Biomarkers in a cohort of HIV-Infected Patients Single- or Co-Infected with HTLV-1, HTLV-2, and/or HCV: a Cross-Sectional, Observational Study
Viruses
; 14(9): 1-13, 3 Sept. 2022. tab, graf
Article
en En
| SES-SP, SESSP-IALPROD, SES-SP, SESSP-IALACERVO
| ID: biblio-1400069
Biblioteca responsable:
BR91.2
Ubicación: BR76.1; Digital
ABSTRACT
HIV, HTLV-1/-2, and HCV share routes of transmission, and such virus co-infections could account for worse outcomes of associated diseases. Measuring cytokines/chemokines, CD4 and CD8 T cells, andHIV viral load (VL) inHIV single-infected and co-infected individuals has prognostic value. We analyzed such biomarkers in 129 blood samples ofHIV-infected individualsmatched for age and sex and divided into six groups (G1 (69 HIV); G2 (9 HIV/HTLV-1); G3 (6 HIV/HTLV-2); G4 (11 HIV/HCV); G5 (19 HIV/HCV/HTLV-1); and G6 (15 HIV/HCV/HTLV-2)). Eight cytokines/chemokines from fifteen analytes could be compared. The highest levels of Th1 and pro-inflammatory cytokines were detected in G2 (IFN-) and G6 (IL-6 and IL1- ) and of chemokines in G1 (MIG, IP10, RANTES), G4 (MCP1), and G6 (MIP1- ). The highest CD4 cells number and the lowest HIV VL were identified in G3 and the opposite results in G2. Positive correlations between CD4 and CD8 cells counts and IL-6 levels were detected in G2 and G5 and of HIV VL and RANTES in G4. Negative correlations were detected between CD8 and IFN- in G4 and HIV VL and RANTES in G6. Despite the small number of the cohort analyzed, and although the cross-sectional study design does not allow firm conclusions, the homogeneity of the characteristics of HIV/HTLV-co-infected individuals regarding age, time and route of HIV acquisition, and criteria for introducing ART enable us to suggest a negative impact of HTLV-1 and a possible protective role of HTLV-2 in HIV infection progression in such patients. (AU)
Palabras clave
Texto completo:
1
Colección SES:
Acervo_geral
/
Producao_cientifica
Banco de datos:
SES-SP
/
SESSP-IALACERVO
/
SESSP-IALPROD
Asunto principal:
Biomarcadores
/
Virus Linfotrópico T Tipo 1 Humano
/
Virus Linfotrópico T Tipo 2 Humano
/
Antígenos CD4
/
Estudios Transversales
/
Citocinas
/
VIH
/
Antígenos CD8
/
Hepacivirus
/
Quimiocinas
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Año:
2022
Tipo del documento:
Article