Alterations in splenic architecture and the localization of anti-double-stranded DNA B cells in aged mice.
Int Immunol
; 12(6): 915-26, 2000 Jun.
Article
en En
| MEDLINE
| ID: mdl-10837419
ABSTRACT
Aging is characterized by a decline in humoral immunity and a concommitant increased incidence of anti-DNA and other autoantibodies. To define how the regulation of autoreactive B cells is altered with age, we have used BALB/c mice with an Ig heavy H chain transgene to track the fate of anti-double-stranded (ds) DNA B cells in vivo. In young adult mice, anti-dsDNA B cells are developmentally arrested and excluded from the splenic B cell follicle, whereas in most aged mice they are mature and localize within the B cell follicle. Furthermore, we have detailed global changes in lymphoid architecture that accompany aging CD4(+) T cells are found not only in the periarteriolar lymphoid sheath, but also in the B cell follicles. Strikingly, these disruptions are similar to those that precede serum anti-dsDNA antibody expression in autoimmune MRL-lpr/lpr mice.
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Banco de datos:
MEDLINE
Asunto principal:
Bazo
/
Envejecimiento
/
ADN
/
Linfocitos B
/
Anticuerpos Antinucleares
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Año:
2000
Tipo del documento:
Article