High frequency of chlamydia pneumoniae and risk factors in children with acute respiratory infection
Alves, Matheus Silva; Cariolano, Marilha da Silva; Ferreira, Hivylla Lorrana Dos Santos; Silva, Elen Sousa de Abreu; Felipe, Karen Karollynny Pereira; Monteiro, Silvio Gomes; Sousa, Eduardo Martins de; Abreu, Afonso Gomes; Campbell, Lee Ann; Rosenfeld, Michael E; Hirata, Mario Hiroyuki; Hirata, Rosario Dominguez Crespo; Bastos, Gisele Medeiros; Silva, Ilana Cristina de Paula Abreu; Lima-Neto, Lidio Gonçalves.
Braz. j. microbiol
; 51(2): 629-636, Jun., 2020. graf., tab.
Artículo
Inglés
| SES-SP, SES SP - Instituto Dante Pazzanese de Cardiologia, SES-SP | ID: biblio-1100142
This study was performed as a contribution for a better understanding of Chlamydia pneumoniae frequency in children with respiratory infections. A total of 416 children were recruited from two clinical centers in Sao Luis, Brazil. Of these patients, 165 children had upper respiratory tract infections (URTI), 150 had community-acquired pneumonia (CAP), and 101 were asymptomatic volunteer children. Clinical and epidemiological data from the participants were recorded. Nasopharyngeal swab samples were collected to extract DNA. C. pneumoniae DNA positivity and copy numbers were obtained by an absolute quantitative real-time PCR method.
RESULTS:
Positivity for C. pneumoniae DNA was higher in samples from URTI children (38.2%) and from CAP children (18.0%) than in those from the control group (7.9%; p < 0.001). Moreover, C. pneumoniae DNA was denser in children with URTI than in asymptomatic children. Considering the cutoff, the highest value of C. pneumoniae DNA found in asymptomatic children of the 3.98 log10 copies/mL, 8.5% (14/165) of the children with URTI, and 3.3% (5/150) with CAP presented high copy numbers of C. pneumoniae DNA.CONCLUSION:
Taken together, these results revealed a high frequency of C. pneumoniae in both children with URTI and CAP.
Biblioteca responsable:
BR79.1
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