Discovery of novel and potent retinoic acid receptor alpha agonists: syntheses and evaluation of benzofuranyl-pyrrole and benzothiophenyl-pyrrole derivatives.
J Med Chem
; 43(15): 2929-37, 2000 Jul 27.
Article
en En
| MEDLINE
| ID: mdl-10956201
ABSTRACT
In the course of our studies on retinoic acid receptor (RAR) agonists, we have designed and synthesized a series of benzofuran and benzothiophene derivatives. Some of these compounds (1a,b,e,f,j) markedly inhibited LPS-induced B-lymphocyte proliferation and exerted RARalpha selectivity. One of them, 4-[5-(4,7-dimethylbenzofuran-2-yl)pyrrol-2-yl]benzoic acid (1b), when orally administered significantly inhibited mouse antibody production and delayed type hypersensitivity (DTH) responses from a dose of 0.1 mg/kg.
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Banco de datos:
MEDLINE
Asunto principal:
Pirroles
/
Linfocitos B
/
Receptores de Ácido Retinoico
/
Furanos
/
Inmunosupresores
Límite:
Animals
Idioma:
En
Año:
2000
Tipo del documento:
Article