Adaptive evolution of relish, a Drosophila NF-kappaB/IkappaB protein.
Genetics
; 154(3): 1231-8, 2000 Mar.
Article
en En
| MEDLINE
| ID: mdl-10757765
ABSTRACT
NF-kappaB and IkappaB proteins have central roles in regulation of inflammation and innate immunity in mammals. Homologues of these proteins also play an important role in regulation of the Drosophila immune response. Here we present a molecular population genetic analysis of Relish, a Drosophila NF-kappaB/IkappaB protein, in Drosophila simulans and D. melanogaster. We find strong evidence for adaptive protein evolution in D. simulans, but not in D. melanogaster. The adaptive evolution appears to be restricted to the IkappaB domain. A possible explanation for these results is that Relish is a site of evolutionary conflict between flies and their microbial pathogens.
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1
Banco de datos:
MEDLINE
Asunto principal:
Factores de Transcripción
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Evolución Molecular
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Proteínas de Insectos
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Proteínas de Drosophila
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Drosophila
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Drosophila melanogaster
Límite:
Animals
Idioma:
En
Año:
2000
Tipo del documento:
Article