An Improved RAIM Availability Assessment Method Based on the Characteristic Slope.

The availability assessment is an important step for onboard application in Receiver Autonomous Integrity Monitoring (RAIM)s. It is commonly implemented using the protection level (PL)-based method. This paper analyzes the deficiencies of three kinds of PL-based methods: RAIM availability might be optimistically or conservatively assessed using the classic-PL-base method; might be conservatively assessed using the enhanced-PL-based method, and neither be optimistically nor conservatively assessed using the ideal-PL-based method with the cost of large calculation amount on-board. An improved slope-based RAIM availability assessment method is proposed, in which the characteristic slope is designed as the assessment basis, and its threshold that can exactly match the integrity risk requirement is derived. The slope-based method has the same RAIM availability assessment result as the ideal-PL-based method. Moreover, because the slope threshold can be calculated offline and searched online, the on-board calculation burden can be reduced using the slope-based method. Simulation is presented to verify the theoretical analysis of the RAIM availability assessment performances for the three PL-based and the slope-based methods.

LEGAL CONFLICTS IN MEDICAL PRACTICE AND METHODS OF THEIR RESOLUTION.

OBJECTIVE: The aim: A theoretical and applied study of the essence of legal conflicts in the field of medical activity in order to determine the proper system of ways to protect the interests of patients, doctors and other participants in medical legal relations. PATIENTS AND METHODS: Materials and methods: Various methods of scientific knowledge make up the methodological basis of research. Thus, the comparative legal method was used to compare the features of the legal regulation of the rights protection of medical legal relations subjects in different countries. The essence and classification criteria of both legal conflicts and methods of protection in the field of medical activity were investigated with the help of a system-complex method. The following other methods were used in the study, in particular: formal-logical, dialectical, analysis and synthesis. CONCLUSION: Conclusions: The classification of dispute resolution methods in the aspect of medical activity indicates the possibility of distinguishing non-jurisdictional (self-defense) and jurisdictional (special, administrative, judicial protection) forms of patients' rights protection, as well as distinguishing two levels of such protection (pre-trial and judicial), each of which has its distinctive features and the patient himself is able to determine in what way and by what level to protect his rights. An important role in the conflict resolution in the field of health care is primarily played by the pre-trial protection, the defining features of which are the voluntary nature of conflict resolution, the availability, convenience and speed of dispute resolution as well as the possibility of compensation for the damage caused.

Derivation of occupational exposure limits: Differences in methods and protection levels.

Frameworks for deriving occupational exposure limits (OELs) and OEL-analogue values (such as derived-no-effect levels [DNELs]) in various regulatory areas in the EU and at national level in Germany were analysed. Reasons for differences between frameworks and possible means of improving transparency and harmonisation were identified. Differences between assessment factors used for deriving exposure limits proved to be one important reason for diverging numerical values. Distributions for exposure time, interspecies and intraspecies extrapolation were combined by probabilistic methods and compared with default values of assessment factors used in the various OEL frameworks in order to investigate protection levels. In a subchronic inhalation study showing local effects in the respiratory tract, the probability that assessment factors were sufficiently high to protect 99% and 95% of the target population (workers) from adverse effects varied considerably from 9% to 71% and 17% to 87%, respectively, between the frameworks. All steps of the derivation process, including the uncertainty associated with the point of departure (POD), were further analysed with two examples of full probabilistic assessments. It is proposed that benchmark modelling should be the method of choice for deriving PODs and that all OEL frameworks should provide detailed guidance documents and clearly define their protection goals by stating the proportion of the exposed population the OEL aims to cover and the probability with which they intend to provide protection from adverse effects. Harmonisation can be achieved by agreeing on the way to perform the methodological steps for deriving OELs and on common protection goals.

ARAIM Stochastic Model Refinements for GNSS Positioning Applications in Support of Critical Vehicle Applications.

Integrity monitoring (IM) is essential if GNSS positioning technologies are to be fully trusted by future intelligent transport systems. A tighter and conservative stochastic model can shrink protection levels in the position domain and therefore enhance the user-level integrity. In this study, the stochastic models for vehicle-based GNSS positioning are refined in three respects: (1) Gaussian bounds of precise orbit and clock error products from the International GNSS Service are used; (2) a variable standard deviation to characterize the residual tropospheric delay after model correction is adopted; and (3) an elevation-dependent model describing the receiver-related errors is adaptively refined using least-squares variance component estimation. The refined stochastic models are used for positioning and IM under the Advanced Receiver Autonomous Integrity Monitoring (ARAIM) framework, which is considered the basis for multi-constellation GNSS navigation to support air navigation in the future. These refinements are assessed via global simulations and real data experiments. Different schemes are designed and tested to evaluate the corresponding enhancements on ARAIM availability for both aviation and ground vehicle-based positioning applications.

Drivers of ecological effectiveness of marine protected areas: A meta-analytic approach from the Southwestern Atlantic Ocean (Brazil).

With the rapid global increase in the number and extent of marine protected areas (MPAs), there is a need for methods that enable an assessment of their actual contribution to biodiversity conservation. In Brazil, where MPAs have been designated to replenish biodiversity, there is a lack of regional-scale analysis of MPA impacts and the factors related to positive ecological change. This study aims to quantify the magnitude of the ecological effects of Brazilian MPAs and test whether some study and MPA characteristics (e.g., taxonomic group studied, exploitation level of species, MPA area, protection time, management effectiveness, level of connectedness, etc.) were underlying factors associated with their performance. We conducted a structured search in a database of scientific articles, selecting comparative studies of direct biodiversity metrics inside and outside MPAs offering different protection levels (i.e., fully- or partially-protected MPAs) or within MPAs with distinct zones. We then carried out a meta-analysis based on 424 observations found in 18 articles. Averaged across all studies, we found that MPAs had a 17% increase in the abundance of species, length of individuals, and community diversity. When compared to open-access areas, fully-protected MPAs increased biodiversity by 45%. However, MPAs offering partial protection had variable effects, ranging from significant positive to significant negative effects. MPA effects depended on the taxonomic group and exploitation level of species, with the strongest positive effects seen on exploited fish species and benthic invertebrates. Partially-protected MPAs that reported strong positive effects required long time of protection (>15years) and high level of connectivity. Conversely, fully-protected MPAs (i.e., no-take ones) could be effective even when small, under intense fishing pressure in their surroundings, and regardless of their level of connectivity. We used the Brazilian MPAs as a case study, but these results can contribute to a more comprehensive assessment of the association between ecological impacts of MPAs and drivers of conservation success, and offer key information to consolidate MPA networks that sustain biodiversity.

Seroepidemiology of enterovirus D68 in a healthy population in Beijing, China, between 2012 and 2017: A retrospective study.

To investigate the seroepidemiological features of enterovirus D68 (EV-D68) in the healthy population from 2012 to 2017 in Beijing, China. A retrospective cross-sectional investigation was conducted using serum specimens collected from healthy individuals in Beijing from 2012 to 2017. These samples were tested for neutralization antibodies (NtAbs) against EV-D68. The sera from six EV-D68 infected patients in the acute or convalescent phase were used to determine the protection level of NtAbs against EV-D68. The geometric means of the titers (GMT) of EV-D68 NtAbs in 2012 and 2017 were 92.82 and 242.91, respectively; the seroprevalences of EV-D68 were 89.43% and 98.43%, respectively. The GMT reached its peak in the 11 to 15 age group in 2012, while in 16 to 20 age group in 2017. We also observed that EV-D68 NtAbs titers of six sera from the acute phase were all less than equal to 1:64 and that of three sera from the convalescent phase were all more than 1:64. Anti-EV-D68 NtAbs in the population remained low from 2012 to 2016 but increased significantly in 2017. Although most of the EV-D68 infections remain undetected in Beijing, the risk of a large outbreak of EV-D68 exists and should be taken seriously.

Analysis of the Single Frequency Network Gain in Digital Audio Broadcasting Networks.

The single frequency network (SFN) is a popular solution in modern digital audio and television system networks for extending effective coverage, compared to its traditional single-transmitter counterpart. As benefits of this configuration appear to be obvious, this paper focuses on the exact analysis of so-called SFN gain-a quantitative effect of advantage in terms of the received signal strength. The investigations cover a statistical analysis of SFN gain values, obtained by means of computer simulations, with respect to the factors influencing the coverage, i.e., the protection level, the reception mode (fixed, portable, mobile), and the receiver location (outdoor, indoor). The analyses conclude with an observation that the most noteworthy contribution of the SFN gain is observed on the far edges of the networks, and the least one close to the transmitters. It is also observed that the highest values of the SFN gain can be expected in the fixed mode, while the protection level has the lowest impact.

An Online SBAS Service to Improve Drone Navigation Performance in High-Elevation Masked Areas.

Owing to the high demand for drone operation in high-elevation masked areas, it is necessary to develop a more effective method of transmitting and applying Satellite-Based Augmentation System (SBAS) messages for drones. This study proposes an onboard module including correction conversion, integrity information calculation, and fast initialization requests, which can enable the application of an online SBAS to drone operation. The proposed system not only improves the position accuracy with timely and proper protection levels in an open sky, but also reduces the initialization time from 70-100 s to 1 s, enabling a drone of short endurance to perform its mission successfully. In SBAS signal-denied cases, the position accuracy was improved by 40% and the uncorrected 13.4 m vertical error was reduced to 5.6 m by applying an SBAS message delivered online. The protection levels calculated with the accurate position regardless of the current location could denote the thrust level and availability of the navigation solution. The proposed system can practically solve the drawbacks of the current SBAS, considering the characteristics of the low-cost receivers on the market. Our proposed system is expected to be a useful and practical solution to integrate drones into the airspace in the near future.

Integrity Monitoring of Multimodal Perception System for Vehicle Localization.

Autonomous driving systems tightly rely on the quality of the data from sensors for tasks such as localization and navigation. In this work, we present an integrity monitoring framework that can assess the quality of multimodal data from exteroceptive sensors. The proposed multisource coherence-based integrity assessment framework is capable of handling highway as well as complex semi-urban and urban scenarios. To achieve such generalization and scalability, we employ a semantic-grid data representation, which can efficiently represent the surroundings of the vehicle. The proposed method is used to evaluate the integrity of sources in several scenarios, and the integrity markers generated are used for identifying and quantifying unreliable data. A particular focus is given to real-world complex scenarios obtained from publicly available datasets where integrity localization requirements are of high importance. Those scenarios are examined to evaluate the performance of the framework and to provide proof-of-concept. We also establish the importance of the proposed integrity assessment framework in context-based localization applications for autonomous vehicles. The proposed method applies the integrity assessment concepts in the field of aviation to ground vehicles and provides the Protection Level markers (Horizontal, Lateral, Longitudinal) for perception systems used for vehicle localization.

Protection level of anti-hepatitis B vaccine and immunoglobulin in a pediatric Cameroonian population.

Despite the availability for nearly twenty years of an effective vaccine, hepatitis B remains one of the most frequent viral diseases throughout the world. Mother-to-child transmission is one of the primary routes of transmission in children. To assess the vaccine response in children born to HBV infected mothers. HBsAg-positive consenting mothers registered in the antenatal care (ANC) service database of Centre Hospitalier Dominicain St-Martin de Porres, Yaounde were enrolled with their children. Socio-demographic characteristics were collected using a tested questionnaire. The 5 markers of hepatitis B were tested and the quantification of anti-HBsAg antibodies was done by indirect ELISA method. The data collected was analyzed using Microsoft excel and Epi-info softwares. Out of 5,996 women registered, 143 were identified as HBsAg positive (2.38% prevalence) and none was HBeAg positive. Of these 143 HBsAg positive women, 50 were enrolled in the study. Of the 50 positive mothers, 78 children were included with a mean age ± standard deviation of 2.33±2.86 years. No child was infected with HBV, but all have been exposed to the virus (HBeAb-positive). Overall 64 (82.05%) received at birth both anti-HBs immunoglobulin (HBIG) and a dose of vaccine, while 14 (17.95%) received only the birth dose of vaccine. 72 (92.31%) children received all three recommended doses of vaccine. Vaccine responders were 62.82% (above 10 IU/ml), while 37.18% of children were non-responders; representing a higher risk group if not boosted. The coverage of the anti-HBV vaccine in children in this study was 92.31%. The protection level of 62.82% is below the 95% recommended rate by WHO. The factors sustaining this suboptimal protection should be investigated.

Occupational Dust Exposure and Respiratory Protection of Migrant Interior Construction Workers in Two Chinese Cities.

Migrant interior construction workers are increasing in China. Construction workers are at an increased risk of work-related illness (WRI) due to prolonged exposure to and inhalation of dust. Dust concentrations in the air can be reduced significantly with effective respiratory protection measures. We assessed the dust exposure and factors associated with respiratory protection of migrant interior construction workers. The total dust concentration in the workplace ranged from 0.07 to 335.27 mg/m3, with a total dust exceedance rate of 50.00%. The respiratory dust loading ranged from 0.03 to 220.27 mg/m3, with a respiratory dust exceedance rate of 71.42 %. The highest total dust concentration occurred when masons were polishing cement walls. We performed a questionnaire survey of 296 persons in two cities in China, in which 87.84% had no respiratory protection or only one protection measure. Gender, workplace, respiratory disease, and protective attitude all had an effect on the level of respiratory protection. The dust exposure in most jobs exceeds hygiene standards. The respiratory protection of migrant interior construction workers in China is inadequate.

Attenuation of antibody titer of measles and rubella virus among university students of department of healthcare providers during 2015-2018 in Japan.

BACKGROUND: In Japan, measles elimination was confirmed in March 2015. Nevertheless, some outbreaks with cases imported from abroad were reported even after certification. A large rubella outbreak has been occurring since 2017. This study examines measurement of the speed of attenuation of antibody titer for a measles virus comparison with rubella virus. METHOD: Student subjects born from April 2, 1996 through April 1, 2000 were selected at Ibaraki Prefectural University of Health Sciences for this study: 177 for measles and 114 for rubella. They had available dates of additional immunization and antibodies in the following period and were judged as requiring additional immunization. We used enzyme immunoassay for IgG antibody testing. We regressed post-antibody titers of measles or rubella on pre-antibody titers and functions of duration between inoculation to post-evaluation. Functions of duration were selected according to the adjusted coefficient of determination. RESULTS: For measles, only a linear term of duration or log of duration was found to be significant without the quadratic terms. For rubella, we selected a five-order linear model which indicated that titer after vaccination would converge to 19.2. DISCUSSION: Results demonstrate that measles antibody decreased monotonically. If the pre-antibody titer was 15, vaccination raised titer quickly to 26; then it attenuated by 0.014 per day. Antibody titer is expected to be less than 16, which is the protection level of titer, after 704 days. For rubella, however, when pre-vaccination titer was evaluated at its average, the lower limit was 19.2. Therefore, protection can be maintained for a long time. This difference might reflect some circumstances of outbreaks of the respective diseases. CONCLUSION: This report describes the speed of attenuation and the epidemiological situation. The speed of attenuation can be expected to rise. Therefore, additional vaccination every several years might be necessary to maintain a protection level if a disease is almost eliminated.

Analysis of quality control and protection level test results of medical electron linear accelerators in Shanghai, China / 中国辐射卫生

@#<b>Objective</b> To investigate the quality control and protection level of medical electron linear accelerators in Shanghai, China. <b>Methods</b> The startified random sampling method was used to cover tertiary, secondary and ungraded hospitals, and a total of 30 medical electron linear accelerators in 15 hospitals were tested for quality control and protection level according to relevant standards. <b>Results</b> Five medical electron linear accelerators failed the quality control test, with an overall inspection pass rate of 83.3% and a re-inspection pass rate of 100%. The pass rate of flatness of square X-ray irradiation field (5 cm × 5 cm)-(30 cm × 30 cm) was 83.3%, the pass rate of symmetry of square X-ray irradiation field was 96.7%, and other indices were qualified. All medical electron linear accelerator rooms passed the protection test. <b>Conclusion</b> The protection of medical electron linear accelerator rooms in Shanghai meets the requirements of national standards, and some indices do not meet the requirements of national standards in the preliminary inspection. The quality control of medical electron linear accelerators should be further strengthened to ensure the treatment effect of patients.

Protection level of anti­hepatitis B vaccine and immunoglobulin in a pediatric Cameroonian population

Despite the availability for nearly twenty years of an effective vaccine, hepatitis B remains one of the most frequent viral diseases throughout the world. Mother to child transmission is one of the primary routes of transmission in children. To assess the vaccine response in children born to HBV infected mothers. HBsAg positive consenting mothers registered in the antenatal care (ANC) service database of Centre Hospitalier Dominicain St Martin de Porres, Yaounde were enrolled with their children. Socio demographic char acteristics were collected using a tested questionnaire. The 5 markers of hepatitis B were tested and the quantification of anti HBsAg antibodies was done by indirect ELISA method. The data collected was analyzed using Microsoft excel and Epi info softwares. Out of 5,996 women registered, 143 were identified as HBsAg positive (2.38% prevalence) and none was HBeAg positive. Of these 143 HBsAg positive women, 50 were enrolled in the study. Of the 50 positive mothers, 78 children were included with a mean age ± standard deviation of 2.33±2.86 years. No child was infected with HBV, but all have been exposed to the virus (HBeAb positive). Overall 64 (82.05%) received at birth both anti HBs immunoglobulin (HBIG) and a dose of vaccine, while 14 (17.95%) received only the birth dose of vaccine. 72 (92.31%) children received all three recommended doses of vaccine. Vaccine responders were 62.82% (above 10 IU/ml), while 37.18% of children were non responders; representing a higher risk group if not boosted. The coverage of the anti HBV vaccine in children in this study was 92.31%. The protection level of 62.82% is below the 95% recommended rate by WHO. The factors sustaining this suboptimal protection should be investigated