Farmland expansion and intensification do not foster local food self-sufficiency. Insights from the Mediterranean area.

Bridging the gap between the micro and the macro scale in modelling food security to inform context-specific regionalised policies remains a major scientific challenge. A better understanding of the relations between global and local drivers impacting local food self-sufficiency (LFSS) is essential. We applied to the whole Mediterranean environmental area (Southern and Northern) a modelling framework for structural estimates (PLS-PM) using qualitative and quantitative methods to combine local-level information from field surveys and participatory workshops with global-level data. Our findings show that farmland expansion and intensification spatially disconnected from urban consumption areas do not appear to foster LFSS. On the other hand, public policies appear key to enhancing LFSS in the Mediterranean area if appropriate to the particular regional context. We outline how this multi-level modelling methodology can contribute to a place-based approach by informing context-specific regionalised policies aimed at food security.

Heads or tails: making the spinal cord.

The central nervous system contains a vast array of cell types that are produced along the length of the rostrocaudal axis. This diversity in cell identity is established during embryonic development, and ensures that physiologically distinct cell types develop in the appropriate position in the body. Understanding how this cellular diversity arises remains a major challenge central to the field of developmental biology. In more recent years, approaches using pluripotent embryonic stem cells (ESCs) as in vitro models of development have revealed many insights into nervous system regionalisation. Here, we outline advances in the directed differentiation of ESCs, focusing on the generation of the spinal cord. We discuss the regionalisation events that impact the caudal part of the nervous system, highlighting general principles underpinning rostrocaudal differences within the mammalian body plan.

Light intensity mediates phenotypic plasticity and leaf trait regionalization in a tank bromeliad.

BACKGROUND AND AIMS: Phenotypic plasticity allows plants to cope with environmental variability. Plastic responses to the environment have mostly been investigated at the level of individuals (plants) but can also occur within leaves. Yet the latter have been underexplored, as leaves are often treated as functional units with no spatial structure. We investigated the effect of a strong light gradient on plant and leaf traits and examined whether different portions of a leaf show similar or differential responses to light intensity. METHODS: We measured variation in 27 morpho-anatomical and physiological traits of the rosette and leaf portions (i.e. base and apex) of the tank bromeliad Aechmea aquilega (Bromeliaceae) when naturally exposed to a marked gradient of light intensity. KEY RESULTS: The light intensity received by A. aquilega had a strong effect on the structural, biochemical and physiological traits of the entire rosette. Plants exposed to high light intensity were smaller and had wider, shorter, more rigid and more vertical leaves. They also had lower photosynthetic performance and nutrient levels. We found significant differences between the apex and basal portions of the leaf under low-light conditions, and the differences declined or disappeared for most of the traits as light intensity increased (i.e. leaf thickness, adaxial trichome density, abaxial and adaxial trichome surface, and vascular bundle surface and density). CONCLUSIONS: Our results reveal a strong phenotypic plasticity in A. aquilega, particularly in the form of a steep functional gradient within the leaf under low-light conditions. Under high-light conditions, trait values were relatively uniform along the leaf. This study sheds interesting new light on the functional complexity of tank bromeliad leaves, and on the effect of environmental conditions on leaf trait regionalization.

Joint programmes in paediatric cardiac surgery: an update and descriptive analysis.

OBJECTIVE: Joint programmes are an alternative model that may aid in improving congenital cardiac surgery outcomes while avoiding the potential resource and accessibility challenges that could result from regionalisation. This study aims to characterise current joint programmes, identify factors that are associated with joint programme success and failure, and gauge attitudes within the profession regarding joint programmes as an alternative. METHODS: A multiple choice survey with 23 standard questions for all programmes and additional 42 additional questions for each participant hospital in a joint programme was addressed to paediatric cardiac surgeons in the United States of America. Questions were designed to qualitatively and quantitatively characterise congenital cardiac surgery joint programmes. RESULTS: Of the 34 unique congenital cardiac surgery programmes identified in this survey, 14 have participated in a joint programme and 50% of those joint programmes existed for more than 10 years. Most joint programmes (86%) participate or participated in a model where the hospital participants are engaged in a "mother-daughter" relationship in both perception and case volume distribution. In three out of four defunct joint programmes, there were case complexity limitations placed on partner institutions, but the now independent partner institutions operate with no limitation on complexity. Most (71%) hospital participants in a joint programme felt that the joint programme produced better outcomes than two separate programmes; however, among those who participate or have participated in a joint programme, only 18% felt that joint programmes were the optimal model for delivery of congenital cardiac surgical care.

Patterns of intracolumnar size variation inform the heterochronic mechanisms underlying extreme body shape divergence in microcephalic sea snakes.

Sea snakes (Hydrophiinae) that specialize on burrowing eel prey have repeatedly evolved tiny heads and reduced forebody relative to hindbody girths. Previous research has found that these "microcephalic" forms have higher counts of precaudal vertebrae, and postnatal ontogenetic changes cause their hindbodies to reach greater girths relative to their forebodies. We examine variation in vertebral size along the precaudal axis of neonates and adults of three species. In the nonmicrocephalic Hydrophis curtus, these intracolumnar patterns take the form of symmetrical curved profiles, with longer vertebrae in the midbody (50% of body length) relative to distal regions. In contrast, intracolumnar profiles in the microcephalic H. macdowelli and H. obscurus are strongly asymmetrical curves (negative skewness) due to the presence of numerous, smaller-sized vertebrate in the forebody (anterior to the heart). Neonate and adult H. macdowelli and H. obscurus specimens all exhibit this pattern, implying an onset of fore- versus hindbody decoupling in the embryo stage. Based on this, we suggest plausible developmental mechanisms involving the presence and positioning of Hox boundaries and heterochronic changes in segmentation. Tests of our hypotheses would give new insights into the drivers of rapid convergent shifts in evolution, but will ultimately require studies of gene expression in the embryos of relevant taxa.

Facilitating market access: risk assessment, equivalence and regionalisation provisions in the Agreement on the Application of Sanitary and Phytosanitary Measures.

The World Trade Organization (WTO) Agreement on the Application of Sanitary and Phytosanitary Measures contains several key provisions that are important for trade in animals and animal products, namely on risk assessment, equivalence and regionalisation. The risk assessment provision allows countries to adopt, on the basis of a risk assessment, measures which achieve a higher level of sanitary protection than that embodied in existing relevant international standards. The equivalence provision requires importing countries to acknowledge that, while the production methods of the exporting country may differ from their own, they may still provide an equivalent level of health protection. Finally, the regionalisation provision enables countries to export animals and animal products from diseasefree areas, even if other areas within that country have experienced outbreaks of a particular animal disease. This paper explores how these provisions, and the scientific concept of the appropriate level of protection, facilitate trade while at the same time allowing Members to establish their sanitary measures. This paper also provides information on the relevant discussions of these provisions within the Committee on Sanitary and Phytosanitary Measures.

L'Accord de l'Organisation mondiale du commerce (OMC) sur l'application des mesures sanitaires et phytosanitaires contient d'importantes dispositions relatives aux échanges internationaux d'animaux et de produits d'origine animale qui concernent les aspects suivants : l'évaluation du risque, l'équivalence et la régionalisation. La disposition sur l'évaluation du risque permet à un pays d'adopter des mesures conférant un niveau de protection plus élevé que celui prévu dans les normes internationales en vigueur, dès lors que cette décision se fonde sur une évaluation du risque. En vertu du principe d'équivalence, un pays importateur est tenu de reconnaître que les méthodes de production appliquées par un pays exportateur peuvent différer de celles qu'il applique luimême et apporter néanmoins des garanties de protection sanitaire équivalentes aux siennes. Enfin, la régionalisation permet aux pays d'exporter des animaux et des produits d'origine animale à partir des régions de leur territoire qui sont indemnes de maladies, même si des foyers d'une maladie animale particulière ont été enregistrés dans d'autres régions. L'auteure explique en quoi ces dispositions et le concept scientifique de « niveau approprié de protection ¼ facilitent le commerce tout en permettant aux Membres d'instaurer leurs propres mesures sanitaires. L'auteure décrit également les discussions dont ces dispositions font l'objet au sein du Comité des mesures sanitaires et phytosanitaires.

El Acuerdo sobre la Aplicación de Medidas Sanitarias y Fitosanitarias (Acuerdo MSF) de la Organización Mundial del Comercio (OMC) contiene varias disposiciones básicas que son importantes para el comercio de animales y productos de origen animal, a saber, las relativas a la determinación del riesgo, a la equivalencia y a la regionalización. La disposición sobre determinación del riesgo permite que los países, basándose en una determinación del riesgo, adopten medidas que conlleven un nivel de protección sanitaria mayor que el que establecen las normas internacionales existentes en la materia. La disposición sobre equivalencia exige que los países importadores reconozcan que los métodos de producción del país exportador, aun pudiendo diferir de los propios, pueden ofrecer un nivel equivalente de protección sanitaria. La disposición sobre regionalización, por último, permite que un país exporte animales y productos de origen animal procedentes de zonas libres de enfermedad aun cuando otras zonas de ese mismo país hayan sufrido brotes de una enfermedad animal en particular. La autora explica cómo estas disposiciones y el concepto científico de «nivel apropiado de protección¼ facilitan el comercio y a la vez permiten a los Miembros instaurar sus propias medidas sanitarias. Asimismo, proporciona información sobre los debates y reflexiones del Comité de Medidas Sanitarias y Fitosanitarias en torno a estas disposiciones.

Soil quality index: Exploring options for a comprehensive assessment of land use impacts in LCA.

Impacts associated with land use are increasingly recognized as important aspects to consider when conducting Life Cycle Assessment (LCA). Across the existing models accounting for land use activities in life cycle impact assessment, a balance is yet to be found between complexity and comprehensiveness on one hand, and applicability on the other hand. This work builds on the LANd use indicator value CAlculation (LANCA®) model, assessing the impacts of land use activities on five soil properties, and aims at developing an aggregated index to improve its applicability. First a statistical analysis is conducted, leading to the shortlisting of the four most significant soil quality indicators. Then two options for aggregating the selected indicators are presented: the soil quality index (SQI), based on linear aggregation, and the normalisation-based soil quality index (NSQI), where the aggregation process involves normalisation integrated into the characterisation step. Country-specific and global average characterisation factors (CFs) are calculated for 57 land use types considering both land occupation and land transformation interventions with the two suggested approaches. The two indices present similar ranking of land use types but the relative contribution of the separate indicators to the aggregated index varies according to the approach adopted. The differences between the aggregation approaches suggested are discussed, together with the limitations related to both the LANCA® model and the aggregation approaches. This work represents a first step towards the widespread application of a comprehensive and robust land use model at midpoint level in LCA. Finally, a number of recommendations for the future development of the LANCA® model and of the related soil quality models are provided.

Assessment of agroforestry residue potentials for the bioeconomy in the European Union.

The biobased chemical industry is characterised by strong growth. Innovative products and materials such as biopolymers have been developed, and current European demand for biopolymers exceeds the domestic supply. Agroforestry residues can serve as main sources of the basic building blocks for chemicals and materials. This work assesses sustainably available agroforestry residues to feed a high added-value materials and product bioeconomy. To evaluate bioeconomic potential, a structured three-step approach is applied. Cultivation practices, sustainability issues, legislative restrictions, technical limitations and competitive applications are considered. All data regarding bioeconomic potential are processed on a regional level and mapped by ArcGIS. Our results identify wheat straw as the most promising source in the agricultural sector, followed by maize stover, barley straw and rape straw, which all contain a total concentration of lignocellulose of more than 80% of dry matter. In the forestry sector, residue bark from two coniferous species, spruce and pine, is the most promising source, with approximately 70% lignocellulose. Additionally, coniferous bark contains considerable amounts of tannin, which has attracted increasing interest for industrial utilisation. A sensitivity analysis concerning removal rates, residue-to-crop ratios, changes in farming technologies and competing applications is applied at the end of the study to consolidate our results.

The neuroanatomy of autism - a developmental perspective.

Autism Spectrum Disorders (ASDs) are a heterogeneous group of neurodevelopmental disorders that are diagnosed solely on the basis of behaviour. A large body of work has reported neuroanatomical differences between individuals with ASD and neurotypical controls. Despite the huge clinical and genetic heterogeneity that typifies autism, some of these anatomical features appear to be either present in most cases or so dramatically altered in some that their presence is now reasonably well replicated in a number of studies. One such finding is the tendency towards overgrowth of the frontal cortex during the early postnatal period. Although these reports have been focused primarily on the presumed pathological anatomy, they are providing us with important insights into normal brain anatomy and are stimulating new ideas and hypotheses about the normal trajectory of brain development and the function of specific anatomical brain structures. The use of model systems that include genetic model organisms such as the mouse and, more recently, human induced pluripotent stem cell-derived brain organoids to model normal and pathological human cortical development, is proving particularly informative. Here we review some of the neuroanatomical alterations reported in autism, with a particular focus on well-validated findings and recent advances in the field, and ask what these observations can tell us about normal and abnormal brain development.

Serious maternal complications in relation to severe pre-eclampsia: a retrospective cohort study of the impact of hospital volume.

OBJECTIVE: We examined rates of serious maternal complications in relation to severe pre-eclampsia based on the delivering hospital's annualised volume. DESIGN: Retrospective cohort study. POPULATION AND SETTING: Singleton deliveries (n = 25 782 235) in 439 hospitals in the USA. METHODS: Annualised hospital volume was categorised as 25-500, 501-1000, 1001-2000 and >2000. MAIN OUTCOME MEASURES: Rates of in-hospital maternal death and serious maternal complications, including puerperal cerebrovascular disorders, pulmonary oedema, disseminated intravascular coagulation, acute renal, heart and liver failure, sepsis, haemorrhage and intubation in relation to severe pre-eclampsia. We derived adjusted risk ratio (RR) and 95% confidence interval (CI), from hierarchical Poisson regression models. RESULTS: Severe pre-eclampsia was associated with an 8.7-fold (95% CI 7.6, 10.1) risk of composite maternal complications, with similar RRs across levels of hospital volumes. However, compared with hospitals with low annual volume (<2000), maternal mortality rates in relation to severe pre-eclampsia were lower in high volume hospitals. The rates of serious maternal complications were 410.7 per 10 000 to women who delivered in hospitals with a high rate of severe pre-eclampsia (≥2.12%) and 584.8 per 10 000 to women who delivered in hospitals with low severe pre-eclampsia rates (≤0.41; RR 1.75, 95% CI 1.24, 2.45). CONCLUSIONS: While the risks of serious maternal complications in relation to severe pre-eclampsia was similar across hospital delivery volume categories, deaths showed lower rates in large delivery volume hospitals than in smaller volume hospitals. The risk of complications was increased in hospitals with low compared with high severe pre-eclampsia rates. TWEETABLE ABSTRACT: Hospital volume had little impact on the association between severe pre-eclampsia and maternal complications.

Paediatric cardiac surgery in a peripheral European region: is a joint programme a safe alternative to regionalisation?

BACKGROUND: In 2007, a partnership was initiated between a small-volume paediatric cardiac surgery unit located in Las Palmas de Gran Canaria, Spain, and a large-volume cardiac surgery unit located in Milan, Italy. The main goal of this partnership was to provide surgical treatment to children with CHD in the Canary Islands. METHODS: An operative algorithm for performing surgery in elective, urgent, and emergency cases was adopted by the this joint programme. Demographic and in-hospital variables were collected from the medical records of all the patients who had undergone surgical intervention for CHD from January, 2009 to March, 2013. Data were introduced into the congenital database of the European Congenital Heart Surgeons Association Congenital Database and the database was interrogated. RESULTS: In total, 65 surgical mission trips were performed during the period of this study. The European Congenital Heart Surgeons Association Congenital Database documented 214 total patients with a mean age at operation of 36.45 months, 316 procedures in total with 198 cardiopulmonary bypass cases, 46 non-cardiopulmonary bypass cases, 26 cardiovascular cases without cardiopulmonary bypass, 22 miscellaneous other types of cases, 16 interventional cardiology cases, six thoracic cases, one non-cardiac, non-thoracic procedure on a cardiac patient with cardiac anaesthesia, and one extracorporeal membrane oxygenation case. The 30-day mortality was 6.07% (13 patients). CONCLUSIONS: A joint programme between a small-volume centre and a large-volume centre may represent a valid and reproducible model for safe paediatric cardiac surgery in the context of a peripheral region.

Distinct roles of homeoproteins in brain topographic mapping and in neural circuit formation.

The construction of the brain is a highly regulated process, requiring coordination of various cellular and molecular mechanisms that together ensure the stability of the cerebrum architecture and functions. The mature brain is an organ that performs complex computational operations using specific sensory information from the outside world and this requires precise organization within sensory networks and a separation of sensory modalities during development. We review here the role of homeoproteins in the arealization of the brain according to sensorimotor functions, the micropartition of its cytoarchitecture, and the maturation of its sensory circuitry. One of the most interesting observation about homeoproteins in recent years concerns their ability to act both in a cell-autonomous and non-cell-autonomous manner. The highlights in the present review collectively show how these two modes of action of homeoproteins confer various functions in shaping cortical maps.

Elements of regional beetle faunas: faunal variation and compositional breakpoints along climate, land cover and geographical gradients.

Regional faunas are structured by historical, spatial and environmental factors. We studied large-scale variation in four ecologically different beetle groups (Coleoptera: Dytiscidae, Carabidae, Hydrophiloidea, Cerambycidae) along climate, land cover and geographical gradients, examined faunal breakpoints in relation to environmental variables, and investigated the best fit pattern of assemblage variation (i.e. randomness, checkerboards, nestedness, evenly spaced, Gleasonian, Clementsian). We applied statistical methods typically used in the analysis of local ecological communities to provide novel insights into faunal compositional patterns at large spatial grain and geographical extent. We found that spatially structured variation in climate and land cover accounted for most variation in each beetle group in partial redundancy analyses, whereas the individual effect of each explanatory variable group was generally much less important in accounting for variation in provincial species composition. We also found that climate variables were most strongly associated with faunal breakpoints, with temperature-related variables alone accounting for about 20% of variation at the first node of multivariate regression tree for each beetle group. The existence of faunal breakpoints was also shown by the 'elements of faunal structure' analyses, which suggested Clementsian gradients across the provinces, that is, that there were two or more clear groups of species responding similarly to the underlying ecological gradients. The four beetle groups showed highly similar biogeographical patterns across our study area. The fact that temperature was related to faunal breakpoints in the species composition of each beetle group suggests that climate sets a strong filter to the distributions of species at this combination of spatial grain and spatial extent. This finding held true despite the ecological differences among the four beetle groups, ranging from fully aquatic to fully terrestrial and from herbivorous to predaceous species. The existence of Clementsian gradients may be a common phenomenon at large scales, and it is likely to be caused by crossing multiple species pools determined by climatic and historical factors on the distributions of species.

Benefit in regionalisation of care for patients treated with radical cystectomy: a nationwide inpatient sample analysis.

OBJECTIVE: To quantify in absolute terms the potential benefit of regionalisation of care from low- to high-volume hospitals. PATIENTS AND METHODS: Patients with a primary diagnosis of bladder cancer treated with radical cystectomy (RC) were identified within the Nationwide Inpatient Sample, a retrospective observational population-based cohort of the USA, between 1998 and 2009. Intraoperative and postoperative complications, blood transfusions, prolonged length of stay, and in-hospital mortality rates represented the outcomes of interest. Potentially avoidable outcomes were calculated by subtracting predicted rates (i.e. estimated outcomes if care was delivered at a high-volume hospital) from observed rates (i.e. actual observed outcomes after care delivered at a low-volume hospital). Multivariable logistic regression models and number needed to treat were generated. RESULTS: Patients treated at high-volume hospitals had lower odds of complications during hospitalisation than those treated in low-volume hospitals. Potentially avoidable intraoperative complications, postoperative complications, blood transfusions, prolonged hospitalisation, and in-hospital mortality rates were 0.6, 7.4, 2.8, 9.4, and 2.0%, respectively. This corresponds to a number needed to redirect from low- to high-volume hospitals in order to avoid one adverse event of 166, 14, 36, 11 and 50, respectively. CONCLUSION: This is the first report to quantify the potential benefit of regionalisation of RC for muscle-invasive bladder cancer to high-volume hospitals.

Rich north, poor south - Regionalization of European water retention: The landscape hydric potential concept.

Natural water retention varies greatly across Europe. Understanding the key ecosystem factors that affect the quantity, quality, availability, and spatiotemporal distribution of water resources is essential for effective landscape management. This study presents the Landscape Hydric Potential (LHP) index of Europe, which serves as an indicator of the natural environment's ability to infiltrate and retain water. The LHP index was aggregated into 12 relatively homogeneous regions, each representing similar values of natural water retention. The main factors influencing the hydric potential, and thus the water resources of Europe, include climatic conditions, geomorphology, soil properties, and land cover and use, especially the proportion of urbanized areas. Northern Europe, in comparison to southern Europe, exhibits higher LHP index values, indicating greater retention capacities. The climatic water balance is the main factor determine poorer retention capacities in the southern part of Europe. In northern Europe positive values of climatic water balance and slope inclination promote to higher LHP value and thus higher retention capacity. The results also demonstrate that there are sufficient, freely available, and precise data to assess water retention potential - landscape hydric potential - even at a continental scale.

Machine Learning Model Stability for Sub-Regional Classification of Barossa Valley Shiraz Wine Using A-TEEM Spectroscopy.

With a view to maintaining the reputation of wine-producing regions among consumers, minimising economic losses caused by wine fraud, and achieving the purpose of data-driven terroir classification, the use of an absorbance-transmission and fluorescence excitation-emission matrix (A-TEEM) technique has shown great potential based on the molecular fingerprinting of a sample. The effects of changes in wine composition due to ageing and the stability of A-TEEM models over time had not been addressed, however, and the classification of wine blends required investigation. Thus, A-TEEM data were combined with an extreme gradient boosting discriminant analysis (XGBDA) algorithm to build classification models based on a range of Shiraz research wines (n = 217) from five Barossa Valley sub-regions over four vintages that had aged in bottle for several years. This spectral fingerprinting and machine learning approach revealed a 100% class prediction accuracy based on cross-validation (CV) model results for vintage year and 98.8% for unknown sample prediction accuracy when splitting the wine samples into training and test sets to obtain the classification models. The modelling and prediction of sub-regional production area showed a class CV prediction accuracy of 99.5% and an unknown sample prediction accuracy of 93.8% when modelling with the split dataset. Inputting a sub-set of the current A-TEEM data into the models generated previously for these Barossa sub-region wines yielded a 100% accurate prediction of vintage year for 2018-2020 wines, 92% accuracy for sub-region for 2018 wines, and 91% accuracy for sub-region using 2021 wine spectral data that were not included in the original modelling. Satisfactory results were also obtained from the modelling and prediction of blended samples for the vintages and sub-regions, which is of significance when considering the practice of wine blending.

Regionalisation of climate change sensitive forest development types for potential afforestation areas.

This paper describes how to use sectoral planning information from forestry to predict and up-scale information on Climate Change sensitive forest development types for potential afforestation areas. The method was developed and applied in the frame of the project RegioPower with focus on the case study region 'Oberes Elbtal-Osterzgebirge'. The data for our study was taken from forest management planning at level of the Federal State of Saxony, Germany. Here, a silvicultural system is implemented, which describes best practices to develop our actual forests into Climate Change adapted forest development types. That includes the selection of drought resistant tree species, a broad range of tree species mixtures per eligible forest development type and the tending, harvesting and regeneration strategies to be applied. This information however, exists only for forest areas and not for areas which could be potentially afforested. The eligibility of the forest development types within the actual forest areas depends on site information, such as nutrient potential, exposition and hydrological soil parameters. The regionalisation of the forest development types to landscape scale had to be based on topographical parameters from the digital elevation model and hydrological soil parameters from soil mapping. In result, we could provide maps for regional planning and decision making with spatially explicit information on the eligible forest development types based on forest management planning information. These maps form a valuable input for testing and optimising afforestation areas with regard to improving the ability of our case study region to mitigate Climate Change effects such as water erosion or drought.

Research on regionalised digital image slope monitoring methods.

The digital image correlation method is a high precision and non-contact ground deformation monitoring method, which is widely used in surface deformation monitoring. However, according to its principle, different surface characteristics have great influence on the monitoring results. In this paper, a regional digital image slope monitoring method is established to meet the monitoring requirements of different areas of the same slope. Firstly, the features of different regions in the image are identified according to the optical region detection, and then the deformation calculation method is matched according to the features of different regions. Finally, according to the binocular vision principle, the three-dimensional displacement of the slope is obtained. Taking a highway slope in Qinhuangdao as an example, we realised all-weather and full-field deformation monitoring of slope, and verified the applicability and feasibility of regional digital image slope monitoring method. The applicability of digital image correlation method in slope monitoring is improved.

Measuring Regional Performance in the Italian NHS: Are Disparities Decreasing?

Given the regional disparities that historically characterize the Italian context, in this paper we propose a framework to evaluate the regional health care systems' performance in order to contribute to the debate on the relationship between decentralisation of health care and equity. To investigate the regional health systems performance, we refer to the OECD Health Care Quality Indicators project to construct of a set of five composite indexes. The composite indexes are built on the basis of the non-compensatory Adjusted Mazziotta-Pareto Index, that allows comparability of the data across units and over time. We propose three indexes of health system performance, namely Quality Index, Accessibility Index and Cost-Expenditure Index, along with a Health Status Index and a Lifestyles Index. Our framework highlights that regional disparities still persist. Consistently with the evidence at the institutional level, there are regions, particularly in Southern Italy, which record lower levels of performance with high levels of expenditure. Continuous research is needed to provide policy makers with appropriate data and tools to build a cohesive health care system for the benefit of the whole population. Even if future research is needed to integrate our framework with new indicators for the calculation of the indexes and with the identification of new indexes, the study shows that a scientific reflection on decentralisation of health systems is necessary in order to reduce inequalities.

New distributional records for ants and the evaluation of ant species richness and endemism patterns in Mexico.

BACKGROUND: Ants (Formicidae) in Mexico have usually been undersampled despite their ecological significance and their utility as environmental service providers and bioindicators. This study estimates the species richness and the narrow endemic species number of ants across Mexico. It also documents the presence of one species newly recorded in Mexico and 19 new state-based records of 14 species from central and north Mexico. No surveys have been performed in most of the localities where we report those records, suggesting the need for a higher sampling effort across the country. NEW INFORMATION: We present an ant species richness estimation and a narrow endemic ant species estimation in a grid of 0.5 degrees in Mexico. Stenamma schmitii is recorded for the first time from Mexico. Additionally, new state-based records of Azteca velox, Dorymyrmex insanus, Camponotus coruscus, Camponotus striatus, Formica propatula, Lasius latipes, Neivamyrmex melanocephalus, Neivamyrmex rugulosus, Syscia augustae, Atta texana, Cephalotes scutulatus, Crematogaster crinosa and Temnothorax andrei are recorded.