1.
J Enzyme Inhib Med Chem
; 36(1): 1387-1401, 2021 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34167419
RESUMO
Five pathways involving different ring structures led to generation of fourteen thienylbenzamides (7-20) which display the structure-activity relationships of class I HDAC inhibitors. All the synthesised compounds inhibit HDAC1 and HDAC2 selectively over other isoforms and many inhibit DLD1 and HCT116 cells more effectively than a parent compound. Compounds 8 and 16 inhibit HCT116 cells by activation of the apoptosis pathway.