New enamine derivatives of lapachol and biological activity
An. acad. bras. ciênc
; 74(2): 211-221, June 2002. ilus, tab
Article
en En
| LILACS
| ID: lil-314019
Biblioteca responsable:
BR1.1
ABSTRACT
A convenient synthesis of the new enamine derivatives 2-(4-morpholinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione, 2-(1-piperidinyl)-3-(3-methyl-2-butenyl)-1,4-naphtalenedione and 2-(1-pyrrolidinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione was carried out from natural 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione (lapachol) and morpholine, piperidine and pyrrolidine. The structures of the products were established mainly by NMR analysis, including 2D experiments. Biological activities of these products were evaluated against Artemia salina, Aedes aegypti and cytotoxicity using A549 human breast cells
Texto completo:
1
Banco de datos:
LILACS
Asunto principal:
Naftoquinonas
/
Aminas
/
Antineoplásicos Fitogénicos
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Año:
2002
Tipo del documento:
Article