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1.
J Cutan Pathol ; 47(4): 339-345, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31837162

RESUMO

INTRODUCTION: Bullous pemphigoid is an autoimmune bullous disease characterized by subepidermal separation. We encountered cases of bullous pemphigoid confirmed by direct immunofluorescence study but demonstrating spongiotic dermatitis without subepidermal clefting. Many of them occurred in volar sites, mimicking dyshidrotic dermatitis. METHODS: We retrospectively collected patients who were pathologically and/or immunopathologically diagnosed with bullous pemphigoid from 2002 to 2017. Patients who presented with prominent spongiosis without subepidermal clefting were included and compared with patients who were diagnosed with dyshidrotic dermatitis. RESULTS: A total of nine cases of spongiform pemphigoid out of 385 bullous pemphigoid patients (2.3%) were identified and compared with 15 patients with dyshidrotic dermatitis. Average age of spongiform pemphigoid patients (76 years) was much older than that of the control group (34 years). Microvesicles in the mid- to lower epidermis (P < 0.001), eosinophils exocytosis (P < 0.001), and eosinophils microabscess (P < 0.001) in both the epidermis and papillary dermis were more common in spongiform pemphigoid. CONCLUSION: Spongiform pemphigoid mimics spongiotic dermatitis may result in a pathological diagnostic pitfall. The presence of eosinophil microabscess and exocytosis in the epidermis and papillary dermis were important clues. Immunofluorescence studies should be conducted to confirm the diagnosis of bullous pemphigoid.


Assuntos
Doenças Autoimunes , Penfigoide Bolhoso , Idoso , Idoso de 80 Anos ou mais , Doenças Autoimunes/diagnóstico , Doenças Autoimunes/imunologia , Doenças Autoimunes/metabolismo , Doenças Autoimunes/patologia , Eczema Disidrótico/diagnóstico , Eczema Disidrótico/imunologia , Eczema Disidrótico/metabolismo , Eczema Disidrótico/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Penfigoide Bolhoso/diagnóstico , Penfigoide Bolhoso/imunologia , Penfigoide Bolhoso/metabolismo , Penfigoide Bolhoso/patologia , Estudos Retrospectivos
2.
J Cutan Pathol ; 43(1): 5-11, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-26265086

RESUMO

BACKGROUND: Mechanic's hands are a well-known symptom often associated with dermatomyositis and are similar to hand eczema clinically. Histopathology of them usually shows hyperkeratosis, focal parakeratosis, psoriasiform acanthosis, basal vacuolar changes and necrotic keratinocytes in the epidermis and upper dermal mucin deposition. However, there have been few comparative histopathologic evaluations of mechanic's hands and palmoplantar eczema. METHODS: We evaluated the histopathology of mechanic's hands in 6 patients with dermatomyositis who visited our hospital between 2006 and 2014 comparing with histopathology of 27 patients with palmoplantar eczema, retrospectively. RESULTS: As previously reported, hyperkeratosis, basal vacuolar change and necrotic keratinocytes were seen in all cases of mechanic's hands. Basal vacuolar change was not observed in any cases of palmoplantar eczema. Three cases of mechanic's hands demonstrated a characteristic finding, a pseudocheckerboard pattern, in the hyperkeratotic horny layer; there were areas of alternating parakeratosis and orthokeratosis in a vertical arrangement and these areas alternated with the completely orthokeratotic areas in a horizontal arrangement. This pattern has not been focused in mechanic's hands so far. Same pattern was also observed in four patients with palmoplantar eczema. CONCLUSION: 'Pseudocheckerboard pattern' was not specific but may be a possible diagnostic clue for mechanic's hands.


Assuntos
Dermatite Ocupacional/patologia , Dermatomiosite/patologia , Dermatoses da Mão/patologia , Adulto , Idoso , Dermatite Ocupacional/tratamento farmacológico , Dermatomiosite/tratamento farmacológico , Eczema Disidrótico/patologia , Feminino , Humanos , Ceratose/patologia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
5.
Int J Dermatol ; 63(6): 780-786, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38214207

RESUMO

BACKGROUND: Palmoplantar pustulosis (PPP) and pompholyx are chronic diseases characterized by pustules and vesicles on the palms and soles. These disorders often have similar clinicopathological features, which lead to diagnostic difficulties. We aimed to investigate the expression patterns of keratins and involucrin in PPP and pompholyx using immunohistochemical staining. METHODS: Skin biopsies from patients with PPP (n = 40) and pompholyx (n = 22) were immunohistochemically analyzed for Keratin 5, 9, 14, and involucrin expression. RESULTS: K5 expression was higher in PPP than in pompholyx, with diffusely positive expression in the basal, spinous, and granular layers. K14 expression did not differ between groups. K9 expression was observed near the pompholyx vesicle (P = 0.014) and stratum spinosum (P < 0.001) but was almost absent around PPP pustules. Involucrin expression was diffused around the PPP pustules and partially around the pompholyx vesicles, but without statistical significance (P = 0.123). Involucrin expression was elevated in the basal layer of the PPP compared with that in the pompholyx (P = 0.023). CONCLUSION: PPP and pompholyx exhibited distinctive differentiation in the expression of K5, K9, and involucrin.


Assuntos
Imuno-Histoquímica , Queratinas , Precursores de Proteínas , Psoríase , Humanos , Precursores de Proteínas/metabolismo , Precursores de Proteínas/análise , Psoríase/metabolismo , Psoríase/patologia , Psoríase/diagnóstico , Masculino , Feminino , Queratinas/metabolismo , Queratinas/análise , Pessoa de Meia-Idade , Adulto , Diagnóstico Diferencial , Idoso , Adulto Jovem , Eczema Disidrótico/diagnóstico , Eczema Disidrótico/metabolismo , Eczema Disidrótico/patologia , Biópsia , Adolescente , Pele/patologia , Pele/metabolismo , Queratina-9/metabolismo , Queratina-9/análise , Queratina-14/metabolismo , Queratina-14/análise
6.
J Eur Acad Dermatol Venereol ; 27(7): 889-93, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-22691103

RESUMO

BACKGROUND: Palmoplantar pustulosis (PPP) is a chronic and intensely inflammatory skin disease with pustules, erythema and scaling localized to the palms and soles. Pompholyx is characterized by recurrent crops of vesicles on the lateral aspects of the fingers and the palms and soles. Because both PPP and pompholyx share similar clinical and histological features, it is difficult to differentiate between these two diseases even for dermatologists. OBJECTIVE: To compare the histological features of PPP and pompholyx and to analyse their clinical characteristics. METHODS: The clinical history from 45 patients with PPP and 42 with pompholyx was evaluated. Among these patients, the punch biopsies from acute lesions of 40 PPP patients and 35 pompholyx ones were analysed, blind to the clinical diagnosis. RESULTS: There was no sexual predilection in either group, and 65.5% of PPP patients had smoking history. About half of the patients had concomitant palmoplantar lesions in PPP and pompholyx respectively. In histological evaluation, loss of granular layer, suprapapillary plates thinning, eosinophils in the pustules or vesicles, tortuous capillaries, capillaries touching the undersurface of epidermis and extravasated erythrocytes were statistically significant features of PPP. Confluent parakeratosis, psoriasiform epidermal hyperplasia, clubbing and anastomosing of the rete ridges favoured PPP. Meanwhile, multiple foci of parakeratosis, irregular epidermal hyperplasia and thinning of rete ridges were more often observed in pompholyx. However, dyskeratotic cells, papillary dermal oedema, dilated capillaries and acrosyringium were not significantly different between the two diseases. CONCLUSIONS: Several histological features could serve as useful 'clues' to differentiate between PPP and pompholyx.


Assuntos
Eczema Disidrótico/patologia , Psoríase/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Adulto Jovem
7.
Contact Dermatitis ; 68(2): 76-85, 2013 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23046099

RESUMO

BACKGROUND: It is unclear whether the respiratory tract is involved in eliciting or aggravating eczematous lesions in patients with vesicular hand eczema. Objectives. To investigate the effect of inhalation of house dust mite (HDM) on vesicular hand eczema. METHODS: Eighteen patients with vesicular hand eczema and HDM allergy received inhalation challenges with four concentrations of HDM in a randomized, double-blind, placebo-controlled, cross-over study. Early asthmatic reactions and late asthmatic reactions were defined as a placebo-corrected fall of 15% or more from baseline of forced expiratory volume in 1 second. Hand eczema was scored according to the Dyshidrotic Eczema Area and Severity Index (DASI) at baseline, and 1, 6, 24 and 48 hr. RESULTS: The median DASI increased significantly as compared with baseline at 6 and 48 hr after HDM inhalation. This increase was significantly different between the provocations at 6 hr. The median vesicles score increased significantly from baseline at 24 and 48 hr. Patients with a placebo-corrected increase in the number of vesicles at 24 hr and 48 hr had significantly more often late asthmatic reactions than those without an increase in the number of vesicles. Patients with a placebo-corrected increase of the DASI score at 24 hours had as a group a higher mean total IgE level than those without an increase of the DASI score. CONCLUSION: Hand eczema increased significantly more after HDM provocation than after placebo provocation. An increase in the number of vesicles was preceded by late asthmatic reactions. The group patients with an increase of hand eczema tended to have a higher mean total IgE level.


Assuntos
Alérgenos/efeitos adversos , Antígenos de Dermatophagoides/efeitos adversos , Eczema Disidrótico/etiologia , Dermatoses da Mão/etiologia , Hipersensibilidade/etiologia , Adulto , Animais , Testes de Provocação Brônquica , Estudos Cross-Over , Dermatophagoides pteronyssinus , Método Duplo-Cego , Poeira , Eczema Disidrótico/patologia , Eosinófilos , Feminino , Volume Expiratório Forçado , Dermatoses da Mão/patologia , Humanos , Imunoglobulina E , Exposição por Inalação/efeitos adversos , Contagem de Leucócitos , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Adulto Jovem
8.
J Dtsch Dermatol Ges ; 10(11): 814-8, 2012 Nov.
Artigo em Inglês, Alemão | MEDLINE | ID: mdl-22738245

RESUMO

BACKGROUND: Numerous studies have confirmed the short-term effectiveness of 8-methoxypsoralen bath PUVA therapy in patients with chronic palmoplantar dermatoses; however, little is known about long-term results. PATIENTS AND METHODS: In this retrospective study we examined the long-term results in 79 patients (mean age: 48 years) with chronic palmoplantar dermatoses who were treated with bath PUVA three times a week over an 8-year period. A good clinical response (a reduction of more than 50% of the skin lesions) occurred after a mean of 23 treatments and a mean cumulative UVA dose of 39 J/cm(2) in 51 patients (65%). In 2007 a questionnaire was sent to these 51 patients to assess the long-term outcome. RESULTS: With bath PUVA treatment, the best results were found in patients with hyperkeratotic eczema (17/22; 77% good clinical response) followed by patients with palmoplantar psoriasis (26/41; 63%) and patients with dyshidrotic eczema (8/16; 50%). Thirty-four patients (67%) answered the questionnaire after a mean follow-up interval of 4.3 years (10-87 months). Among these patients, 36% reported an improved course of disease after PUVA therapy with reduced frequency and/or intensity of the skin rash, and 29% of patients reported continued complete clearance. 79% of our patients reported a long-term reduction in the use of topical corticosteroids during the follow-up period (mean: 4.3 years). In addition, 67% of patients reported a lasting improvement in quality of life. CONCLUSIONS: These data show that bath PUVA may have a long-term, beneficial influence on the course of disease in a majority of patients with recalcitrant chronic palmoplantar dermatoses.


Assuntos
Banhos/estatística & dados numéricos , Eczema Disidrótico/tratamento farmacológico , Eczema Disidrótico/epidemiologia , Ceratodermia Palmar e Plantar/tratamento farmacológico , Ceratodermia Palmar e Plantar/epidemiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Doença Crônica , Terapia Combinada/estatística & dados numéricos , Eczema Disidrótico/patologia , Feminino , Seguimentos , Furocumarinas/uso terapêutico , Alemanha/epidemiologia , Humanos , Ceratodermia Palmar e Plantar/patologia , Masculino , Pessoa de Meia-Idade , Terapia PUVA , Prevalência , Radiossensibilizantes/uso terapêutico , Estudos Retrospectivos , Fatores de Risco , Resultado do Tratamento
9.
Skinmed ; 10(2): 116-8, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22545332

RESUMO

A 16-year-old young man presented with intensely itchy erythematous dermatitis on the body for 1 week and vesicular lesions on the palms and soles for 4 to 5 days. Lesions on the palms and soles were accompanied by severe burning and itching. The patient gave a history of sore throat and fever, 1 week prior to the onset of lesions. A general physical examination was normal, and cutaneous examination revealed multiple, well-defined erythematous scaly plaques with collaret scaling on the trunk and extremities (Figure 1). Vesicular lesions were seen on the palms and soles (Figure 2). The differential diagnoses we considered were pityriasis rosea and secondary syphilis. The possibility of dermatophytid, vesicular pityriasis rosea, and pompholyx was limited to the palms and sole lesions. Complete blood cell count was within normal limits. Results from antistreptolysin O titer, potassium hydroxide mount, and venereal disease research laboratory were negative. Skin biopsies were taken from the back and left palm. The biopsy specimen from the back revealed focal spongiosis, lymphocyte exocytosis, vacuolar changes in the basal layer, and perivascular lymphocytic infiltrate in the dermis (Figure 3). The biopsy obtained from the vesicular lesion on the left palm revealed an intraepidermal vesicle with no evidence of acantolytic process (Figure 4). A diagnosis of pityriasis rosea was made and the patient was started on clarithromycin 500 mg once a day for 7 days, along with antihistamines and emollients. The lesions faded dramatically in a very short period, and there was significant involution of almost all of the lesions after 7 days of clarithromycin. During the 6 months of follow-up, no recurrence was observed.


Assuntos
Eczema Disidrótico/patologia , Pitiríase Rósea/patologia , Adolescente , Antibacterianos/uso terapêutico , Claritromicina/uso terapêutico , Humanos , Masculino , Pitiríase Rósea/diagnóstico , Pitiríase Rósea/tratamento farmacológico
10.
Dermatol Online J ; 18(5): 1, 2012 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-22630571

RESUMO

We report a case of adult-onset acquired zinc deficiency after bariatric surgery. Zinc deficiency may be inherited in the form of acrodermatitis enteropathica or acquired by low nutritional intake, malabsorption, excessive loss of zinc, or a combination of these factors.


Assuntos
Acrodermatite/diagnóstico , Acrodermatite/etiologia , Derivação Gástrica/efeitos adversos , Desnutrição/tratamento farmacológico , Desnutrição/etiologia , Zinco/uso terapêutico , Acrodermatite/patologia , Biópsia , Diagnóstico Diferencial , Eczema Disidrótico/diagnóstico , Eczema Disidrótico/etiologia , Eczema Disidrótico/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Pele/patologia , Zinco/deficiência
11.
Arerugi ; 60(11): 1543-9, 2011 Nov.
Artigo em Japonês | MEDLINE | ID: mdl-22270129

RESUMO

BACKGROUND: Pompholyx-like reactions may develop for aggressive atopic dermatitis treatments in the incipient phase despite of improvement of other skin symptoms. METHODS: Eighty-nine patients admitted to National Center for Child Health and Development for treatment of atopic dermatitis between April 2007 and March 2009 were recruited. RESULTS: Pompholyx-like reactions were seen in thirteen out of eighty-nine patients between 4 and 32 (mean 16.7±10.4) days following admission. The mean age of patients with these reactions was 6.2±6.1 years (range of 3 months to 23 years). At the time of admission, practical issues of scoring atopic dermatitis: the SCORAD was assessed. The values of SCORAD index with pompholyx were ranging from 16-91 (mean 50.8±17.9), and the index except under one-year old were significantly higher than unaffected patients. These patients were evaluated into their medical record, for evidence of Pompholyx-like lesions: a bilateral vesicular eruption confined to the skin of the palms, soles, or sides of the fingers. Topical corticosteroids are used to treat Pompholyx-like reactions, all them achieved remission between 4 and 50 days (mean 18.5±12.0). In general, pompholyx is more common in summer. However, it seems that there were no significant differences in the pompholyx-like reactions incidence between in summer and in winter. CONCLUSION: The factor for the occurrence of pompholyx-like lesions remains unexplained. Although the original symptoms of eczema were improved, pompholyx-like eczema breakout, therefore, patients often feel uneasy. We should be aware of this clinical condition.


Assuntos
Dermatite Atópica/complicações , Eczema Disidrótico/etiologia , Adolescente , Criança , Pré-Escolar , Dermatite Atópica/tratamento farmacológico , Eczema Disidrótico/patologia , Feminino , Humanos , Lactente , Masculino , Adulto Jovem
12.
Dermatol Online J ; 16(7): 10, 2010 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-20673538

RESUMO

Dyshidrosiform Bullous pemphigoid is a well-known entity, but dyshidrosiform pemphigus vulgaris has rarely been described. Our patient, a 36-year-old female, with a known case of pemphigus vulgaris (PV) for the last 6 years, presented with a 3 month history of a dyshidrosiform eruption of the soles. On the basis of histopathological and direct immunofluorence (DIF) findings, the new eruption was diagnosed as PV. We report our case as dyshidrosiform pemphigus vulgaris.


Assuntos
Eczema Disidrótico/diagnóstico , Penfigoide Bolhoso/diagnóstico , Pênfigo , Adulto , Vesícula/diagnóstico , Vesícula/tratamento farmacológico , Vesícula/patologia , Ciclofosfamida/uso terapêutico , Eczema Disidrótico/tratamento farmacológico , Eczema Disidrótico/patologia , Feminino , Dermatoses do Pé/diagnóstico , Dermatoses do Pé/tratamento farmacológico , Dermatoses do Pé/patologia , Humanos , Imunoglobulina G/análise , Mucosa Bucal/patologia , Penfigoide Bolhoso/tratamento farmacológico , Penfigoide Bolhoso/patologia , Prednisolona/uso terapêutico , Automedicação , Resultado do Tratamento
13.
Br J Dermatol ; 161(1): 177-80, 2009 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-19298277

RESUMO

Hand dermatitis is common, with lymphoedema of the hand and forearm a rare complication. The mechanism of lymphoedema in such cases is poorly understood, hence management can be challenging. To investigate the underlying mechanism of lymphoedema associated with hand dermatitis and outline recommendations for management, we identified all patients with lymphoedema associated with hand dermatitis referred to our lymphoedema service, a tertiary referral centre. Treatment outcome was assessed by telephone interview and through correspondence with primary physicians and therapists. In total, nine patients, six with bilateral and three with unilateral lymphoedema associated with hand dermatitis, attended our service over a 4-year period. Most had long-standing bilateral pompholyx eczema. Three patients reported no signs of infection prior to the onset of swelling. All patients had recurrent episodes of infection after the onset of swelling. Lymphoscintigraphy, when used, revealed a failure of small initial lymphatics of the hand to absorb and drain lymph to regional nodes. Prophylactic antibiotics together with aggressive management of the dermatitis, often with systemic therapy, were required to reduce swelling. Possible mechanisms for lymphoedema associated with hand dermatitis include obliterative lymphangitis from infection, an inflammatory effect of the dermatitis on local lymphatics or a constitutive weakness of lymph drainage exposed to chronic inflammation, or any combination of the three. Treatment is only successful once both infection and inflammation from the dermatitis are controlled.


Assuntos
Dermatoses da Mão/etiologia , Linfedema/complicações , Adulto , Antibioticoprofilaxia , Azatioprina/uso terapêutico , Eczema Disidrótico/tratamento farmacológico , Eczema Disidrótico/patologia , Feminino , Dermatoses da Mão/tratamento farmacológico , Humanos , Imunossupressores/uso terapêutico , Linfedema/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Penicilina V/uso terapêutico , Prednisolona/uso terapêutico , Resultado do Tratamento
14.
Am J Dermatopathol ; 31(8): 834-7, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19770630

RESUMO

Adult T-cell leukemia/lymphoma (ATL) is an aggressive type of leukemia/lymphoma associated with the human T-cell lymphotropic virus (HTLV-I). We describe an adult male patient clinically and pathologically diagnosed as mycosis fungoides and treated with chemotherapy after which complete involution of the lesions occurred. The disease relapsed with confluent dyshidrosis-like vesicles on the palmoplantar regions, followed by disseminated vesiculopapules and associated lymphocytosis. A serological test performed at this time revealed HTLV-I infection, and a diagnosis of chronic ATL was made. Monoclonal integration of HTLV-I was detected in peripheral blood mononuclear cells by inverse long polymerase chain reaction. A skin biopsy revealed spongiosis, Pautrier abscesses, and intraepidermal vesicles with atypical lymphocytes and an infiltration of small and atypical CD4 lymphocytes in the superficial dermis. Proliferative index (Ki-67) was 70%. This is the first reported vesicular cutaneous ATL with confirmation of HTLV-I proviral integration. The delay that occurred in diagnosing ATL was due to the fact that mycosis fungoides and ATL may present the same clinical, histopathological, and immunohistochemical features.


Assuntos
Eczema Disidrótico/patologia , Infecções por HTLV-I/patologia , Leucemia-Linfoma de Células T do Adulto/patologia , Micose Fungoide/patologia , Neoplasias Cutâneas/patologia , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Ciclofosfamida , Diabetes Mellitus , Diagnóstico Diferencial , Doxorrubicina , Eczema Disidrótico/virologia , Infecções por HTLV-I/complicações , Vírus Linfotrópico T Tipo 1 Humano , Humanos , Imuno-Histoquímica , Interferon-alfa/uso terapêutico , Leucemia-Linfoma de Células T do Adulto/tratamento farmacológico , Leucemia-Linfoma de Células T do Adulto/virologia , Masculino , Micose Fungoide/tratamento farmacológico , Reação em Cadeia da Polimerase , Prednisona , Neoplasias Cutâneas/tratamento farmacológico , Neoplasias Cutâneas/virologia , Vincristina , Zidovudina/uso terapêutico
16.
J Dermatol ; 46(5): 399-408, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30919463

RESUMO

Palmoplantar pustulosis (PPP) and pompholyx are both chronic and relapsing diseases occurring on the palms and soles. Although these two diseases have been considered completely different from each other, it is sometimes very difficult even for dermatologists to differentiate them from each other because of their similarities in clinical presentation. In this study, we aimed to analyze the histopathological features of PPP and pompholyx and find out "clues" to differentiate between PPP and pompholyx by their histopathological features. The histopathology of 11 PPP and six pompholyx patients, who were diagnosed with typical clinical history and histopathology, were carefully observed. PPP cases were divided into three phases (vesicle, pustulovesicule and pustule) and pompholyx cases were divided into two phases (vesicle and pustule), and histopathological findings and a 4-point checklist to distinguish between PPP and pompholyx were preliminarily established. To confirm whether the checklist establishes the clues for diagnosis, biopsy samples from 43 patients (32 PPP and 11 pompholyx) who had been already diagnosed at five hospitals were examined according to our checklist without any additional clinical information. According to our 4-point checklist, 31 of 32 PPP patients and all 11 pompholyx patients were diagnosed histopathologically consistent with their clinical diagnosis. In conclusion, histopathological findings of "vesicles without spongiosis" and "microabscess on the edges of vesicles" would be impact points for the differential diagnosis between PPP and pompholyx. The 4-point checklist was trustworthy to distinguish between PPP and pompholyx.


Assuntos
Lista de Checagem/métodos , Eczema Disidrótico/diagnóstico , Psoríase/diagnóstico , Pele/patologia , Adulto , Idoso , Biópsia , Diagnóstico Diferencial , Eczema Disidrótico/patologia , Estudos de Viabilidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Psoríase/patologia
19.
J Invest Dermatol ; 126(2): 300-4, 2006 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-16374448

RESUMO

Pompholyx is a rather common disorder characterized by recurrent crops of vesicles or bullae on the lateral aspects of the fingers, as well as the palms and soles with non-erythematous skin. Until now, very few large families have been reported, so no gene or locus has been identified. Here, we performed a genome-wide search in a large Chinese family to map the chromosome location of the responsible gene. We identified a locus at chromosome 18q22.1-18q22.3 with a maximum two-point LOD score of 3.61 at marker D18S1131 (theta = 0.00). Haplotype analyses indicated that the disease gene is located within 12.07 cM region between markers D18S465 and D18S1362, which corresponds to 8.0 Mb. This is the first locus identified for pompholyx. It will aid future identification of the responsible gene, which will be useful for the understanding of the molecular mechanism of pompholyx.


Assuntos
Cromossomos Humanos Par 18/genética , Eczema Disidrótico/genética , Genes Dominantes , Linhagem , Adolescente , Adulto , Idoso , Povo Asiático , Criança , Mapeamento Cromossômico , Eczema Disidrótico/patologia , Feminino , Ligação Genética , Haplótipos , Humanos , Masculino , Pele/patologia
20.
Curr Probl Dermatol ; 51: 80-5, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27584966

RESUMO

Dyshidrotic eczema, also known as dyshidrotic dermatitis or pompholyx, is characterized by pruritic, small tense vesicles mainly on the palmoplantar region and lateral and ventral surfaces of the fingers. While its etiology appears to be related to sweating, as dyshidrotic eczema often occurs in an individual with hyperhidrosis, and the spring allergy season, histologic examination shows an eczematous reaction around the sweat ducts which is not associated with abnormalities of the sweat ducts. More recently, the nomenclature of 'acute and recurrent vesicular hand dermatitis' has been proposed to reflect clinical features of dyshidrotic eczema. Although the exact etiology of dyshidrotic eczema remains unknown, given the presence of metal allergy in patients with dyshidrotic eczema and the improvement of the symptoms by removing metal allergen, metal allergy is regarded as one of the important potential etiologic factors for dyshidrotic eczema.


Assuntos
Eczema Disidrótico/fisiopatologia , Dermatoses da Mão/fisiopatologia , Hipersensibilidade/diagnóstico , Dermatite Alérgica de Contato/diagnóstico , Dermatite Alérgica de Contato/etiologia , Dermatite Alérgica de Contato/fisiopatologia , Dermoscopia , Eczema Disidrótico/complicações , Eczema Disidrótico/diagnóstico por imagem , Eczema Disidrótico/patologia , Dermatoses da Mão/complicações , Dermatoses da Mão/diagnóstico por imagem , Dermatoses da Mão/patologia , Humanos , Hipersensibilidade/etiologia , Metais/efeitos adversos , Testes do Emplastro , Glândulas Sudoríparas/diagnóstico por imagem , Glândulas Sudoríparas/patologia , Tomografia de Coerência Óptica
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