Is the telomere length associated with neurocognitive disabilities in HIV-1-infected subjects?
Araujo, Marilia Ladeira de; Duarte, Wellington; Oliveira, Augusto Cesar Penalva de; Gascon, Maria Rita Polo; Fonseca, Luiz Augusto Marcondes; Paiva, Raquel de Melo Alves; Santana, Barbara; Calado, Rodrigo Tocantins; Casseb, Jorge.
Rev. Inst. Med. Trop. São Paulo (Online)
; 60: 16, Apr. 2018. ilus, tab
Artículo
Inglés
| SES-SP, SES SP - Instituto de Infectologia Emílio Ribas, SES-SP | ID: biblio-1022175
OBJECTIVE:
We evaluated the association between cognitive deficits and leukocyte telomere length (LTL) in HIV-1-infected individuals.DESIGN:
73 HIV-1-infected patients undergoing neuropsychological evaluation and 91 healthy controls were included in this study. Fifteen HIV-1 positive patients did not have cognitive disorders whereas 26 had asymptomatic neurocognitive disorder (ANI), 13 presented mild to moderate neurocognitive disorder (MND), and 10 had HIV-associated dementia (HAD).METHODS:
DNA from the peripheral blood of HIV-1-infected patients was used for measurement of telomere length by real-time PCR. HIV-1 viral load was determined in blood.RESULTS:
LTL decreased with age in healthy controls (p=0.0001). Regardless of the HIV status, age-matched LTL from HIV patients, including those with ANI and MND, were shortened in comparison to the healthy control group (p=0.0073); however, no association was found among the HIV-1-infected individuals with cognitive deficits (p=0.01). In addition, no gender-related association with LTL was observed (p=0.80), smoking, physical exercise, and plasma viral load were not correlated to telomere length (p=0.66).CONCLUSIONS:
We concluded that leukocyte telomere length may not be a marker of cellular senescence in individuals with HIV infection and neurocognitive disorders
Biblioteca responsable:
BR31.1
Ubicación: BR31.1; 2018_P-019
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