Determination of an unrelated donor pool size for human leukocyte antigen-matched platelets in Brazil
Rev. bras. hematol. hemoter
; 38(1): 1-6, Jan.-Feb. 2016. tab, graf
Article
en En
| LILACS
| ID: lil-777433
Biblioteca responsable:
BR1.1
ABSTRACT
ABSTRACT Background:
Successful transfusion of platelet refractory patients is a challenge. Many potential donors are needed to sustain human leukocyte antigen matched-platelet transfusion programs because of the different types of antigens and the constant needs of these patients. For a highly mixed population such as the Brazilian population, the pool size required to provide adequate platelet support is unknown.Methods:
A mathematical model was created to estimate the appropriate size of an unrelated donor pool to provide human leukocyte antigen-compatible platelet support for a Brazilian population. A group of 154 hematologic human leukocyte antigen-typed patients was used as the potential patient population and a database of 65,500 human leukocyte antigen-typed bone marrow registered donors was used as the donor population. Platelet compatibility was based on the grading system of Duquesnoy.Results:
Using the mathematical model, a pool containing 31,940, 1710 and 321 donors would be necessary to match more than 80% of the patients with at least five completely compatible (no cross-reactive group), partial compatible (one cross-reactive group) or less compatible (two cross-reactive group) donors, respectively.Conclusion:
The phenotypic diversity of the Brazilian population has probably made it more difficulty to find completely compatible donors. However, this heterogeneity seems to have facilitated finding donors when cross-reactive groups are accepted as proposed by the grading system of Duquesnoy. The results of this study may help to establish unrelated human leukocyte antigen-compatible platelet transfusions, a procedure not routinely performed in most Brazilian transfusion services.Palabras clave
Texto completo:
1
Banco de datos:
LILACS
Asunto principal:
Médula Ósea
/
Transfusión de Plaquetas
/
Antígenos HLA
Tipo de estudio:
Prognostic_studies
Límite:
Humans
País como asunto:
America do sul
/
Brasil
Idioma:
En
Año:
2016
Tipo del documento:
Article