Strain-invariant stretchable radio-frequency electronics.

Wireless modules that provide telecommunications and power-harvesting capabilities enabled by radio-frequency (RF) electronics are vital components of skin-interfaced stretchable electronics1-7. However, recent studies on stretchable RF components have demonstrated that substantial changes in electrical properties, such as a shift in the antenna resonance frequency, occur even under relatively low elastic strains8-15. Such changes lead directly to greatly reduced wireless signal strength or power-transfer efficiency in stretchable systems, particularly in physically dynamic environments such as the surface of the skin. Here we present strain-invariant stretchable RF electronics capable of completely maintaining the original RF properties under various elastic strains using a 'dielectro-elastic' material as the substrate. Dielectro-elastic materials have physically tunable dielectric properties that effectively avert frequency shifts arising in interfacing RF electronics. Compared with conventional stretchable substrate materials, our material has superior electrical, mechanical and thermal properties that are suitable for high-performance stretchable RF electronics. In this paper, we describe the materials, fabrication and design strategies that serve as the foundation for enabling the strain-invariant behaviour of key RF components based on experimental and computational studies. Finally, we present a set of skin-interfaced wireless healthcare monitors based on strain-invariant stretchable RF electronics with a wireless operational distance of up to 30 m under strain.

Short and long-term 2100 MHz radiofrequency radiation causes endoplasmic reticulum stress in rat testis.

Long-term radiofrequency radiation (RFR) exposure, which adversely affects organisms, deteriorates testicular functions. Misfolding or unfolding protein accumulation in the endoplasmic reticulum (ER) initiates an intracellular reaction known as ER stress (ERS), which activates the unfolded protein response (UPR) for proteostasis. Since both RFR exposure and ERS can cause male infertility, we hypothesized that RFR exposure causes ERS to adversely affect testicular functions in rats. To investigate role of ERS in mediating RFR effects on rat testis, we established five experimental groups in male rats: control, short-term 2100-megahertz (MHz) RFR (1-week), short-term sham (sham/1-week), long-term 2100-MHz RFR (10-week), and long-term sham (sham/10-week). ERS markers Grp78 and phosphorylated PERK (p-Perk) levels and ERS-related apoptosis markers Chop and caspase 12 were investigated by immunohistochemistry, immunoblotting, and quantitative real-time polymerase chain reaction (qPCR). Long-term RFR exposure increased Grp78, p-Perk, and Chop levels, while short-term RFR exposure elevated Chop and caspase 12 levels. Chop expression was not observed in spermatogonia and primary spermatocytes, which may protect spermatogonia and primary spermatocytes against RFR-induced ERS-mediated apoptosis, thereby allowing transmission of genetic material to next generations. While short and long-term RFR exposures trigger ERS and ERS-related apoptotic pathways, further functional analyses are needed to elucidate whether this RFR-induced apoptosis has long-term male infertility effects.

Radiation damping at clinical field strength: Characterization and compensation in quantitative measurements.

PURPOSE: In any MR experiment, the bulk magnetization acts on itself, caused by the induced current in the RF receiver circuit that generates an oscillating damping field. This effect, known as "radiation damping" (RD), is usually weak and, therefore, unconsidered in MRI, but can affect quantitative studies performed with dedicated coils that provide a high SNR. The current work examined RD in a setup for investigations of small tissue specimens including a quantitative characterization of the spin-coil system. THEORY AND METHODS: A custom-made Helmholtz coil (radius and spacing 16 mm) was interfaced to a transmit-receive (Tx/Rx) switch with integrated passive feedback for modulation or suppression of RD similar to preamplifier decoupling. Pulse sequences included pulse-width arrays to demonstrate the absence/ presence of RD and difference techniques employing gradient pulses or composite RF pulses to quantify RD effects during free precession and transmission, respectively. Experiments were performed at 3T in small samples of MnCl2 solution. RESULTS: Significant RD effects may impact RF pulse application and evolution periods. Effective damping time constants were comparable to typical T2 * times or echo spacings in multi-echo sequences. Measurements of the phase relation showed that deviations from the commonly assumed 90° angle between the damping field and the transverse magnetization may occur. CONCLUSION: Radiation damping may affect the accuracy of quantitative MR measurements performed with dedicated RF coils. Efficient mitigation can be achieved hardware-based or by appropriate consideration in the pulse sequence.

The restricted SAR protocol: A method to assess MRI coil prototypes in an unconditionally safe manner.

PURPOSE: Testing an RF coil prototype on subjects involves laborious verifications to ensure its safety. In particular, it requires preliminary electromagnetic simulations and their validations on phantoms to accurately predict the specific absorption rate (SAR). For coil design validation with a simpler safety procedure, the restricted SAR (rS) mode is proposed, enabling representative first experiments in vivo. The goal of the developed approach is to accelerate the transition of a custom coil system from prototype to clinical use. METHODS: The restricted specific absorption rate (SAR) (rS) mode imposes a radical limitation on the transmitted RF power based on a worst-case scenario of local RF power absorption. The limitations used are independent of the SAR spatial distribution, making this approach unconditionally safe. The developed rS protocol contains the sequences required for coil evaluation and satisfies the imposed rS conditions. It provides a quantitative characterization of the coil transmission and reception profiles and a qualitative evaluation of the anatomical images. Protocol validation was performed on commercial and pre-industrial prototype coils on a small cohort of healthy volunteers. RESULTS: The proposed rS protocol enables coil evaluation within an acquisition time compatible with common clinical protocol duration. The total time of all evaluation steps does not exceed 17 min. At the same time, the global SAR remains 100 times less than the International Electrotechnical Commission safety limit for played sequences. CONCLUSION: The rS protocol allows characterizing and comparing coil prototypes on volunteers without extensive electromagnetic calculations and phantom validations in an unconditionally safe way.

Intra-scan RF power amplifier drift correction.

PURPOSE: The drift in radiofrequency (RF) power amplifiers (RFPAs) is assessed and several contributing factors are investigated. Two approaches for prospective correction of drift are proposed and their effectiveness is evaluated. METHODS: RFPA drift assessment encompasses both intra-pulse and inter-pulse drift analyses. Scan protocols with varying flip angle (FA), RF length, and pulse repetition time (TR) are used to gauge the influence of these parameters on drift. Directional couplers (DICOs) monitor the forward waveforms of the RFPA outputs. DICOs data is stored for evaluation, allowing calculation of correction factors to adjust RFPAs' transmit voltage. Two correction methods, predictive and run-time, are employed: predictive correction necessitates a calibration scan, while run-time correction calculates factors during the ongoing scan. RESULTS: RFPA drift is indeed influenced by the RF duty-cycle, and in the cases examined with a maximum duty-cycle of 66%, the potential drift is approximately 41% or 15%, depending on the specific RFPA revision. Notably, in low transmit voltage scenarios, FA has minimal impact on RFPA drift. The application of predictive and run-time drift correction techniques effectively reduces the average drift from 10.0% to less than 1%, resulting in enhanced MR signal stability. CONCLUSION: Utilizing DICO recordings and implementing a feedback mechanism enable the prospective correction of RFPA drift. Having a calibration scan, predictive correction can be utilized with fewer complexity; for enhanced performance, a run-time approach can be employed.

Stealth RF energy harvesting in MRI using selective shielding.

PURPOSE: To utilize the transmit radiofrequency (RF) field in MRI as a power source, near or within the field of view but without affecting image quality or safety. METHODS: Power harvesting is performed by RF induction in a resonant coil. Resulting RF field distortion in the subject is canceled by a selective shield that couples to the harvester while being transparent to the RF transmitter. Such shielding is designed with the help of electromagnetic simulation. A shielded harvester of 3 cm diameter is implemented, assessed on the bench, and tested in a 3T MRI system, recording power yield during typical scans. RESULTS: The concept of selective shielding is confirmed by simulation. Bench tests show effective power harvesting in the presence of the shield. In the MRI system, it is confirmed that selective shielding virtually eliminates RF perturbation. In scans with the harvester immediately adjacent to a phantom, up to 100 mW of average power are harvested without affecting image quality. CONCLUSION: Selective shielding enables stealthy RF harvesting which can be used to supply wireless power to on-body devices during MRI.

Improved 1 H body imaging at 10.5 T: Validation and VOP-enabled imaging in vivo with a 16-channel transceiver dipole array.

PURPOSE: To increase the RF coil performance and RF management for body imaging at 10.5 T by validating and evaluating a high-density 16-channel transceiver array, implementing virtual observation points (VOPs), and demonstrating specific absorption rate (SAR) constrained imaging in vivo. METHODS: The inaccuracy of the electromagnetic model of the array was quantified based on B1 + and SAR data. Inter-subject variability was estimated using a new approach based on the relative SAR deviation of different RF shims between human body models. The pTx performance of the 16-channel array was assessed in simulation by comparison to a previously demonstrated 10-channel array. In vivo imaging of the prostate was performed demonstrating SAR-constrained static RF shimming and acquisition modes optimized for refocused echoes (AMORE). RESULTS: The model inaccuracy of 29% and the inter-subject variability of 85% resulted in a total safety factor of 1.91 for pelvis studies. For renal and cardiac imaging, inter-subject variabilities of 121% and 141% lead to total safety factors of 2.25 and 2.45, respectively. The shorter wavelength at 10.5 T supported the increased element density of the 16-channel array which in turn outperformed the 10-channel version for all investigated metrics. Peak 10 g local SAR reduction of more than 25% without a loss of image quality was achieved in vivo, allowing a theoretical improvement in measurement efficiency of up to 66%. CONCLUSIONS: By validating and characterizing a 16-channel dipole transceiver array, this work demonstrates, for the first time, a VOP-enabled RF coil for human torso imaging enabling increased pTx performance at 10.5 T.

Local SAR management strategies to use two-channel RF shimming for fetal MRI at 3 T.

PURPOSE: This study evaluates the imaging performance of two-channel RF-shimming for fetal MRI at 3 T using four different local specific absorption rate (SAR) management strategies. METHODS: Due to the ambiguity of safe local SAR levels for fetal MRI, local SAR limits for RF shimming were determined based on either each individual's own SAR levels in standard imaging mode (CP mode) or the maximum SAR level observed across seven pregnant body models in CP mode. Local SAR was constrained either indirectly by further constraining the whole-body SAR (wbSAR) or directly by using subject-specific local SAR models. Each strategy was evaluated by the improvement of the transmit field efficiency (average |B1 + |) and nonuniformity (|B1 + | variation) inside the fetus compared with CP mode for the same wbSAR. RESULTS: Constraining wbSAR when using RF shimming decreases B1 + efficiency inside the fetus compared with CP mode (by 12%-30% on average), making it inefficient for SAR management. Using subject-specific models with SAR limits based on each individual's own CP mode SAR value, B1 + efficiency and nonuniformity are improved on average by 6% and 13% across seven pregnant models. In contrast, using SAR limits based on maximum CP mode SAR values across seven models, B1 + efficiency and nonuniformity are improved by 13% and 25%, compared with the best achievable improvement without SAR constraints: 15% and 26%. CONCLUSION: Two-channel RF-shimming can safely and significantly improve the transmit field inside the fetus when subject-specific models are used with local SAR limits based on maximum CP mode SAR levels in the pregnant population.

Investigation of alternative RF power limit control methods for 0.5T, 1.5T, and 3T parallel transmission cardiac imaging: A simulation study.

PURPOSE: To investigate safety and performance aspects of parallel-transmit (pTx) RF control-modes for a body coil at B 0 ≤ 3 T $$ {B}_0\le 3\mathrm{T} $$ . METHODS: Electromagnetic simulations of 11 human voxel models in cardiac imaging position were conducted for B 0 = 0.5 T $$ {B}_0=0.5\mathrm{T} $$ , 1.5 T $$ 1.5\mathrm{T} $$ and 3 T $$ 3\mathrm{T} $$ and a body coil with a configurable number of transmit channels (1, 2, 4, 8, 16). Three safety modes were considered: the 'SAR-controlled mode' (SCM), where specific absorption rate (SAR) is limited directly, a 'phase agnostic SAR-controlled mode' (PASCM), where phase information is neglected, and a 'power-controlled mode' (PCM), where the voltage amplitude for each channel is limited. For either mode, safety limits were established based on a set of 'anchor' simulations and then evaluated in 'target' simulations on previously unseen models. The comparison allowed to derive safety factors accounting for varying patient anatomies. All control modes were compared in terms of the B 1 + $$ {B}_1^{+} $$ amplitude and homogeneity they permit under their respective safety requirements. RESULTS: Large safety factors (approximately five) are needed if only one or two anchor models are investigated but they shrink with increasing number of anchors. The achievable B 1 + $$ {B}_1^{+} $$ is highest for SCM but this advantage is reduced when the safety factor is included. PCM appears to be more robust against variations of subjects. PASCM performance is mostly in between SCM and PCM. Compared to standard circularly polarized (CP) excitation, pTx offers minor B 1 + $$ {B}_1^{+} $$ improvements if local SAR limits are always enforced. CONCLUSION: PTx body coils can safely be used at B 0 ≤ 3 T $$ {B}_0\le 3\mathrm{T} $$ . Uncertainties in patient anatomy must be accounted for, however, by simulating many models.

Beat Pilot Tone (BPT): Simultaneous MRI and RF motion sensing at arbitrary frequencies.

PURPOSE: To introduce a simple system exploitation with the potential to turn MRI scanners into general-purpose radiofrequency (RF) motion monitoring systems. METHODS: Inspired by Pilot Tone (PT), this work proposes Beat Pilot Tone (BPT), in which two or more RF tones at arbitrary frequencies are transmitted continuously during the scan. These tones create motion-modulated standing wave patterns that are sensed by the receiver coil array, incidentally mixed by intermodulation in the receiver chain, and digitized simultaneously with the MRI data. BPT can operate at almost any frequency as long as the intermodulation products lie within the bandwidth of the receivers. BPT's mechanism is explained in electromagnetic simulations and validated experimentally. RESULTS: Phantom and volunteer experiments over a range of transmit frequencies suggest that BPT may offer frequency-dependent sensitivity to motion. Using a semi-flexible anterior receiver array, BPT appears to sense cardiac-induced body vibrations at microwave frequencies ( ≥ $$ \ge $$ 1.2 GHz). At lower frequencies, it exhibits a similar cardiac signal shape to PT, likely due to blood volume changes. Other volunteer experiments with respiratory, bulk, and head motion show that BPT can achieve greater sensitivity to motion than PT and greater separability between motion types. Basic multiple-input multiple-output ( 4 × 22 $$ 4\times 22 $$ MIMO) operation with simultaneous PT and BPT in head motion is demonstrated using two transmit antennas and a 22-channel head-neck coil. CONCLUSION: BPT may offer a rich source of motion information that is frequency-dependent, simultaneous, and complementary to PT and the MRI exam.

Enhanced and robust contrast in CEST MRI: Saturation pulse shape design via optimal control.

PURPOSE: To employ optimal control for the numerical design of Chemical Exchange Saturation Transfer (CEST) saturation pulses to maximize contrast and stability against B 0 $$ {\mathrm{B}}_0 $$ inhomogeneities. THEORY AND METHODS: We applied an optimal control framework for the design pulse shapes for CEST saturation pulse trains. The cost functional minimized both the pulse energy and the discrepancy between the corresponding CEST spectrum and the target spectrum based on a continuous radiofrequency (RF) pulse. The optimization is subject to hardware limitations. In measurements on a 7 T preclinical scanner, the optimal control pulses were compared to continuous-wave and Gaussian saturation methods. We conducted a comparison of the optimal control pulses with Gaussian, block pulse trains, and adiabatic spin-lock pulses. RESULTS: The optimal control pulse train demonstrated saturation levels comparable to continuous-wave saturation and surpassed Gaussian saturation by up to 50 % in phantom measurements. In phantom measurements at 3 T the optimized pulses not only showcased the highest CEST contrast, but also the highest stability against field inhomogeneities. In contrast, block pulse saturation resulted in severe artifacts. Dynamic Bloch-McConnell simulations were employed to identify the source of these artifacts, and underscore the B 0 $$ {\mathrm{B}}_0 $$ robustness of the optimized pulses. CONCLUSION: In this work, it was shown that a substantial improvement in pulsed saturation CEST imaging can be achieved by using Optimal Control design principles. It is possible to overcome the sensitivity of saturation to B0 inhomogeneities while achieving CEST contrast close to continuous wave saturation.

Design of calibration-free RF pulses for T 2 $$ {}_2 $$ -weighted single-slab 3D turbo-spin-echo sequences at 7T utilizing parallel transmission.

PURPOSE: T 2 $$ {}_2 $$ -weighted turbo-spin-echo (TSE) sequences are a fundamental technique in brain imaging but suffer from field inhomogeneities at ultra-high fields. Several methods have been proposed to mitigate the problem, but were limited so far to nonselective three-dimensional (3D) measurements, making short acquisitions difficult to achieve when targeting very high resolution images, or needed additional calibration procedures, thus complicating their application. METHODS: Slab-selective excitation pulses were designed for flexible placement utilizing the concept of k T $$ {}_T $$ -spokes. Phase-coherent refocusing universal pulses were subsequently optimized with the Gradient Ascent Pulse Engineering algorithm and tested in vivo for improved signal homogeneity. RESULTS: Implemented within a 3D variable flip angle TSE sequence, these pulses led to a signal-to-noise ratio (SNR) improvement ranging from 10% to 30% compared to a two-dimensional (2D) T2w TSE sequence employing B 1 + $$ {\mathrm{B}}_1^{+} $$ -shimmed pulses. B 1 + $$ {\mathrm{B}}_1^{+} $$ field inhomogeneities could be mitigated and artifacts from B 0 $$ {\mathrm{B}}_0 $$ deviations reduced. The concept of universal pulses was successfully applied. CONCLUSION: We present a pulse design method which provides a set of calibration-free universal pulses (UPs) for slab-selective excitation and phase-coherent refocusing in slab-selective TSE sequences.

Head-and-neck multichannel B1+ mapping and RF shimming of the carotid arteries using a 7T parallel-transmit head coil.

PURPOSE: Neurovascular MRI suffers from a rapid drop in B1 + into the neck when using transmit head coils at 7 T. One solution to improving B1 + magnitude in the major feeding arteries in the neck is to use custom RF shims on parallel-transmit head coils. However, calculating such shims requires robust multichannel B1 + maps in both the head and the neck, which is challenging due to low RF penetration into the neck, limited dynamic range of multichannel B1 + mapping techniques, and B0 sensitivity. We therefore sought a robust, large-dynamic-range, parallel-transmit field mapping protocol and tested whether RF shimming can improve carotid artery B1 + magnitude in practice. METHODS: A pipeline is presented that combines B1 + mapping data acquired using circularly polarized (CP) and CP2-mode RF shims at multiple voltages. The pipeline was evaluated by comparing the predicted and measured B1 + for multiple random transmit shims, and by assessing the ability of RF shimming to increase B1 + in the carotid arteries. RESULTS: The proposed method achieved good agreement between predicted and measured B1 + in both the head and the neck. The B1 + magnitude in the carotid arteries can be increased by 43% using tailored RF shims or by 37% using universal RF shims, while also improving the RF homogeneity compared with CP mode. CONCLUSION: B1 + in the neck can be increased using RF shims calculated from multichannel B1 + maps in both the head and the neck. This can be achieved using universal phase-only RF shims, facilitating easy implementation in existing sequences.

Robust EMI elimination for RF shielding-free MRI through deep learning direct MR signal prediction.

PURPOSE: To develop a new electromagnetic interference (EMI) elimination strategy for RF shielding-free MRI via active EMI sensing and deep learning direct MR signal prediction (Deep-DSP). METHODS: Deep-DSP is proposed to directly predict EMI-free MR signals. During scanning, MRI receive coil and EMI sensing coils simultaneously sample data within two windows (i.e., for MR data and EMI characterization data acquisition, respectively). Afterward, a residual U-Net model is trained using synthetic MRI receive coil data and EMI sensing coil data acquired during EMI signal characterization window, to predict EMI-free MR signals from signals acquired by MRI receive and EMI sensing coils. The trained model is then used to directly predict EMI-free MR signals from data acquired by MRI receive and sensing coils during the MR signal-acquisition window. This strategy was evaluated on an ultralow-field 0.055T brain MRI scanner without any RF shielding and a 1.5T whole-body scanner with incomplete RF shielding. RESULTS: Deep-DSP accurately predicted EMI-free MR signals in presence of strong EMI. It outperformed recently developed EDITER and convolutional neural network methods, yielding better EMI elimination and enabling use of few EMI sensing coils. Furthermore, it could work well without dedicated EMI characterization data. CONCLUSION: Deep-DSP presents an effective EMI elimination strategy that outperforms existing methods, advancing toward truly portable and patient-friendly MRI. It exploits electromagnetic coupling between MRI receive and EMI sensing coils as well as typical MR signal characteristics. Despite its deep learning nature, Deep-DSP framework is computationally simple and efficient.

Flexible multi-purpose integrated RF/shim coil array for MRI and localized B0 shimming.

PURPOSE: To develop a flexible, lightweight, and multi-purpose integrated parallel reception, excitation, and shimming (iPRES) coil array that can conform to the subject's anatomy and perform MR imaging and localized B0 shimming in different anatomical regions with a high SNR, shimming performance, ease of positioning, and subject comfort. METHODS: A four-channel flexible iPRES coil array was constructed by enabling RF and direct currents to flow on the same flexible coil elements for imaging and shimming, respectively. Shimming experiments were performed with the coil array wrapped around the knee or neck of healthy subjects to demonstrate its high shimming performance and versatility. Additionally, its SNR and shimming performance in the knee were compared to those obtained with the coil array wrapped around a larger rigid tube designed to fit most knee sizes. RESULTS: Shimming with the coil array wrapped around the knee or neck resulted in an average reduction in B0 RMSE of 50.1% and 40.5% relative to first-order and second-order spherical harmonic shimming, respectively, and substantially reduced distortions in DWI images. In contrast, shimming the knee with the coil array wrapped around the rigid tube only provided a 29.6% reduction in B0 RMSE, whereas the SNR was reduced by 58.7%. CONCLUSION: The flexible iPRES coil array can conform to different anatomical regions and perform imaging and localized B0 shimming with a higher SNR, shimming performance, ease of positioning, and comfort compared to a rigid iPRES coil array, which should be valuable for many applications throughout the human body.

Fat suppression using frequency-sweep RF saturation and iterative reconstruction.

PURPOSE: To introduce an alternative idea for fat suppression that is suited both for low-field applications where conventional fat-suppression approaches become ineffective due to narrow spectral separation and for applications with strong B0 homogeneities. METHODS: Separation of fat and water is achieved by sweeping the frequency of RF saturation pulses during continuous radial acquisition and calculating frequency-resolved images using regularized iterative reconstruction. Voxel-wise signal-response curves are extracted that reflect tissue's response to RF saturation at different frequencies and allow the classification into fat or water. This information is then utilized to generate water-only composite images. The principle is demonstrated in free-breathing abdominal and neck examinations using stack-of-stars 3D balanced SSFP (bSSFP) and gradient-recalled echo (GRE) sequences at 0.55 and 3T. Moreover, a potential extension toward quantitative fat/water separation is described. RESULTS: Experiments with a proton density fat fraction (PDFF) phantom validated the reliability of fat/water separation using signal-response curves. As demonstrated for abdominal imaging at 0.55T, the approach resulted in more uniform fat suppression without loss of water signal and in improved CSF-to-fat signal ratio. Moreover, the approach provided consistent fat suppression in 3T neck exams where conventional spectrally-selective fat saturation failed due to strong local B0 inhomogeneities. The feasibility of simultaneous fat/water quantification has been demonstrated in a PDFF phantom. CONCLUSION: The proposed principle achieves reliable fat suppression in low-field applications and adapts to high-field applications with strong B0 inhomogeneity. Moreover, the principle potentially provides a basis for developing an alternative approach for PDFF quantification.

Detunable wireless Litzcage coil for human head MRI at 1.5 T.

Inductively coupled radiofrequency (RF) coils are an inexpensive and simple method to realize wireless RF coils in magnetic resonance imaging (MRI), which can significantly ease the MRI scan setup and improve patient comfort because they do not require bulky components such as cables, baluns, preamplifiers, and connectors. However, volume-type wireless coils are typically operated in transmit/receive mode because detuning such coils is much more challenging due to their complex structure and multiple resonant modes. Meanwhile, adding too many detuning circuits to a wireless coil would decrease the coil's quality factor, impair the signal-to-noise ratio, and increase the cost. In this work, we proposed, constructed, and tested a novel wireless volume coil based on the Litzcage design for 1.5-T head imaging. Being an inductively coupled coil, it has a much simpler structure, resulting in a lighter weight and less bulky design. Despite its simpler structure, it exhibits comparable imaging performance with a commercial receive array, providing an alternative to conventional wired coils with a high cost and complex structure. The unique figure-of-8 conductor pattern within the rungs ensures that the proposed wireless Litzcage can be efficiently detuned with minimal detuning circuits.

The impact of variations in subject geometry, respiration and coil repositioning on the specific absorption rate in parallel transmit abdominal imaging at 7 T.

Parallel transmit MRI at 7 T has increasingly been adopted in research projects and provides increased signal-to-noise ratios and novel contrasts. However, the interactions of fields in the body need to be carefully considered to ensure safe scanning. Recent advances in physically flexible body coils have allowed for high-field abdominal imaging, but the effects of increased variability on energy deposition need further exploration. The aim of this study was to assess the impact of subject geometry, respiration phase and coil positioning on the specific absorption rate (SAR). Ten healthy subjects (body mass index [BMI] = 25 ± 5 kg m-2 ) were scanned (at 3 T) during exhale breath-hold and images used to generate body models. Seven of these subjects were also scanned during inhale. Simplifications of the coil and body models were first explored, and then finite-difference time-domain simulations were run with a typical eight-channel parallel transmit coil positioned over the abdomen. Simulations were used to generate 10 g averaged SAR (SAR10g ) maps across 100,000 phase settings, and the worst-case scenario 10 g averaged SAR (wocSAR10g ) was identified using trigonometric maximisation. The average maximum SAR10g across the 10 subjects with 1 W input power per channel was 1.77 W kg-1 . Hotspots were always close to the body surface near the muscle wall boundary. The wocSAR10g across the 10 subjects ranged from 2.3 to 3.2 W kg-1 and was inversely correlated to fat volume percentage (R = 8) and BMI (R = 0.6). The coefficient of variation values in SAR10g due to variations in subject geometry, respiration phase and realistic coil repositioning were 12%, 4% and 12%, respectively. This study found that the variability due to realistic coil repositioning was similar to the variability due to differing healthy subject geometries for abdominal imaging. This is important as it suggests that population-based modelling is likely to be more useful than individual modelling in setting safe thresholds for abdominal imaging.

Robust dual-angle T 1 measurement in magnetization transfer spectroscopy by time-optimal control.

Magnetization transfer spectroscopy relies heavily on the robust determination of T 1 relaxation times of nuclei participating in metabolic exchange. Challenges arise due to the use of surface RF coils for transmission (high B 1 + variation) and the broad resonance band of most X nuclei. These challenges are particularly pronounced when fast T 1 mapping methods, such as the dual-angle method, are employed. Consequently, in this work, we develop resonance offset and B 1 + robust excitation RF pulses for 31P magnetization transfer spectroscopy at 7T through ensemble-based time-optimal control. In our approach, we introduce a cost functional for designing robust pulses, incorporating the full Bloch equations as constraints, which are solved using symmetric operator splitting techniques. The optimal control design of the RF pulses developed demonstrates improved accuracy, desired phase properties, and reduced RF power when applied to dual-angle T 1 mapping, thereby improving the precision of exchange-rate measurements, as demonstrated in a preclinical in vivo study quantifying brain creatine kinase activity.

Optimization of flip angle and radiofrequency pulse phase to maximize steady-state magnetization in three-dimensional missing pulse steady-state free precession.

Missing pulse (MP) steady-state free precession (SSFP) is a magnetic resonance imaging (MRI) pulse sequence that is highly tolerant to the magnetic field inhomogeneity. In this study, optimal flip angle and radiofrequency (RF) phase scheduling in three-dimensional (3D) MP-SSFP is introduced to maximize the steady-state magnetization while keeping broadband excitation to cover widely distributed frequencies generated by inhomogeneous magnetic fields. Numerical optimization based on extended phase graph (EPG) simulation was performed to maximize the MP-SSFP steady-state magnetization. To limit the specific absorption rate (SAR) associated with the broadband excitation in 3D MP-SSFP, SAR constraint was introduced in the numerical optimization. Optimized flip angle and RF phase settings were experimentally tested by introducing a linear inhomogeneous magnetic field in a range of 10-20 mT/m and using a phantom with known T1/T2 relaxation and diffusion parameters at 3 T. The experimental results were validated through comparisons with EPG simulation. Image contrasts and molecular diffusion effects were investigated in in vivo human brain imaging with 3D MP-SSFP with the optimal flip angle and RF phase settings. In the phantom measurements, the optimal flip angle and RF phase settings improved the MP-SSFP steady-state magnetization/signal-to-noise ratio by up to 41% under the fixed SAR conditions, which matched well with EPG simulation results. In vivo brain imaging with the optimal RF pulse settings provided T2-like image contrasts. Diffusion effects were relatively minor with the linear inhomogeneous field of 10-20 mT/m for white and gray matter, but cerebrospinal fluid showed conspicuous signal intensity attenuation as the linear inhomogeneous field increased. Numerical optimization achieved significant improvement in the steady-state magnetization in MP-SSFP compared with the RF pulse settings used in previous studies. The proposed flip angle and RF phase optimization is promising to improve 3D MP-SSFP image quality for MRI in inhomogeneous magnetic fields.