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Chlorpropamide toxicity with survival despite 27-day hypoglycemia.
Ciechanowski, K; Borowiak, K S; Potocka, B A; Nowacka, M; Dutkiewicz, G.
  • Ciechanowski K; Pomeranian Medical University, Szczecin, Poland.
J Toxicol Clin Toxicol ; 37(7): 869-71, 1999.
Article en En | MEDLINE | ID: mdl-10630272
ABSTRACT
CASE REPORT In the past 5 years at our institution, 12 cases involving the ingestion of chlorpropamide 3-15 g were fatal. We report a 23-year-old woman with an estimated ingestion of chlorpropamide 5-10 g. Initial cardiovascular collapse, attributed to the blockade of potassium channel transport, responded to intensive support including 3 days of cardiac pacing. Urinary excretion of chlorpropamide and hypoglycemia persisted until day 27. The toxic mechanisms and high risk of chlorpropamide are summarized. A fatal therapeutic dose ratio as low as 41 has made this antidiabetic agent obsolete.
Asunto(s)
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Banco de datos: MEDLINE Asunto principal: Clorpropamida / Hipoglucemia / Hipoglucemiantes Límite: Adult / Female / Humans Idioma: En Año: 1999 Tipo del documento: Article
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Banco de datos: MEDLINE Asunto principal: Clorpropamida / Hipoglucemia / Hipoglucemiantes Límite: Adult / Female / Humans Idioma: En Año: 1999 Tipo del documento: Article