RESUMO
BACKGROUND: Primate populations are in decline, mainly affected by agriculture leading to habitat loss, fragmentation but also chemical pollution. Kibale National Park (Uganda), Sebitoli forest, surrounded by tea and crop fields, is the home range of chimpanzees presenting congenital facial dysplasia. This study aimed to identify to what extent the same phenotypical features are observed in baboons (Papio anubis) of this area. METHODS: A total of 25 390 clips recorded by 14 camera traps between January 2017 and April 2018 were analyzed. RESULTS: We identified 30 immature and adult baboons of both sexes with nose and lip deformities. They were more frequently observed in the northwestern part of the area. CONCLUSIONS: A possible effect of pesticides used in crops at the border of their habitat is suspected to alter the embryonic development. This study emphasizes the importance of non-invasive methods to detect health problems in wild primates that can act as sentinels for human health.
Assuntos
Anormalidades Craniofaciais/induzido quimicamente , Face/anormalidades , Doenças dos Macacos/congênito , Papio anubis/anormalidades , Animais , Feminino , Masculino , Doenças dos Macacos/induzido quimicamente , Parques Recreativos , UgandaRESUMO
BACKGROUND: Emesis has significant evolutionary value as a defense mechanism against ingested toxins; however, it is also one of the most common adverse symptoms associated with both disease and medical treatments of disease. The development of improved antiemetic pharmacotherapies has been impeded by a shortage of animal models. METHODS: The present studies characterized the responses of the squirrel monkey to pharmacologically diverse emetic drugs. Subjects were administered nicotine (0.032-0.56 mg/kg), lithium chloride (150-250 mg/kg), arecoline (0.01-0.32 mg/kg), or apomorphine (0.032-0.32 mg/kg) and observed for emesis and prodromal hypersalivation. RESULTS: Nicotine rapidly produced emesis and hypersalivation. Lithium chloride produced emesis with a longer time course without dose-dependent hypersalivation. Arecoline produced hypersalivation but not emesis. Apomorphine failed to produce emesis or hypersalivation. CONCLUSIONS: The squirrel monkey is sensitive to drug-induced emesis by a variety of pharmacological mechanisms and is well-positioned to examine antiemetic efficacy and clinically important side effects of candidate antiemetic pharmacotherapies.
Assuntos
Eméticos/farmacologia , Doenças dos Macacos/induzido quimicamente , Saimiri , Vômito/induzido quimicamente , Animais , Apomorfina/farmacologia , Arecolina/farmacologia , Cloreto de Lítio/farmacologia , Masculino , Nicotina/farmacologiaRESUMO
A female rhesus macaque developed two episodes of generalized convulsions during transcutaneous spinal cord stimulation (TSCS) and urodynamic studies under ketamine anesthesia. The seizures took place in the absence of active TSCS and bladder pressure elevation. Ketamine anesthesia remains the primary risk factor for the convulsions during these experimental procedures.
Assuntos
Anestesia/efeitos adversos , Anestésicos Dissociativos/efeitos adversos , Ketamina/efeitos adversos , Macaca mulatta , Doenças dos Macacos/induzido quimicamente , Convulsões/induzido quimicamente , Animais , Feminino , Fatores de Risco , Estimulação da Medula Espinal , Bexiga Urinária/diagnóstico por imagemRESUMO
BACKGROUND: It remains unknown how single-shot anesthesia influences physical parameters, especially respiratory function and blood oxygen level of common marmosets (Callithrix jacchus) which came to be used for laboratory research. METHODS: We measured blood oxygen levels, both before and after oxygenation, in 13 common marmosets under two single-shot anesthesia conditions: ketamine/xylazine/atropine and alphaxalone. RESULTS AND CONCLUSIONS: We found that SpO2 values decreased to about 80% in the ketamine/xylazine/atropine protocol and fell just below 90% in the alphaxalone protocol. We observed a clear decrease in PaO2 values under the anesthetized condition compared to the awake condition. Our data indicate that single-shot anesthesia may cause hypoxemia in marmosets. Previous studies on other non-human primate have reported no SpO2 decrease and hypoxemia; thus, our experiment suggests that marmosets may have a more fragile respiratory system and require intensive veterinary care during anesthesia.
Assuntos
Adjuvantes Anestésicos/efeitos adversos , Anestesia/veterinária , Anestésicos/efeitos adversos , Callithrix , Hipóxia/veterinária , Doenças dos Macacos/fisiopatologia , Anestesia/efeitos adversos , Animais , Atropina/efeitos adversos , Callithrix/fisiologia , Feminino , Hipóxia/induzido quimicamente , Hipóxia/fisiopatologia , Ketamina/efeitos adversos , Masculino , Doenças dos Macacos/induzido quimicamente , Oxigênio/sangue , Pregnanodionas/efeitos adversos , Respiração/efeitos dos fármacos , Xilazina/efeitos adversosRESUMO
Renal pigmentation due to the administration of exogenous compounds is an uncommon finding in most species. This report describes renal pigmentation and intranuclear inclusions of the proximal convoluted tubules due to chronic bismuth administration in a rhesus macaque. An 11-year-old Indian-origin rhesus macaque with a medical history of chronic intermittent vomiting had been treated with bismuth subsalicylate, famotidine, and omeprazole singly or in combination over the course of 8 years. At necropsy, the renal cortices were diffusely dark green to black. Light and electron microscopy revealed intranuclear inclusions within the majority of renal proximal tubular epithelial cells. These inclusions appeared magenta to brown when stained with hematoxylin and eosin and were negative by the Ziehl-Neelsen acid-fast stain. Elemental analysis performed on frozen kidney measured bismuth levels to be markedly elevated at 110.6 ppm, approximately 500 to 1000 times acceptable limits. To our knowledge, this is the first report of renal bismuth deposition in a rhesus macaque resulting in renal pigmentation and intranuclear inclusions.
Assuntos
Antieméticos/efeitos adversos , Bismuto/efeitos adversos , Nefropatias/veterinária , Doenças dos Macacos/induzido quimicamente , Compostos Organometálicos/efeitos adversos , Transtornos da Pigmentação/veterinária , Salicilatos/efeitos adversos , Animais , Antieméticos/uso terapêutico , Bismuto/uso terapêutico , Rim/efeitos dos fármacos , Rim/patologia , Nefropatias/induzido quimicamente , Nefropatias/patologia , Macaca mulatta , Masculino , Doenças dos Macacos/patologia , Compostos Organometálicos/uso terapêutico , Pigmentação/efeitos dos fármacos , Transtornos da Pigmentação/induzido quimicamente , Transtornos da Pigmentação/patologia , Salicilatos/uso terapêutico , Vômito/tratamento farmacológico , Vômito/veterináriaRESUMO
Contrary to earlier established opinion that tumors in monkeys are found rarely, now the large material confirms that monkey tumors are frequent phenomenon. Tumor incidence clearly increases with age. Frequencies of benign and malignant tumors of various locations and histogenesis are slightly different. Tumors of hematopoietic system are the most frequent. Sporadic cases and enzootic outbreaks of lymphomas are described for different kinds of monkeys, including apes, and probably are caused by viruses. Two viruses were isolated by us from sick monkeys - the retrovirus C-type STLV-1 and the herpes virus papio HVP. Inoculation of virus cultures into monkeys and rabbits induces neoplasms. Monkey neoplasms can be induced by exposure to various chemical agents, and by oncogenic and non-oncogenic viruses. There is no strict species specificity of tumor viruses. The role of polyoma viruses in neoplasms etiology is discussed.
Assuntos
Haplorrinos , Doenças dos Macacos/epidemiologia , Neoplasias Experimentais/epidemiologia , Neoplasias/veterinária , Fatores Etários , Animais , Incidência , Doenças dos Macacos/induzido quimicamente , Doenças dos Macacos/virologia , Neoplasias/induzido quimicamente , Neoplasias/epidemiologia , Neoplasias/virologia , Neoplasias Experimentais/química , Neoplasias Experimentais/virologia , Vírus Linfotrópico T Tipo 1 de Símios/fisiologia , Simplexvirus/fisiologiaRESUMO
In an attempt to establish a primate model of chronic cadmium toxicosis, we ovariectomized cynomolgus monkeys and treated them with CdCl2 by repeated intravenous injections for 13 to 15 months. The animals showed normocytic-normochromic anemia. The cadmium treatment resulted in increases of urinary enzyme activity indicative of renal tubular degeneration. Histopathology of the kidney revealed renal proximal tubular atrophy accompanied by interstitial fibrosis. Decreased bone mineral density was evident in the trabecular and cortical zones of the lumbar vertebra and femur, with osteoid accumulation around the trabeculae and Haversian canals. Iron deposition at the mineralization front and osteoclasts hyperplasia were indicative of impairment of bone mineralization and an increase of resorption. Blood inorganic phosphorus and 1α,25(OH)2 vitamin D3 levels decreased and urinary deoxypyridinoline level increased in cadmium-treated animals. The renal and bone lesions closely resemble those of itai-itai disease patients, the most severe case of cadmium toxicosis in terms of clinical chemistry and histopathology. Thus, ovariectomized monkeys chronically exposed to cadmium can serve as a primate itai-itai disease model, which is beneficial for developing novel therapeutic methods, investigating the mechanisms of the renal and bone lesions, and establishing more clearly defined criteria for diagnosing the disease.
Assuntos
Doenças Ósseas Metabólicas/induzido quimicamente , Intoxicação por Cádmio/fisiopatologia , Cádmio/toxicidade , Nefropatias/induzido quimicamente , Doenças dos Macacos/induzido quimicamente , Animais , Peso Corporal , Densidade Óssea , Doenças Ósseas Metabólicas/fisiopatologia , Osso e Ossos/fisiopatologia , Cádmio/análise , Modelos Animais de Doenças , Feminino , Fêmur/fisiopatologia , Rim/fisiopatologia , Nefropatias/fisiopatologia , Fígado/fisiopatologia , Macaca fascicularis , Doenças dos Macacos/fisiopatologia , Ovariectomia , Fósforo/sangue , Distribuição Aleatória , UrináliseRESUMO
The endocrine mechanism involved in term and preterm delivery in primates, including pregnant women, are poorly understood. In the term monkey, fetal plasma androgen concentration rises to two hundred times the maternal concentration which remains unchanged. Placental conversion of androgen to estrogen results in increased maternal plasma estrogen concentration at term in both pregnant nonhuman primates and women. In the present study, continuous infusion of androstenedione to 0.8 gestation monkeys resulted in the premature occurrence of labor-type myometrial activity and increases in maternal plasma estrogen, oxytocin and amnion fibronectin concentrations similar to those measured at normal-term labor. Androstenedione induction of these normal-term biochemical and endocrine changes accompanied by fetal membrane rupture, cervical dilatation and live delivery provides a rich opportunity to study the molecular and physiological mechanisms of both term and preterm labor in primates.
Assuntos
Androstenodiona/administração & dosagem , Macaca mulatta , Doenças dos Macacos/induzido quimicamente , Miométrio/fisiopatologia , Trabalho de Parto Prematuro/induzido quimicamente , Trabalho de Parto Prematuro/veterinária , Animais , Estrogênios/sangue , Feminino , Fibronectinas/metabolismo , Humanos , Infusões Intravenosas , Trabalho de Parto Prematuro/fisiopatologia , Ocitocina/sangue , Gravidez , Contração Uterina/efeitos dos fármacosRESUMO
The present study examined the effect of high fat and high fructose (HFF) diet on the development of atherosclerosis and vascular contractile responses in the cerebral artery and thoracic aorta in non-human primates. Female cynomolgus monkeys (age: 3 to 4 years) were divided into normal control diet (N=5) and HFF diet groups (N=5). Twenty-eight weeks after feeding the HFF diet, total cholesterol and low-density lipoprotein-cholesterol in serum were significantly increased in the HFF diet group compared to the control group. The ultrastructural analyses of the basilar artery and aorta demonstrated the infiltration of lipid-laden foam cells and the appearance of lipid droplet-filled smooth muscle cells in the monkeys fed with the HFF diet. In terms of vascular reactivity, there was significantly greater vasoconstriction of the aorta and basilar artery in response to 5-hydroxytryptamine in the HFF diet group compared to the normal diet-fed group. In addition, KCl-induced vasoconstriction of the basilar arteries was also significantly enhanced in the HFF diet group compared to the normal diet-fed monkeys. In all, our present study has demonstrated that changes in the vascular responsiveness of the cerebral artery and its cellular architecture may manifest into cerebrovascular complications consistent with a pathological state normally observed with the onset and progression of atherosclerosis.
Assuntos
Aorta Torácica/fisiopatologia , Artéria Basilar/fisiopatologia , Dieta Aterogênica , Gorduras na Dieta/efeitos adversos , Frutose/efeitos adversos , Arteriosclerose Intracraniana/fisiopatologia , Vasoconstrição , Animais , Aorta Torácica/metabolismo , Aorta Torácica/ultraestrutura , Artéria Basilar/metabolismo , Artéria Basilar/ultraestrutura , Cerebelo/irrigação sanguínea , Cerebelo/metabolismo , Cerebelo/fisiopatologia , Cerebelo/ultraestrutura , Artérias Cerebrais/metabolismo , Artérias Cerebrais/fisiopatologia , Artérias Cerebrais/ultraestrutura , LDL-Colesterol/sangue , Gorduras na Dieta/administração & dosagem , Feminino , Células Espumosas/metabolismo , Células Espumosas/ultraestrutura , Frutose/administração & dosagem , Arteriosclerose Intracraniana/sangue , Arteriosclerose Intracraniana/induzido quimicamente , Arteriosclerose Intracraniana/patologia , Arteriosclerose Intracraniana/veterinária , Macaca fascicularis , Doenças dos Macacos/sangue , Doenças dos Macacos/induzido quimicamente , Doenças dos Macacos/patologia , Doenças dos Macacos/fisiopatologia , Cloreto de Potássio/administração & dosagem , Serotonina/administração & dosagem , Serotoninérgicos/administração & dosagem , Vasoconstrição/efeitos dos fármacosRESUMO
To construct informed conservation plans, researchers must go beyond understanding readily apparent threats such as habitat loss and bush-meat hunting. They must predict subtle and cascading effects of anthropogenic environmental modifications. This study considered a potential cascading effect of deforestation on the howler monkeys (Alouatta pigra) of Balancán, Mexico. Deforestation intensifies flooding. Thus, we predicted that increased flooding of the Usumacinta River, which creates large bodies of water that slowly evaporate, would produce increased lead content in the soils and plants, resulting in lead exposure in the howler monkeys. The average lead levels were 18.18 ± 6.76 ppm in the soils and 5.85 ± 4.37 ppm in the plants. However, the average lead content of the hair of 13 captured howler monkeys was 24.12 ± 5.84 ppm. The lead levels in the animals were correlated with 2 of 15 blood traits (lactate dehydrogenase and total bilirubin) previously documented to be associated with exposure to lead. Our research illustrates the urgent need to set reference values indicating when adverse impacts of high environmental lead levels occur, whether anthropogenic or natural, and the need to evaluate possible cascading effects of deforestation on primates.
Assuntos
Alouatta/fisiologia , Conservação dos Recursos Naturais , Inundações , Intoxicação por Chumbo/veterinária , Doenças dos Macacos/epidemiologia , Animais , Ecossistema , Feminino , Intoxicação por Chumbo/epidemiologia , Intoxicação por Chumbo/etiologia , Masculino , México/epidemiologia , Doenças dos Macacos/induzido quimicamenteRESUMO
Fourteen macaque monkeys were injected intravenously with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. All developed the cardinal signs of parkinsonism (akinesia, rigidity, etc.) in varying degrees; some required repeated series of injections of the drug, while others developed the syndrome readily after the first series. Most of the subjects that were kept for longer than 4 weeks after the first dose of the drug showed complete or partial recovery after that time. Measurement, in some of the subjects, of the neostriatal levels of dopamine and dihydroxyphenylacetic acid showed the expected depletion of these substances at the peak of the behavioral action of the drug, but no recovery when the animals had returned to, or near, pre-drug behavioral status. No firm conclusion can be reached at this time as to the reasons for the behavioral recovery or the variability of the effects of the drug across subjects.
Assuntos
Química Encefálica/efeitos dos fármacos , Modelos Animais de Doenças , Doenças dos Macacos/induzido quimicamente , Doença de Parkinson Secundária/veterinária , Piridinas , 1-Metil-4-Fenil-1,2,3,6-Tetra-Hidropiridina , Ácido 3,4-Di-Hidroxifenilacético/metabolismo , Animais , Dopamina/metabolismo , Feminino , Macaca fascicularis , Masculino , Doenças dos Macacos/mortalidade , Doenças dos Macacos/fisiopatologia , Doença de Parkinson Secundária/induzido quimicamente , Doença de Parkinson Secundária/fisiopatologia , Fatores de TempoRESUMO
Pretreatment of rhesus macaques with nonlethal total-body x-irradiation (400 R) prolonged survival time from an average of 15 hours to 101 hours after intravenous (IV) inoculation of 50 microgram of staphylococcal enterotoxin B (SEB)/kg of body weight. Radiation exposure per se did not produce detectable cardiorenal changes; however, the longer survival after SEB challenge exposure in x-irradiated rhesus macaques was associated with improved cardiorenal functions if compared with that of nonirradiated macaques given the same dose of SEB. Total-body radiation exposure 4 days prior to IV SEB inoculation prevented typical SEB-induced decreases (where measured at 5 hours) in cardiac output, stroke volume, TcH2O, CPAH, Cosm, and urine flow, as well as increases in total peripheral and renal resistance. A theory concerning the significance of radiation-induced leukopenia on modification of SEB-induced cardiorenal functions is postulated.
Assuntos
Enterotoxinas/toxicidade , Coração/fisiopatologia , Rim/fisiopatologia , Macaca mulatta , Macaca , Doenças dos Macacos/fisiopatologia , Staphylococcus , Animais , Débito Cardíaco , Feminino , Haplorrinos , Coração/efeitos da radiação , Rim/irrigação sanguínea , Rim/efeitos da radiação , Doenças dos Macacos/induzido quimicamente , Fluxo Sanguíneo Regional , Resistência Vascular , Raios XRESUMO
Experiments were conducted to determine the dose response, survival time, blood biochemical changes, and cardiohepatic responses to a single IV injection of crude Shigella toxin in rhesus macaques (Macaca mulatta). Circulatory shock, hepatic falure, respiratory depression, dyspnea, convulsions, and coma were observed before death. The survival time was inversely related to the administered toxic dose, which ranged from 20 to 200 microgram/kg of body weight. However, the severity of lesions in the heart and gastrointestinal tract was directly correlated with the amount of the injected dose. Macaques exposed to aerosols of crude Shigella toxin did not show any signs of toxicosis within 7 days after exposure and were considered permanent survivors. Seemingly, an IV crude preparation of Shigella toxin is lethal to rhesus macaques, but an aerosol crude preparation of Shigella toxin is not.
Assuntos
Aerossóis , Disenteria Bacilar/veterinária , Doenças dos Macacos/patologia , Shigella dysenteriae , Toxinas Biológicas/farmacologia , Animais , Pressão Sanguínea/efeitos dos fármacos , Disenteria Bacilar/induzido quimicamente , Disenteria Bacilar/patologia , Haplorrinos , Hemodinâmica/efeitos dos fármacos , Macaca mulatta , Doenças dos Macacos/induzido quimicamente , Toxinas Biológicas/administração & dosagemRESUMO
In an attempt to establish a primate model of chronic cadmium (Cd) toxicosis, we ovariectomized cynomolgus monkeys and treated with CdCl2 by repeated intravenous injections for 13 to 15 months. The animals showed an increase in blood glucose from Month 10 and a decrease in blood insulin at Month 11of the Cd-treatment. Histopathological examination of the Cd-treated animals revealed islet atrophy with reduction in islet number and vacuolation of the islet cells, whereas there was no remarkable change in the acinar cells of the exocrine pancreas. In histomorphometrical examination, insulin-positive areas in the islets were significantly decreased, accompanying a relative increase of glucagon-positive areas. Large amounts of Cd accumulated in the pancreas, and metallothionein (MT), a Cd binding protein, was localized in the islets of Cd-treated animals. The present study demonstrated that the chronic intravenous injection of Cd to cynomolgus monkeys induced the accumulation of the metal in the pancreas, degeneration of islet B cells and the diabetic clinical signs. Therefore the islet B cell is one of the major targets of the chronic Cd poisoning in monkeys.
Assuntos
Intoxicação por Cádmio/patologia , Ilhotas Pancreáticas/efeitos dos fármacos , Macaca fascicularis , Doenças dos Macacos/induzido quimicamente , Animais , Glicemia/metabolismo , Cádmio/metabolismo , Cádmio/toxicidade , Modelos Animais de Doenças , Feminino , Glucagon/metabolismo , Insulina/sangue , Ilhotas Pancreáticas/patologia , Metalotioneína/metabolismo , Doenças dos Macacos/patologia , Ovariectomia , Distribuição AleatóriaRESUMO
Gastric tumors were detected in 2 out of 9 apes following MNNG treatment with a total dose of 800-848 mg/kg (40 mg/kg, thrice a month, 49-50 weeks, via gastric probe). The characteristics, course, symptoms and histologic patterns of the tumors proved comparable with similar neoplasms in humans.
Assuntos
Doenças dos Macacos/induzido quimicamente , Nitrosoguanidinas/toxicidade , Neoplasias Gástricas/induzido quimicamente , Animais , Relação Dose-Resposta a Droga , Feminino , Macaca fascicularis , Masculino , Doenças dos Macacos/patologia , Estômago/efeitos dos fármacos , Estômago/patologia , Neoplasias Gástricas/patologia , Fatores de TempoRESUMO
Selective serotonin reuptake inhibitors (SSRI) are associated with an increased bleeding risk in humans. This report describes a bleeding event in a cynomolgus macaque (Macaca fascicularis) treated with the SSRI sertraline HCl (Zoloft). During the treatment course, the subject presented with a maculopapular rash, cutaneous bleeding, epistaxis, bleeding from the eye, melena, and a severe thrombocytopenia. To our knowledge, this report is the first description of an SSRI-related adverse event in a nonhuman primate. This report demonstrates that the clinical presentation of SSRI-associated bleeding in cynomolgus macaques is consistent with that reported in humans and that complications from SSRI treatment should be considered as a differential diagnosis for maculopapular dermatitis or spontaneous bleeding in this species.
Assuntos
Animais de Laboratório , Hemorragia/veterinária , Macaca fascicularis , Doenças dos Macacos/induzido quimicamente , Doenças dos Macacos/patologia , Inibidores Seletivos de Recaptação de Serotonina/efeitos adversos , Sertralina/efeitos adversos , Animais , Depressão/tratamento farmacológico , Hemorragia/induzido quimicamente , Hemorragia/patologia , Trombocitopenia/induzido quimicamente , Trombocitopenia/patologiaRESUMO
We report a case of a generalized seizure in an adult female rhesus macaque ( Macaca mulatta) undergoing a urodynamic evaluation while she was anesthetized with continuous-infusion ketamine. The seizure presented with generalized tonic-clonic activity during bladder infusion with saline. The tonic-clonic phase was self-limited and was followed by focal facial twitching, which was interrupted by bolus administration of intravenous diazepam. The ictal event was documented as pressure oscillations during cystometrogram recordings and a period of external urethral sphincter muscle activation, which was detectable by electromyography. An acute decrease in urethral pressure was demonstrated at the end of the generalized seizures. Ketamine anesthesia combined with relatively rapid infusion of saline into the bladder may have contributed to the onset of seizures. In addition, this case highlights the value of having a fast-acting benzodiazepine agent available to stop continuous or residual seizure activity during diagnostic or experimental procedures in anesthetized nonhuman primates.
Assuntos
Anestésicos/efeitos adversos , Ketamina/efeitos adversos , Doenças dos Macacos/induzido quimicamente , Convulsões/veterinária , Anestésicos/administração & dosagem , Animais , Feminino , Ketamina/administração & dosagem , Macaca mulatta , Convulsões/induzido quimicamente , UrodinâmicaAssuntos
Aflatoxinas , Doença Hepática Induzida por Substâncias e Drogas , Doença Aguda , Animais , Animais de Laboratório , Carcinógenos , Doenças do Gato/induzido quimicamente , Gatos , Bovinos , Doenças dos Bovinos/induzido quimicamente , Galinhas , Doença Crônica , Doenças do Cão/induzido quimicamente , Cães , Patos , Cobaias , Hepatopatias/patologia , Hepatopatias/veterinária , Camundongos , Doenças dos Macacos/induzido quimicamente , Doenças das Aves Domésticas/induzido quimicamente , Coelhos , Ratos , Doenças dos Roedores/induzido quimicamente , Ovinos , Doenças dos Ovinos/induzido quimicamente , Suínos , Doenças dos Suínos , PerusRESUMO
Following initial signs of dural infection, or as prophylactic postoperative therapy, three cynomologus macaques were given an intramuscular or a subcutaneous injection of ceftriaxone dissolved in a 1% lidocaine diluent (CL). Two to 15 min later, all three monkeys experienced a long-lasting generalized apnoeic clonic convulsive seizure. The injected doses of lidocaine (0.7-2 mg/kg) were as low as 7-20-fold less than the experimental intravenous dosage (14.2 +/- 3.2 mg/kg) previously reported to induce seizure in healthy rhesus monkeys. Under different clinical conditions, the same three animals were either once (1 animal) or repeatedly given CL without any resultant neurological alterations. The monkeys had a cranial device implanted and two of them were craniotomized. This first report of accidental lidocaine-induced seizure in laboratory non-human primates following CL injection strongly suggests increased susceptibility when lidocaine administration is associated with central nervous system alteration. A novel hypothesis, the possible role of cytokine in lowering the lidocaine seizure threshold, is suggested.