The effect of cadmium (Cd) treatment on somatosensory evoked potentials (SEPs) and conduction velocity in alloxane-induced diabetic rats: relation to lipid peroxidation.

ABSTRACT

Fifty-two healthy Swiss male albino rats, aged three months, were divided into four groups Control (C), diabetic (D), cadmium (Cd), and diabetic + Cd (D+Cd). Diabetes was induced in D and D+Cd groups by administration of alloxane (5 mg/100 g). Cd and D+Cd groups were injected with CdCl2 i.p. (2 mg/kg/week) for 2 months. Somatosensory evoked potentials (SEPs) of the four groups were recorded following left posterior tibial nerve (PTN) stimulation. The mean latencies of P1, N1, P2 and N2 components were prolonged in all experimental groups compared with the control group. P1N1 and N1P2 amplitudes were significantly decreased in Cd and D+Cd groups in comparison with the control group. P2N2 amplitude was significantly decreased in the Cd group compared with the control group. In addition, conduction velocities and action potential amplitudes were determined from the sciatic nerves. The means of peripheral conduction velocities and action potential amplitudes were decreased significantly in all the experimental groups in comparison with the control group. Thiobarbituric acid reactive substances (TBARS), an indicator of lipid peroxidation, were increased in the kidneys and sciatic nerves of all experimental groups compared with the control group. A significant increase in the TBARS level of the brain was found in the Cd and D+Cd groups.