Cytokeratin markers in patients with prostatic diseases.
Anticancer Res
; 19(4A): 2649-52, 1999.
Article
en En
| MEDLINE
| ID: mdl-10470212
ABSTRACT
OBJECTIVES:
Recently tissue polypeptide specific antigen (TPS), a cytokeratin 18 marker, was described to be discriminative between cancer of the prostate (CaP) and benign prostatic hyperplasia (BPH). Cyfra 8/18, a marker which recognizes both cytokeratin 8 and 18 fragments, is thought to improve sensitivity and specificity of TPS. In our study we investigated the ability of the TPS and cyfra 8/18 serum concentration to discriminate between patients with clinically localized CaP and BPH.METHODS:
Serum levels of TPS and Cyfra 8/18 were determined in patients with untreated CaP (pT1-3pNoMo n = 11) and BPH (n = 22). The TPS and the Cyfra 8/18 concentrations were correlated to the prostate specific antigen (PSA) serum concentration.RESULTS:
Median TPS concentration was 45.3 U/L in CaP-patients and 54.8 U/L in BPH-patients. This difference is statistically not significant (p = 0.2). Median Cyfra 8/18 level was 0.64 ng/mL in CaP-patients and 0.57 ng/mL in BPH-patients. This difference is statistically not significant (p = 0.91). Furthermore no correlation with PSA levels could be established (TPS r = -0.13; Cyfra 8/18 r = 0.17).CONCLUSION:
In contrast to recent reports we found both cytokeratin markers, TPS as well as Cyfra 8/18, to be non-discriminative parameters in CaP and BPH.
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Banco de datos:
MEDLINE
Asunto principal:
Péptidos
/
Hiperplasia Prostática
/
Neoplasias de la Próstata
/
Biomarcadores de Tumor
/
Queratinas
Tipo de estudio:
Diagnostic_studies
Límite:
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
1999
Tipo del documento:
Article