Host-microbial crosstalk relies on "tuft" love.

How commensals influence intestinal immunity is incompletely understood. In this issue of Immunity, Eshleman et al. demonstrate that microbiota-derived butyrate restrains tuft cell development via HDAC3 modulation in intestinal epithelial cells, showing how microbial metabolites impact intestinal type 2 immunity.

Development, regeneration and aging: a bizarre love triangle.

The Jacques Monod Conference on 'Growth and regeneration during development and aging' was organized by Claude Desplan and Allison Bardin in May 2023. The conference took place in Roscoff, France, where participants shared recent conceptual advances under the general motto that developmental processes do not end with embryogenesis. The meeting covered various aspects of how development relates to fitness, regeneration and aging across a refreshing diversity of evolutionarily distant organisms.

Tender love and disassembly: How a TLDc domain protein breaks the V-ATPase.

Vacuolar ATPases (V-ATPases, V1 Vo -ATPases) are rotary motor proton pumps that acidify intracellular compartments, and, when localized to the plasma membrane, the extracellular space. V-ATPase is regulated by a unique process referred to as reversible disassembly, wherein V1 -ATPase disengages from Vo proton channel in response to diverse environmental signals. Whereas the disassembly step of this process is ATP dependent, the (re)assembly step is not, but requires the action of a heterotrimeric chaperone referred to as the RAVE complex. Recently, an alternative pathway of holoenzyme disassembly was discovered that involves binding of Oxidation Resistance 1 (Oxr1p), a poorly characterized protein implicated in oxidative stress response. Unlike conventional reversible disassembly, which depends on enzyme activity, Oxr1p induced dissociation can occur in absence of ATP. Yeast Oxr1p belongs to the family of TLDc domain containing proteins that are conserved from yeast to mammals, and have been implicated in V-ATPase function in a variety of tissues. This brief perspective summarizes what we know about the molecular mechanisms governing both reversible (ATP dependent) and Oxr1p driven (ATP independent) V-ATPase dissociation into autoinhibited V1 and Vo subcomplexes.

Triggers for mother love.

Previous studies showed that baby monkeys separated from their mothers develop strong and lasting attachments to inanimate surrogate mothers, but only if the surrogate has a soft texture; soft texture is more important for the infant's attachment than is the provision of milk. Here I report that postpartum female monkeys also form strong and persistent attachments to inanimate surrogate infants, that the template for triggering maternal attachment is also tactile, and that even a brief period of attachment formation can dominate visual and auditory cues indicating a more appropriate target.

Experienced Love: An Empirical Account.

This article presents new evidence on the prevalence, dynamics, and hedonic correlates of experienced love from data describing the emotion, well-being, and time use of a diverse sample of 3,867 U.S. adults every half hour for 10 days (N = 1.12 million) supplemented by a hedonic snapshot of an additional 7,255 adults. The findings allude to the seemingly functional and adaptive nature of love and to similarities across binary gender-men and women reported comparable degrees of (passionate) partner love overall, elevated partner love after prolonged same-day separations, substantially elevated well-being in love's presence, and reduced (but not extinguished) partner love in mature marital cohorts. The gender differences that were found-women reported more child love than men, and men exhibited a less pronounced reduction in partner love across cohorts-are also consistent with functional accounts of love that recognize the varying role of men and women in the formation and sustenance of relationships.

Love Matters: The Effect of Mating Motive on Female Food Choice.

The prevalence of obesity has been increasing globally in recent decades. Behind the phenomenon, high-fat food consumption has been conceived as an important driver. In the current study, we explored whether mating motive caused an effect on female food choice as well as the psychological mechanism underlying it. In Study 1, we recruited 64 participants from a university and asked them to complete a mating prime, after which they would finish a food choice task in which food with different flavors were shown. In Study 2, we replicated Study 1 with a different mating priming method and examined the mediating role of body shaping desire on the relation between mating motive and female food choice. Results showed that: (1) The salience of mating motive decreased female's high-fat food choice but increased male's high-fat food choice; (2) the effect of mating motive in females was robust and more salient for sweet food rather than salty food; and (3) the body shaping desire partially mediated the effect of mating motive on female food choice.

Reproductive Strategies and Romantic Love in Early Modern Europe.

In Western Europe, the Early Modern Period is characterized by the rise of tenderness in romantic relationships and the emergence of companionate marriage. Despite a long research tradition, the origins of these social changes remain elusive. In this paper, we build on recent advances in behavioral sciences, showing that romantic emotional investment, which is more culturally variable than sexual attraction, enhances the cohesion of long-term relationships and increases investment in children. Importantly, this long-term strategy is considered especially advantageous when living standards are high. Here, we investigate the relationship between living standards, the emotional components of love expressed in fiction work, and behavioral outcomes related to pair bonding, such as nuptial and fertility rates. We developed natural language processing measures of "emotional investment" (tenderness) and "attraction" (passion) and computed romantic love in English plays (N = 847) as a ratio between the two. We found that living standards generally predicted and temporally preceded variations of romantic love in the Early Modern Period. Furthermore, romantic love preceded an increase in nuptial rates and a decrease in births per marriage. This suggests that increasing living standards in the Early Modern Period may have contributed to the emergence of modern romantic culture.

Validation of the Short Version (TLS-15) of the Triangular Love Scale (TLS-45) across 37 Languages.

Love is a phenomenon that occurs across the world and affects many aspects of human life, including the choice of, and process of bonding with, a romantic partner. Thus, developing a reliable and valid measure of love experiences is crucial. One of the most popular tools to quantify love is Sternberg's 45-item Triangular Love Scale (TLS-45), which measures three love components: intimacy, passion, and commitment. However, our literature review reveals that most studies (64%) use a broad variety of shortened versions of the TLS-45. Here, aiming to achieve scientific consensus and improve the reliability, comparability, and generalizability of results across studies, we developed a short version of the scale-the TLS-15-comprised of 15 items with 5-point, rather than 9-point, response scales. In Study 1 (N = 7,332), we re-analyzed secondary data from a large-scale multinational study that validated the original TLS-45 to establish whether the scale could be truncated. In Study 2 (N = 307), we provided evidence for the three-factor structure of the TLS-15 and its reliability. Study 3 (N = 413) confirmed convergent validity and test-retest stability of the TLS-15. Study 4 (N = 60,311) presented a large-scale validation across 37 linguistic versions of the TLS-15 on a cross-cultural sample spanning every continent of the globe. The overall results provide support for the reliability, validity, and cross-cultural invariance of the TLS-15, which can be used as a measure of love components-either separately or jointly as a three-factor measure.

Young Love "Locked Down": Adolescent and Young Adult Perspectives on Sexting During the Covid-19 Pandemic in England.

There were limited opportunities for in-person social, intimate, and sexual interactions in England during 2020-2021, due to restrictions imposed by the UK government in response to the Covid-19 pandemic. While previous studies examined the effects of lockdown on intimate relationships, there is less qualitative research regarding young people's perspectives on and experiences of digitally mediated intimacy (sexting) during the period. This paper discusses findings from focus groups with 80 adolescents and interviews with 38 young adults that explored the topic. Analysis identified a normalization of non-consensual distribution of intimate images within adolescent peer culture and a reluctance to report or intervene in response to incidents of non-consensual distribution that are witnessed or experienced. The adolescent girls and young adult women also described other forms of unwanted and invasive image-sharing and requests for images. Young adults held various perspectives on sexting during lockdown, with some describing sexting as unfulfilling and/or "risky" and others sharing experiences of using sexting to generate intimacy and, among some, engaging in unwanted sexting with partners. By considering both adolescent and young adult perspectives obtained through focus groups and interviews, the study highlighted how group-level norms and meanings surrounding the risks and rewards of sexting may be reproduced or reworked as individuals transition from adolescence to young adulthood. The study underscores the need to support adolescents and young adults in cultivating healthy digital sexual cultures and interpersonal relationships.

A participatory approach to understand what might be most meaningful to people living with dementia in a positive psychology intervention.

OBJECTIVES: This study aimed to understand which character strengths are most important for people living with dementia and therefore which strengths-based psychological interventions could be most meaningful and acceptable. METHODS: A participatory design, utilising Delphi methodology, was incorporated into an iterative three stage framework: (1) literature reviewed for Positive Psychology (PP) interventions and patient public involvement to define the character strengths; (2) modified Delphi (N = 10) identified which character strengths are most important for living with dementia; (3) focus groups (N = 14) explored which PP interventions are most acceptable and meaningful. Qualitative data from the focus groups was analysed using thematic analysis. RESULTS: Love, kindness and humour were deemed the most important character strengths for living with dementia. Qualitative data from the focus groups was captured in three superordinate themes: (1) lack of opportunity not capacity; (2) key considerations of PP interventions for people living with dementia; and (3) potential benefits of PP interventions. CONCLUSIONS: Love, kindness and humour come naturally to people with dementia, but people may lack social opportunities to use these strengths. Therefore, a PP intervention promoting positive emotion, social relationships and connection to one's values appears most meaningful and acceptable as this may provide a social context to use and maintain these strengths.

I and thou in dialogue: Becoming more relational in couple therapy.

Couple therapists have the unique and challenging opportunity of helping people find deeper connection in their intimate relationships. These clinicians apply therapeutic models and interventions designed to help couples. However, many of these models are derived from theoretical, scientific, and sociocultural traditions that conceptualize human phenomena as individualistic and reductionistic, and the language in these theories may not match clients' experiences, which include deeply relational phenomena such as love and loss. We review how Western scientific and sociocultural traditions have shaped conceptualization of problems and clinical intervention in couple therapy. In contrast, we provide an alternative, strongly relational framework for couple therapy that draws upon philosophical perspectives asserting that relational, rather than individual, experience is fundamental in human interaction. These ideas provide relational language which can influence how couple therapy is viewed and enacted. Specifically, we discuss how a strongly relational approach changes how therapists understand and intervene with conflict, abuse, love, and deception. This relational framework can help couples in their own goals to become more unified. Implications for the therapeutic relationship, interventions, and scholarship are provided.

Treatment of Alec: "History does not have to repeat itself".

Treatment of patients with pathological narcissism presents several challenges and there is paucity of published case reports that document meaningful and durable change in patients suffering from this condition. Using descriptive and atheoretical language, this paper presents a treatment of a young man in his transition from young adulthood to middle adulthood while he was negotiating complex residues of his experiences of growing up along with developmental challenges related to work and love. Against the backdrop of these transitions, the patient was working through various aspects of functioning related to pathological narcissism. Initially, given academic pressures and past romantic disappointments, he was confronting issues related to perfectionism, self-criticism, and avoidance. While he was able to move past some of these dynamics and function academically, later challenges related to becoming an independent adult led to a retreat into an avoidant state of futility and pessimism. Working through painful family dynamics related to not being seen and controlled, along with a deepening attachment in therapy as well as confrontation with realities of his life, led him to take steps toward greater independence. Thereafter, his treatment focused on learning from life experiences such as a newly developed career and romantic life, accepting the complexity of self and others, and tolerating disillusionments.

Meditation, Compassionate Love, and Mental Health in Later Life.

PURPOSE: Understanding of the mechanisms by which meditation imparts beneficial effects on later-life mental health is limited. The current study assessed the role of compassionate love in mediating the relationship between meditation and mental health in later life. METHOD: Using data from a nationwide web-based survey (N = 1,861), we examined the indirect effects of meditation on depressive symptoms and anxiety via compassionate love. RESULTS: Participants who practiced meditation (compared to those who did not) had significantly higher feelings of being loved (b = 0.11, p < 0.05); those who experienced more love had lower depressive symptoms (b = -2.10, p < 0.001) and anxiety (b = -0.99, p < 0.001). Meditation also had significant indirect effects (via compassionate love) on depressive symptoms (b = -0.23, p < 0.05) and anxiety (b = -0.11, p < 0.05). CONCLUSION: This study underscores the need for contemplative interventions that foster compassionate love to improve mental health in later life. [Journal of Gerontological Nursing, 50(3), 40-50.].

From love to pain: is oxytocin the key to grief complications?

While most adults confronted with the death of a loved one manage to grieve, about 10-20% of individuals develop complicated grief, characterized by persistent distress and impaired social skills, or pathological grief, defined by the onset or decompensation of a psychiatric disorder. Little is known about the biological causes of these grief complications. Recent work suggests that oxytocin, a major neuroendocrine hormone regulating many neurocognitive mechanisms, may be involved in this process. Oxytocin is widely studied and well known for its impact on the mother-child bond and hormonal and brain systems related to attachment and social interactions. In this article, we propose a neurocognitive model of grief complications based on existing data on the role of oxytocin in interpersonal attachment and its impact on brain activity. We suggest that complicated grief is associated with dysfunctional cerebral oxytocinergic signaling and persistent hyperactivation of the nucleus accumbens. This mechanism is involved in limiting the reduction of interpersonal attachment to the deceased during acute phases and in searching for new interpersonal relationships during the recovery phase. We show how the exploration of cerebral oxytocinergic signaling would improve the understanding of physiological grief mechanisms in the general population and could allow the development of new therapeutic perspectives against the complications of grief.

The Price of Love: Understanding the Financial and Psychosocial Costs of Caring for Children with Medical Complexities.

Parents of children with medical complexities (CMCs) report significant challenges affecting their financial, emotional and social well-being in relation to caring for their child's medical needs. The Complex Care Navigator Program was designed to provide social, emotional and economic support to parents of CMCs. This paper describes the results and outcomes of the program and the challenges experienced during the evaluation process. Overall, results suggest that the program had a positive impact on the parents' psychosocial functioning and social connections. The results demonstrate the importance of providing early screening, psychosocial intervention and peer support.

A Lesbian's Miscarriage: Disengaging Bias and Caring Through Presence and Prayer.

ABSTRACT: In my experience of caring for a lesbian couple suffering a miscarriage, I disengaged my bias about their sexual orientation and compassionately cared for their needs. After praying with the couple, I felt a deep connection with them and a palpable peace. Joy shone on their faces and they verbally expressed gratitude. God used me as a caring presence. Christian nurses are vessels for God's love to bring peace and healing.

Love in the time of climate change: A review of sexual reproduction in the order Onygenales.

Life-threatening infections caused by fungi in the order Onygenales have been rising over the last few decades. Increasing global temperature due to anthropogenic climate change is one potential abiotic selection pressure that may explain the increase in infections. The generation of genetically novel offspring with novel phenotypes through the process of sexual recombination could allow fungi to adapt to changing climate conditions. The basic structures associated with sexual reproduction have been identified in Histoplasma, Blastomyces, Malbranchea, and Brunneospora. However, for Coccidioides and Paracoccidioides, the actual structural identification of these processes has yet to be identified despite having genetic evidence that suggests sexual recombination is occurring in these organisms. This review highlights the importance of assessing sexual recombination in the order Onygenales as a means of understanding the mechanisms these organisms might employ to enhance fitness in the face of a changing climate and provides details regarding the known reproductive mechanisms in the Onygenales.