Double-blind comparison of addition of a second mood stabilizer versus an antidepressant to an initial mood stabilizer for treatment of patients with bipolar depression.
Am J Psychiatry
; 157(1): 124-6, 2000 Jan.
Article
en En
| MEDLINE
| ID: mdl-10618026
ABSTRACT
OBJECTIVE:
This study's purpose was to clarify the appropriate treatment of bipolar depression by comparing the addition of an antidepressant versus a second mood stabilizer for inpatients being treated with lithium carbonate or divalproex sodium.METHOD:
Twenty-seven patients were randomly assigned to groups that received double-blind treatment with paroxetine or a second mood stabilizer (lithium carbonate or divalproex sodium) for 6 weeks.RESULTS:
Both groups showed significant improvement in depressive symptoms during the 6-week trial. There were significantly more noncompleters in the group being treated with the two mood stabilizers than in the group being treated with a mood stabilizer and paroxetine.CONCLUSIONS:
Both treatments appeared to be effective; however, the addition of an antidepressant may have greater clinical utility in the treatment of bipolar depression.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Trastorno Bipolar
/
Ácido Valproico
/
Paroxetina
/
Cloruro de Litio
/
Antimaníacos
/
Antidepresivos de Segunda Generación
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Año:
2000
Tipo del documento:
Article