RESUMO
Syringomas are benign neoplasms derived from eccrine sweat glands. Eruptive syringomas are a subtype of syringomas and are typically located on the chest, neck, and abdomen during puberty or childhood. Herein, we present a 20-year-old African American female with an atypical case of eruptive syringomas, characterized by an unusual distribution on her chest, abdomen, and anterior and posterior bilateral extremities. This case underscores the importance of recognizing diverse presentations of skin conditions in patients with skin of color and adds to the limited reports of eruptive syringoma in these populations. We present and emphasize this atypical manifestation of eruptive syringomas in an individual with darker skin to promote awareness and improve diagnosis and patient outcomes.J Drugs Dermatol. 2024;23(7):564-566. doi:10.36849/JDD.8103.
Assuntos
Pigmentação da Pele , Neoplasias das Glândulas Sudoríparas , Siringoma , Humanos , Siringoma/patologia , Siringoma/diagnóstico , Feminino , Neoplasias das Glândulas Sudoríparas/diagnóstico , Neoplasias das Glândulas Sudoríparas/patologia , Adulto Jovem , Negro ou Afro-AmericanoRESUMO
An 11-year-old boy presented generalized eruptive syringomas (ESs) associated with multiple milia-like whitish palmar papules corresponding to dermal calcium deposits. A relationship between calcium deposits distribution to an underlying eccrine duct was noted on pathology. The observation of dermal calcium deposits and its association with generalized ESs may support a possible sweat duct origin of this uncommon and peculiar form of superficial calcinosis cutis.
Assuntos
Calcinose , Neoplasias das Glândulas Sudoríparas , Siringoma , Humanos , Masculino , Calcinose/patologia , Calcinose/etiologia , Siringoma/patologia , Criança , Neoplasias das Glândulas Sudoríparas/patologia , Neoplasias das Glândulas Sudoríparas/complicações , Dermatopatias/patologia , Dermatopatias/etiologia , Calcinose Cutânea , CeratoseRESUMO
Syringomatous tumor of the nipple is a benign, locally infiltrative tumor. There are reports in the literature of tumor recurrence in cases of incomplete excision. Clinical and mammographic findings in syringomatous tumors are like those of breast carcinoma and the pathologist has a fundamental role in final tumor diagnosis. Therefore, the aim of this study was to report a case of syringoma located in the areolar region. A 33-year-old woman reported that she had noticed a nodule in her left areolar region 4 years previously (February 2019). A breast ultrasound was performed, detecting intraparenchymatous breast cysts. Surgical resection of the nodule was indicated although it was not performed. Two years later, in August 2021, the patient underwent a mastopexy with prosthesis inclusion. Histopathology study of the surgical specimen revealed a syringomatous tumor with positive margins. Thirteen (13) months after diagnosis (September 3, 2021 - October 16, 2022), the patient is doing well and receives clinical follow-up.
Assuntos
Neoplasias da Mama , Mamilos , Siringoma , Ultrassonografia Mamária , Humanos , Feminino , Adulto , Neoplasias da Mama/patologia , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/cirurgia , Mamilos/patologia , Siringoma/patologia , Siringoma/diagnóstico , Siringoma/cirurgia , Neoplasias das Glândulas Sudoríparas/patologia , Neoplasias das Glândulas Sudoríparas/diagnóstico , Neoplasias das Glândulas Sudoríparas/cirurgia , Seguimentos , Mamoplastia/métodosRESUMO
INTRODUCCIÓN: Los siringomas son tumores benignos derivados de la porción intraepidérmica de los conductos sudoríparos ecrinos. Ocasionalmente pueden iniciar de forma súbita como siringomas eruptivos o localizarse en sitios atípicos que retrasan el diagnóstico por años. La dermatoscopía tiene un rol incipiente en diferenciar siringomas de su extenso diagnóstico diferencial. MÉTODOS: Estudio retrospectivo descriptivo de serie de casos de siringomas de localización atípica. Los datos fueron extraídos de fichas clínicas electrónicas. Todos incluyen dermatoscopía y correlación histopatológica. RESULTADOS: Cinco pacientes. Cuatro hombres y una mujer entre 40 y 79 años de edad con siringomas atípicos: cuatro casos eruptivos y un caso de siringomas vulvares. DISCUSIÓN: Proponemos la dermatoscopía basada en nuestros hallazgos como una herramienta útil con estructuras ovales amarillas y una pseudo-red café clara difusa en su superficie. Estas estructuras amarillas se pueden correlacionar con la proliferación ductal ecrina y el denso estroma en la histopatología. CONCLUSIÓN: Enfatizamos que se debe considerar esta entidad en el diagnóstico diferencial de dermatosis papulares y conocer sus manifestaciones clínicas para optimizar la sospecha diagnóstica.
INTRODUCCTION: Syringomas are common benign tumors, probably of origin derived from the intraepidermal portion of the eccrine sweat ducts. Occasionally they may develop suddenly and extensively as eruptive syringomas or be located in atypical sites delaying the diagnosis for years. Dermoscopy has an incipient role in differentiating syringomas from their extensive differential diagnosis. METHODS: Retrospective descriptive case-series study of atypical location syringomas. Data extraction from clinical history from electronic files. They all include dermoscopy and histopathological correlation. RESULTS: Five patients: Four men and one woman between 40 and 79 years old, with atypical syringomas diagnosis: four eruptive and one vulvar syringomas. DISCUSSION: We propose dermoscopy, based on our findings, as a useful tool to this entity, with its oval yellow structures and a diffuse light-brown network-like structure on its surface. These yellow enlargements may be correlated with the ductal eccrine proliferation and the dense stroma seen in the histopathology. CONCLUSION: We emphasize that they should be considered in the differential diagnosis of papular dermatosis, as they tend to be underdiagnosed, and to know their clinical manifestations to optimize the diagnostic suspicion.
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Neoplasias Cutâneas/diagnóstico , Neoplasias das Glândulas Sudoríparas/diagnóstico , Siringoma/diagnóstico , Neoplasias Cutâneas/patologia , Neoplasias das Glândulas Sudoríparas/patologia , Neoplasias Vulvares/diagnóstico , Estudos Retrospectivos , Siringoma/patologia , Dermoscopia , Diagnóstico DiferencialRESUMO
Introducción: El siringocistoadenoma papilífero (SP) es un tumor anexial benigno inusual, de etiología desconocida. Por lo general, se presenta desde el nacimiento, o en la primera infancia como una lesión aislada, frecuentemente asociada a un nevo sebáceo de Jadassohn. Objetivo: Describir y analizar las características demográficas, clínicas e histopatológicas del SP. Materiales y métodos: Revisión retrospectiva de informes histopatológicos del Departamento de Anatomía Patológica del Hospital Clínico de la Universidad de Chile entre los años 2005 y 2016. Se incluyeron todas las muestras que describieron dentro del diagnóstico histológico las palabras "siringocistoadenoma papilífero". Resultados: La muestra está compuesta por 11 pacientes; 9 mujeres y 2 hombres. En 5 pacientes, se desarrolló un SP a partir de un nevo sebáceo y en 6 surgió de novo. El total de la muestra desarrolló el SP durante o posterior a la pubertad. Tanto los pacientes con SP solitario, como aquellos asociados a un nevo sebáceo, presentaron clínica similar con una placa o pápula verrucosa aislada. Los principales diagnósticos diferenciales fueron el nevo sebáceo, nevo verrucoso y verruga. Conclusiones: Este estudio constituye la primera serie de casos de SP en un hospital en Santiago de Chile. La forma clínica más frecuente fue como placa verrucosa solitaria asintomática, con casos aislados como pápula verrucosa y sólo un caso con aspecto de cuerno cutáneo. Se destaca el rol de la extirpación quirúrgica completa, tanto para establecer el diagnóstico, como para ofrecer un tratamiento definitivo, disminuyendo el riesgo de transformación maligna a siringocistoadenocarcinoma papilífero.
Introduction: Syringocystoadenoma papilliferum (SCAP) is an unusual benign adnexal tumor of unknown etiology. Usually it is presented at birth or in early childhood as an isolated lesion associated with nevus sebaceous of Jadassohn. Objective: To describe and analyze the demographic, clinical and histopathological characteristics of SCAP. Materials and methods: A retrospective review of histopathological reports was performed at the Clinical Hospital´s Department of Pathological Anatomy from the University of Chile including biopsies from 2005 to 2016. All the samples that described the histological diagnosis of "syringocystoadenoma papilliferum" were included. Results: The sample consists of 11 patients; 9 women and 2 men. In 5 patients, an SCAP was developed from a sebaceous nevus and in 6 it developed de novo. The total sample developed SCAP during or after puberty. Both the patients with solitary SCAP, and those associated with nevo sebaceous, presented similar clinical signs with an isolated verrucous plaque or papule. The main differential diagnoses were the nevo sebaceous, warty nevus and wart. Conclusions: This study is the first SCAP case series in Santiago, Chile. The most frequent clinical form was an asymptomatic solitary verrucous plaque, with isolated cases as a verrucous papule and a single case as a cutaneous horn. The role of complete surgical resection is highlighted, both to establish the diagnosis and to offer a definitive treatment, reducing the risk of malignant transformation to syringocystadenocarcinoma papilliferum.
Assuntos
Humanos , Masculino , Feminino , Siringoma/patologia , Neoplasias de Anexos e de Apêndices Cutâneos/patologia , Adenoma de Glândula Sudorípara/patologia , Cistadenoma/patologia , Verrugas , Estudos Retrospectivos , Nevo Sebáceo de Jadassohn/patologiaRESUMO
Abstract Collision or contiguous tumors, defined as two or more distinct tumors occurring at one site, are often an unexpected finding and may represent a diagnostic challenge, as clinical and histological presentations do not always coincide. Various combinations of collision tumors have been described with respect to melanocytic lesions, with the most frequently reported being the combination of nevus and basal cell carcinoma. We present an unusual case on the nose involving a melanoma in situ and a clinically-inapparent syringoma, which, to the best of our knowledge, is the first report of this combination.
Assuntos
Humanos , Masculino , Idoso de 80 Anos ou mais , Neoplasias Cutâneas/patologia , Neoplasias das Glândulas Sudoríparas/patologia , Siringoma/patologia , Melanoma/patologia , Biópsia , Imuno-Histoquímica , Neoplasias Primárias MúltiplasRESUMO
Abstract: Syringocystadenoma papilliferum and tubular apocrine adenoma are rare benign sweat gland tumors. Syringocystadenoma papilliferum occurs alone or in association with other tumors. Although it is rare, the association of tubular apocrine adenoma with syringocystadenoma papilliferum developing in a sebaceous nevus on the scalp is well documented. However, the co-existence of these two tumors without the background of a sebaceous nevus has not been frequently reported. Syringocystadenoma papilliferum and tubular apocrine adenoma may have a histopathological overlap, but a few cases of a syringocystadenoma papilliferum combined with a tubular apocrine adenoma have been reported. Herein we describe an unusual case of syringocystadenoma papilliferum co-existing with a tubular apocrine adenoma located on the back of a 14-year-old patient in the absence of a pre-existing sebaceous nevus.
Assuntos
Humanos , Masculino , Adolescente , Neoplasias das Glândulas Sudoríparas/patologia , Siringoma/patologia , Cistadenoma/patologia , Adenomas Tubulares de Glândulas Sudoríparas/patologia , Neoplasias Primárias Múltiplas/patologia , Neoplasias das Glândulas Sudoríparas/cirurgia , Diagnóstico Diferencial , Adenomas Tubulares de Glândulas Sudoríparas/cirurgia , Neoplasias Primárias Múltiplas/cirurgiaRESUMO
The case of a 34-year-old woman, who consulted because she observed the appearance of numerous yellow-white asymptomatic papules on the vulva, is presented. Clinical diagnosis of syringoma of vulva was established. The pathological and immunohistochemical studies confirmed the diagnosis. Vulvar syringoma usually occurs as a multiple flesh-colored or brownish papules on both sides of labia majora of women in their third decade. Its diagnosis should be considered when the patient complaints of vulvar pruritus and/or sweating.
Se presenta un caso de una paciente de 34 años de edad quien consultó por presentar la aparición de numerosas pápulas de color blanco-amarillentas en la vulva. El diagnóstico clínico de siringoma de vulva fue realizado. Los estudios de patología y de inmunohistoquimica confirmaron el diagnóstico. El siringoma vulvar usualmente se presenta como múltiples pápulas del color de la piel o marrones en ambos labios mayores en mujeres en su tercera década de la vida. Su diagnóstico debe ser considerado en pacientes que se quejan de prurito y/o sudoración vulvar
Assuntos
Adulto , Feminino , Humanos , Neoplasias Vulvares/patologia , Siringoma/patologia , Imuno-HistoquímicaRESUMO
Syringoma is a benign, adnexal tumor of the eccrine sweat gland ducts. Eruptive syringomas are a rare variant, occurring before or during puberty in most cases. A 57-year-old man was observed in our department, with a 10-year history of multiple brownish papules (1-4mm in diameter), localized on the neck, shoulders, trunk and axillae. The clinical diagnosis was cutaneous mastocytosis. Histopathological examination from a papule in the trunk was compatible with the diagnosis of syringoma. The patient was treated with isotretinoin, without any improvement. The clinical diagnosis of eruptive syringoma is diffi cult and histological examination is crucial for its diagnosis. Long-term morbidity is not associated with syringomas; they are treated for cosmetic reasons with unsatisfactory results.
.Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Cutâneas/patologia , Neoplasias das Glândulas Sudoríparas/patologia , Siringoma/patologia , Idade de Início , Biópsia , Diagnóstico Diferencial , Derme/patologia , Mastocitose Cutânea/patologiaRESUMO
Abstract: Syringocystadenoma papilliferum is a rare benign hamartomatous adnexal tumor of the apocrine or eccrine sweat glands. Most patients present a solitary lesion in the head and neck region. Presentation outside the head and neck region is even more uncommon. We present a case of Syringocystadenoma papilliferum with papulonodular lesion located on the vulva of an infant girl. This case illustrates the atypical location of this rare disease and adds to the differential diagnosis of lesions on the vulva.
Assuntos
Criança , Feminino , Humanos , Cistadenoma/patologia , Neoplasias das Glândulas Sudoríparas/patologia , Siringoma/patologia , Neoplasias Vulvares/patologia , Biópsia , Pele/patologiaRESUMO
No disponible
Assuntos
Humanos , Feminino , Adulto , Hiperpigmentação/patologia , Hiperpigmentação/diagnóstico por imagem , Siringoma/diagnóstico , Pigmentação da Pele , Tronco/patologia , Ultrassonografia , Biópsia , Siringoma/patologia , Diagnóstico DiferencialRESUMO
Eccrine syringofibroadenoma is a rare benign adnexal neoplasm derived from cells of the acrosyringium of eccrine sweat glands. ESFA usually manifests as a solitary nodule on the extremities of elderly patients, but it may also present as papules, nodules or plaques. Its clinical appearance is nonspecific and malignant neoplasms should beconsidered in the differential diagnosis. However, histopathological findings are typical. The main treatment is surgical excision. In order to illustrate a typical presentation of the tumor, we report a case of solitary eccrine syringofibroadenoma, including the surgical treatment used and its result.
.Assuntos
Idoso de 80 Anos ou mais , Feminino , Humanos , Glândulas Écrinas/patologia , Fibroadenoma/patologia , Neoplasias das Glândulas Sudoríparas/patologia , Siringoma/patologia , Tornozelo , Biópsia , Glândulas Écrinas/cirurgia , Fibroadenoma/cirurgia , Neoplasias das Glândulas Sudoríparas/cirurgia , Siringoma/cirurgia , Resultado do TratamentoRESUMO
No disponible
Assuntos
Humanos , Feminino , Adulto , Siringoma/diagnóstico , Siringoma/tratamento farmacológico , Siringoma/patologia , Biópsia , Tretinoína/administração & dosagem , Administração Tópica , Neoplasias Cutâneas/tratamento farmacológicoRESUMO
Sarcoidosis is a granulomatous disease of unknown etiology. The skin is commonly affected. Cutaneous manifestations can mimic other diseases and autoimmune disorders. The dermatologist plays a critical role in elucidating the clinical diagnosis and assisting other specialists in the investigation of a systemic disease. We report a patient with typical cutaneous manifestation of sarcoidosis with pulmonary involvement.
A sarcoidose é uma doença granulomatosa de etiologia desconhecida. A pele é comumente afetada. As manifestações cutâneas podem mimetizar outras afecções e desordens auto-imunes. Assim, o dermatologista assume papel fundamental para elucidar o diagnóstico clínico e auxiliar outros especialistas na investigação de uma doença sistêmica. Relatamos um caso de paciente com manifestação cutânea típica de sarcoidose associada com acometimento pulmonar.
Assuntos
Idoso , Feminino , Humanos , Pneumopatias/patologia , Sarcoidose/patologia , Siringoma/patologia , Diagnóstico DiferencialRESUMO
Se presenta el caso de una mujer de 32 años, quien consultó por presentar desde hace 6 meses nódulos múltiples y pruriginosos en ambos labios mayores, prurito que se exacerbaba durante la menstruación. El estudio anatomo-patológico demostró una proliferación dérmica de conductos pequeños revestidos por una doble capa de células cuboídeas normotípicas, y rodeados por un estroma fibroso compatibes con un siringoma...
We report a case of a 32 year-old woman, who consulted to present for 6 months and multiple and itchy nodules in both labia majora, itching that was exacerbated during menstruation. The pathological study showed a dermal proliferation of small ducts lined by a double layer of normotipic cuboidal cells, and surrounded by a fibrous stroma compatibes a syringoma...
Assuntos
Humanos , Adulto , Feminino , Neoplasias Vulvares/patologia , Neoplasias das Glândulas Sudoríparas/patologia , Siringoma/patologiaRESUMO
O siringocistoadenoma papilífero é uma neoplasia anexial benigna rara, com frequente diferenciação apócrina. Localiza-se preferencialmente no couro cabeludo e está associado ao nevo sebáceo em 40 por cento dos casos. Apesar da variabilidade clínica, a histologia é característica. Há relatos da dermatoscopia de tumores anexiais, como poroma écrino, hidradenoma e angio-histiocitoma; porém, até o momento, não há descrição da dermatoscopia do siringocistoadenoma. Apresentamos aspectos dermatoscópicos de um caso de siringocistoadenoma associado a nevo sebáceo, visualizando-se padrão vascular polimorfo e vasos em ferradura.
Syringocystadenoma papilliferum is a rare benign adnexal tumor that frequently shows apocrine differentiation. It usually develops on the scalp and is associated with a nevus sebaceus in 40 percent of cases. Although the clinical presentation may differ, its histology is characteristic. Reports have been made of dermoscopy used in cases of adnexal tumors such as eccrine poromas, hidradenomas and angiohistiocytomas; however, up to the present moment there have been no reports of dermoscopy in a case of syringocystadenoma. This paper describes the dermoscopic features found in a case of syringocystadenoma associated with a nevus sebaceus, revealing a polymorphous vascular pattern including a horseshoe-shaped arrangement of vessels.
Assuntos
Feminino , Humanos , Pessoa de Meia-Idade , Cistadenoma/patologia , Neoplasias de Cabeça e Pescoço/patologia , Neoplasias das Glândulas Sudoríparas/patologia , Siringoma/patologia , Dermoscopia , Nevo Sebáceo de Jadassohn/patologia , Couro Cabeludo/patologiaRESUMO
Los siringomas son tumores anexiales benignos con diferenciación principalmente ductal. Se presentan con mayor frecuencia en la cara, especialmente en párpados, pero pueden aparecer en cualquier zona del cuerpo. Son más frecuentes en el sexo femenino y se inician por lo general en la pubertad. Pueden aparecer en forma de pápulas pequeñas y firmes, habitualmente múltiples, y existen variadas presentaciones clínicas. Presentamos dos casos clínicos que corresponden a dos mujeres con el diagnóstico de siringomas eruptivos.
Syringomas are benign adnexal tumors with mainly ductal differentiation, more frequently seen in the face, especially in the eyelids, yet may appear in any part of the body. In general, they start a puberty, being more frequent in women. They may present as multiple, small and firm papules, and there are various clinical types. We present two clinical cases corresponding to two women with eruptive syringoma.
Assuntos
Humanos , Feminino , Adulto , Pessoa de Meia-Idade , Neoplasias das Glândulas Sudoríparas/diagnóstico , Neoplasias das Glândulas Sudoríparas/patologia , Siringoma/diagnóstico , Siringoma/patologia , Diagnóstico DiferencialRESUMO
No disponible