There were no differences in demographic, anthropometric, surgical procedure, or baseline data on ICU. Prefrail patients had more adverse events during the 3year followup period with rehospitalization compared to nonfrail (39.4% vs 14.3%, respectively). Rehospitalizations in prefrail patients were in the first year after cardiac surgery (P < .05), and higher cumulative events in prefrail have occurred with increased odds ratio (OR) (2.828, 95% confidence interval [CI] 1.2986.160; P = .001) and hazard ratio (HR) (3.560, 95% CI 1.50884.04; P = .004). The OR and HR for stroke or death were similar between groups when analyzed separately.