Return to athletics after total knee arthroplasty: a survey study of 784 recreational athletes across 12 sports.

BACKGROUND: Postoperative return to recreational activity is a common concern among the increasingly active total knee arthroplasty (TKA) patient population, though there is a paucity of research characterizing sport-specific return and function. This study aimed to assess participation level, postoperative return to activity, sport function, and limitations for recreational athletes undergoing TKA. METHODS: A survey of recreational sports participation among primary, elective TKA patients from a single academic center between June 2011 and January 2022 was conducted. Of the 10,777 surveys administered, responses were received from 1,063 (9.9%) patients, among whom 784 indicated being active in cycling (273 [34.8%]), running (33 [4.2%]), jogging (68 [8.7%]), swimming (228 [29.1%]), tennis (63 [8.0%]), skiing (55 [7.0%]), or high-impact team sports (64 [8.2%]) between two years preoperatively and time of survey administration, and were included for analyses. RESULTS: Cycling (62.3% at two years preoperatively vs. 59.0% at latest follow-up) and swimming (62.7% at two years preoperatively vs. 63.6% at latest follow-up) demonstrated the most favorable participation rate changes, while running (84.0% at two years preoperatively vs. 48.5% at latest follow-up) and skiing (72.7% at two years preoperatively vs. 45.5% at latest follow-up) demonstrated the least favorable participation rate changes. The majority of respondents were "satisfied" or "very satisfied" with their return across all sports, though dissatisfaction was highest among runners and joggers. For cycling, running, jogging, and swimming, respondents most commonly reported no change in speed or distance capacity, though among these cyclists reported the highest rates of improved speed and distance. The majority of returning skiers reported improved balance, form, and ability to put on skis. CONCLUSION: Return to sport is feasible following TKA with high satisfaction. Swimming and cycling represent manageable postoperative activities with high return-rates, while runners and joggers face increased difficulty returning to equal or better activity levels. Patients should receive individualized, sports-specific counseling regarding their expected postoperative course based on their goals of treatment.

[Medical emergencies during running events]. / Notfallmedizinische Aspekte bei Laufveranstaltungen.

Background: The number of short- and long-distance running events in Germany is increasing. Running as a popular sport is practiced by a large number of people of different ages, risk groups, and degrees of professionalism, which results in a wide range of medical emergencies. Objective: The present article elucidates incidence, pathophysiology and therapy of relevant emergencies during running events. Aim was the optimization of work processes of emergency personnel. Materials and methods: A literature search was conducted in PubMed. Results: Exercise-associated muscle cramps, gastrointestinal symptoms, collapse, compartment syndrome, and tendinopathy are common clinical manifestations. Cardiac arrest and sudden cardiac death are rare events. Consciousness and seizures are major complications. Disseminated intravascular coagulation, exercise-associated hyponatremia, heat stroke, rhabdomyolysis, and thromboembolism are associated with high morbidity and mortality. Substances increasing pain resilience as well as performance-enhancing substances are popular among amateur and professional runners and are associated with a high incidence of side effects. Conclusion: General symptoms including vomiting, fever, collapse, muscle-pain, nausea and weakness are the leading symptoms during running events. A careful anamnesis is important for targeted clinical therapy. Symptom control is the main task. Fluid management the most challenging task for healthcare providers in the prehospital setting.

Intrinsic and extrinsic factors contributing to running-related lower limb injuries among adolescent runners.

The purpose of this study was to assess which combination of intrinsic and extrinsic factors contribute to running-related injury (RRI)among adolescent cross-country, track, and long-distance runners. We conducted a retrospective study at a hospital-affiliated sports injury prevention centre of 130 adolescent runners (F: 62.1%, M: 37.9%; cross-country: 34.1%, track: 56.1%, long-distance running: 9.8%) who underwent an Injury Prevention Evaluation between 2013 and 2021. The evaluation included a questionnaire on personal and training factors, and standardised physical assessments. We used a binomial logistic regression to assess the influence of demographics, lower extremity strength and alignment, training (running volume and intensity, weight training), and dietary factors on RRIs. There were 38 adolescent runners who reported RRIs (ankle sprains: N = 16, shin splints: N = 9, stress fractures: N = 13). Female sex (odds ratio [OR]: 4.58 [1.37, 15.37]; p = 0.01), reduced weekday hours of sleep (OR: 1.75 [1.04, 2.95]; p = 0.04), reduced hip abduction strength (OR: 1.02 [1.00, 1.04]; p = 0.05), and intention to lose weight to improve athletic performance (OR: 4.58 [1.00, 21.28]; p = 0.05) were associated with RRIs. These intrinsic and extrinsic risk factors may represent targets for injury prevention for adolescent runners.

Thermal comfort analyses on jogging trails: The effect of trail direction and tree shading on trial surface and physiological equivalent temperatures.

Jogging trails have been constructed in residential areas in Kuwait City to encourage people to exercise in outdoor spaces. The weather is hot and arid for most of the year. To create a comfortable and healthy local microclimate condition, trails were constructed along a certain direction with respect to the direction of the main prevailing wind and shaded with trees. In this study, the combined effects of tree shading and trail direction on trail surface temperature and physiological equivalent temperature (PET) were investigated. The prime focus is on a PET thermal comfort range between 21.6 °C and 30.1 °C and the period between 5:00 p.m. and 10:00 p.m. The results indicate that the shade of trees effectively protects the trail surface if the shaded trail is along the N-S direction, but it is ineffective if the shaded trail is along the E-W direction. PET analyses indicate that tree shading is irrelevant to thermal comfort only in spring, during which the thermal comfort of all trials was neutral between 5:00 p.m. and 10:00 p.m. E-W is the most comfortable trail in winter and summer. The trees along the E-W direction trail slow down wind speed and increase the relative humidity, which is desirable in arid environments. The E-W trail is the most comfortable because the trees protect people from hot winds in the summer and cold winds in winter. The results of the present investigation provide information of interest for urban designers, who can attain comfortable and healthy local microclimate conditions by choosing the correct trail direction and considering tree shading.

Left-right asymmetric heart jogging increases the robustness of dextral heart looping in zebrafish.

Building a left-right (L-R) asymmetric organ requires asymmetric information. This comes from various sources, including asymmetries in embryo-scale genetic cascades (including the left-sided Nodal cascade), organ-intrinsic mechanical forces, and cell-level chirality, but the relative influence of these sources and how they collaborate to drive asymmetric morphogenesis is not understood. During zebrafish heart development, the linear heart tube extends to the left of the midline in a process known as jogging. The jogged heart then undergoes dextral (i.e. rightward) looping to correctly position the heart chambers relative to one another. Left lateralized jogging is governed by the left-sided expression of Nodal in mesoderm tissue, while looping laterality is mainly controlled by heart-intrinsic cell-level asymmetries in the actomyosin cytoskeleton. The purpose of lateralized jogging is not known. Moreover, after jogging, the heart tube returns to an almost midline position and so it is not clear whether or how jogging may impact the dextral loop. Here, we characterize a novel loss-of-function mutant in the zebrafish Nodal homolog southpaw (spaw) that appears to be a true null. We then assess the relationship between jogging and looping laterality in embryos lacking asymmetric Spaw signals. We found that the probability of a dextral loop occurring, does not depend on asymmetric Spaw signals per se, but does depend on the laterality of jogging. Thus, we conclude that the role of leftward jogging is to spatially position the heart tube in a manner that promotes robust dextral looping. When jogging laterality is abnormal, the robustness of dextral looping decreases. This establishes a cooperation between embryo-scale Nodal-dependent L-R asymmetries and organ-intrinsic cellular chirality in the control of asymmetric heart morphogenesis and shows that the transient laterality of the early heart tube has consequences for later heart morphogenetic events.

[Jogging/running activity and quality of life in the elderly].

Objectives　The number of elderly joggers/runners in Japan has been on the rise. This study aimed to investigate the practice of jogging/running activity, features of quality of life (QOL) among the elderly, and the relationships between jogging/running activity and QOL features.Methods　A questionnaire survey was conducted with 83 older adults aged 60-81 who had participated in 7 marathons held from November 2014 to July 2015. Sex, age, experience (years), mileage (kms/month), frequency of jogging/running activity (times/week), frequency of participation in marathons (times/year), and QOL were assessed. QOL was measured with the WHOQOL26, which is composed of "overall QOL", "physical," "psychological," "social relationships," and "environment." The relations between these variables were estimated using correlation and multiple regression analyses.Results　In the majority of the participants, experience was 5 or more years, mileage was less than 150 kms/month, frequency of jogging/running activity was 1-4 times a week, and frequency of participation in marathons was 1-10 times a year. As for the participants above the age of 65, the mean QOL for men was 3.8 (standard deviation (SD)=0.4) and for women was 4.1 (SD=0.5). These scores were higher than those previously reported in studies among Japanese older adults. And there was no evidence which showed the bodily pain such as lower limb disorders, which older joggers or runners may often get. Overall QOL was positively associated with age and frequency of jogging/running activity. The social relationships domain was positively associated with sex and experience. The environment domain was positively correlated with experience. All these associations were significant.Conclusions　The results suggest that among the elderly, a high frequency and/or experience of jogging/running activity is significantly associated with a high level of QOL. In the future, a case-control or longitudinal study with a larger sample size and/or more variables is required to obtain a more definitive interpretation of the present findings.

Effect of long-term exercise training on static postural control in older adults: a cross-sectional study.

We examined the effects of long-term exercise on age-related decline in static balance control through centre-of-pressure (CoP) measurements of four groups of participants: older controls, younger controls, older Tai Chi exercisers and older joggers. The participants stood quietly in a tandem stance on a force platform for 30 s with eyes open (EO) and eyes closed (EC). The older controls showed remarkably larger CoP and EC/EO ratios than younger controls and older Tai Chi exercisers. The EC/EO ratios of velocity in the mediolateral direction of older joggers were significantly smaller than those of older controls. Results suggest that the static balance of older controls showed a significant decline caused by age-related changes. Long-term Tai Chi and jogging, particularly the former, contributed to static balance control in older people. Older adults relied more on visual information in static postural control than young people. Tai Chi would be an ideal exercise for improving static balance in older people.

The Physiological Cost Index and Some Kinematic Parameters of Walking and Jogging in Blind and Sighted Students.

BACKGROUND: Vision plays an important role in supporting efficient locomotion. The present study aimed to measure the physiological cost index (PCI) and some kinematic parameters of preferred walking and jogging in blind and sighted students. METHODS: A cross-sectional study was conducted among blind (n=18) and sighted (n=27) students aged 8-16 years. The following parameters were measured during a standard test procedure: step length (meter), cadence (steps/min), mean speed (meter/min), and the PCI of preferred walking (PCIW) and jogging (PCIJ) over a distance of 100 meters. RESULTS: Univariate linear regression analysis revealed that the weight of an individual as well as the test duration were significant predictors of heart rate (HR) and PCI. Overall, the PCI (beats/meter) of sighted (PCIW=0.22±0.08 and PCIJ=0.24±0.07) and blind students (PCIW=0.27±0.07 and PCIJ=0.31±0.08) were significantly different (all P≤0.05). In addition, the speed of preferred walking (PW) in sighted students was significantly higher than that of the blind students (67±8 versus 62.8±9 m/min; all P≤0.05), while this difference was insignificant in jogging mode (105±9 versus 102±11 m/min). CONCLUSION: Although the blind students were familiar with the ambient environment and the walking route, they demonstrated a different pattern of PW and jogging modes with respect to kinematic parameters. We also demonstrated that the blind students spent more energy (i.e., PCI) to achieve a lower or equal gait kinematics compared to the sighted students.

Exercise in the treatment of clinical anxiety in general practice - a systematic review and meta-analysis.

BACKGROUND: Anxiety disorders are common, yet treatment options in general practice are often limited to medication or CBT. There is a lack of evidence for the effectiveness of exercise in the treatment of anxiety in patients who present to general practice and also about the intensity of exercise required to lead to improvement. The aim of this systematic review was to assess the use of exercise versus waiting list control groups in the treatment of anxiety and also to assess the benefit of high intensity exercise vs low intensity exercise. Long term follow up scores were also analysed. We included patients who met diagnostic criteria for anxiety disorders or had clinically raised anxiety levels on a validated rating scale and performed a subgroup analysis of the outcomes between the two groups. The intervention was any aerobic exercise programme carried out for at least two weeks, or exercise carried out at high intensity for at least two weeks. The comparison groups were either a waiting list control group or low intensity exercise. METHOD: Systematic review of randomised controlled trials. Three databases were searched; CENTRAL, Medline and Embase. Outcome assessment was based on validated anxiety rating scales. The quality of the studies was appraised according to the Cochrane Risk of Bias tool. Effect sizes were calculated using the standardised mean difference. RESULTS: Fifteen studies were identified with a total of 675 patients. Nine trials had participants with diagnosed anxiety disorders and six trials had participants with raised anxiety on a validated rating scale. Aerobic exercise was effective in the treatment of raised anxiety compared to waiting list control groups (effect size - 0.41, 95% CI = - 0.70 to - 0.12). High intensity exercise programmes showed greater effects than low intensity programmes. There was no significant difference in outcomes between groups of patients with diagnosed anxiety disorders and patients who had raised anxiety on a rating scale. Conclusions were limited by the small number of studies and wide variation in the delivery of exercise interventions. CONCLUSION: Exercise programmes are a viable treatment option for the treatment of anxiety. High intensity exercise regimens were found to be more effective than low intensity regimens. The results have implications for the use of exercise schemes in General Practice.

Effects of high-intensity interval training on cardiometabolic risk in overweight and obese African-American women: a pilot study.

OBJECTIVE: Little is known about high-intensity interval training (HIIT) in African-American (AA) women. The purpose of this pilot study was to evaluate the effects of HIIT and steady-state (SS) exercise on cardiometabolic risk factors in young AA women. DESIGN: A 16-week exercise intervention was conducted 3x/week. Twenty-seven AA women were randomized to SS (n = 11; 32 continuous minutes of treadmill walking at 60-70% of maximum heart rate (HRmax)), or HIIT (n = 16; 32 min of treadmill HIIT alternating 3 min at 60-70% of HRmax with 1 min at 80-90% of HRmax). Two-way repeated measures ANOVA with intention-to-treat analysis was used to identify changes between groups. Significance was accepted at P ≤ 0.05. RESULTS: Of the 27 women who entered the study (age: 30.5 ± 6.8 years; BMI: 35.1 ± 5.1 kg/m2; 5274 ± 1646 baseline steps/day), 14 completed the intervention. HIIT significantly decreased waist circumference (107.0 ± 11.3 to 105.1 ± 11.9 cm) compared to SS, which showed no change. There was a significant time effect for steps where HIIT increased steps/day (5334 ± 1586 to 7604 ± 1817 steps/day), and SS had no change. There were no significant changes in either group for any other measurements. CONCLUSION: HIIT was more effective at reducing waist circumference and increasing daily steps/day than SS treadmill exercise over 16 weeks. Further research in a larger sample is indicated to evaluate the effects of each protocol on cardiometabolic risk factors.

Effects of a 12-week, short-interval, intermittent, low-intensity, slow-jogging program on skeletal muscle, fat infiltration, and fitness in older adults: randomized controlled trial.

PURPOSE: We developed a short-interval, low-intensity, slow-jogging (SJ) program consisting of sets of 1 min of SJ at walking speed and 1 min of walking. We aimed to examine the effects of an easily performed SJ program on skeletal muscle, fat infiltration, and fitness in older adults. METHODS: A total of 81 community-dwelling, independent, older adults (70.8 ± 4.0 years) were randomly assigned to the SJ or control group. The SJ group participants were encouraged to perform 90 min of SJ at their anaerobic threshold (AT) intensity and 90 min of walking intermittently per week. Aerobic capacity at the AT and sit-to-stand (STS) scores were measured. Intracellular water (ICW) in the legs was assessed by segmental multi-frequency bioelectrical impedance analysis. Subcutaneous (SAT) and intermuscular (IMAT) adipose tissue and muscle cross-sectional area (CSA) were measured at the mid-thigh using computed tomography. RESULTS: A total of 75 participants (37 SJ group, 38 controls) completed the 12-week intervention. The AT and STS improved in the SJ group compared with the controls (AT 15.7 vs. 4.9 %, p < 0.01; STS 12.9 vs. 4.5 %, p < 0.05). ICW in the upper leg increased only in the SJ group (9.7 %, p < 0.05). SAT and IMAT were significantly decreased only in the SJ group (p < 0.01). CONCLUSION: The 12-week SJ program was easily performed by older adults with low skeletal muscle mass, improved aerobic capacity, muscle function, and muscle composition in older adults.

A Nutrition Recovery Station Following Recreational Exercise Improves Fruit Consumption but Does Not Influence Fluid Recovery.

Immediate postexercise access to fruit/fluid via a recovery "station" is a common feature of mass participation sporting events. Yet little evidence exists examining their impact on subsequent dietary intake. The aim of this study was to determine if access to fruit/water/sports drinks within a recovery station significantly alters dietary and fluid intakes in the immediate postexercise period and influences hydration status the next morning. 127 (79 males) healthy participants (M ± SD, age = 22.5 ± 3.5y, body mass (BM) = 73 ± 13kg) completed two self-paced morning 10km runs separated by 1 week. Immediately following the first run, participants were randomly assigned to enter (or not) the recovery station for 30min. All participants completed the alternate recovery option the following week. Participants recorded BM before and after exercise and measured Urine Specific Gravity (USG) before running and again the following morning. For both trial days, participants also completed 24h food and fluid records via a food diary that included photographs. Paired-sample t tests were used to assess differences in hydration and dietary outcome variables (Recovery vs. No Recovery). No difference in preexercise USG or BM change from exercise were observed between treatments (p's > .05). Attending the recovery zone resulted in a greater total daily fluid (Recovery = 3.37 ± 1.46L, No Recovery = 3.16 ± 1.32L, p = .009) and fruit intake (Recovery = 2.37 ± 1.76 servings, No Recovery = 1.55 ± 1.61 servings, p > .001), but had no influence on daily total energy (Recovery = 10.15 ± 4.2MJ, No Recovery = 10.15 ± 3.9MJ), or macronutrient intakes (p > .05). Next morning USG values were not different between treatments (Recovery = 1.018 ± 0.007, No Recovery = 1.019 ± 0.009, p > .05). Recovery stations provide an opportunity to modify dietary intake which promote positive lifestyle behaviors in recreational athletes.

Effects of regular Tai Chi practice and jogging on neuromuscular reaction during lateral postural control in older people.

This study examined the effects of regular Tai Chi practice and jogging on the neuromuscular activity of the trunk, hip, and ankle joint muscles of older people during lateral postural perturbation. A total of 42 older people participated in the study and formed the Tai Chi, jogging, and sedentary control groups. Electromyography signals were collected from the peroneus longus, anterior tibialis, gluteus medius, and erector spinae during unpredictable mediolateral perturbation. The Tai Chi group exhibited significantly faster latencies of the tibialis anterior and erector spinae than the control group. The jogging group showed a significantly shorter neuromuscular reaction time of the erector spinae than the control group. No significant difference was observed between the Tai Chi and jogging groups. Long-term regular Tai Chi practice enhanced the neuromuscular reaction of the erector spinae and tibialis anterior to lateral perturbation and will help timely posture correction when lateral postural distributions occur.

Pelvic floor muscle electromyography during different running speeds: an exploratory and reliability study.

PURPOSE: Stress urinary incontinence (SUI) affects women of all ages including young athletes, especially those involved in high-impact sports. To date, hardly any studies are available testing pelvic floor muscles (PFM) during sports activities. The aim of this study was the description and reliability test of six PFM electromyography (EMG) variables during three different running speeds. The secondary objective was to evaluate whether there was a speed-dependent difference between the PFM activity variables. METHODS: This trial was designed as an exploratory and reliability study including ten young healthy female subjects to characterize PFM pre-activity and reflex activity during running at 7, 9 and 11 km/h. Six variables for each running speed, averaged over ten steps per subject, were presented descriptively, tested regarding their reliability (Friedman, ICC, SEM, MD) and speed difference (Friedman). RESULTS: PFM EMG variables varied between 67.6 and 106.1 %EMG, showed no systematic error and were low for SEM and MD using the single value model. Applying the average model over ten steps, ICC (3,k) were >0.75 and SEM and MD about 50 % lower than for the single value model. Activity was found to be highest in 11 km/h. CONCLUSION: EMG variables showed excellent ICC and very low SEM and MD. Further studies should investigate inter-session reliability and PFM reactivity patterns of SUI patients using the average over ten steps for each variable as it showed very high ICC and very low SEM and MD. Subsequently, longer running distances and other high-impact sports disciplines could be studied.

Jogging Therapy for Hikikomori Social Withdrawal and Increased Cerebral Hemodynamics: A Case Report.

Severe social withdrawal, called hikikomori, has drawn increased public attention. However, an optimal clinical approach and strategy of treatment has not been well established. Here, we report a case of hikikomori for which an exercise intervention using jogging therapy was effective, showing cerebral hemodynamic improvement. The patient was a 20 year old Japanese male who was hospitalized in order to evaluate and treat severe social withdrawal. Although depressive and anxiety symptoms partially subsided with sertraline alone, social withdrawal persisted due to a lack of self confidence. With his consent, we implemented exercise therapy with 30 minutes of jogging three times a week for three months. We did not change the pharmacotherapy, and his social withdrawal remarkably improved with continuous jogging exercise. Using near infrared spectroscopy to evaluate hemodynamic alteration, bilateral temporal hemodynamics considerably increased after the three-month jogging therapy. Regarding exercise therapy for mental illness, numerous studies have reported the effectiveness of exercise therapy for major depression. This case implied, however, that the applicability of exercise therapy is not limited to major depressive disorder. Jogging therapy may contribute to reinforcing self confidence associated with "resilience" in conjunction with neurophysiological modulation of neural networks.

The history of a habit: jogging as a palliative to sedentariness in 1960s America.

This article provides an account of the emergence of jogging as mass physical fitness practice in America in the 1960s. It explores how jogging was configured as a physical fitness activity suitable for sedentary middle-aged men and women. Jogging developed as a counter to the ill-effects of habits entrained by the increasingly sedentary lifestyles of modern industrialized urban and suburban dwellers. The paper traces the development of jogging as a defined exercise routine at the University of Oregon, Eugene, Oregon. Focusing on the moment when jogging is 'invented' as a recognizable fitness practice tells a great deal about the origin of contemporary regimes of physical fitness for the middle-aged population and how they have evolved. It also points to the significance of understanding how the shaping of corporeal habits play into the making of (1) individual bodies, (2) common practices of corporeal care and activity, and (3) environments of physical activity.

Influence of running on femoroacetabular joint bone-to-bone distances.

There is limited data quantifying the influence of running on hip cartilage mechanics. The goal of this investigation was to quantify changes in hip joint bone-to-bone distance in response to a 3-mile treadmill run. We acquired magnetic resonance (MR) images of the dominant hip of eight young, asymptomatic runners (five males, three females) before and immediately after they ran 3 miles at a self-selected pace on a level treadmill. The femoral heads and acetabula were semiautomatically segmented from the pre- and post-exercise MR images to generate three-dimensional models of each participant's hip that were used to compute changes in the bone-to-bone distances incurred by the running exercise. We observed a significant 3% decrease in bone-to-bone distance from 3.47 ± 0.20 to 3.36 ± 0.22 mm between the femoral head and acetabulum after a 3-mile treadmill run (mean ± 95% confidence interval; p = 0.03). These findings provide new baseline data describing how running impacts the hip joint in young, asymptomatic runners.

Cooperation between Nodal and FGF signals regulates zebrafish cardiac cell migration and heart morphogenesis.

Asymmetric vertebrate heart development is driven by an intricate sequence of morphogenetic cell movements, the coordination of which requires precise interpretation of signaling cues by heart primordia. Here we show that Nodal functions cooperatively with FGF during heart tube formation and asymmetric placement. Both pathways act as migratory stimuli for cardiac progenitor cells (CPCs), but FGF is dispensable for directing heart tube asymmetry, which is governed by Nodal. We further find that Nodal controls CPC migration by inducing left-right asymmetries in the formation of actin-based protrusions in CPCs. Additionally, we define a developmental window in which FGF signals are required for proper heart looping and show cooperativity between FGF and Nodal in this process. We present evidence FGF may promote heart looping through addition of the secondary heart field. Finally, we demonstrate that loss of FGF signaling affects proper development of the atrioventricular canal (AVC), which likely contributes to abnormal chamber morphologies in FGF-deficient hearts. Together, our data shed insight into how the spatiotemporal dynamics of signaling cues regulate the cellular behaviors underlying organ morphogenesis.

Association between outdoor jogging behavior and PM2.5 exposure: Evidence from massive GPS trajectory data in Beijing.

Outdoor jogging is one of the most popular practised exercises worldwide, providing various benefits for health and wellbeing. However, PM2.5 exposure risks of jogging behaviors were rarely explored. This study aims to investigate the association between jogging behavior and PM2.5 exposure with big data. PM2.5 exposure concentration and dose inhalation of individuals were calculated by integrating hourly PM2.5 concentration data and jogging GPS trajectory recorded by a sports app during 2015 in Beijing, after which relationships between jogging behaviors and PM2.5 exposure were unpacked using statistics analysis and structural equation modelling. Experimental results on massive jogging trajectories show that: (1) the average jogging PM2.5 exposure concentration is 60.43 µg/m3, and female joggers inhaled significantly less air pollution dose (19.70 µg) than men (24.91 µg). (2) There exist significant spatiotemporal disparities in jogging exposure to PM2.5. Joggings in the city center, in the morning, on weekdays and in autumn and winter seasons were exposed to higher pollution concentrations. (3) Jogging behavior characteristics, especially distance, activity space size, duration and rotation, were systematically associated with PM2.5 exposure across space and time. (4) The role of gender directly shaped joggers' dose inhalation of PM2.5 pollution and indirectly via duration, timing choice and distance. (5) The effects of weather conditions on joggers' exposure to PM2.5 are mainly via direct effects, whereas the direct impacts of precipitation and wind speed are mitigated by indirect effects stemming from jogging behavior patterns. Our findings provide insights for personal guidance and policy intervention for the sake of promoting physical activity and reducing PM2.5 exposure.

Harnessing Passive Pulsatile Shear Stress for Alzheimer's Disease Prevention and Intervention.

 Alzheimer's disease (AD) affects more than 40 million people worldwide and is the leading cause of dementia. This disease is a challenge for both patients and caregivers and puts a significant strain on the global healthcare system. To address this issue, the Lancet Commission recommends focusing on reducing modifiable lifestyle risk factors such as hypertension, diabetes, and physical inactivity. Passive pulsatile shear stress (PPSS) interventions, which use devices like whole-body periodic acceleration, periodic acceleration along the Z-axis (pGz), and the Jogging Device, have shown significant systemic and cellular effects in preclinical and clinical models which address these modifiable risks factors. Based on this, we propose that PPSS could be a potential non-pharmacological and non-invasive preventive or therapeutic strategy for AD. We perform a comprehensive review of the biological basis based on all publications of PPSS using these devices and demonstrate their effects on the various aspects of AD. We draw from this comprehensive analysis to support our hypothesis. We then delve into the possible application of PPSS as an innovative intervention. We discuss how PPSS holds promise in ameliorating hypertension and diabetes while mitigating physical inactivity, potentially offering a holistic approach to AD prevention and management.