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All aerobic life on Earth depends on oxygenic photosynthesis, occurring in both prokaryotic and eukaryotic organisms. This process can be divided into light reactions and carbon fixation. This special issue is a result of the International Conference on "Photosynthesis and Hydrogen Energy Research for Sustainability 2023," held in honor of Robert Blankenship, Gyozo Garab, Michael Grätzel, Norman Hüner, and Gunnar Öquist. After extensive discussions on various aspects of photosynthesis and hydrogen energy, eight high-quality papers were selected. These papers cover studies on abiotic stress, an overview of photosynthesis, thylakoid membrane lipid organization, energy transfer, and the genomics of both prokaryotic and eukaryotic photosynthesis, as well as biohydrogen production from cyanobacteria. The authors used new methods and techniques, likely bringing fresh ideas for improving biomass and crop yield.
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Hidrogênio , Fotossíntese , Hidrogênio/metabolismo , Cianobactérias/metabolismo , Cianobactérias/genéticaRESUMO
The first use of the word 'chlorophyll' (chlorophile or chlorophyle in the French original) appeared in two papers by Pierre-Joseph Pelletier and Joseph Bienaimé Caventou, pharmacists in Paris who isolated and studied the green pigment from plants. Here, we provide English translations of their 1818 note and the slightly longer 1817 paper. Historical context is provided including a timeline of key discoveries in chlorophyll chemistry pertaining to photosynthesis.
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Clorofila , Fotossíntese , PlantasRESUMO
The 11th International Photosynthesis Conference on Hydrogen Energy Research and Sustainability 2023 was organized in honor of Robert Blankenship, Gyozo Garab, Michael Grätzel, Norman Hüner, and Gunnar Öquist, in Istanbul, Türkiye at Bahçesehir University Future Campus from 03 to 09 July 2023. It was jointly supported by the International Society of Photosynthesis Research (ISPR) and the International Association for Hydrogen Energy (IAHE). In this article we provide brief details of the conference, its events, keynote speakers, and the scientific contribution of scientists honored at this conference. Further, we also describe the participation of young researchers, their talks, and their awards.
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Hidrogênio , Fotossíntese , Hidrogênio/metabolismo , Distinções e Prêmios , História do Século XXI , PesquisaRESUMO
This computational study of line-broadening effects is based on an accurate, analytical representation of the intermonomer potential energy surface (PES) of the CO2 â Ar van der Waals (vdW) complex. The PES is employed to compute collisional broadening coefficients for rovibrational lines of CO2 perturbed by Ar. The semiclassical computations are performed using the modified Robert-Bonamy approach, including real and imaginary terms, and the exact trajectory model. The lines investigated are in the 10001â00011, 01101â00001, 00011â00001, and 00031â00001 vibrational bands and the computations are repeated at multiple temperatures. The computed results are in good agreement with the available experimental values, validating both the intermonomer PES developed and the methodology used. For lines in the 01101â00001 band of CO2 , temperature-dependent Ar-broadening coefficients are reported for the first time. The parameters presented should prove useful, among other applications, for the accurate experimental determination of CO2 and Ar abundances in planetary atmospheres.
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With a new Netflix film Joy telling the dramatic story of IVF, Dr Kamal Ahuja recalls the inspirational role that the late Sir Robert Edwards played in his own career and in the foundation of the London Women's Clinic.
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PURPOSE: To provide a method for the differential diagnosis of Robert's uterus with adenomyosis, a rare uterine malformation, and determine the best course of treatment. METHODS: A patient who had Robert's uterus with adenomyosis was admitted to our hospital in December 2022. We analyzed and summarized her case . RESULTS: Our patient complained of progressively worsening primary dysmenorrhea over the course of 3 years and lower abdominal pain lasting for 2 days. Her carbohydrate antigen 125 (CA125) level was 372.10 U/mL. Examinations conducted by several hospitals indicated that she had a single-horned uterus and a residual horned uterus, and our hospital's examination identified Robert's uterus. This malformation was corrected by open abdominal surgery. For the procedure, pelvic adhesions were first isolated, after which the closed uterine cavity and adenomyosis were resected. Subsequently, the left ovarian endometriosis cyst was resected and right tubal ligation was performed. After surgery, three injections of gonadotropin-releasing hormone A (GnRH-A) were administered, which lowered the patient's CA125 level to 14 U/mL and normalized her condition. CONCLUSION: We pioneered a new therapeutic approach for the treatment of Robert's uterus with adenomyosis. Some valuable references are provided for clinical practice.
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Adenomiose , Útero , Humanos , Feminino , Adenomiose/cirurgia , Adenomiose/complicações , Adenomiose/diagnóstico , Útero/anormalidades , Útero/cirurgia , Adulto , Antígeno Ca-125/sangue , Anormalidades Urogenitais/cirurgia , Anormalidades Urogenitais/diagnóstico , Anormalidades Urogenitais/complicações , Hormônio Liberador de Gonadotropina/análogos & derivados , Hormônio Liberador de Gonadotropina/uso terapêutico , Dismenorreia/etiologia , Endometriose/cirurgia , Endometriose/complicações , Endometriose/diagnósticoRESUMO
Robert's uterus was firstly reported in 1970, it's a rare Müllerian duct anomaly with 2 intra-uterine cavities divided by asymmetrical septum. One of the cavities is completely obstructed to cervix by septum and menstruation fluid retents in this blind cavity, periodical pelvic pain during menstruation can lead attendance to hospital. We report a gravida of Robert's uterus with missed abortion in the blind cavity, who had mild dysmenorrhoea since adolescent age, diagnosed and treated by minimally invasive surgical methods. To our knowledge, it's a previously unreported case which gynaecologists terminated pregnancy in blind cavity of Robert's uterus without resecting the septum while dysmenorrhoea relieved entirely and postoperative volume of menstruation stayed the same as preoperative.
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Aborto Incompleto , Aborto Retido , Feminino , Gravidez , Adolescente , Humanos , Aborto Retido/cirurgia , Dismenorreia/etiologia , Dismenorreia/cirurgia , Pelve , Útero/cirurgiaRESUMO
Quality in biomedical research is a much-discussed topic among experts, research institutes, and funding organizations. Quality issues are frequently reported in the scientific and general press (e.g., stability of study results after test retake - "replication crisis"). Quality management systems are a globally accepted and established tool to guide and manage quality and to address quality problems. However, the notion of quality management is often met with resistance among researchers: low resources, too much regulation, restriction of research, and unnecessary bureaucracy are counter-arguments.The idea of implementing a quality management system for research laboratories is nothing new worldwide. There are various approaches by scientists and organizations to establish a quality management system in research laboratories and to develop a value-added system for themselves. Their expectations are an optimization of the research processes as well as an increase in effectiveness and efficiency.This report summarizes publications concerning quality measures and management in biomedical research and explains the background and advantages of quality management systems in organizations, laboratories, and research. A currently ongoing project of the Robert Koch Institute is presented as an outlook. The article is based on a literature review in English and German. In addition, internationally and nationally applicable and relevant guidelines were considered.
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Pesquisa Biomédica , Laboratórios , AlemanhaRESUMO
Background: Prevalence of substance use disorders (SUD) is high among adolescents and young adults (AYAs) with complex medical needs. Little is known about risk factors for SUD in this population. Methods: This retrospective cohort study used electronic health record data from a large academic hospital system (2015-2019) to identify adolescents (aged 10-17) and young adults (aged 18-27) with intellectual/developmental disorders, psychiatric conditions, or complex medical conditions. Logistic regression was used to identify demographic, clinical, and neighborhood-level risk factors associated with SUD in this population. Results: A total of 149 adolescents and 536 young adults had a SUD diagnosis (6.7% and 20.6%, respectively). Among adolescents, notable risk factors for SUD included age (adjusted odds ratio [aOR] = 1.42, 95% confidence interval [CI] = [1.31, 1.54]), Hispanic ethnicity (aOR = 2.10, 95% CI = [1.10, 3.99]), additional psychoactive medication classes (aOR = 1.27, 95% CI = [1.11, 1.46]), and living in a "high" child opportunity index (COI) (aOR = 2.06, 95% CI [1.02, 4.14]) or a "very high" COI (aOR = 3.04, 95% CI [1.56,5.95]) area. Among young adults, notable risk factors included being male (aOR = 2.41, 95% CI [1.91, 3.05]), being Black (aOR = 1.64, 95% CI [1.28, 2.09]), and additional non-psychoactive (aOR = 1.07, 95% CI [1.03, 1.11]) or psychoactive medication classes (aOR = 1.17, 95% CI [1.07, 1.28]). Limitations: These descriptive analyses are limited to one large academic hospital system in North Carolina and may not be representative of all high-need AYAs in the state. Conclusions: Several demographic, clinical, and neighborhood risk factors are associated with SUD in high-need AYAs.
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Transtornos Relacionados ao Uso de Substâncias , Humanos , Adolescente , North Carolina/epidemiologia , Masculino , Feminino , Transtornos Relacionados ao Uso de Substâncias/epidemiologia , Adulto Jovem , Fatores de Risco , Estudos Retrospectivos , Adulto , Criança , PrevalênciaRESUMO
In this paper we examine the traditional mortuary rites of the South Fore people of Papua New Guinea using Robert Hertz's theory of secondary burial and the three mechanisms of mourning identified by Daniel Lagache. The ethnographic data that we obtained on South Fore interpretations of their own mortuary rites showed that all forms of corpse handling achieved the same end results through the process of secondary burial. Furthermore, the three mechanisms of mourning applied equally to all forms of corpse disposal and we found no evidence to support psychosexual interpretations of mortuary anthropophagy which emphasise aggression. South Fore interpretations of mortuary anthropophagy show that the dead were eaten out of love, and to protect the mourners from the painful emotion of witnessing the decomposition of the corpse. These findings affirm the relevance of the concepts of Hertz and Lagache to the universal human experiences of death and mourning.
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During the English Civil War and subsequent Restoration, beekeeping provided a ready set of moral examples for those seeking answers about the 'natural' structure of society. The practice itself also underwent a number of substantial changes, moving from a traditional craft practice to a more knowledge-focused, technologically complex one. The advent of glass-windowed hives in the latter half of the sixteenth century allowed intellectuals from across the political spectrum to directly observe bees as a way of gathering knowledge about how to understand the divine plan and, with that understanding, improve human society.
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Criação de Abelhas , Abelhas , História do Século XVII , Inglaterra , Criação de Abelhas/história , Animais , Humanos , CoragemRESUMO
BACKGROUND: Robert's uterus is a rare congenital anomaly, characterized as an asymmetric septate uterus that has a blind hemicavity with unilateral menstrual fluid retention and a unicornuate hemicavity connecting to the cervix unimpededly. Patients with Robert's uterus generally present with menstrual disorders and dysmenorrhea, and some may have reproductive problems as well, including infertility, recurrent miscarriage, preterm labor and obstetric complications. In this case, we describe a successful pregnancy implanted on the obstructed hemicavity and delivered a liveborn girl. Meanwhile, we highlight diagnostic and therapeutic difficulties in patients with atypical symptoms of Robert's uterus. CASE PRESENTATION: A 30-year-old Chinese primigravida sought for emergency treatment at 26 weeks and 2 days of gestation because of preterm premature rupture of membranes (PPROM). At the age of 19, the patient was misdiagnosed with hyperprolactinemia and pituitary microadenoma for showing symptom of hypomenorrhea and was suspected to have a uterine septum in the first trimester. She was diagnosed with Robert's uterus at 22 weeks of gestation by repetitious prenatal transvaginal ultrasonography, which was subsequently confirmed by magnetic resonance imaging. At 26 weeks and 3 days of gestation, the patient was suspected to have oligohydramnion, irregular uterine contraction, and umbilical cord prolapse, and she expressed a strong will of saving the baby. Emergency cesarean delivery was performed and a small hole, together with several weak spots, was found at the lower and back wall of the septum of the patient. The treatment was effective and both the mother and the infant, who had an extremely low birth weight, were discharged in good health conditions. CONCLUSIONS: Pregnancy in the blind cavity of Robert's uterus with living neonates is incredibly rare. In our case, the favorable outcome may result from the unusual hole found at the septum, which may play a role in communicating amniotic fluid between the two hemicavities so to keep the neonate alive. we highlight the importance of early diagnosis and pre-pregnancy treatment of this uterine malformation, and the timely termination of pregnancy, for improving birth quality and reducing mortality.
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Ruptura Prematura de Membranas Fetais , Infertilidade , Anormalidades Urogenitais , Útero , Adulto , Feminino , Humanos , Recém-Nascido , Gravidez , Dismenorreia/etiologia , Pelve , Anormalidades Urogenitais/diagnóstico , Anormalidades Urogenitais/diagnóstico por imagem , Útero/anormalidades , Útero/patologia , Ruptura Prematura de Membranas Fetais/etiologia , Imageamento por Ressonância Magnética , UltrassonografiaRESUMO
PURPOSE: Antenatal detection of limb anomalies is not uncommon, and pregnancies are usually terminated in view of the expected physical handicap. The aim of this retrospective observational study is to delineate the spectrum of fetal limb anomalies and provide evidence in support of complete postnatal evaluation in establishing recurrence risk. METHODS: We present 54 cases of limb malformations detected antenatally and discuss the spectrum of abnormalities, the utility of fetal autopsy, and genetic testing to establish recurrence risk in subsequent pregnancies. RESULTS: 16/54 cases were isolated radial ray anomalies. There were five cases of amniotic band syndrome, five limb body wall complex cases, three VACTERL (vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal anomalies, and limb abnormalities) associations, one case of sirenomelia, two cases of limb pelvis hypoplasia, and one case of OEIS (Omphalocele Exstrophy Imperforate anus and spinal defects). Four fetuses with non-isolated radial ray anomaly had trisomy 18. One case with bilateral radial ray defect had a mutation in the FANC-E gene confirming fanconi anemia. Twelve cases were unclassified. CONCLUSION: Autopsy is the most important investigation in fetuses with limb anomalies. We suggest chromosomal microarray (CMA) as a first-tier test after autopsy. However, in cases of bilaterally symmetrical limb anomalies, in case of previous similarly affected child, or history of consanguinity, whole exome sequencing (WES) can be offered as the primary investigation, followed by CMA if WES is normal.
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Cardiopatias Congênitas , Deformidades Congênitas dos Membros , Fístula Traqueoesofágica , Feminino , Humanos , Gravidez , Feto/diagnóstico por imagem , Cardiopatias Congênitas/diagnóstico por imagem , Cardiopatias Congênitas/genética , Rim/anormalidades , Deformidades Congênitas dos Membros/diagnóstico por imagem , Deformidades Congênitas dos Membros/genética , Traqueia/anormalidades , Fístula Traqueoesofágica/diagnóstico por imagem , Fístula Traqueoesofágica/genética , Diagnóstico Pré-NatalRESUMO
The Journal of Helminthology (JHL) was first published in 1923 and was originally created as a house journal of the London School of Hygiene and Tropical Medicine. The JHL was devised by its first Editor, Robert Leiper, to allow for rapid publication of results from the Department of Helminthology and its offshoot the Institute of Agricultural Parasitology. From this initial narrow focus the JHL has subsequently become not only internationally recognized but also retained its original emphasis on morphological, taxonomic and life cycle studies while embracing the emergence of new fields and technological advancements. The present review covers the historical development of the JHL over the last century from 1923 to 2023.
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Parasitologia , Publicações Periódicas como Assunto , Medicina Tropical , Animais , Parasitologia/história , Instituições Acadêmicas , Medicina Tropical/história , EditoraçãoRESUMO
BACKGROUND: The challenge to increase the diversity, inclusivity, and equity of nurse scientists is a critical issue to enhance nursing knowledge development, health care, health equity, and health outcomes in the United States. PURPOSE: The purpose of this paper is to highlight the current nurse scholars in the Robert Wood Johnson Foundation (RWJF) Harold Amos Medical Faculty Development Program (AMFDP). DISCUSSION: Profiles and the programs of research and scholarship of the current AMFDP nurse scholars are described and discussed. Scholars share lessons learned, and how the AMFDP program has influenced their thinking and commitments to future action in service of nursing science, diversity efforts, legacy leadership, issues of health equity. CONCLUSION: RWJF has a history of supporting the development of nursing scholars. AMFDP is an example of legacy leadership program that contributes to a culture of health and the development of next-generation nursing science scholars.
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Currículo , Docentes de Medicina , Humanos , Estados Unidos , Avaliação de Programas e Projetos de Saúde , Docentes de Enfermagem , Fundações , Liderança , Desenvolvimento de ProgramasRESUMO
BACKGROUND: To address the need for faculty scientists, Robert Wood Johnson Foundation (RWJF) provided support for an accelerated PhD program: Future of Nursing Scholars (FNS). PURPOSE: To describe the experience of faculty mentoring PhD students in the RWJF FNS program pursuing a 3-year accelerated PhD degree, including faculty members' support activities for students, time commitment, student productivity in manuscript dissemination, and challenges and opportunities for supporting students. METHODS: Surveys were sent to faculty mentors of FNS to understand mentoring activities, strategies used, and mentee productivity. FINDINGS: Of 93 faculty mentors, they reported most FNS students (n = 61, 65.6%) completed a manuscript format dissertation. FNS students required academic/dissertation mentoring, with frequent emotional support and positive reinforcement. DISCUSSION AND CONCLUSION: Mentors reported providing more frequent mentoring and spent more time mentoring FNS students than with other PhD students. Alignment of the student's research to that of the faculty mentor was identified as valuable.
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Tutoria , Estudantes de Enfermagem , Humanos , Mentores , Docentes de Enfermagem/educação , Previsões , Estudantes de Enfermagem/psicologiaRESUMO
When the sociobiology debate erupted in 1975, there were almost too many contributions to the heated exchanges between sociobiologists and their critics to count. In the fall of 1976, a Canadian educational film entitled Sociobiology: Doing What Comes Naturally sparked further controversy due to its graphic visuals and outrageous narration. While critics claimed the film was a promotional tool to further the sociobiological agenda in educational settings, sociobiologists quickly distanced themselves from the film and, in turn, accused the critics of consciously misrepresenting sociobiology by organizing showings of the film. Using audio, video, archival, and published sources, this paper explores the complicated history of Sociobiology: Doing What Comes Naturally and demonstrates how the public debate about the film reflects the positions, polemics, and polarization of the sociobiology debate as a whole.
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PURPOSE: The present study aimed to treat fractures of the distal end of the radius in children with Robert Jones (RJ) bandage. The objective was to compare this treatment modality with the cast regarding the frequency of the complication occurrence, child comfortability, and family satisfaction. METHODS: The study was a randomized controlled non-inferiority clinical trial including children with recent (less than 5 days) fractures at the distal end of the radius OTA/AO 23-A2, which is usually treated conservatively. Those with open fractures, pathological fracture, severely displaced fracture that needs reduction or multiple injuries were excluded. The participants were divided randomly into 2 groups according to the treatment modalities. Group 1 was treated by plaster of Paris cast (the control group), and Group 2 by modified RJ bandage (the trial group). The difference between the 2 groups was found by the Chi-squared test. The difference was considered statistically significant when the p value was less than 0.05. RESULTS: There were 150 children (aged 2 - 12 years, any gender) included in the study, 75 in each group. The complications occured in 5 (3.3%) cases only, pressure sores of 3 cases in Group 1 and fracture displacement of 2 cases in Group 2. There was no statistically significant difference in the rate of complication occurrence between both modalities of treatment (p = 0.649). Children treated by RJ bandages were more comfortable than those treated by the cast (97.3% vs. 73.3%, p < 0.001) with a statistically significant difference between them. Contrary to that, the families were more satisfied with the cast than RJ bandage (88.0% vs. 81.3%), but without a statistically significant difference (p = 0.257). CONCLUSION: RJ bandage is a non-inferior alternative to the cast for the treatment of fractures at the distal end of the radius that can be treated conservatively in children.
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Fraturas do Rádio , Fraturas do Punho , Humanos , Criança , Fraturas do Rádio/terapia , Fixação de Fratura , Bandagens , Extremidade Superior , Moldes CirúrgicosRESUMO
A hybrid theory is any moral theory according to which different classes of individuals ought to be treated according to different principles. We argue that some hybrid theories are able to meet standards of psychological plausibility, by which we mean that it's feasible for ordinary human beings to understand and act in accord with them. Insofar as psychological plausibility is a theoretical virtue, then, such hybrid theories deserve more serious consideration. To make the case for this view, we explain what psychological plausibility is and why we might value it, why the human/animal divide appears to be an entrenched feature of human psychology, and why Robert Nozick's hybrid theory doesn't go far enough. Finally, we make the case that a more promising psychologically plausible hybrid theory, with respect to humans and animals, will be (at least) at tribrid theory-that is, positing three domains rather than two.
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Robert Nozick famously raised the possibility that there is a sense in which both deontology and utilitarianism are true: deontology applies to humans while utilitarianism applies to animals. In recent years, there has been increasing interest in such a hybrid views of ethics. Discussions of this Nozickian Hybrid View, and similar approaches to animal ethics, often assume that such an approach reflects the commonsense view, and best captures common moral intuitions. However, recent psychological work challenges this empirical assumption. We review evidence suggesting that the folk is deontological all the way down-it is just that the moral side constraints that protect animals from harm are much weaker than those that protect humans. In fact, it appears that people even attribute some deontological protections, albeit extremely weak ones, to inanimate objects. We call this view Multi-level Weighted Deontology. While such empirical findings cannot show that the Nozickian Hybrid View is false, or that it is unjustified, they do remove its core intuitive support. That support belongs to Multi-level Weighted Deontology, a view that is also in line with the view that Nozick himself seemed to favour. To complicate things, however, we also review evidence that our intuitions about the moral status of humans are, at least in significant part, shaped by factors relating to mere species membership that seem morally irrelevant. We end by considering the potential debunking upshot of such findings about the sources of common moral intuitions about the moral status of animals.