Reversal of resistance in multidrug resistance protein (MRP1)-overexpressing cells by LY329146.
Bioorg Med Chem Lett
; 9(23): 3381-6, 1999 Dec 06.
Article
en En
| MEDLINE
| ID: mdl-10612603
ABSTRACT
The benzothiophene LY329146 reverses the drug resistance phenotype in multidrug resistance protein (MRP1)-overexpressing cells when dosed in combination with MRP1-associated oncolytics doxorubicin and vincristine. Additionally, LY329146 inhibited MRP1-mediated uptake of the MRP1 substrate LTC4 into membrane vesicles prepared from MRP1-overexpressing cells.
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Banco de datos:
MEDLINE
Asunto principal:
Sulfonamidas
/
Tiofenos
/
Resistencia a Múltiples Medicamentos
/
Transportadoras de Casetes de Unión a ATP
Límite:
Humans
Idioma:
En
Año:
1999
Tipo del documento:
Article