Blood eosinophilia in tacrolimus-treated patients: an indicator of Pneumocystis carinii pneumonia.
Transplantation
; 68(10): 1606-8, 1999 Nov 27.
Article
en En
| MEDLINE
| ID: mdl-10589963
ABSTRACT
BACKGROUND:
Pneumocystis carinii pneumonia (PcP) in immunocompromised patients is suggested if the following symptoms develop dyspnea, fever, and interstitial infiltrates on chest x-ray. We observed a significant blood eosinophilia in kidney recipients with PcP under immunosuppressive treatment with tacrolimus.METHODS:
Blood eosinophil counts of kidney recipients under immunosuppression with tacrolimus suffering from PcP were compared to eosinophil counts of patients without evidence of PcP and to patients showing PcP under immunosuppression with cyclosporine.RESULTS:
PcP-positive patients treated with tacrolimus showed a significantly higher blood eosinophil count compared to PcP-positive patients treated with cyclosporine (P=0.01), and to patients under immunosuppression with tacrolimus without PcP, respectively (P=0.006). Eosinophilia preceded the time of a definitive PcP diagnosis by bronchoalveolar lavage and decreased after successful treatment.CONCLUSIONS:
An increasing blood eosinophil count can be an indicator of P. carinii pneumonia in patients under immunosuppressive therapy with tacrolimus.
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Banco de datos:
MEDLINE
Asunto principal:
Neumonía por Pneumocystis
/
Trasplante de Riñón
/
Tacrolimus
/
Eosinofilia
/
Inmunosupresores
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
1999
Tipo del documento:
Article