Transcriptome of normal lung distinguishes mouse lines with differentsusceptibility to inflammation and to lung tumorigenesis
Franco, Marcelo De; Colombo, Francesca; Galvan, Antonella; Cecco, Loris de; Spada, Elena; Milani, Silvano; Ibanez, Olga M; Dragani, Tommaso A.
Cancer lett
; 294(2): 187-194, 2010.
Artículo
Inglés
| SES-SP, SES SP - Instituto Butantan, SES-SP, SES SP - Acervo Instituto Butantan | ID: biblio-1061796
AIRmax and AIRmin mouse lines show a differential lung inflammatory response and differential lung tumor susceptibility after urethane treatment. The transcript profile of 24,000 known genes was analyzed in normal lung tissue of untreated and urethane-treatedAIRmax and AIRmin mice. In lungs of untreated mice, inflammation-associated genes involved in pathways such as leukocyte transendothelial migration, cell adhesion and tight junctions were differentially expressed. Moreover, gene expression levels differed significantly in urethane-treated mice; in AIRmin mice, modulation of expression of genes involved in pathways associated with inflammatory response paralleled the previously observed persistent infiltration of inflammatory cells in the lung of these mice.
Biblioteca responsable:
BR78.1
Ubicación: BR78.1
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