Expression of gicerin, a cell adhesion molecule, in the abnormal retina in silver plumage color mutation of Japanese quail (Coturnix japonica).
Neurosci Lett
; 266(1): 53-6, 1999 Apr 30.
Article
en En
| MEDLINE
| ID: mdl-10336182
ABSTRACT
Silver plumage color mutant (B/B) quail has an abnormal retina characterizing the transdifferentiation of retinal pigment epithelium (RPE) following the retinal separation in the early developmental stage. In the present study; (i) the expression of gicerin, an immunoglobulin-superfamily cell adhesion molecule, was examined in the retina of B/B quail. In the wild-type quail, gicerin protein was enriched in the apical membrane (facing the neural retina, NR) of RPE cells on embryonic day (E) 4 and then appeared also in NR cells from E5. However, in the B/B retina, no gicerin expression was found in the transdifferentiation area of RPE prior to the retinal separation. (ii) In addition to this, microinjection of anti-gicerin polyclonal antibody into the eyeball of wild-type quail on E3 caused the retinal separation and induced the transdifferentiation of RPE into new NR. These observations suggest that the decrease of gicerin expression might participate in the retinal separation and RPE-transdifferentiation in B/B quail.
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Banco de datos:
MEDLINE
Asunto principal:
Retina
/
Pigmentación
/
Proteínas Portadoras
/
Moléculas de Adhesión Celular
/
Coturnix
/
Proteínas Aviares
/
Plumas
/
Mutación
/
Proteínas del Tejido Nervioso
Límite:
Animals
Idioma:
En
Año:
1999
Tipo del documento:
Article