Distinct early inflammatory events during ear tissue regeneration in mice selected for high inflammation bearing Slc11a1 R and S alleles
Canhamero, Tatiane; Reines, Brandom; Peters, Luciana C; Borrego, Andrea; Carneiro, Patrícia S; Albuquerque, Layra L; Cabrera, Wafa H; Ribeiro, Orlando G; Jensen, Jose R; Starobinas, Nancy; Ibañez, Olga M; Franco, Marcelo De.
Inflammation
; 34(5): 303-313, Oct.2011.
Artículo
Inglés
| SES-SP, SES SP - Instituto Butantan, SES-SP, SES SP - Acervo Instituto Butantan | ID: biblio-1063444
High inflammatory AIRmax mice homozygous for Slc11a1 R and S alleles were produced. AIRmaxSS mice showed faster ear tissue regeneration than AIRmaxRR mice, suggesting that the Sallele favored tissue restoration. Here, we investigated the gene expression profiles and the inflammatory reactions of AIRmaxRR and AIRmaxSS mice during the initial phase of ear tissue regeneration. We observed superior levels of analysis of wound myeloperoxidase and edema inAIRmaxSS mice, although similar cell influx was verified in both lines. Of the genes, 794 were up- and 674 down-regulated in AIRmaxRR, while 735 genes were found to be up- and 1616 down-regulated in AIRmaxSS mice 48 h after punch. Both mouse lines showed significant over-represented genes related to cell proliferation; however AIRmaxSS displayed up-regulation of inflammatory response genes. Quantitative PCR experiments showed higher expressions of Tgfb1, Dap12 and Trem1 genes in AIRmaxSS mice. These results indicate that Slc11a1 gene modulated the early inflammatory events of ear tissue regeneration.
Biblioteca responsable:
BR78.1
Ubicación: BR78.1
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