose in response to the economic crises of the 1980s. Despite the noted analytic deficiencies in the concept of disruption, and its association with product innovation, the term has been extended to academic research, where it connotes radical novelty in research practice, typically accompanied by profound organisational and managerial change. 'Disruption' has become wedded to the word 'transformation' as national funders seek to support more radically innovative research that will maintain Western economic hegemony. A distorted version of Kuhn's model of scientific revolutions underpins the discourse of transformation, which fits humanities research to a template in which revolutionary, transformative shifts can be instrumentally favoured by funders, at the expense of inferior 'incremental' progress. Disruptive and transformative research are, according to funders, more readily produced in organisations that have broken through silos between disciplines. The silo metaphor misleadingly models academic disciplines as if they were essentially unitary entities, akin to the functionally specialised units of a business organisation. The discourse of silos arises from the guru doctrine of the learning organisation. This theory supposes that the organisation-including the university-is literally a living organism, and thereby susceptible to corporate sickness, mortality, infection and disability. Medical humanity researchers should be aware of, and reject, this vitalist metaphysic in which the optimal organisation is a culturally homogeneous supra-personal organism whose immense capacities are harnessed by visionary leaders. Moreover, a new vocabulary should be developed for research evaluation, superseding the supposed hierarchical opposition between transformative and incremental research.

The quality of qualitative research.

In this contribution, we discuss criteria for the quality of qualitative research. We consider reliability and validity as specifications of the comprehensive requirement for 'intersubjective replicability', with which qualitative research should comply. In the data collection phase, 'argumentative' reliability generally must suffice; in the data analysis phase, attention must also be given to 'technical' reliability. Validation of qualitative research has to take place via three approaches: 'communicative', 'critical' or 'empirical' validation. This clarifies the relative validity or 'authenticity' of qualitative research.

Edgeworth's mathematization of social well-being.

Francis Ysidro Edgeworth's unduly neglected monograph New and Old Methods of Ethics (1877) advances a highly sophisticated and mathematized account of social well-being in the utilitarian tradition of his 19th-century contemporaries. This article illustrates how his usage of the 'calculus of variations' was combined with findings from empirical psychology and economic theory to construct a consequentialist axiological framework. A conclusion is drawn that Edgeworth is a methodological predecessor to several important methods, ideas, and issues that continue to be discussed in contemporary social well-being studies.

The notorious man-in-the-street: Hermann Weyl and the problem of knowledge.

Hermann Weyl's philosophical reflections remain a topic of considerable interest in the history and philosophy of science. In particular, Weyl's commitment to a form of idealism, as it pertains to his reading of Husserl and Fichte, has garnered much discussion. However, much less attention has been given to Weyl's later, and at that only partial, turn towards a form of empiricism (i.e. from the late 1920s onward). This lack of focus on Weyl's later philosophy has tended to obscure some of the most significant lessons that Weyl sought to draw from his decades of research in the foundations of mathematics and physics. In this paper, I develop some aspects of what I will term as Weyl's 'modest' empiricism. I will argue that Weyl's turn toward empiricism can be read in the context of a development of Helmholtz's epistemological program and his unique form of 'Kantianism'. The hope is that this reading will not only provide a better understanding of Weyl's later thought, especially his (1954) criticism of Cassirer, but that it may also provide the basis for a novel 'Weylian' account of the mathematization of nature underwriting the group-theoretic methodology of parts of modern physics.

Perplexity as a provocation: revisiting the role of metaphor as a 'place holder' for the potential of COVID-19 antibodies.

This article revisits long-standing critiques of the role of metaphor in immunological discourse. Drawing on Alfred North Whitehead's speculative philosophy of organism, I focus on the use of metaphor to explain the process by which COVID-19 vaccine research is able to generate protective antibodies, the challenge of autoimmune disease and dengue fever antibodies. I suggest that metaphors are provoked by the perplexity that arises from presupposing that distinct morphological substances are the first order of reality. I conclude that rather than seeing metaphors as typically skewing conceptions of the body, as has been previously argued, those of memory, recognition and misrecognition may be instructive of a body in transition. Indeed, a process of transition that shows degrees of creativity. When gesturing towards the processual nature of infection and immunity, metaphors invite new modes of shared thinking across the disciplinary divide.

[Critical Gerontology : An orientation]. / Kritische Gerontologie : Eine Ortsbestimmung.

OBJECTIVE: Critical gerontology remained unheard of in German language research on ageing for a long time and has so far only hesitantly been taken up in the discourse. This article first traces the development of the approaches that today are assembled under the label of the "thought space" of critical gerontology. Subsequently, the concept of the critique of critical gerontology is examined more closely in order to clarify the question of what is critical about critical gerontology and which social theoretical considerations underlie the respective directions. RESULTS: It is argued that despite their shared orientation towards the emancipation and autonomy of older and old people, the individual approaches differ considerably in their understanding of critique and their conception of the status of scientific theories. Thus, it remains diffuse what the specific perspective of critical gerontology is in order to distinguish it from other social gerontological approaches. CONCLUSION: A total of four criteria are formulated that critical gerontology should fulfil.

Creating theory: Encouragement for using creativity and deduction in qualitative nursing research.

Texts about theory in nursing often refer to theory construction by using inductive methods in a rigid way. In this paper, it is instead argued that theories are created, which is in line with most philosophers of science. Theory creation is regarded as a creative process that does not follow a specific method or logic. As in any creative endeavour, the inspiration for theory creation can come from many sources, including previous research and existing theory. The main idea put forward is that deductive qualitative research approaches should play a key role in theory creation. Furthermore, there is a need to differentiate between theory creation and theory justification. A model that emphasizes the creative aspects of theory creation and theory justification using qualitative approaches is presented. The model suggests that knowledge development is a deductive trial-and-error process where theory creation is followed by testing. Scientific theory creation and justification are presented as an iterative process that is deductive in that a testable hypothesis is derived from the theory. If the hypothesis is falsified, then the theory needs modification or might be altogether wrong. Several factors can block the creative process, both in theory development and in finding ways to test a theory in the justification phase. Some of these blockers are the idea of 'building blocks' and the inductive view of science often brought forward in nursing. Other blockers include striving for consensus and adherence to existing nursing philosophies and existing theories. Research and knowledge development are creative processes, and following predefined methods is not enough to ensure scientific rigour in qualitative nursing research.

Diagrams, images and conceptual maps in nursing education.

The way in which one understands information and concepts, and the way a student works to develop this, is an individual aspect of learning that cannot be universally defined as (at least manifested) the same for everyone. 'Understanding' is a broad term, and the way one achieves understanding is dependent on the way that material is presented. In this article, we argue that the philosophy of science can be important to nursing education-in particular, by showing that the way we imbue understanding might depend on the meaning of 'understanding'. Diagrams and concept maps are meant to guide newly formed knowledge and connections to develop proper thinking (e.g., the order in which nursing students must prioritize data) that a student requires in the field. We argue that whether or not an image/diagram/concept map confers understanding will depend on both what the object is and what we mean by 'understanding'.

Thinking in 3 dimensions: philosophies of the microenvironment in organoids and organs-on-chip.

Organoids and organs-on-a-chip are currently the two major families of 3D advanced organotypic in vitro culture systems, aimed at reconstituting miniaturized models of physiological and pathological states of human organs. Both share the tenets of the so-called "three-dimensional thinking", a Systems Physiology approach focused on recapitulating the dynamic interactions between cells and their microenvironment. We first review the arguments underlying the "paradigm shift" toward three-dimensional thinking in the in vitro culture community. Then, through a historically informed account of the technical affordances and the epistemic commitments of these two approaches, we highlight how they embody two distinct experimental cultures. We finally argue that the current systematic effort for their integration requires not only innovative "synergistic" engineering solutions, but also conceptual integration between different perspectives on biological causality.

Innovations, Challenges and Future Directions in Nature of Science Research: Reflections from Early Career Academics.

There has been sustained research interest in the role of early career researchers in advancing the field and the challenges that they face. However, efforts to document lived experiences of researchers working in a specific research area within science education have been scarce. This paper considers the meaning of innovation in the context of nature of science (NOS) research, drawing from a collective reflection of five early career academics from different backgrounds. After discussing the sources of our motivation to innovate in NOS research, we identify four distinct pathways of innovation. These pathways include (1) delving into specific aspects of NOS in greater depth, (2) exploring the interface of NOS and other established research areas, and (3) using NOS to address pressing social issues, and (4) expanding the methodological repertoire of NOS research. We illustrate these four modes of research innovation using examples from our own work. Barriers to early-career innovation such as the absence of NOS in curricula and initial teacher education, the lack of time to engage with practitioners to develop and implement instructional resources, and the underrepresentation of diverse education systems in NOS research literature are discussed.

On the pursuitworthiness of qualitative methods in empirical philosophy of science.

While the pursuitworthiness of philosophical ideas has changed over time, philosophical practice and methodology have not kept pace. The worthiness of a philosophical pursuit includes not only the ideas and objectives one pursues but also the methods with which one pursues them. In this paper, we articulate how empirical approaches benefit philosophy of science, particularly advocating for the use of qualitative methods for understanding the social and normative aspects of scientific inquiry. After situating qualitative methods within empirical philosophy of science, we discuss how to adapt these traditionally sociological methods to empirically inform philosophical questions. Our aim is to normalize and legitimize qualitative methods for philosophical purposes and discuss how they can elucidate descriptive and normative components of scientific practice in a more generalizable non-idealized manner. We contend that qualitative methods are particularly well suited to philosophical interest in the social norms of science, their achievability, and their mutability. Furthermore, unlike more historical case studies in philosophy, qualitative methods enable more confidence in generalizability, albeit limited, from a concrete sample to a larger class. We conclude by addressing anxieties about the distinctness of empirical philosophy of science from social epistemology and from sociology of science.

Putting the "Decision" in Ramsey's "Theories".

Frank Ramsey's philosophy of science is considered abstruse due to the incompleteness and difficulty of his paper "Theories". This has not prevented various authors from arguing that Ramsey is committed to meaning holism for scientific theories, and that his philosophy of science is anti-realist but anti-reductionist. However, it is unclear exactly how meaning holism works for Ramsey, and how he can be both anti-realist and anti-reductionist. I argue that clarity can be gained on both issues by examining Ramsey's philosophy of science through a reconstruction of his decision theory compatible with his later philosophical beliefs. I develop an account of how credences can be formed over singular, theoretical propositions despite those propositions being fictions. Credences are ultimately measured by preferences over conditionals whose antecedents are the verification conditions of theoretical propositions and outcomes are elements of a privileged partition on an agent's possibility space induced by the language of the theory. Those verification conditions are the observational elements formed from the unions of this induced partition. Meaning holism is explained as the sensitivity of theoretical propositions to their verification conditions. And anti-realism and anti-reductionism can be maintained due to theoretical propositions forming a finer partition of possibility space than observational propositions, which prevents the former from being truth-functions of the latter.

The elephant in the room: The biomimetic principle in bio-robotics and embodied AI.

In recent years, bio-inspired robots have shaped numerous domains of technical and scientific production. Bio-inspired robots can now be found in all areas of industry, medicine, architecture, and even culture. Despite the wealth of historiographic and philosophical studies published on this topic, a philosophical investigation of the mimetic principle used in bio-robotics is still missing. In this paper, I will ask a simple question: what is the role of biomimetic and bio-inspired processes in the different practices of bio-robotics? In the following pages, I will first make some conceptual order. I discuss the differences between several bio-inspired disciplines to clearly identify the biomimetic principle. Second, I introduce the discussion on the necessity of imitating nature in early twentieth-century bio-robotics. Third, I state the broader philosophical issue at stake in the debate on the biomimetic principle: the model-world relation, as discussed in the philosophical literature on models and idealization. In section 4, I address several emblematic case studies in which the imitation of nature, variously declined, is fundamental for producing knowledge, thus providing cursory taxonomy of the biomimetic principle. In the conclusion, I will come back to the elephant in the room and suggest how to tackle it further in a fruitful manner. As a broader result, my proposed taxonomy might be used by historians of science and technology as a starting point for historicizing the different practices of current bio-robotics as well as by philosophers to further problematize the various philosophical frameworks that have been accepted and developed in bio-robotics.

Causation and causal inference in obstetrics-gynecology.

Causation and causal inference are of utmost importance in obstetrics and gynecology. In many clinical situations, causal reasoning is involved in etiological explanations, diagnostic considerations, and conversations about prognosis. In this paper, we offer an overview of the philosophical accounts of causation that may not be familiar to, but still be appreciated by, the busy clinician. In our discussion, we do not try to simplify what is a rather complex range of ideas. We begin with an introduction to some important basic ideas, followed by 2 sections on the metaphysical and epistemological aspects of causality, which offer a more detailed discussion of some of its specific philosophical facets, using examples from obstetrical and gynecologic research and practice along the way. We hope our discussion will help deepen the thinking and discourse about causation and causal inference in gynecology and obstetrics.

Design in biology and rational design in vaccinology: A conceptual analysis.

This review discusses the philosophical foundations of what used to be called "the scientific method" and is nowadays often known as the scientific attitude. It used to be believed that scientific theories and methods aimed at the truth especially in the case of physics, chemistry and astronomy because these sciences were able to develop numerous scientific laws that made it possible to understand and predict many physical phenomena. The situation is different in the case of the biological sciences which deal with highly complex living organisms made up of huge numbers of constituents that undergo continuous dynamic processes; this leads to novel emergent properties in organisms that cannot be predicted because they are not present in the constituents before they have interacted with each other. This is one of the reasons why there are no universal scientific laws in biology. Furthermore, all scientific theories can only achieve a restricted level of predictive success because they remain valid only under the limited range of conditions that were used for establishing the theory' in the first place. Many theories that used to be accepted were subsequently shown to be false, demonstrating that scientific theories always remain tentative and can never be proven beyond and doubt. It is ironical that as scientists have finally accepted that approximate truths are perfectly adequate and that absolute truth is an illusion, a new irrational sociological phenomenon called Post-Truth conveyed by social media, the Internet and fake news has developed in the Western world that is convincing millions of people that truth simply does not exist. Misleading information is circulated with the intention to deceive and science denialism is promoted by denying the remarkable achievements of science and technology during the last centuries. Although the concept of intentional design is widely used to describe the methods that biologists use to make discoveries and inventions, it will be argued that the term is not appropriate for explaining the appearance of life on our planet nor for describing the scientific creativity of scientific investigators. The term rational for describing the development of new vaccines is also unjustified. Because the analysis of the COVID-19 pandemic requires contributions from biomedical and psycho-socioeconomic sciences, one scientific method alone would be insufficient for combatting the pandemic.

Phenomenological Research in Health Professions Education: Tunneling from Both Ends.

Issue: The term "phenomenology" is increasingly being used in Health Professions Education research. Phenomenology refers to a philosophical tradition or discipline. For researchers in Health Professions Education without a philosophical or humanities background, there are two practical problems. The first is that it is not always clear how studies that call themselves "phenomenological" are distinct from studies that use other methods; phenomenology as a label seems to be used for any study that is interested in the experiences of participants. The second problem is that a more in-depth study of phenomenology in the literature yields either abstract definitions such as "examining the underlying structures of consciousness," or contrasting translations of phenomenology to concrete research tools. What would phenomenology in medical education research look like that is both true to its philosophical roots and yields research findings that contribute to the quality of medical education? Evidence: Two medical education researchers, one with a medical background and the other with a philosophy background, engaged in a dialogue with the purpose of formulating an approach for phenomenology in medical education research. The first departed from the practical demands of his research project in which phenomenology was suggested as a methodology, but guidance was lacking. The other departed from the philosophical tradition of phenomenology with the purpose of exploring how phenomenological insights can be valuable for medical education research. The paper presents these journeys and the results of this dialogue where they formulate starting points for an approach to conducting HPE research that has scientific phenomenological integrity and yields practical results. Implications: Phenomenology has been one of the defining developments in philosophy and the humanities in the 20th century. A basic grasp of its insights is useful for medical education researchers since any research today takes place in the light of these insights. Within medical education, there are certain types of phenomena, research questions, and research goals that call for an explicitly phenomenological approach. Rather than prescribing specific methods or methodologies, phenomenology offers signposts for how to think about the relationship between our research object, methods, and data, and our own role as researchers. We suggest that researchers in HPE, when reporting a phenomenological study, instead of claiming to have followed a certain phenomenological method, explain how their research question, methods, and results fit the purposes and standards of phenomenology. We illustrate this with an example of how to use phenomenology in an interview study.

The Lifecycle of a Clinical Cadaver: A Practice-Based Ethnography.

PhenomenonCadavers have long played an important and complex role in medical education. While research on cadaver-based simulation has largely focused on exploring student attitudes and reactions or measuring improvements in procedural performance, the ethical, philosophical, and experiential aspects of teaching and learning with cadavers are rarely discussed. In this paper, we shed new light on the fascinating philosophical moves in which people engage each and every time they find themselves face to face with a cadaver. ApproachOver a two-year period (2018/19-2019/20), we applied ethnographic methods (137 hours of observation, 24 interviews, and the analysis of 22 documents) to shadow the educational cadaver through the practical stages involved in cadaver-based simulation: 1. cadaver preparation, 2. cadaver-based skill practice with physicians and residents, and 3. interment and memorial services. We used Deleuze and Guattari's concepts of becoming and acts of creation to trace the ontological "lifecycle" of an educational cadaver as embedded within everyday work practices. FindingsWe delineated six sub-phases of the lifecycle, through which the cadaver transformed ontologically from person to donor, body, cadaver, educational cadaver, teacher, and loved one/legacy. These shifts involved a network of bureaucratic, technical, educational, and humanistic practices that shaped the way the cadaver was perceived and acted upon at different moments in the lifecycle. By highlighting, at each phase, 1) the ontological transitions of the cadaver, itself, and 2) the practices, events, settings, and people involved in each of these transitions, we explored questions of "being" as it related to the ontological ambiguity of the cadaver: its conceptualization as both person and tool, simultaneously representing life and death. InsightsEngaging deeply with the philosophical questions of cadaver-based simulation (CBS) helped us conceptualize the lifecycle as a series of meaningful and purposeful acts of becoming. Following the cadaver from program entry to interment allowed us to contemplate how its ontological ambiguity shapes every aspect of cadaver-based simulation. We found that in discussions of fidelity in medical simulation, beyond both the physical and functional, it is possible to conceive of a third type: ontological. The humanness of the cadaver makes CBS a unique, irreplaceable, and inherently philosophical, practice.