Paraffinoma, siliconoma and Co: Disastrous consequences of failed penile augmentation-A single-centre successful surgical management of a challenging entity.

The purpose of this study was to present our series of patients with disastrous consequences of failed penile self-augmentation and suggested surgical reconstruction. Ten patients with median age of 23 years and a variety of penile and scrotal deformities due to injections of several substances had undergone successful surgical reconstruction of external genitalia. The injections were self-performed in nine cases and the patients reported from 4 to 20 substance injections throughout the penile shaft. Three patients presented with fibrotic scirrhous masses in their scrotum, although they did not report any injections in scrotal area. All patients underwent extended penile-shaft skin excision, while all palpable scrotal lesions were removed in one-by-one fashion, as an attempt to destroy the less possible scrotal tissue. All patients were discharged on first post-operative day and reassessed at 2 months post-operatively. As a result, penile self-augmentation with injected substances may cause severe complications. Our proposed single-staged procedure seems safe and effective.

A case series and a review of the literature on foreign modelling agent reaction: an emerging problem.

Foreign modelling agent reactions (FMAR) are the result of the injection of unapproved high-viscosity fluids with the purpose of cosmetic body modelling. Its consequences lead to ulceration, disfigurement and even death, and it has reached epidemic proportions in several regions of the world. We describe a series of patients treated for FMARs in a specialised wound care centre and a thorough review of the literature. A retrospective chart review was performed from January 1999 to September 2015 of patients who had been injected with non-medical foreign agents and who developed cutaneous ulceration needing treatment at the dermatology wound care centre. This study involved 23 patients whose ages ranged from 22 to 67 years with higher proportion of women and homosexual men. The most commonly injected sites were the buttocks (38·5%), legs (18%), thighs (15·4%) and breasts (11·8%). Mineral oil (39%) and other unknown substances (30·4%) were the most commonly injected. The latency period ranged from 1 week to 17 years. Complications included several skin changes such as sclerosis and ulceration as well as systemic complications. FMAR is a severe syndrome that may lead to deadly complications, and is still very common in Latin America.

Siliconoma: Report of Two Cases.

UNLABELLED: Injectable silicone has been used illegally for more than 60 years. Siliconoma is the term used to describe a foreign body reaction in the human body caused by the presence of silicone. The aim of this study is to report two cases of patients who underwent application of large volumes of injectable silicone with non-medical and unqualified professionals, which led to serious complications sometime after the procedure. LEVEL OF EVIDENCE V: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

Siliconomas of the lower limb: Tumour-like excision and reconstruction.

BACKGROUND: Silicone oil injection can cause several complications including pain, cellulitis, abscesses, skin compromise, migration, embolism and multiorgan failure. Oil-infested tissue excision remains the solely treatment to prevent such complications. OBJECTIVES: The authors evaluate tumor-like excision of the oil-infested tissue as a treatment for patients experiencing silicone injections in the lower limbs, to both preserve aesthetic appearance and solve further risk of complication from silicone. METHODS: Between January 2004 and January 2011 a total of 12 consecutive, nonrandomized female patients underwent surgical management of siliconoma of the lower limb. The mean age was 41-years, range from 22 to 61 years and all patients didn't referred comorbidities. Eight siliconomas were located on the leg and 4 were on the thigh. The mean area of siliconoma was 35 cm2, range from 25 to 60 cm2. Each patient was evaluated by ultrasonography and EchocolorDoppler of the soft tissue and in order to achieve a "staging" of siliconoma. RESULTS: Healing was uneventful in all cases. Three patients (25%) suffering hypertrophic scarring underwent further injection of corticosteroids to improve hypertrophic scars quality. Two patients (16.6%) required a further session of structural fat grafting to improve thigh's profile. All patients were satisfied with the cosmetic results and indispositions requiring medical therapy disappeared. CONCLUSIONS: Tumor-like excision and immediate reconstruction appears to be a safe and consistent surgical option that preserves aesthetic appearance for patients victims of illegal oil silicone injection of the lower limbs.

Axillary Silicone Granulomas in Patients With Melanoma. / Siliconomas axilares en pacientes con melanoma.

Subcutaneous lesions may be detected during follow-up of patients with melanoma. The main entities that should be contemplated in the differential diagnosis in such cases are in-transit and regional lymph node metastases. We describe 2 cases of women with breast implants who developed palpable subcutaneous lesions in the axillary region during follow-up of melanoma. In both cases, the ultrasound study showed diffuse hyperechoic signals forming the characteristic snowstorm sign in the subcutaneous tissue. Ultrasound proved to be a key diagnostic tool for ruling out melanoma-related disease, such as in-transit metastases and regional lymph node metastases.

A Case of a Giant Siliconoma Mimicking Localized Breast Cancer.

Silicone gel-filled breast implants are widely used for breast augmentation and reconstruction after mastectomy. However, there are some known complications associated with silicone implants: Leakage and migration of silicone particles from the implant cause a granulomatous reaction. Granulomas may present as masses with features of malignancy on breast MRI. We present a case of a giant breast siliconoma in a woman who had undergone reconstruction with breast prostheses, which were surgically removed because of rupture 8 years ago. Teaching point: Despite increasingly efficient diagnostic tools, siliconoma diagnosis remains challenging.

Prevalence, clinical characteristics, and management of silicone lymphadenopathy: A systematic review of the literature.

INTRODUCTION: Implant-based breast augmentations and reconstructions are one of the most common surgical procedures performed by plastic surgeons in the United States, which has rapidly increased in popularity since the 2000s. Silicone lymphadenopathy (SL) is a complication of breast implants that involves migration of silicone to nearby soft tissue/lymph nodes. Data on its clinical features and management is scarce. METHODS: SL-related search terms were used to find articles in 3 databases. Of 598 articles, 101 studies met the inclusion criteria. Demographics, clinical presentation, workup, and management data were analyzed. RESULTS: Of 279 cases of SL and 107 with information on initial diagnosis, 35 (33%) were incidental. The most common symptom was painless lymphadenopathy, followed by painful lymphadenopathy. 251 (95%) and 13 (5%) patients had silicone and saline implants, respectively. 149 (68%) patients had implant rupture. Axillary lymphadenopathy was the most affected region (136 cases, 72%), followed by internal mammary (40 cases, 21%), cervical/supraclavicular (36 cases, 19%), and mediastinal (24 cases, 13%) regions. 25% of patients underwent fine-needle aspiration, 12% core needle biopsy, and 59% excisional biopsy. 32% of cases underwent explantation and/or implant exchange. The most common indication for surgery was implant rupture. Histology showed multinucleated giant cells, large histiocytes, and silicone accumulation. CONCLUSIONS: SL is a complication associated with breast implants. The majority of patients are asymptomatic, and most cases are managed conservatively. Minority need a biopsy and surgical interventions due to abnormal imaging, persistent symptoms, and/or implant rupture. Workup and management should be tailored to the patient.

Diagnosis and Management of Rare Siliconomas in an HIV Patient.

Siliconomas are rare conditions stemming from uses of silicone injections for soft tissue augmentation, most commonly in the breast and buttocks areas. Siliconomas are known to present with suspicious morphology that mimics cases of embolism or systemic metastasis as the silicone travels through blood and lymphatics. We present the case of a 45-year-old HIV-positive male who presented with siliconomas in the breast region, chest heaviness, shortness of breath, dyspnea, and a physical exam showing gynecomastia. The patient denied any surgeries or injections around his chest. Further imaging showed abnormal fat deposition in the chest and possible metastatic lymphadenopathy to axillary, supraclavicular, and mammillary lymph nodes. Although the complications arising from silicone injections are well documented, the pathogenesis remains unknown, leaving a narrow range of therapeutic options. Despite these shortcomings, diagnostic imaging tools have shown to be vital in the diagnosis and localization of suspected siliconomas.

Internal mammary lymph node siliconoma in absence of prosthesis rupture: a case series that raises concern for potential risk of overdiagnosis.

BACKGROUND: Silicon migration after rupture is an adverse event of breast implant, whose risk increases with the aging of prosthesis. The exact prevalence of this complication remains unclear and reported data are inconsistent. In addition, microscopic diffusion of silicone gel through intact implant, known as gel bleeding, might verify thus complicating diagnosis. Although high cohesive gel has reduced the occurrence of gel bleeding, this phenomenon is still possible and its occurrence rate remains underestimated. If silicon droplets migrate in locoregional lymph node, a swelling that mimics recurrence can arise. Therefore, a risk of overdiagnosis is possible when clinicians rely only on imaging techniques. The aim of this study is to evaluate the actual prevalence of metastasis in internal mammary lymph node (IMLN) in presence of PET positive uptake and no prosthesis rupture. METHODS: We retrospectively evaluated our patient's records and selected those with intact breast implants and suspected relapse in IMLN that underwent biopsy, either surgical or imaging guided. All patients performed PET/CT scan showing pathological uptake in IMLNs. A breast magnetic resonance (MRI) or ultrasound (US) imaging confirmed a suspicious adenopathy and excluded prosthesis rupture. From 2015 to 2019 a total of nine patients underwent biopsy of the IMLN and only six of them met inclusion criteria. RESULTS: Four biopsies were CT-guided, two were surgical. Three patients (50%) were diagnosed with breast cancer relapse while two (33.3%) were found with siliconoma and one (16.7%) was inflammatory. CONCLUSIONS: Siliconoma can occur even without evidence of capsule rupture, challenging the clinicians and leading to a risk of relapse over diagnosis. Echographic, MRI and nuclear medicine imaging criteria may be not sufficient in differential diagnosis. To overcome the issue, we suggest introducing into the clinical practice the biopsy of suspicious enlarged IMLN with minimally invasive technique.

Treatment of giant siliconomas of the breasts after injection of silicone.

Breast enhancement by injectable materials is known to be used for decades. Possible complications can lead to complex management issues for treating physicians. This case demonstrates the challenges in managing giant siliconomas of the breasts, especially concerning breast reconstruction, in the quest for an aesthetically pleasing outcome with minimum risks.

A Presentation of Penile Siliconoma in Primary Care after a Dubious Implant Injection: A Case Report

Abstract@#Cases of penile siliconoma are unusual and less commonly present to medical practitioners. The siliconoma is a subsequence of injecting high viscous solution into the penis; commonly sillicone with the aim to enhance its size and performance. This case will look at a patient who developed penile siliconoma after a dubious penile implant injection gone wrong. It will also look at what surgical options are available to the unfortunate patients to ease their suffering. Physician should have a high index of suspicion on the use of such substances to enhance sexual performances in patients presenting with atypical penile swelling.

Injerto dermo-epidérmico como tratamiento del siliconoma de extremidad inferior / Dermoepidermal graft as treatment of lower extremity siliconoma

Resumen Introducción A pesar de la evidencia sobre los malos resultados y riesgos del uso de inyecciones subcutáneas de silicona para mejorar el contorno corporal, esta técnica sigue siendo utilizada por personas no calificadas. Caso clínico Paciente de 56 años quien consultó por cuadro de celulitis en pierna izquierda. Se obtuvo el antecedente de intervención con silicona en cara, dorso de las manos, glúteos y piernas el año 2000. El cuadro progresó con múltiples abscesos en la totalidad de la pierna y sepsis. Se realizaron aseos quirúrgicos exponiendo planos fascial y muscular, se utilizó terapia local con sistemas de presión negativa y posterior injerto dermo-epidérmico (IDE). El manejo multidisciplinario se realizó en unidades críticas. Los resultados del manejo fueron satisfactorios, salvando la extremidad con cobertura total, logrando el alta luego de 4 meses. Conclusión A pesar de conocerse los peligros de la inyección de silicona, este sigue siendo un procedimiento frecuente. En nuestra paciente se manifestó como fascitis de la pierna, requiriendo tratamiento quirúrgico agresivo. Conocer esta entidad, su diagnóstico y tratamiento es fundamental para tratar pacientes con complicaciones graves.

Introduction Despite the evidence of poor performance and risks of using silicone subcutaneous injections to improve body contour, this technique is still used by untrained people, generating an iatrogenic entity with serious complications. Case report 56 year old female presented left lower extremity cellulitis. A history of previous intervention with silicone injections in face, back of hands, buttocks and legs in year 2000 was obtained. An inflammatory process progressed locally and systemically with multiple abscesses, subcutaneous thickness in the entire leg and sepsis, requiring multiple surgical procedures, reaching fascial and muscle planes exposition of the left leg. The patient underwent local therapy with negative pressure systems and subsequent dermoepidermal graft. Multidisciplinary management was performed on a critical unit. The results were satisfactory, preserving the limb with full coverage. She was discharged after four months of inpatient management. Conclusion Despite knowing the risks of silicone injection (industrial or medical) it remains a common procedure. In our patient she presented as leg fasciitis, requiring aggressive surgical treatment. Knowing this entity, its diagnosis and treatment is essential to treat patients with serious complications.

Siliconoma of the breasts.

Despite prohibiting of the foreign material injection for aesthetic breast augmentation in many countries. Its late complications still bring patients back for corrective and reconstructive surgery. There is no clinical management consensus or international guideline. Most of the literatures recommend surgical removal with immediate reconstruction with autologous tissue. We report a case of bilateral breast siliconoma which was treated by total mastectomy with two stage tissue expander-prosthesis reconstruction.

Lipotransferencia: una nueva estrategia para el tratamiento de siliconomas en región glútea. Reporte de un caso / Lipotransfer: new strategy for treatment of siliconomas

Introducción. La inyección de silicona líquida y sus complicaciones a largo plazo fueron descriptas por Winer en 1964. Los siliconomas representan la reacción infl amatoria mediada por el organismo en respuesta a la inyección de un cuerpo extraño, produciendo complicaciones tales como deformidad, dolor y celulitis. Material y método. Se presenta el caso de un paciente de sexo masculino de 64 años de edad con antecedente de inyección de silicona líquida en región glútea en el año 2000. Evolucionó con deformidad en glúteos y ambas regiones trocantéricas asociadas a dolor en posición supina y sedestación. Se trató mediante dermolipectomía de las regiones comprometidas asociado a lipotransferencia glútea en el plano profundo del tejido celular subcutáneo en dos tiempos quirúrgicos. Resultados. La remisión del dolor fue del 100% a los 7 días con escaso requerimiento de analgésicos vía oral. Se observó mejoría de la calidad de la piel y menor congestión tisular. Además, se observó una recuperación del contorno corporal con atenuación de la celulitis y deformidad lateral. A los 8 meses posoperatorios los resultados estéticos fueron satisfactorios. Conclusión. El tratamiento quirúrgico resectivo de las regiones comprometidas por la disgregación de silicona líquida más lipotransferencia corregiría las complicaciones tanto estéticas (deformidad anatómica, celulitis) y funcionales disminuyendo el dolor vinculado a la presencia de estos cuerpos extraños, con mejoría en la calidad de los tejidos lesionados.

Background. Silicone injection and its further complications were fi rst reported by Winner in the 1960s. Siliconomas represent the chronic infl ammatory reaction of the organism in response to the presence of a foreign body. The latter complications such as deformity, cellulitis and pain are often seen and very diffi cult to treat. Material and method. A case of a 64 year-old male with medical history of silicone injection in gluteal region in year 2000. At physical examination, he had deformity of the gluteal and trochanteric regions associated with pain. The surgical strategy consisted in dermolipectomy of the thights and buttocks associating mechanical liposuction of the damaged region with posterior lipofi llingin the deep cellular tissue in both gluteal zones. The fat grafting was done in to separated sessions. Results. Pain decreased in 100% at 7 days postoperative with a low consume of analgesics. There was an improvement in skin quality with less local tissue congestion. Cellulitis and lateral deformity of tights were well-treated with surgery. With a follow-up of 8 months, cosmetic and functional results were satisfactory. Conclusion. The association of dermolipectomy with mechanical liposuction and lipofi lling may be a good surgical strategy in the correction of silicone injection sequelae improving not only the aesthetic results but also the remission of pain providing a better quality of life in these patients.

Linfadenopatía axilar por siliconas: revisión. algoritmo de estudio y tratamiento / Axillary lymphadenopathy by silicones: review, algorithm of study and treatment

Introducción. La linfadenopatía por siliconas es un efecto colateral muy raro de la mastoplastia de aumento con implantes o por inyección de siliconas. Es una patología benigna. Los ganglios afectados más frecuentemente son los axilares. La presencia de una adenopatía axilar unilateral en una paciente adulta siempre debe generar la sospecha de una enfermedad neoplásica, que debe ser estudiada. La magnitud del problema va a depender del grado de infi ltración ganglionar, el número de ganglios afectados y la reacción de los tejidos que los rodean. Terapéutica. La decisión respecto al estudio y tratamiento debe hacerse de acuerdo al algoritmo diseñado a tal efecto. Descartar una patología neoplásica mamaria es el primer gesto. Descartada la malignidad, se puede adoptar una conducta expectante o, si fuera necesario, iniciar tratamiento sintomático con inmunomoduladores, pero nunca con cirugía en esta etapa. Si a pesar del tratamiento médico persisten las tumoraciones dolorosas, puede procederse a la remoción conservadora de los siliconomas. Si existe afectación del plexo braquial o vascular deben convocarse a neurocirujanos y cirujanos vasculares. Conclusión. La linfadenopatía por siliconas es una complicación rara de los procedimientos que involucran siliconas. Los ganglios linfáticos axilares son los más frecuentemente afectados. El diagnóstico diferencial más importante es el origen neoplásico. Recurrir a la biopsia por PAAF o excisional. Se debe evaluar y resolver la fuente de siliconas. Los cuadros sintomáticos deben encararse primero con tratamiento médico. Como principio, siliconas en axila, no es quirúrgico.

Introduction. Lymphadenopathy due to silicones is a very rare side eff ect of breast enlargement with implants or silicone injection. It is a benign pathology. The most frequently aff ected lymph nodes are axillary lymph nodes. The presence of a unilateral axillary adenopathy in an adult patient should always generate the suspicion of a neoplastic disease, which should be studied. The magnitude of the problem will depend on the degree of lymph node infi ltration, the number of aff ected lymph nodes and the reaction of the tissues that surround them. Therapy. The decision regarding the study and treatment must be made according to the algorithm designed for that purpose. Discarding a mammary neoplastic pathology is the fi rst gesture. Once malignancy has been ruled out, expectant management can be adopted or, if necessary, symptomatic treatment with immunomodulators, but never with surgery at this stage. If, despite medical treatment, painful masses persist, the siliconomas can be removed conservatively. If there is involvement of the brachial or vascular plexus, neurosurgeons and vascular surgeons should be called. Conclusion. Silicone lymphadenopathy is a rare complication of procedures involving silicones. The axillary lymph nodes are the most frequently aff ected. The most important diff erential diagnosis is the neoplastic origin. Biopsy by Fine Needle Aspiration or excisional. The source of silicones must be evaluated and resolved. Symptomatic symptoms must fi rst be treated with medical treatment. As a principle, silicones in axilla, is not surgical.

A false positive F-FDG PET/CT scan caused by breast silicone injection.

We present here the case of a 40-year-old woman with a greater than 10 year prior history of bilateral breast silicone injection and saline bag implantation. Bilateral palpable breast nodules were observed, but the ultrasound scan was suboptimal and the magnetic resonance imaging showed no gadolinium-enhanced tumor. The (18)F-FDG PET/CT scan showed a hypermetabolic nodule in the left breast with a 30% increase of (18)F-FDG uptake on the delayed imaging, and this mimicked breast cancer. She underwent a left partial mastectomy and the pathology demonstrated a siliconoma.

Sequela de injeção de silicone em lábio inferior: correção cirúrgica pela técnica do biquíni modificada / Sequelae of inferior lip silicone injection: surgical correction using the modified "bikini" technique

Pacientes portadores de sequelas devido a injeções de substâncias inabsorvíveis tem se tornado cada vez mais frequentes. O silicone injetável ou polidimetilsiloxano fluido é um polímero manufaturado que contém silicone elementar. As complicações consequentes ao uso desta substância podem ser precoces ou tardias. Apresentamos um relato de caso onde uma deformidade por injeção de silicone em lábios foi tratada cirurgicamente usando a técnica do biquíni modificada obtendo um bom resultado funcional e estético.

Increasing numbers of patients have sequelae due to the injection of non-absorbable substances. Injectable silicone or polydimethylsiloxane fluid is a manufactured polymer containing elemental silicon. The complications associated with the use of this substance can present early or late. Here we present a case report in which a deformity due to a silicone injection in the lips was surgically treated using the modified "bikini" technique that produced a functionally and aesthetically favorable result.

A False Positive 18F-FDG PET/CT Scan Caused by Breast Silicone Injection

We present here the case of a 40-year-old woman with a greater than 10 year prior history of bilateral breast silicone injection and saline bag implantation. Bilateral palpable breast nodules were observed, but the ultrasound scan was suboptimal and the magnetic resonance imaging showed no gadolinium-enhanced tumor. The 18F-FDG PET/CT scan showed a hypermetabolic nodule in the left breast with a 30% increase of 18F-FDG uptake on the delayed imaging, and this mimicked breast cancer. She underwent a left partial mastectomy and the pathology demonstrated a siliconoma.