[Administration Accuracy of Automated Infusion Device for PET Using Improved Disposable Kit].

PURPOSE: The AI-300 automated infusion device (Sumitomo Heavy Industries, Ltd., Tokyo, Japan) is subject to administration error as a function of smaller volumes of 18F-FDG dispensed via a three-way cock supplied with a disposable kit. The present study aimed to validate the administration accuracy of the AI-300 using an improved disposable kit for quantitative positron emission tomography (PET) assessment. METHODS: We determined administration accuracy between the improved and previous disposable kits by measuring variations in dispensed volumes and radioactive concentrations of 18F-FDG according to the criteria of the Japanese Society of Nuclear Medicine. A reference value was generated by measuring radioactivity using a standard dose calibrator. RESULTS: The values obtained using the previous kit deviated from the reference values by a maximum of -10.6%, and the deviation depended on dispensed volumes of 18F-FDG<0.25 mL. In contrast, the values were relatively stable when using the improved kit with dispensed 18F-FDG volumes < 0.25 mL. Variations in radioactive concentrations were relatively stable using the improved kit, whereas that of the previous kit was slightly unstable at high radioactive concentrations. CONCLUSION: The administration accuracy of the AI-300 using the previous kit varied considerably according to smaller dispensed volumes, but the improved kit might alleviate this problem. The present results indicated that the improved disposal kit should be immediately implemented to eliminate uncertainty surrounding quantitative PET findings.

[Investigation of the Administration Accuracy of an Auto Infusion Device in 18F-FDG PET].

PURPOSE: The administration accuracy of the automated infusion device for the positron emission radiopharmaceutical affects to calculation of the standardized uptake value (SUV) in 18F-fluorodeoxyglucose (18F-FDG) PET examination. The purpose of this study was to investigate the administration error in the clinical use of an automated infusion device for quantitative management in PET examination. METHODS: We assumed clinical use of the automated infusion device and investigated two types of administration errors. First, for investigating the administration error over time in a day (errorday), a total of 13 infusion works were performed every 30 minutes. Second, for investigating the long period administration error (errorperiod), the infusion work was performed once before clinical use of an automated infusion device. The dispensed radioactivity was set to 150 MBq. The administration error was calculated using output values from the automated infusion device and measured values from the dose calibrator. RESULTS: The administration errorday was 0.9±1.3%, and the maximum error was 2.7%. The administration errorperiod was 1.1±2.0%, and the maximum error was 5.9%. CONCLUSION: We investigated the administration error of the automated infusion device. We confirmed the approximately 1% administration error and high-accuracy injection in an automated-device method.

Comparison of 3 Devices for Automated Infusion of Positron-Emitting Radiotracers.

The administration accuracy and precision of an automated infusion device for positron-emitting radiotracers are directly associated with bias and variance in the SUVs of 18F-FDG PET/CT. Therefore, the accuracy of such devices must be confirmed and calibrated at locations in which they are used. The present study aimed to validate the administration accuracy of 3 automated infusion devices for quantitative PET assessment. Methods: Temporal variations as well as variations in radioactive concentrations and dispensed volumes of 18F-FDG were determined for the M-130, AI-300, and UG-05 automated infusion devices. The total-test dispensed volumes were 25, 20, and 18.5 mL, respectively. A reference value was generated by measuring amounts of radioactivity using a standard dose calibrator. Administration accuracy was validated according to the criteria of the Japanese Society of Nuclear Medicine. Results: The temporal variation in the M-130 and UG-05 for a specified 185 MBq was relatively stable, in the range of -1.60%-0.92% and 1.16%-5.35%, respectively, whereas that in the AI-300 was -0.55%-8.68%. For the M-130 and UG-05 devices, the difference between measured and reference value was in the range of -5%-5%. The values measured by the AI-300 deviated from the reference values by a maximum of 30%, which depends on radioactive concentration and dispensed volume of 18F-FDG. Conclusion: The administration accuracy of the AI-300 varied considerably under different conditions, but a software update might somewhat improve this. Our findings indicate that dispensed volumes of 18F-FDG should be carefully considered when the radioactive concentration is high. Administration accuracy should be regularly confirmed at each location to maintain the quality of quantitative PET assessment. The present study provides useful information about how to confirm the administration accuracy of automated infusion devices.