Tec family kinases in lymphocyte signaling and function.

Schaeffer, E M; Schwartzberg, P L

Schaeffer, E M; Schwartzberg, P L.

Schaeffer EM; Department of Pathology, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. USA, USA. tschaeffer@uchichago.edu.

Curr Opin Immunol ; 12(3): 282-8, 2000 Jun.

Article en En | MEDLINE | ID: mdl-10781397

ABSTRACT

ABSTRACT

The Tec kinases are required for full Ca(2+) mobilization in lymphocytes. Recent data suggest that this process occurs via a multiprotein complex that includes LAT and SLP-76 in T cells and BLNK/SLP-65 in B cells. Mutational analyses have revealed critical roles for Tec kinases in lymphocyte development and function.

Asunto(s)

Linfocitos/inmunología; Proteínas Tirosina Quinasas/metabolismo; Receptores de Antígenos de Linfocitos T/metabolismo; Receptores de Antígenos/metabolismo; Linfocitos B/inmunología; Activación Enzimática; Modelos Inmunológicos; Receptores de Antígenos de Linfocitos B/metabolismo; Transducción de Señal; Linfocitos T/inmunología

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Banco de datos: MEDLINE Asunto principal: Proteínas Tirosina Quinasas / Linfocitos / Receptores de Antígenos / Receptores de Antígenos de Linfocitos T Idioma: En Año: 2000 Tipo del documento: Article

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