Study of omeprazole-gamma-cyclodextrin complexation in the solid state.
Drug Dev Ind Pharm
; 26(3): 253-9, 2000 Mar.
Article
en En
| MEDLINE
| ID: mdl-10738642
ABSTRACT
The possibility of obtaining inclusion complexes between omeprazole (OME) and gamma-cyclodextrin (gamma-CD) by kneading, spray-drying, coprecipitation, and freeze-drying was evaluated. All these methods lead to the isolation of a true inclusion compound, as evidenced by differential scanning calorimetry (DSC), infrared spectroscopy, and X-ray diffractometry on powder (PXRD). Moreover, PXRD and scanning electron microscopy (SEM) afforded data concerning crystallinity and surface characteristics of the solid phases obtained. In all cases, a significant increase of the release rate with respect to the drug alone was found, and it was attributed to the formation of an inclusion compound. Among the solid phases obtained, the comprecipitated product presented the highest dissolution rate.
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Banco de datos:
MEDLINE
Asunto principal:
Omeprazol
/
Ciclodextrinas
/
Antiulcerosos
Límite:
Humans
Idioma:
En
Año:
2000
Tipo del documento:
Article