Chlorpropamide toxicity with survival despite 27-day hypoglycemia.
J Toxicol Clin Toxicol
; 37(7): 869-71, 1999.
Article
en En
| MEDLINE
| ID: mdl-10630272
ABSTRACT
CASE REPORT In the past 5 years at our institution, 12 cases involving the ingestion of chlorpropamide 3-15 g were fatal. We report a 23-year-old woman with an estimated ingestion of chlorpropamide 5-10 g. Initial cardiovascular collapse, attributed to the blockade of potassium channel transport, responded to intensive support including 3 days of cardiac pacing. Urinary excretion of chlorpropamide and hypoglycemia persisted until day 27. The toxic mechanisms and high risk of chlorpropamide are summarized. A fatal therapeutic dose ratio as low as 41 has made this antidiabetic agent obsolete.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Clorpropamida
/
Hipoglucemia
/
Hipoglucemiantes
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Año:
1999
Tipo del documento:
Article