Genetic Ancestry, Race, and Severity of Acutely Decompensated Cirrhosis in Latin America.

BACKGROUND & AIMS: Genetic ancestry or racial differences in health outcomes exist in diseases associated with systemic inflammation (eg, COVID-19). This study aimed to investigate the association of genetic ancestry and race with acute-on-chronic liver failure (ACLF), which is characterized by acute systemic inflammation, multi-organ failure, and high risk of short-term death. METHODS: This prospective cohort study analyzed a comprehensive set of data, including genetic ancestry and race among several others, in 1274 patients with acutely decompensated cirrhosis who were nonelectively admitted to 44 hospitals from 7 Latin American countries. RESULTS: Three hundred ninety-five patients (31.0%) had ACLF of any grade at enrollment. Patients with ACLF had a higher median percentage of Native American genetic ancestry and lower median percentage of European ancestry than patients without ACLF (22.6% vs 12.9% and 53.4% vs 59.6%, respectively). The median percentage of African genetic ancestry was low among patients with ACLF and among those without ACLF. In terms of race, a higher percentage of patients with ACLF than patients without ACLF were Native American and a lower percentage of patients with ACLF than patients without ACLF were European American or African American. In multivariable analyses that adjusted for differences in sociodemographic and clinical characteristics, the odds ratio for ACLF at enrollment was 1.08 (95% CI, 1.03-1.13) with Native American genetic ancestry and 2.57 (95% CI, 1.84-3.58) for Native American race vs European American race CONCLUSIONS: In a large cohort of Latin American patients with acutely decompensated cirrhosis, increasing percentages of Native American ancestry and Native American race were factors independently associated with ACLF at enrollment.

The socio-demographic profile associated with perinatal depression during the COVID-19 era.

BACKGROUND: Coronavirus disease 2019 (COVID-19) has caused an increase in perinatal depression. The aim of this research was to identify which sociodemographic variables are related to the increase in perinatal depression due to the pandemic. In addition to estimating to what extent they predict perinatal depression, differentiating the prenatal and postnatal periods. METHODS: The sample consisted of 3,356 subjects, 1,402 in the prenatal period and 1,954 in the postnatal period. The Edinburgh Postnatal Depression Scale was used to assess depressive symptomatology. A subset of 14 questions was included to collect demographic data. Items from the Spanish version of the Coronavirus Perinatal Experiences Survey were also included. RESULTS: Experiencing the change of environment due to COVID-19 as negative and having a history of mental health predict perinatal depression, otherwise having higher education decreases the risk. In the prenatal stage having symptoms compatible with COVID-19 is a predictor of perinatal depression and having more than 3 years living together with the partner and being a housewife decreases the risk. In the postnatal stage being unemployed is a predictor of prenatal depression and being a first-time mother decreases the risk. CONCLUSIONS: This study highlights the relevance of sociodemographic status. It is essential to be aware of the risk factors of perinatal depression, to make adequate prevention, and to create health policies to alleviate the consequences of the pandemic.

The predictors of general knowledge: Data from a Spanish megastudy.

Studies on sociodemographic data and crystallized intelligence have often struggled to recruit enough participants to achieve sufficient validity. However, the advent of the internet now allows this problem to be solved through the creation of megastudies. Yet, this methodology so far has only been used in studies on vocabulary size, while general knowledge, another key component of crystallized intelligence, remains unexamined. In the present study, regression models were used to examine the impact of sociodemographic variables-gender, age, years of study and socioeconomic status-on general knowledge scores. The sample comprised 48,234 participants, each of whom answered 60 general knowledge questions, their data being fully available online. Men were found to score higher than women in general knowledge. Years of study and socioeconomic status acted as strong and weak positive predictors, respectively. Age acted as a strong positive predictor until the age of 50, where it became progressively detrimental. These results are discussed relative to other studies on crystallized intelligence, highlighting the need to study each of its components individually.

Distinct risks, clinical characteristics and outcomes by age at time of HIV diagnosis.

OBJECTIVES: New HIV diagnoses in persons aged > 50 years (hereafter 'older persons') are becoming more common; the clinical features and outcomes of these older individuals are poorly described. METHODS: We conducted a retrospective cohort study of all new adult HIV diagnoses between October 1989 and December 2019 in southern Alberta, Canada. Differences in risk for HIV acquisition and screening, sociodemographic/clinical characteristics, and causes of death were compared between individuals younger and older than 50 years at the time of diagnosis. RESULTS: New HIV diagnoses in persons > 50 years old increased from 7% in 1990 to 18% in 2019. Risk for HIV acquisition and screening reasons differed by age. Heterosexual sex (29%) was the greatest risk factor among older persons, contrasting with male same sex activity in younger persons (51%) (P < 0.001). Illness was the most common indication for testing in older persons (47%), whereas younger persons were more likely to have requested testing (34%) (P < 0.001). Relationship status differed, with 33% of older persons being married to an opposite sex partner versus 12% in younger persons (P < 0.001). Although older persons had a lower mean nadir CD4 count (132 cells/µL) than younger persons (181 cells/µL) (P < 0.001), 80% of deaths between 2010 and 2019 in the older group were attributable to non-AIDS-related causes versus 47% in younger patients. Since 2000, AIDS-related deaths and potential years of life lost have declined for both age groups. CONCLUSION: The increase in new HIV diagnoses in persons aged > 50 years in southern Alberta suggests that older individuals require customized approaches for optimizing HIV diagnosis and treatment.

[Dropout behavior during inpatient psychotherapy ]. / Behandlungsabbrüche während einer stationären Psychotherapie.

OBJECTIVES: Dropouts result in far-reaching consequences for the individual patient, fellow patients, therapists, and the clinic. This study was aimed at early identification of patients with a dropout risk. METHODS: Data from patients of the Department of Psychosomatic Medicine and Psychotherapy of the Medical University Clinic of Tübingen (Germany) were analyzed retrospectively in a case-control study (matched). Differences in the results of various questionnaires (SCL-90-R, IIP-D, SF-36) regarding reasons for dropout and sociodemographic data were analyzed. A total of 59 dropouts, 50 females and 9 males, were included. They were split into 28 early dropouts and 31 late dropouts. The data were compared between early and late dropouts and control group. RESULTS: Early dropouts were significantly younger than late dropouts; they tended to live with their parents or on their own, and suffered more frequently from eating disorders. Late dropouts lived together with partners and suffered from somatoform disorders more frequently than early dropouts. The reasons given for dropout did not differ between the groups. No differences between dropouts and the controls were found with respect to psychopathology (SCL- 90-R) and quality of life (SF-36). Late dropouts did show significantly lower scores on the scale "autocracy/dominance" than the controls (IIP). CONCLUSIONS: Therapy dropout is a multifactorial occurrence. It is generally not predictable, though it may be predicted with different instruments on the basis of a diagnosis, especially with respect to interpersonal behavior patterns. In further studies, targeted interventions should be developed and tested which enable procedures to minimize the risk of dropout and to achieve complete treatment according to patients' intentions.

Improving Randomized-Controlled Trials in Foot and Ankle Orthopaedics: The Need to Include Sociodemographic Patient Data.

BACKGROUND: The representation of sociodemographic data within randomized-controlled trials (RCT) regarding foot and ankle surgery is undefined. The purpose of this study was to determine the incidence of sociodemographic data being reported in contemporary foot and ankle RCTs. METHODS: Randomized-controlled trials within the PubMed database from 2016 to 2021 were searched and the full text of 40 articles was reviewed to identify sociodemographic variables reported in the manuscript. Data regarding race, ethnicity, insurance status, income, work status, and education were collected. RESULTS: Race was reported in the results in 4 studies (10.0%), ethnicity in 1 (2.5%), insurance status in 0 (0%), income in 1 (2.5%), work status in 3 (7.5%) and education in 2 (5.0%). In any section other than the results, race was reported in 6 studies (15.0%), ethnicity in 1 (2.5%), insurance status in 3 (7.5%), income in 6 (15.0%), work status in 6 (15.0%), and education in 3 (7.5%). There was no difference in sociodemographic data by journal (P = .212), year of publication (P = .216), or outcome study (P = .604). CONCLUSION: The overall rate of sociodemographic data reported in foot and ankle RCTs is low. There was no difference in the reporting of sociodemographic data between journal, year of publication, or outcome study. LEVEL OF EVIDENCE: Level II.

Prevalence and Incidence of Patients With Fibromyalgia in Catalonia Between 2010 and 2017: A Descriptive Observational Study.

OBJECTIVE: To measure the prevalence and cumulative incidence of individuals diagnosed with fibromyalgia (FM) in Catalonia between 2010 and 2017. METHODS: A retrospective observational study of the population of Catalonia between 2010 and 2017, both included, was designed to describe the incidence, prevalence, and sociodemographic characteristics of individuals diagnosed with fibromyalgia. A total of 56 098 patients were included in the study. The scope of the study were the 283 Primary Care Teams (PCT), all managed by the Instituto Catalán de la Salud [Catalan Institute of Health] (ICS). RESULTS: The diagnosis of FM is higher in females (95.4%) than males (4.55%), with a mean age of 53.0 [45.0-61.0] years. The prevalence of FM in the total population was 0.4% in 2010 and 1.4% in 2017. The highest prevalence was found in the 55 to 65 age group (1.05% in 2010, and 2.46% in 2017). A relationship was found between the prevalence of FM and the degree of socioeconomic deprivation in urban areas: the greater the deprivation, the greater the prevalence of FM. The cumulative incidence of FM in the population remained constant over time (0.11% in 2010 and 0.10% in 2017), being more prevalent in women than men (0.18% women, 0.01% men in 2017). CONCLUSIONS: Our study confirms that FM is a prevalent disease in Catalonia, with an upward trend in recent years and it is more prevalent in women.

The circadian preferences in the context of sociodemographic indicators and lifestyle.

Circadian preferences are frequently used as a synonym for chronotype. Both terms are based on different principles and are measured by a variant questionnaire. We focused on circadian preferences, delimited as an individual preference for the timing of various activities, and their relationship to the selected sociodemographic factors. All participants (n = 2068) filled out online questionnaires including MEQ, MCTQ, and sociodemographic information (age, sex, place of residence, marital status, childcare, education, financial security, physical and mental health). Although the concept of chronotype and circadian preference differ, the mutual correlation was high. Our results of the observed variables are similar to other studies. We revealed evening preference is related to a higher probability of living in a big city, having a single life, a higher risk of smoking, worse health status, and worse financial security. We observed a higher social jet lag among them. Our research complies with previous studies, which found that in some areas, people with evening preferences evince worse results. Due to the evening preference, these people are at a disadvantage, and the society's setting for morning operations can lead to a deepening of these differences. We recommend further research, which would focus on the practical application of results to the everyday life of participants to create preventive programs aimed at reducing the negative impact of evening preferences on life.

Correlates of suicidal ideation related to the COVID-19 Pandemic: Repeated cross-sectional nationally representative Canadian data.

OBJECTIVE: With significant levels of mental distress reported by populations, globally, the magnitude of suicidal ideation during and beyond the COVID-19 pandemic is a central concern. The goal of this study was to quantify the extent of pandemic-related suicidal ideation in the Canadian population during the first ten months of the pandemic and identify sociodemographic and pandemic-related stressors associated with increased risk of ideation. METHOD: Data were derived from three rounds of a mental health monitoring survey, nationally representative by age, gender, household income, and region, delivered online in May 2020, September 2020, and January 2021. Bivariate analyses were used to quantify the proportion of respondents in Canada reporting suicidal ideation by sociodemographic factors and pandemic-related stressors. Unadjusted and adjusted multivariable logistic regression was used to study the association between suicidal ideation and correlates within four pandemic-related stressor categories (financial, relationship, substance use, COVID-19 exposure). RESULTS: Of the 7002 respondents, 6.2% (n = 433) reported experiencing suicidal thoughts or feelings as a result of the pandemic within the two weeks prior to taking the survey. In terms of sociodemographic factors, suicidal ideation was more commonly reported among those who were not cisgender, <65 years-old, single, Indigenous, LGBT2Q+, and who experience a pre-existing mental health condition. After adjusting for sociodemographic factors, indicators across all four pandemic-related stressor categories were associated with two or more times the odds of suicidal ideation. CONCLUSION: Disparities in COVID-19 related suicidal ideation have persisted throughout the first year of the pandemic for specific sociodemographic sub-groups and those who have faced stressors related to finances, relationships, increased substance use, and COVID-19 virus exposure. To best address these disparities and to prevent a transition from suicidal ideation to action, appropriate planning, resources, and policies are needed to ensure health and well-being for everyone.

Dataset for country profile and mobility analysis in the assessment of COVID-19 pandemic.

Understanding the COVID-19 pandemic is a multidisciplinary effort that requires a significant number of variables. This dataset comprises (i) sociodemographic characteristics, compiled from 35 datasets obtained at UN Data; (ii) mobility metrics that can assist the analysis of social distancing, from Google Community Mobility Reports and; (iii) daily counts of cases and deaths by COVID-19, from the European Centre for Disease Prevention and Control and the Johns Hopkins University Center for Systems Science and Engineering. This unified dataset ranges from February 15, 2020 to May 7, 2020, a total of 83 days, and is provided as a collection of time series for 131 countries with 192 variables. The pipeline to preprocess and generate the dataset, along with the dataset itself, are versioned with the Data Version Control tool (DVC) and are thus easily reproducible.

Comprehensive survey of vitiligo patients in the northeast of China using a predesigned questionnaire.

To assess the sociodemographic data and clinical information of outpatients affected by vitiligo in the northeast of China, vitiligo patients or guardians who presented to the clinic were invited to participate in an exploratory questionnaire. The questionnaire consisted of two sections related to vitiligo, including sociodemographic data and clinical information. A total of 983 vitiligo patients answered the questionnaire. The rates of female and male patients were comparable. The investigated patients were mostly young and middle-aged. Most patients suffered from vitiligo in childhood or young adulthood. Vitiligo vulgaris was the most common type of vitiligo in clinic and 53.0% of patients were categorized as body surface area (BSA) of 10% or less. In response to the latest treatment, 43.6% of patients achieved good response (completely stopped or almost disappeared). More patients at active stage showed good response than the patients at stable stage (χ2 = 7.866, P < 0.05). Chronic comorbid condition(s) were observed in 12.6% of patients with BSA of more than 10%, whereas those were seen in 6.0% of patients with BSA of 10% or less (χ2 = 12.969, P < 0.05). In conclusion, active vitiligo seems to respond better than stable vitiligo and complications with other autoimmune diseases more frequently observed in severe patients than mild patients. The current study presented a comprehensive understanding of vitiligo in the northeast of China.

Normative data for the Brief Cognitive Screening Battery stratified by age and education.

INTRODUCTION: Diagnosing neurocognitive disorders is challenging in low-educated individuals. OBJECTIVE: To report normative data for the Brief Cognitive Screening Battery (BCSB) and to assess the association of age and education with performance on the BCSB in 240 community-dwelling elderly from Ermelino Matarazzo, São Paulo city. METHODS: The inclusion criteria were scoring above the education-adjusted cut-off points on the Mini-Mental State Examination (MMSE) and below six points on the Geriatric Depression Scale (GDS). RESULTS: Age was associated with performance on the Naming, Incidental Memory, Verbal Fluency, Clock Drawing Test, Delayed Recall and Recognition subtests. Education was associated with performance on Naming, Recognition, Verbal Fluency and the Clock Drawing Test. CONCLUSION: The normative values reported are relevant for diagnosing neurocognitive disorders in low-educated elderly.

INTRODUÇÃO: O diagnóstico de transtornos neurocognitivos é desafiador na presença de baixa escolaridade. OBJETIVO: Relatar dados normativos para a Bateria Breve de Rastreio Cognitivo (BBRC) e avaliar a associação da idade e da escolaridade com o desempenho na BBRC, em 240 idosos residentes na comunidade em Ermelino Matarazzo, município de São Paulo. MÉTODOS: Os critérios de inclusão foram pontuação acima de pontos de corte ajustados para escolaridade no Mini-Exame do Estado Mental (MEEM) e abaixo de seis pontos na Escala de Depressão Geriátrica (EDG). RESULTADOS: A idade esteve associada aos subtestes Nomeação, Memória Incidental, Fluência Verbal, Teste do Desenho do Relógio, Memória Tardia e Reconhecimento. A escolaridade associou-se à Nomeação e Reconhecimento, Fluência Verbal e Teste do Desenho do Relógio. CONCLUSÃO: As normas reportadas são relevantes para o diagnóstico de transtornos neurocognitivos em idosos com baixa escolaridade.

The prevalence of dental anxiety and fear in patients referred to Isfahan Dental School, Iran.

BACKGROUND: Dental anxiety and fear are major complications for both patient and dental care provider. The purpose of this study was to assess the prevalence of dental anxiety and fear in patients who referred to Isfahan Dental School and their relation to their age, gender, educational level, past traumatic experiences and frequency of dental visits. MATERIALS AND METHODS: In this cross-sectional study, 473 patients were provided with a questionnaire including three sections. First section contained questions concerning their age, gender, educational level, frequency of dental visits, reasons for irregular attendance and existence of past traumatic experiences. Second section comprised a Farsi version of Modified Dental Anxiety Scale (MDAS); and third included a Farsi version of dental fear survey (DFS). Data were analyzed by t-test, ANOVA, Pearson and Spearman correlation tests. RESULTS: The prevalence of dental anxiety among the study population was 58.8%. No correlation was found between age and MDAS (r = -0.08, P = 0.07) and DFS (r = -0.03, P = 0.53). Women demonstrated higher anxiety (P < 0.001) and fear (P = 0.003). Education had no significant effect on dental anxiety (r = -0.046, P = 0.32) and dental fear (r = -0.017, P = 0.79). Previous traumatic experiences were found to result in elevated anxiety and fear (P < 0.001). There was an inverse relationship between frequency of dental attendance and anxiety (r = -0.128, P = 0.008). CONCLUSIONS: Within the limitations of this study, anxiety associated with dental treatment was widespread in the study population. Dental fear and anxiety were not affected by age or education level. Dental fear and anxiety were higher in women. In addition, people who visited the dentist more regularly and individuals without previous traumatic dental experiences were less anxious.

Normative data for the Brief Cognitive Screening Battery stratified by age and education / Dados normativos para a Bateria Breve de Rastreio Cognitivo: normas segundo idade e escolaridade

ABSTRACT Introduction: Diagnosing neurocognitive disorders is challenging in low-educated individuals. Objective: To report normative data for the Brief Cognitive Screening Battery (BCSB) and to assess the association of age and education with performance on the BCSB in 240 community-dwelling elderly from Ermelino Matarazzo, São Paulo city. Methods: The inclusion criteria were scoring above the education-adjusted cut-off points on the Mini-Mental State Examination (MMSE) and below six points on the Geriatric Depression Scale (GDS). Results: Age was associated with performance on the Naming, Incidental Memory, Verbal Fluency, Clock Drawing Test, Delayed Recall and Recognition subtests. Education was associated with performance on Naming, Recognition, Verbal Fluency and the Clock Drawing Test. Conclusion: The normative values reported are relevant for diagnosing neurocognitive disorders in low-educated elderly.

RESUMO Introdução: O diagnóstico de transtornos neurocognitivos é desafiador na presença de baixa escolaridade. Objetivo: Relatar dados normativos para a Bateria Breve de Rastreio Cognitivo (BBRC) e avaliar a associação da idade e da escolaridade com o desempenho na BBRC, em 240 idosos residentes na comunidade em Ermelino Matarazzo, município de São Paulo. Métodos: Os critérios de inclusão foram pontuação acima de pontos de corte ajustados para escolaridade no Mini-Exame do Estado Mental (MEEM) e abaixo de seis pontos na Escala de Depressão Geriátrica (EDG) . Resultados: A idade esteve associada aos subtestes Nomeação, Memória Incidental, Fluência Verbal, Teste do Desenho do Relógio, Memória Tardia e Reconhecimento. A escolaridade associou-se à Nomeação e Reconhecimento, Fluência Verbal e Teste do Desenho do Relógio. Conclusão: As normas reportadas são relevantes para o diagnóstico de transtornos neurocognitivos em idosos com baixa escolaridade.

Caracterização de adultos com paralisia cerebral / Caracterization of adults with cerebral palsy

CONTEXTUALIZAÇÃO: Paralisia Cerebral (PC) é um grupo de perturbações permanentes no desenvolvimento de movimentos e posturas que causam limitação nas atividades funcionais e que são atribuídas a distúrbios não-progressivos que ocorrem no cérebro fetal ou infantil. Nos últimos anos, com o aumento na expectativa de vida dos indivíduos com PC, vários estudos têm descrito a instalação de deficiências musculoesqueléticas e limitações funcionais ao longo do ciclo vital. OBJETIVO: Caracterizar adultos com PC por meio de informações sociodemográficas, classificações, saúde geral e condições associadas, complicações físicas e locomoção. MÉTODOS: Participaram deste estudo 22 adultos com PC residentes em uma cidade no interior do Brasil, recrutados nos centros de reabilitação locais. Aplicou-se um questionário para caracterização sociodemográfica, de comorbidades e complicações físicas. Além disso, realizou-se breve avaliação fisioterapêutica e aplicaram-se as classificações padronizadas, Sistema de Classificação da Função Motora Grossa (GMFCS) e Sistema de Classificação das Habilidades Manuais (MACS). Os dados foram analisados de forma descritiva. RESULTADOS: A média de idade foi de 28,7 anos, 86,4 por cento participantes moravam com os pais, 4,5 por cento possuíam emprego. A maior parte da amostra era composta por quadriplégicos espásticos, níveis IV e V do GMFCS e do MACS. Houve presença de diferentes comorbidades e importantes complicações físicas, como escoliose e contraturas musculares. Mais da metade dos participantes não deambula. Conclusões: A maioria dos participantes demonstrou ter importante restrição na participação social, além de escolaridade baixa. Adultos com PC estão sujeitos ainda a instalação de várias complicações físicas e limitações progressivas na marcha.

BACKGROUND: Cerebral Palsy (CP) is a group of permanent disorders of the development of movement and posture that cause functional limitation and are attributed to non-progressive disorders which occur in the fetal or infant brain. In recent years, with the increase in life expectancy of individuals with CP, several studies have described the impact of musculoskeletal disabilities and functional limitations over the life cycle. OBJECTIVE: To characterize adults with CP through sociodemographic information, classifications, general health, associated conditions, physical complications and locomotion. METHODS: Twenty-two adults with CP recruited from local rehabilitation centers in an inner town of Brazil participated in this study. A questionnaire was used to collect data on sociodemographic characteristics, comorbities, and physical complications. A brief physical therapy evaluation was carried out, and the Gross Motor Function Classification System (GMFCS) and the Manual Ability Classification System (MACS) were applied. Data were analyzed through descriptive statistics. RESULTS: The mean age was 28.7 (SD 10.6) years, 86.4 percent of participants lived with parents, and 4.5 percent were employed. Most of the sample consisted of spastic quadriplegic subjects, corresponding to levels IV and V of the GMFCS and MACS. Different comorbidities and important physical complications such as scoliosis and muscle contractures were present. More than half of the participants were unable to walk. CONCLUSIONS: Most participants demonstrated important restrictions in social participation and lower educational level. Adults with CP can be affected by several physical complications and progressive limitations in gait.