MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis.
Nat Cell Biol
; 1(2): 94-7, 1999 Jun.
Article
en En
| MEDLINE
| ID: mdl-10559880
ABSTRACT
MAPKAP kinase 2 (MK2) is one of several kinases that are regulated through direct phosphorylation by p38 MAP kinase. By introducing a targeted mutation into the mouse MK2 gene, we have determined the physiological function of MK2 in vivo. Mice that lack MK2 show increased stress resistance and survive LPS-induced endotoxic shock. This is due to a reduction of approximately 90% in the production of tumor necrosis factor-alpha (TNF-alpha) and not to a change in signalling from the TNF receptor. The level and stability of TNF-alpha mRNA is not reduced and TNF-alpha secretion is not affected. We conclude that MK2 is an essential component in the inflammatory response which regulates biosynthesis of TNF-alpha at a post-transcriptional level.
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Banco de datos:
MEDLINE
Asunto principal:
Regulación de la Expresión Génica
/
Lipopolisacáridos
/
Citocinas
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Factor de Necrosis Tumoral alfa
/
Proteínas Serina-Treonina Quinasas
Límite:
Animals
Idioma:
En
Año:
1999
Tipo del documento:
Article