Changes in blood flow of growing experimental tumor determined by the clearance of 133Xe.

133Xe clearance method has been employed for measurement of the blood flow in 6C3HED lymphosarcoma implanted in flank of C3H mice. In small tumors (9-day old) the mean rate of blood flow was 9.4 +/- 5.0 ml/100g/min. but with progressing growth of tumors the rate of blood flow significantly decreased. In large tumors (14-day old) the mean rate of the blood flow was only 5.4 +/- 2.8. Our results demonstrate that this type of tumor, similarly as most of transplanted tumors are not well perfused and, that there is an inverse relationhip between the blood flow and the tumor size.

[Radiologic diagnosis of malignant lymphomas at a supradiaphragmatic site]. / Diagnosi radiologica dei linfomi maligni in sede sopradiaframmatica.

The possibility of a radiological diagnosis of supradiaphragmatic localizations of malignant lymphoma are discussed, with particular reference to the employment of special techniques: xeroradiography, bronchography, selective arteriography. A number of examples are presented in detail.

Prognostic significance of parafollicular small lymphocytes in follicular lymphoma: clinicopathological studies of 82 cases of primary nodal origin.

Pretreatment biopsy material of 82 cases of follicular lymphoma of lymph node origin was reviewed. According to the amount of small lymphocytes in the parafollicular lymphoid tissue (PSL), tumors were classified: PSL++, abundant lymphocytes with prominent postcapillary venules; PSL+, a number of lymphocytes readily recognizable, postcapillary venules present but not prominent; PSL+/-, lymphocytes barely appreciable or absent. Five-year actuarial survival rates were 82.7% in PSL++, 42.3% in PSL+, and 0% in PSL+/-. Ten-year actuarial survival rates were 51.5% and 4.7% in PSL++ and +, respectively. The PSL++ pattern was often associated with localized disease. Patients surviving more than 5 years with disseminated disease had either PSL++ or +. Survival was better correlated with PSL patterns than histologic tumor types or clinical stages. Transition of the pattern from nodular to diffuse occurred in 17 of 26 cases observed and was concomitant with the progressive loss of parafollicular (or interfollicular) components, namely small lymphocytes and lymphocyte-associated vasculature. Classification of follicular lymphoma based on parafollicular small lymphocytes (PSL) offers a new set of prognostic criteria and a guide to improved clinical management.

Angiography in reticulum cell sarcoma.

Angiography was performed in 14 patients with reticulum cell sarcoma. When located in the retroperitoneal tissues, the spleen or the pancreas, the tumor is hypervascular with encasement of arteries and compression or invasion of veins. Tumors of the kidneys may have a similar appearance. A gastric tumor displays slight abnormalities, mainly hypervascularity, the lesion being better demonstrated by barium examination. A case of reticulum cell sarcoma in the small bowel demonstrated arterial encasement and arteriovenous shunting.