Brain mitochondrial alterations after chronic alcohol consumption
J. physiol. biochem
; 65(3): 305-312, sept. 2009.
Article
en En
| IBECS
| ID: ibc-122875
Biblioteca responsable:
ES1.1
Ubicación: BNCS
RESUMEN
No disponible
ABSTRACT
The aim of this study was to demonstrate the existence of alterations in glutathione and cholesterol homeostasis in brain mitochondria from alcoholic rats. Glutathione concentration decreased, whereas oxidized glutathione and cholesterol contents increased in these organelles, suggesting the ethanol-induced generation of reactive oxygen species, and the impairment of mitochondrial uptake of glutathione, possibly due to the increase in cholesterol deposition. The release of apoptogenic proteins was increased after stimulating mitochondria from the brain of alcoholic rats with atractyloside. As a conclusion, chronic alcohol consumption might sensitize brain mitochondria to apoptotic stimuli, and promote the subsequent release of apoptotic proteins (AU)
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Banco de datos:
IBECS
Asunto principal:
Consumo de Bebidas Alcohólicas
/
Apoptosis
/
Glutatión
/
Mitocondrias
Límite:
Animals
Idioma:
En
Año:
2009
Tipo del documento:
Article