[Attention deficit hyperactivity disorder. Cerebral asymmetry observed on magnetic resonance]. / Trastorno por déficit de atención con hiperactividad. Asimetrías cerebrales observadas en resonancia magnética.
Rev Neurol
; 30(10): 920-5, 2000.
Article
en Es
| MEDLINE
| ID: mdl-10919186
ABSTRACT
INTRODUCTION:
Anatomical and functional neuroimaging data from subjects with Attention Deficit Hyperactivity Disorder (ADHD) have consistently implicated a reversal of cerebral asymmetry and suggested a fronto-striatal dysfunction in this disorder.OBJECTIVE:
The aim of this study is to investigate the brain asymmetries in a homogeneous and non-medicated sample of adolescents with ADHD who had been previously studied in our laboratory. PATIENTS ANDMETHODS:
T1-weighted magnetic resonance images were obtained for 11 adolescents with ADHD and 19 control subjects. Frontal and posterior brain regions, caudate nucleus, and ventricular system were quantitatively measured.RESULTS:
A reversed pattern of asymmetry for the caudate nucleus (right > left) was found in ADHD when compared to the control group. We also found a reversed pattern of asymmetry for the frontal lobe (right < left) and a smaller right frontal volume (prefrontal specifically) in the ADHD subjects most severely impaired. Right caudate and frontal measures were inversely correlated.CONCLUSIONS:
ADHD is associated with fronto-striatal abnormalities, which may be explicable via extant neurodevelopmental theories. Enlargement of the right caudate nucleus may suggest the failure of a process of synaptic 'pruning' by which attentional functions could be improperly transferred from the basal ganglia to frontal regions during development.
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Banco de datos:
MEDLINE
Asunto principal:
Trastorno por Déficit de Atención con Hiperactividad
/
Encéfalo
Límite:
Adolescent
/
Female
/
Humans
/
Male
Idioma:
Es
Año:
2000
Tipo del documento:
Article