Combination therapy with liposomal amphotericin b (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate in a refractory visceral leishmaniasis case
Gomes, Maria Antonia Ferreira; Medeiros, Lana Lira Cantidio de; Lobo, Fernanda Paula Dantas; Wanderley, Nathália Rayane Silva; Matos, Ana Paula Rodrigues; Jácome, Tácito do Nascimento; Monteiro, Maria Goretti Lins; Luz, Kleber Giovanni.
Rev. Soc. Bras. Med. Trop
; 51(3): 393-396, Apr.-June 2018. tab, graf
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| LILACS | ID: biblio-957422
Abstract Visceral leishmaniasis is a systemic disease that is potentially severe and endemic in Brazil. It clinically manifests as fever, weight loss, swelling, hepatosplenomegaly, paleness, and edema. In this study, we discuss a case of a 1-year-old child diagnosed with refractory visceral leishmaniasis after being treated with liposomal amphotericin B in two distinct occasions. Considering the persistent clinical features and weak response to conventional treatment, a combination therapy with liposomal amphotericin B (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate was initiated, and response to treatment was good.
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