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1.
Clin Infect Dis ; 2024 Jun 24.
Artigo em Inglês | MEDLINE | ID: mdl-38913762

RESUMO

BACKGROUND: In 2023, Tennessee replaced $6.2 M in US Centers for Disease Control and Prevention (CDC) human immunodeficiency virus (HIV) prevention funding with state funds to redirect support away from men who have sex with men (MSM), transgender women (TGW), and heterosexual Black women (HSBW) and to prioritize instead first responders (FR), pregnant people (PP), and survivors of sex trafficking (SST). METHODS: We used a simulation model of HIV disease to compare the clinical impact of Current, the present allocation of condoms, preexposure prophylaxis (PrEP), and HIV testing to CDC priority risk groups (MSM/TGW/HSBW); with Reallocation, funding instead increased HIV testing and linkage of Tennessee-determined priority populations (FR/PP/SST). Key model inputs included baseline condom use (45%-49%), PrEP provision (0.1%-8%), HIV testing frequency (every 2.5-4.8 years), and 30-day HIV care linkage (57%-65%). We assumed Reallocation would reduce condom use (-4%), PrEP provision (-26%), and HIV testing (-47%) in MSM/TGW/HSBW, whereas it would increase HIV testing among FR (+47%) and HIV care linkage (to 100%/90%) among PP/SST. RESULTS: Reallocation would lead to 166 additional HIV transmissions, 190 additional deaths, and 843 life-years lost over 10 years. HIV testing reductions were most influential in sensitivity analysis; even a 24% reduction would result in 287 more deaths compared to Current. With pessimistic assumptions, we projected 1359 additional HIV transmissions, 712 additional deaths, and 2778 life-years lost over 10 years. CONCLUSIONS: Redirecting HIV prevention funding in Tennessee would greatly harm CDC priority populations while conferring minimal benefits to new priority populations.

2.
Emerg Infect Dis ; 30(6): 1245-1248, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38782142

RESUMO

Choanephora infundibulifera is a member of the Mucorales order of fungi. The species is associated with plants as a saprophyte or parasite and may be responsible for spoilage or disease but is an uncommon cause of human infection. We describe C. infundibulifera rhinosinusitis in a young man with leukemia in Tennessee, USA.


Assuntos
Sinusite , Humanos , Masculino , Tennessee , Sinusite/microbiologia , Sinusite/diagnóstico , Sinusite/parasitologia , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações , Mucormicose/diagnóstico , Mucormicose/microbiologia , Mucormicose/tratamento farmacológico , Mucorales/isolamento & purificação , Mucorales/classificação , Rinite/microbiologia , Rinite/diagnóstico , Adulto , Antifúngicos/uso terapêutico , Rinossinusite
3.
Emerg Infect Dis ; 30(1): 192-194, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38147514

RESUMO

Fewer than 30 cases of Mycobacterium senegalense infection have been reported. We report a complicated case of M. senegalense infection in Memphis, Tennessee, in the southeastern United States. The patient's comorbidities of past organ transplant and insulin-dependent diabetes required delicate consideration of those health conditions to guide treatment.


Assuntos
Diabetes Mellitus , Transplante de Rim , Infecções por Mycobacterium não Tuberculosas , Infecções por Mycobacterium , Mycobacterium , Humanos , Mycobacterium/genética , Tennessee/epidemiologia , Transplante de Rim/efeitos adversos , Infecções por Mycobacterium/diagnóstico , Infecções por Mycobacterium/tratamento farmacológico , Infecções por Mycobacterium/etiologia , Infecções por Mycobacterium não Tuberculosas/diagnóstico , Infecções por Mycobacterium não Tuberculosas/tratamento farmacológico , Infecções por Mycobacterium não Tuberculosas/microbiologia
4.
Subst Use Misuse ; 59(4): 638-642, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38189325

RESUMO

BACKGROUND: Diphenhydramine (DPH), known as the brand name Benadryl, is an over-the-counter medication associated with accidental ingestion leading to nonfatal overdoses. Additionally, DPH has been used in tandem with illicit substances leading to fatal drug overdoses. OBJECTIVE: In response to DPH being seized with illicit drugs as an adulterant, as well as its growing intentional misuse, we sought to explore its recent involvement in fatal and nonfatal drug overdoses in the state of Tennessee. METHODS: We conducted a statewide cross-sectional study to determine the characteristics of DPH-involved fatal and nonfatal overdoses in Tennessee during 2019-2022 using data from the State Unintentional Drug Overdose Reporting System, the Electronic Surveillance System for the Early Notification of Community-based Epidemics, and the National Forensic Laboratory Information System Public Data Query System. Frequencies were generated to compare demographic characteristics, circumstances, and toxicology between fatal and nonfatal DPH-involved overdoses. RESULTS: We identified 143 suspected nonfatal DPH and 409 fatal DPH-involved overdoses in Tennessee from 2019 to 2022. Nonfatal overdoses remained consistent while fatal overdoses peaked in 2021. Most nonfatal overdoses were under 18 (63.4%), while most fatal overdoses were between 18 and 64 years of age (95.7%). For fatal overdoses, fentanyl was the most prevalent substance on toxicology followed by prescription opioids. CONCLUSION: Nonfatal overdoses remained consistent while fatal overdoses peaked in 2021 in Tennessee. Use of DPH among other illicit substances lends to evidence suggesting its use as an adulterant. Monitoring of DPH-involved fatal and nonfatal overdoses is critical to inform harm reduction initiatives.


Assuntos
Difenidramina , Overdose de Drogas , Humanos , Tennessee/epidemiologia , Estudos Transversais , Overdose de Drogas/epidemiologia , Analgésicos Opioides
5.
BMC Infect Dis ; 23(1): 136, 2023 Mar 07.
Artigo em Inglês | MEDLINE | ID: mdl-36882755

RESUMO

BACKGROUND: Rhinovirus (RV) is one of the most common etiologic agents of acute respiratory infection (ARI), which is a leading cause of morbidity and mortality in young children. The clinical significance of RV co-detection with other respiratory viruses, including respiratory syncytial virus (RSV), remains unclear. We aimed to compare the clinical characteristics and outcomes of children with ARI-associated RV-only detection and those with RV co-detection-with an emphasis on RV/RSV co-detection. METHODS: We conducted a prospective viral surveillance study (11/2015-7/2016) in Nashville, Tennessee. Children < 18 years old who presented to the emergency department (ED) or were hospitalized with fever and/or respiratory symptoms of < 14 days duration were eligible if they resided in one of nine counties in Middle Tennessee. Demographics and clinical characteristics were collected by parental interviews and medical chart abstractions. Nasal and/or throat specimens were collected and tested for RV, RSV, metapneumovirus, adenovirus, parainfluenza 1-4, and influenza A-C using reverse transcription quantitative polymerase chain reaction assays. We compared the clinical characteristics and outcomes of children with RV-only detection and those with RV co-detection using Pearson's χ2 test for categorical variables and the two-sample t-test with unequal variances for continuous variables. RESULTS: Of 1250 children, 904 (72.3%) were virus-positive. RV was the most common virus (n = 406; 44.9%), followed by RSV (n = 207; 19.3%). Of 406 children with RV, 289 (71.2%) had RV-only detection, and 117 (28.8%) had RV co-detection. The most common virus co-detected with RV was RSV (n = 43; 36.8%). Children with RV co-detection were less likely than those with RV-only detection to be diagnosed with asthma or reactive airway disease both in the ED and in-hospital. We did not identify differences in hospitalization, intensive care unit admission, supplemental oxygen use, or length of stay between children with RV-only detection and those with RV co-detection. CONCLUSION: We found no evidence that RV co-detection was associated with poorer outcomes. However, the clinical significance of RV co-detection is heterogeneous and varies by virus pair and age group. Future studies of RV co-detection should incorporate analyses of RV/non-RV pairs and include age as a key covariate of RV contribution to clinical manifestations and infection outcomes.


Assuntos
Asma , Infecções por Enterovirus , Influenza Humana , Vírus Sincicial Respiratório Humano , Infecções Respiratórias , Criança , Humanos , Pré-Escolar , Adolescente , Rhinovirus/genética , Estudos Prospectivos , Tennessee/epidemiologia , Infecções Respiratórias/diagnóstico , Infecções Respiratórias/epidemiologia
6.
Emerg Infect Dis ; 28(4): 833-836, 2022 04.
Artigo em Inglês | MEDLINE | ID: mdl-35318922

RESUMO

We report an outbreak of severe acute respiratory syndrome coronavirus 2 involving 3 Malayan tigers (Panthera tigris jacksoni) at a zoo in Tennessee, USA. Investigation identified naturally occurring tiger-to-tiger transmission; genetic sequence change occurred with viral passage. We provide epidemiologic, environmental, and genomic sequencing data for animal and human infections.


Assuntos
COVID-19 , Tigres , Animais , COVID-19/epidemiologia , Surtos de Doenças , Humanos , SARS-CoV-2 , Tennessee/epidemiologia , Tigres/genética
7.
Health Econ ; 31(1): 233-249, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34727396

RESUMO

We study the role of access to health insurance coverage as a determinant of individuals' subjective well-being (SWB) by analyzing large-scale healthcare reforms in the United States. Using data from the Behavioral Risk Factor Surveillance System and Panel Study of Income Dynamics, we find that the 2006 Massachusetts reform and 2014 Affordable Care Act Medicaid expansion improved the overall life satisfaction of Massachusetts residents and low-income adults in Medicaid expansion states, respectively. The results are robust to various sensitivity and falsification tests. Our findings imply that access to health insurance plays an important role in improving SWB. Without considering psychological benefits, the actual benefits of health insurance may be underemphasized.


Assuntos
Reforma dos Serviços de Saúde , Patient Protection and Affordable Care Act , Adulto , Acessibilidade aos Serviços de Saúde , Humanos , Cobertura do Seguro , Seguro Saúde , Massachusetts , Medicaid , Estados Unidos
8.
BMC Vet Res ; 18(1): 91, 2022 Mar 08.
Artigo em Inglês | MEDLINE | ID: mdl-35255907

RESUMO

BACKGROUND: Multidrug- and methicillin-resistant staphylococci are both veterinary and public health concerns due to their zoonotic potential. Therefore, the objective of this study was to investigate patterns of antimicrobial, multidrug, and methicillin resistance among four Staphylococcus spp. commonly isolated from canine clinical specimens submitted to the Clinical Bacteriology Laboratory at the University of Tennessee College of Veterinary Medicine (UTCVM). METHODS: Results of antimicrobial susceptibility testing and mecA polymerase chain reaction (PCR) for isolates of four common Staphylococcus spp. isolates were obtained from the Bacteriology Laboratory at the UTCVM between 01/01/2006 and 12/31/2017. Cochran-Armitage trend test was used to assess temporal trends of antimicrobial resistance (AMR), multidrug resistance (MDR), and methicillin resistance. Kappa test of agreement was used to assess agreement between the results of PCR and disk diffusion tests. RESULTS: Most of the 7805 isolates were S. pseudintermedius (6453 isolates), followed by S. coagulans (860), S. aureus (330), and S. schleiferi (162). Among S. pseudintermedius isolates, 45.5% were MDR, and 30.8% were methicillin-resistant (MRSP). There was a significant temporal increase in MRSP (p = 0.017). Chloramphenicol resistance increased among both MRSP and methicillin-susceptible (MSSP) isolates (p <  0.0001). Among S. aureus isolates, 40.9% were MDR, 37.4% were methicillin-resistant (MRSA), and the proportion of MRSA isolates increased significantly (p = 0.0480) over time. There was an increasing temporal trend in the proportion of MDR isolates among MSSP (p = 0.0022), but a decrease among MRSP (p <  0.0001) and MRSA (p = 0.0298). S. schleiferi had the highest percentage (56.9%) of methicillin-resistant isolates. Oxacillin disk diffusion was superior to cefoxitin for the detection of mecA-mediated resistance and had almost perfect agreement with mecA PCR assay for S. pseudintermedius (95.4% agreement, kappa (κ) = 0.904; p <  0.0001), S. coagulans (95.6%, κ = 0.913; p <  0.0001) and S. schleiferi (97.7%, κ = 0.945; p <  0.0001). However, cefoxitin disk diffusion was superior to oxacillin disk diffusion and had almost perfect agreement with mecA PCR assay for S. aureus (95.3%, κ = 0.834; p <  0.0001). CONCLUSIONS: The levels of resistance and increasing temporal trends are concerning. These findings have implications for treatment decisions and public health due to the zoonotic potential of staphylococci. Continued surveillance and use of antibiograms to guide clinical decisions will be critical.


Assuntos
Anti-Infecciosos , Doenças do Cão , Infecções Estafilocócicas , Animais , Antibacterianos/farmacologia , Doenças do Cão/tratamento farmacológico , Doenças do Cão/epidemiologia , Doenças do Cão/microbiologia , Cães , Humanos , Resistência a Meticilina , Testes de Sensibilidade Microbiana/veterinária , Infecções Estafilocócicas/tratamento farmacológico , Infecções Estafilocócicas/epidemiologia , Infecções Estafilocócicas/veterinária , Staphylococcus , Staphylococcus aureus , Tennessee/epidemiologia
9.
Int J Refrig ; 133: 313-325, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34776559

RESUMO

Most COVID-19 vaccines require ambient temperature control for transportation and storage. Both Pfizer and Moderna vaccines are based on mRNA and lipid nanoparticles requiring low temperature storage. The Pfizer vaccine requires ultra-low temperature storage (between -80 °C and -60 °C), while the Moderna vaccine requires -30 °C storage. Pfizer has designed a reusable package for transportation and storage that can keep the vaccine at the target temperature for 10 days. However, the last stage of distribution is quite challenging, especially for rural or suburban areas, where local towns, pharmacy chains and hospitals may not have the infrastructure required to store the vaccine. Also, the need for a large amount of ultra-low temperature refrigeration equipment in a short time period creates tremendous pressure on the equipment suppliers. In addition, there is limited data available to address ancillary challenges of the distribution framework for both transportation and storage stages. As such, there is a need for a quick, effective, secure, and safe solution to mitigate the challenges faced by vaccine distribution logistics. The study proposes an effective, secure, and safe ultra-low temperature refrigeration solution to resolve the vaccine distribution last mile challenge. The approach is to utilize commercially available products, such as refrigeration container units, and retrofit them to meet the vaccine storage temperature requirement. Both experimental and simulation studies are conducted to evaluate the technical merits of this solution with the ability to control temperature at -30 °C or -70 °C as part of the last mile supply chain for vaccine candidates.

10.
Omega (Westport) ; : 302228221086058, 2022 Apr 13.
Artigo em Inglês | MEDLINE | ID: mdl-35416727

RESUMO

Comprehensively defining end-of-life healthcare is a challenge due to the diverse areas of healthcare involved, the various stakeholders, and the range of patient options. This qualitative study examined many areas of end-of-life healthcare including quality, areas for improvement, and healthcare policy in Tennessee, in which the definition of end-of-life healthcare was a focus. Data were collected using semi-structured interviews with 19 participants who included end-of-life healthcare experts and Tennessee legislators. Through this research an operational definition of end-of-life healthcare, encompassing five concepts, was developed. Concepts include: a diagnosis, a timeframe, type of care, location of care, and planning for the future. When considered together, they are the embodiment of what end-of-life healthcare encompasses. Not in a one-fits-all definition, but individually tailored. An understanding of what end-of-life healthcare denotes is essential to maintaining open communication, high quality standards of care, and the protection of patient autonomy.

11.
Emerg Infect Dis ; 27(10): 2521-2528, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34545796

RESUMO

As of March 2021, coronavirus disease (COVID-19) had led to >500,000 deaths in the United States, and the state of Tennessee had the fifth highest number of cases per capita. We reviewed the Tennessee Department of Health COVID-19 surveillance and chart-abstraction data during March 15‒August 15, 2020. Patients who died from COVID-19 were more likely to be older, male, and Black and to have underlying conditions (hereafter comorbidities) than case-patients who survived. We found 30.4% of surviving case-patients and 20.3% of deceased patients had no comorbidity information recorded. Chart-abstraction captured a higher proportion of deceased case-patients with >1 comorbidity (96.3%) compared with standard surveillance deaths (79.0%). Chart-abstraction detected higher rates of each comorbidity except for diabetes, which had similar rates among standard surveillance and chart-abstraction. Investing in public health data collection infrastructure will be beneficial for the COVID-19 pandemic and future disease outbreaks.


Assuntos
COVID-19 , Pandemias , Comorbidade , Hospitalização , Humanos , Masculino , Estudos Retrospectivos , SARS-CoV-2 , Tennessee/epidemiologia , Estados Unidos/epidemiologia
12.
BMC Womens Health ; 21(1): 186, 2021 05 03.
Artigo em Inglês | MEDLINE | ID: mdl-33941168

RESUMO

BACKGROUND: Tennessee women experience the 12th highest breast cancer mortality in the United States. We examined the geographic differences in breast cancer incidence in Tennessee between Appalachian and non-Appalachian counties from 2005 to 2015. METHODS: We used ArcGIS 10.7 geospatial analysis and logistic regression on the Tennessee Cancer Registry incidence data for adult women aged ≥ 18 years (N = 59,287) who were diagnosed with breast cancer from 2005 to 2015 to evaluate distribution patterns by Appalachian county designation. The Tennessee Cancer Registry is a population-based, central cancer registry serving the citizens of Tennessee and was established by Tennessee law to collect and monitor cancer incidence. The main outcome was breast cancer stage at diagnosis. Independent variables were age, race, marital status, type of health insurance, and county of residence. RESULTS: Majority of the sample were White (85.5%), married (58.6%), aged ≥ 70 (31.3%) and diagnosed with an early stage breast cancer (69.6%). More than half of the women had public health insurance (54.2%), followed by private health insurance coverage (44.4%). Over half of the women resided in non-Appalachian counties, whereas 47.6% were in the Appalachian counties. We observed a significant association among breast cancer patients with respect to marital status and type of health insurance coverage (p = < 0.0001). While the logistic regression did not show a significant result between county of residence and breast cancer incidence, the spatial analysis revealed geographic differences between Appalachian and non-Appalachian counties. The highest incidence rates of 997.49-1164.59/100,000 were reported in 6 Appalachian counties (Anderson, Blount, Knox, Rhea, Roane, and Van Buren) compared to 3 non-Appalachian counties (Fayette, Marshall, and Williamson). CONCLUSIONS: There is a need to expand resources in Appalachian Tennessee to enhance breast cancer screening and early detection. Using geospatial techniques can further elucidate disparities that may be overlooked in conventional linear analyses to improve women's cancer health and associated outcomes.


Assuntos
Neoplasias da Mama , Adulto , Região dos Apalaches/epidemiologia , Neoplasias da Mama/epidemiologia , Feminino , Humanos , Incidência , Tennessee/epidemiologia , Estados Unidos , População Branca
13.
Plant Dis ; 105(10): 3000-3007, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-33736467

RESUMO

Phytophthora blight is a destructive disease caused by the oomycete Phytophthora capsici, which affects vegetable production throughout the state of Tennessee and worldwide. Fungicides are a primary control method used in managing Phytophthora blight, but in some cases the efficacy of these products has been reduced or lost in the field. In 2018 and 2019, the efficacy of six fungicides was tested in vitro on 184 P. capsici isolates collected in Tennessee using radial growth assays. The fungicides included in the study were mefenoxam, fluopicolide, oxathiapiprolin, dimethomorph, mandipropamid, and cyazofamid. Seven isolates were resistant to mefenoxam, 86 were resistant to fluopicolide, one was resistant to oxathiapiprolin, and 13 were resistant to cyazofamid. None were resistant to dimethomorph or mandipropamid. Of the 86 isolates resistant to fluopicolide, five were also resistant to mefenoxam. Resistance to fluopicolide and cyazofamid was widespread in Tennessee, and it was more localized for mefenoxam and oxathiapiprolin. The results of this study show that fungicide resistance is widespread in P. capsici in Tennessee, and the implications for Phytophthora blight management are discussed.


Assuntos
Fungicidas Industriais/farmacologia , Phytophthora , Doenças das Plantas/microbiologia , Alanina/análogos & derivados , Amidas , Benzamidas , Ácidos Carboxílicos , Hidrocarbonetos Fluorados , Imidazóis , Morfolinas , Phytophthora/efeitos dos fármacos , Pirazóis , Sulfonamidas , Tennessee
14.
Policy Polit Nurs Pract ; 22(2): 93-104, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33567969

RESUMO

The rising prevalence of opioid use disorder (OUD) among those living in the United States has demanded a collaborative response from health care and policy spheres. Addressing OUD among pregnant women is especially difficult, given the controversies surrounding the medical and ethical balance between meeting maternal versus fetal/newborn needs. Most medical organizations discourage the criminalization of drug use in pregnancy due to the adverse public health outcomes of such an approach. Despite this recommendation, many states continue to use punitive law to address drug use in pregnancy. In 2014, the Fetal Assault Law in Tennessee (TN) became the first law in the United States to directly allow women to be prosecuted for drug use in pregnancy. Since its expiration in 2016, this law has been re-introduced several times to the TN legislature in support of permanent implementation. This article outlines the impact of the initial Fetal Assault Law on maternal/newborn health in TN and provides alternative immediate, short-term, and long-term health policy strategies through which health care providers and legislators can better advocate for the well-being of both mothers with OUD and their infants.


Assuntos
Síndrome de Abstinência Neonatal , Transtornos Relacionados ao Uso de Opioides , Complicações na Gravidez , Feminino , Política de Saúde , Humanos , Recém-Nascido , Transtornos Relacionados ao Uso de Opioides/epidemiologia , Gravidez , Tennessee , Estados Unidos
15.
Emerg Infect Dis ; 26(3)2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-32091385

RESUMO

Recently, Tennessee, USA, has seen an increase in the use of commonly injected drugs, such as heroin and fentanyl. Injection drug use (IDU) practices can lead to life-threatening methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSIs) and other serious diseases. We matched MRSA BSIs identified through the National Healthcare Safety Network to the Tennessee Hospital Discharge Data System to characterize the prevalence, demographics, and clinical characteristics associated with IDU in this disease population. Of the 7,646 MRSA BSIs identified during 2015-2017, we found that 1,839 (24.1%) were IDU-related. IDU-related BSIs increased by 118.9%; the greatest rise occurred among emergency department-onset infections (197.4%). IDU was more often associated with white, female, 18-49-year-old, and uninsured persons (p<0.001). We found >1 additional IDU-related diagnoses in 84.2% of IDU-related BSIs. Targeted harm reduction strategies for persons at high risk of IDU are necessary to reduce MRSA BSIs in acute care settings.


Assuntos
Bacteriemia/epidemiologia , Staphylococcus aureus Resistente à Meticilina/isolamento & purificação , Infecções Estafilocócicas/epidemiologia , Abuso de Substâncias por Via Intravenosa , Adolescente , Adulto , Fatores Etários , Bacteriemia/etiologia , Bases de Dados Factuais , Etnicidade , Feminino , Humanos , Masculino , Pessoas sem Cobertura de Seguro de Saúde , Pessoa de Meia-Idade , Infecções Estafilocócicas/etiologia , Tennessee/epidemiologia , Adulto Jovem
16.
Subst Abus ; 41(1): 11-13, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31800375

RESUMO

Effective treatment of opioid use disorder (OUD) must target both the medical and psychosocial aspects of a patient's condition. This, in turn, requires a collaboration between medical providers and social supports. We would like to illustrate a key difficulty in this collaboration for some patients in our country: many post-discharge recovery houses continue to refuse to allow patients to remain on medication treatment for OUD (M-OUD). This barrier to M-OUD access in recovery houses is a significant obstacle to effective OUD treatment.


Assuntos
Casas para Recuperação/tendências , Cobertura do Seguro/tendências , Colaboração Intersetorial , Transtornos Relacionados com Narcóticos/reabilitação , Alta do Paciente/tendências , Buprenorfina/uso terapêutico , Análise Custo-Benefício/economia , Análise Custo-Benefício/tendências , Casas para Recuperação/economia , Necessidades e Demandas de Serviços de Saúde/economia , Necessidades e Demandas de Serviços de Saúde/tendências , Pessoas Mal Alojadas/estatística & dados numéricos , Humanos , Cobertura do Seguro/economia , Transtornos Relacionados com Narcóticos/economia , Alta do Paciente/economia , Tennessee
17.
Zoo Biol ; 39(1): 13-22, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31609016

RESUMO

Hematology is a common tool for wildlife health assessments. Manual leukocyte counts are required in reptiles, however, disagreement between quantification methods has been observed in some chelonians. This study determined agreement between two methods of leukocyte quantification, eosinophilic leukopet, and blood film white blood cell (WBC) estimates, in free-living eastern box turtles (Terrapene carolina carolina). Simultaneously, we assessed the impact of handling duration on both leukocyte quantity and corticosterone levels. We collected blood at capture (<2 min from disturbance) and again before release 30-150 min later from 92 box turtles at six sites in Illinois and Tennessee. Constant and proportional error was present in the leukopet results for WBC, lymphocytes, and basophils compared to the estimate method. Both methods were in agreement for heterophils, monocytes, and eosinophils. Agreement between the methods was significantly more likely at WBC counts below 23,241/µl. All hematologic parameters were significantly higher at the final blood draw compared to the initial blood draw using both WBC determination methods, except relative eosinophil and basophil counts. Corticosterone levels varied with time, with maximum concentrations reached at 54 min postcapture, followed by a rapid return to baseline levels. Corticosterone level was not significantly associated with any hematologic parameter or sex. This study provides a framework for understanding the effects of animal handling methodology and diagnostic modality when evaluating hematologic health in box turtles.


Assuntos
Animais Selvagens , Corticosterona/sangue , Estresse Fisiológico , Tartarugas/sangue , Animais , Corticosterona/metabolismo , Tartarugas/fisiologia
18.
BMC Vet Res ; 15(1): 16, 2019 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-30616648

RESUMO

BACKGROUND: In recent years, there has been an increased awareness of antimicrobial resistance in both animals and humans, which has triggered concerns over non-judicious antimicrobial use. In the United States, antimicrobial use in food-producing animals for growth promotion or improved feed efficiency is perceived as non-judicious. To facilitate judicious antimicrobial use, the United States Food and Drug Administration implemented the Veterinary Feed Directive, effective from January 1, 2017. Interventions, such as the VFD, designed to ensure the judicious use of antimicrobials among cattle producers may be more effective if the factors that inform and influence producer AMU practices are addressed. The specific objectives of this study were to determine the following among Tennessee beef cattle producers: (1) the most common drivers for using antimicrobials, (2) the perceived alternatives to antimicrobials, (3) the knowledge and perceptions regarding antimicrobial resistance, and (4) the preferred avenues for receiving information on prudent antimicrobial use. A total of 5 focus group meetings with beef producers were conducted in East, Middle, and West Tennessee. Each focus group was video recorded and thematic analysis was performed using NVivo. RESULTS: The factors that producers considered to drive antimicrobial use were the type of cattle operation, disease and animal welfare, economic factors, veterinarian consultation, producer's experience and peer support, Veterinary Feed Directive, and perceived drug efficacy. Vaccination, proper nutrition, and other good management practices were considered alternatives to antimicrobial use. To encourage vaccine use among small producers, participants suggested packaging vaccines into smaller quantities. Antimicrobial resistance was perceived to be a problem affecting animal and public health. Participants suggested additional education for cattle producers on the prudent use of antimicrobials as a measure for improving antimicrobial use. The veterinarian, producer associations and meetings, and county extension agents emerged as trusted avenues for channeling information on prudent antimicrobial use to cattle producers. CONCLUSIONS: Several factors drive antimicrobial use among cattle producers in Tennessee. Participants generally perceived their antimicrobial use to be discreet and only when necessary. More awareness of drivers for the development of antimicrobial resistance and continuing education on prudent antimicrobial use is needed for Tennessee beef producers.


Assuntos
Criação de Animais Domésticos , Anti-Infecciosos/uso terapêutico , Fazendeiros/psicologia , Conhecimentos, Atitudes e Prática em Saúde , Animais , Bovinos , Doenças dos Bovinos/tratamento farmacológico , Humanos , Masculino , Tennessee
19.
Subst Use Misuse ; 54(3): 449-458, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30618325

RESUMO

BACKGROUND: Disparities in tobacco use exist across regions in the United States. The Central Appalachian region carries some of the very high rates of tobacco use prevalence but research on tobacco use initiation is sparse. OBJECTIVE: To investigate the intention to try tobacco and its associated factors among nonsmoking youth. METHOD: Data were obtained from school-based tobacco surveys (n = 539) conducted in 11 middle schools (6th-8th grades; aged 10-15 years) in Northeast Tennessee in 2015-2016. Nonsmoking participants without firm commitment to abstain from trying tobacco in the next year were considered to have an intention to try tobacco. The Full Information Maximum Likelihood estimation (FIML) method in Mplus was employed to conduct a multivariable logistic regression analysis to delineate correlates of intention to try tobacco. RESULTS: Overall, 20.0% of participants had intention to try tobacco. Among participants with intention to try tobacco, 53.7% owned tobacco-branded item(s), 86.1% believed that tobacco users have more friends, and 88.9% lived with tobacco users. In the adjusted logistic model, ever use of tobacco products, home smoking rules, owning tobacco-branded item(s), living with tobacco users, believing that tobacco users have more friends, and perception of easy access to tobacco products were significantly associated with intention to try tobacco (p < .02). CONCLUSION: This study suggests that individual, interpersonal, and community level factors influence intention to try tobacco in this environment where tobacco pre-emption laws impede development of local tobacco control policies and regulations. Thus, efforts should focus on tobacco use initiation preventive programs, including school-based tobacco control programs.


Assuntos
Intenção , Instituições Acadêmicas , Meio Social , Uso de Tabaco/psicologia , Adolescente , Região dos Apalaches/epidemiologia , Criança , Feminino , Humanos , Masculino , Prevalência , Inquéritos e Questionários , Nicotiana , Uso de Tabaco/epidemiologia
20.
J Environ Manage ; 232: 722-728, 2019 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-30529414

RESUMO

Wild hogs (Sus scrofa) are an invasive, non-native species quickly gaining ground on private, as well as public, lands in Tennessee and much of the United States. Wildlife management personnel may benefit from assessing stakeholders' views towards various management options to control and eradicate wild hogs. A statewide mail survey of 5000 randomly selected landowners in Tennessee counties known to have wild hogs yielded 1620 completed responses (33% response rate). Using this dataset, an index of potential for conflict among landowner groups was computed for each of eleven management options, which varied from leaving the wild hogs alone, to both lethal and non-lethal options. Results indicate varying levels of potential for conflict depending on hunter status, wild hog hunter status, presence of wild hogs on land, percent of income derived from land, and amount of land damage caused by wild hogs. Overall, three management options including leaving the wild hogs alone, allowing sale of wild hogs, and capturing and relocating were found unacceptable whereas many other options including capturing and killing, providing technical assistance to landowners and educating people on preventing damage were found to have high level of acceptability and most consensus among landowner subgroups. Findings will be useful in understanding how support for wild hog control options vary across population segments, and which options are likely to see more or less resistance from certain landowners.


Assuntos
Animais Selvagens , Conservação dos Recursos Naturais , Animais , Espécies Introduzidas , Inquéritos e Questionários , Suínos , Tennessee
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