Systemic inflammation and oxidative stress in adults with bronchiectasis: association with clinical and functional features
Clinics
; Clinics;76: e2474, 2021. tab
Article
en En
| LILACS
| ID: biblio-1286074
Biblioteca responsable:
BR1.1
ABSTRACT
OBJECTIVES:
To compare the inflammatory and oxidative stress (OS) states of adults with bronchiectasis with those of healthy controls and correlate inflammatory and OS levels with lung function and physical capacity.METHODS:
This study used a cross-sectional design. Seventy-four adults with bronchiectasis (age 49±15 years, forced expiratory volume in 1 second [FEV1] 52.5±25.6%) and 42 healthy controls (age 44±17 years, FEV1 95.9±14.0%) performed cardiopulmonary exercise tests and incremental shuttle walking tests. Their physical activity in daily life, inflammatory cytokine, and antioxidant levels in plasma were measured.RESULTS:
Compared to that of the controls, the levels of interleukin (IL)-6 (p<0.001), IL-10 (p<0.001), carbonylated proteins (p=0.001), and superoxide anions (p=0.046) were significantly increased in adults with bronchiectasis. Catalase activity was also reduced in this group (p<0.001). The inflammatory markers IL-1β, IL-6, and tumor necrosis factor-α correlated negatively with aerobic capacity (r=-0.408, r=-0.308, and r=-0.207, respectively). We observed similar correlations with OS markers (thiobarbituric acid and carbonyls; r=-0.290 and r=0.379, respectively), and these markers also significantly correlated with the aerobic capacity.CONCLUSIONS:
Adults with bronchiectasis presented an increased systemic inflammatory response that correlated negatively with physical capacity.Palabras clave
Texto completo:
1
Banco de datos:
LILACS
Asunto principal:
Bronquiectasia
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Adult
/
Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article